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THIS WEEK IN PNAS

In This Issue
PNAS 2006 103: 17067-17068. [Full Text] [PDF]  

COMMENTARIES

Andrew Beenken and Moosa Mohammadi

Hedgehogs like it sweet, too
PNAS 2006 103: 17069-17070; published online before print November 6 2006, 10.1073/pnas.0608456103 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 17208

Craig A. Cooney

Germ cells carry the epigenetic benefits of grandmother's diet
PNAS 2006 103: 17071-17072; published online before print November 13 2006, 10.1073/pnas.0608653103 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 17308

Massimo Cristofanilli and John Mendelsohn

Circulating tumor cells in breast cancer: Advanced tools for "tailored" therapy?
PNAS 2006 103: 17073-17074; published online before print November 7 2006, 10.1073/pnas.0608651103 [Extract] [Full Text] [PDF]  
See companion article on page 17361

NOBEL LECTURE

Robert J. Aumann

War and peace
PNAS 2006 103: 17075-17078; published online before print November 8 2006, 10.1073/pnas.0608329103 [Extract] [Full Text] [PDF]  

SPECIAL FEATURE

Introductory Perspectives

Richard R. Schrock

Nitrogen Fixation Special Feature: Reduction of dinitrogen
PNAS 2006 103: 17087; published online before print November 6 2006, 10.1073/pnas.0603633103 [Extract] [Full Text] [PDF]  

Perspectives

James B. Howard and Douglas C. Rees

Nitrogen Fixation Special Feature: How many metals does it take to fix N₂? A mechanistic overview of biological nitrogen fixation
PNAS 2006 103: 17088-17093; published online before print November 6 2006, 10.1073/pnas.0603978103 [Abstract] [Full Text] [Figures Only] [PDF]  

Research Articles

Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk

Nitrogen Fixation Special Feature: Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen
PNAS 2006 103: 17094-17098; published online before print October 18 2006, 10.1073/pnas.0602132103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller

Nitrogen Fixation Special Feature: Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
PNAS 2006 103: 17099-17106; published online before print November 3 2006, 10.1073/pnas.0602778103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters

Nitrogen Fixation Special Feature: On the feasibility of N₂ fixation via a single-site Fe^I/Fe^IV cycle: Spectroscopic studies of Fe^I(N₂)Fe^I, Fe^IVN, and related species
PNAS 2006 103: 17107-17112; published online before print November 7 2006, 10.1073/pnas.0604402103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt

Nitrogen Fixation Special Feature: A methyldiazene (HNNCH₃)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
PNAS 2006 103: 17113-17118; published online before print November 6 2006, 10.1073/pnas.0602130103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe

From the Cover: Nitrogen Fixation Special Feature: FeMo cofactor maturation on NifEN
PNAS 2006 103: 17119-17124; published online before print October 18 2006, 10.1073/pnas.0602647103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe

From the Cover: Nitrogen Fixation Special Feature: Nitrogenase Fe protein: A molybdate/homocitrate insertase
PNAS 2006 103: 17125-17130; published online before print October 24 2006, 10.1073/pnas.0602651103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt

Nitrogen Fixation Special Feature: Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state
PNAS 2006 103: 17131-17136; published online before print November 3 2006, 10.1073/pnas.0603223103 [Abstract] [Full Text] [Figures Only] [PDF]  

PERSPECTIVES

Robert J. Aumann

War and peace
PNAS 2006 103: 17075-17078; published online before print November 8 2006, 10.1073/pnas.0608329103 [Extract] [Full Text] [PDF]  

James B. Howard and Douglas C. Rees

Nitrogen Fixation Special Feature: How many metals does it take to fix N₂? A mechanistic overview of biological nitrogen fixation
PNAS 2006 103: 17088-17093; published online before print November 6 2006, 10.1073/pnas.0603978103 [Abstract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Matthew E. Stewart, Nathan H. Mack, Viktor Malyarchuk, Julio A. N. T. Soares, Tae-Woo Lee, Stephen K. Gray, Ralph G. Nuzzo, and John A. Rogers Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals PNAS 2006 103: 17143-17148; published online before print November 3 2006, 10.1073/pnas.0606216103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Janina Kneipp, Harald Kneipp, and Katrin Kneipp Two-photon vibrational spectroscopy for biosciences based on surface-enhanced hyper-Raman scattering PNAS 2006 103: 17149-17153; published online before print November 6 2006, 10.1073/pnas.0608262103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Chemistry

Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk

Nitrogen Fixation Special Feature: Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen
PNAS 2006 103: 17094-17098; published online before print October 18 2006, 10.1073/pnas.0602132103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller

Nitrogen Fixation Special Feature: Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
PNAS 2006 103: 17099-17106; published online before print November 3 2006, 10.1073/pnas.0602778103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters

Nitrogen Fixation Special Feature: On the feasibility of N₂ fixation via a single-site Fe^I/Fe^IV cycle: Spectroscopic studies of Fe^I(N₂)Fe^I, Fe^IVN, and related species
PNAS 2006 103: 17107-17112; published online before print November 7 2006, 10.1073/pnas.0604402103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt

Nitrogen Fixation Special Feature: A methyldiazene (HNNCH₃)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
PNAS 2006 103: 17113-17118; published online before print November 6 2006, 10.1073/pnas.0602130103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci

The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution
PNAS 2006 103: 17154-17159; published online before print November 7 2006, 10.1073/pnas.0604048103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Tamara Niazov, Ronan Baron, Eugenii Katz, Oleg Lioubashevski, and Itamar Willner Concatenated logic gates using four coupled biocatalysts operating in series PNAS 2006 103: 17160-17163; published online before print November 6 2006, 10.1073/pnas.0608319103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Engineering

Igor V. Pivkin, Peter D. Richardson, and George Karniadakis

Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi
PNAS 2006 103: 17164-17169; published online before print November 3 2006, 10.1073/pnas.0608546103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movie]  

Environmental Sciences

Basil Gomez

The potential rate of bed-load transport
PNAS 2006 103: 17170-17173; published online before print November 6 2006, 10.1073/pnas.0608487103 [Abstract] [Full Text] [Figures Only] [PDF]  

Juan E. Keymer, Peter Galajda, Cecilia Muldoon, Sungsu Park, and Robert H. Austin Bacterial metapopulations in nanofabricated landscapes PNAS 2006 103: 17290-17295; published online before print November 7 2006, 10.1073/pnas.0607971103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Geology

Basil Gomez

The potential rate of bed-load transport
PNAS 2006 103: 17170-17173; published online before print November 6 2006, 10.1073/pnas.0608487103 [Abstract] [Full Text] [Figures Only] [PDF]  

Physics

Vladimir A. Belyi and M. Muthukumar

Electrostatic origin of the genome packing in viruses
PNAS 2006 103: 17174-17178; published online before print November 7 2006, 10.1073/pnas.0608311103 [Abstract] [Full Text] [Figures Only] [PDF]  

S. K. McCall, M. J. Fluss, B. W. Chung, M. W. McElfresh, D. D. Jackson, and G. F. Chapline

Emergent magnetic moments produced by self-damage in plutonium
PNAS 2006 103: 17179-17183; published online before print November 6 2006, 10.1073/pnas.0608552103 [Abstract] [Full Text] [Figures Only] [PDF]  

Statistics

Sustainability Science

Roger Angel

Feasibility of cooling the Earth with a cloud of small spacecraft near the inner Lagrange point (L1)
PNAS 2006 103: 17184-17189; published online before print November 3 2006, 10.1073/pnas.0608163103 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Psychology

Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson

Cognitive cladistics and cultural override in Hominid spatial cognition
PNAS 2006 103: 17568-17573; published online before print November 1 2006, 10.1073/pnas.0607999103 [Abstract] [Full Text] [Figures Only] [PDF]  

Sustainability Science

BIOLOGICAL SCIENCES

Anthropology

J. Koji Lum, James K. McIntyre, Douglas L. Greger, Kirk W. Huffman, and Miguel G. Vilar

Recent Southeast Asian domestication and Lapita dispersal of sacred male pseudohermaphroditic "tuskers" and hairless pigs of Vanuatu
PNAS 2006 103: 17190-17195; published online before print November 6 2006, 10.1073/pnas.0608220103 [Abstract] [Full Text] [Figures Only] [PDF]  

Andrei Soficaru, Adrian Dobos, and Erik Trinkaus

Early modern humans from the Petera Muierii, Baia de Fier, Romania
PNAS 2006 103: 17196-17201; published online before print November 3 2006, 10.1073/pnas.0608443103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Applied Biological Sciences

Bigang Liu, Eunmi Park, Feng Zhu, Tracie Bustos, Jinsong Liu, Jianjun Shen, Susan M. Fischer, and Yinling Hu

A critical role for IB kinase in the development of human and mouse squamous cell carcinomas
PNAS 2006 103: 17202-17207; published online before print November 1 2006, 10.1073/pnas.0604481103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt

Nitrogen Fixation Special Feature: A methyldiazene (HNNCH₃)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
PNAS 2006 103: 17113-17118; published online before print November 6 2006, 10.1073/pnas.0602130103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe

From the Cover: Nitrogen Fixation Special Feature: FeMo cofactor maturation on NifEN
PNAS 2006 103: 17119-17124; published online before print October 18 2006, 10.1073/pnas.0602647103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe

From the Cover: Nitrogen Fixation Special Feature: Nitrogenase Fe protein: A molybdate/homocitrate insertase
PNAS 2006 103: 17125-17130; published online before print October 24 2006, 10.1073/pnas.0602651103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt

Nitrogen Fixation Special Feature: Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state
PNAS 2006 103: 17131-17136; published online before print November 3 2006, 10.1073/pnas.0603223103 [Abstract] [Full Text] [Figures Only] [PDF]  

Jason S. McLellan, Shenqin Yao, Xiaoyan Zheng, Brian V. Geisbrecht, Rodolfo Ghirlando, Philip A. Beachy, and Daniel J. Leahy From the Cover: Structure of a heparin-dependent complex of Hedgehog and Ihog PNAS 2006 103: 17208-17213; published online before print October 31 2006, 10.1073/pnas.0606738103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 17069

Xiaoke Zhou, Gang Zhao, James J. Truglio, Liqun Wang, Guangtao Li, William J. Lennarz, and Hermann Schindelin

Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module
PNAS 2006 103: 17214-17219; published online before print November 6 2006, 10.1073/pnas.0602954103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jodie E. Guy, Isabel A. Abreu, Martin Moche, Ylva Lindqvist, Edward Whittle, and John Shanklin

A single mutation in the castor ⁹-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry
PNAS 2006 103: 17220-17224; published online before print November 6 2006, 10.1073/pnas.0607165103 [Abstract] [Full Text] [Figures Only] [PDF]  

Asokan Anbanandam, Diana C. Albarado, Catherine T. Nguyen, Georg Halder, Xiaolian Gao, and Sudha Veeraraghavan

Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain
PNAS 2006 103: 17225-17230; published online before print November 3 2006, 10.1073/pnas.0607171103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Vinod K. Batra, David D. Shock, Rajendra Prasad, William A. Beard, Esther W. Hou, Lars C. Pedersen, Jane M. Sayer, Haruhiko Yagi, Subodh Kumar, Donald M. Jerina, and Samuel H. Wilson Structure of DNA polymerase with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features PNAS 2006 103: 17231-17236; published online before print November 1 2006, 10.1073/pnas.0605069103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Xiaowen Yang, Wen Hwa Lee, Frank Sobott, Evangelos Papagrigoriou, Carol V. Robinson, J. Günter Grossmann, Michael Sundström, Declan A. Doyle, and Jonathan M. Elkins

Structural basis for protein–protein interactions in the 14-3-3 protein family
PNAS 2006 103: 17237-17242; published online before print November 3 2006, 10.1073/pnas.0605779103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Amanda L. McClerren, Lisa E. Cooper, Chao Quan, Paul M. Thomas, Neil L. Kelleher, and Wilfred A. van der Donk

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
PNAS 2006 103: 17243-17248; published online before print November 3 2006, 10.1073/pnas.0606088103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci

The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution
PNAS 2006 103: 17154-17159; published online before print November 7 2006, 10.1073/pnas.0604048103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Vladimir A. Belyi and M. Muthukumar

Electrostatic origin of the genome packing in viruses
PNAS 2006 103: 17174-17178; published online before print November 7 2006, 10.1073/pnas.0608311103 [Abstract] [Full Text] [Figures Only] [PDF]  

David F. Holmes and Karl E. Kadler

The 10+4 microfibril structure of thin cartilage fibrils
PNAS 2006 103: 17249-17254; published online before print November 6 2006, 10.1073/pnas.0608417103 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Olga Sozinova, Yi Jiang, Dale Kaiser, and Mark Alber

A three-dimensional model of myxobacterial fruiting-body formation
PNAS 2006 103: 17255-17259; published online before print November 6 2006, 10.1073/pnas.0605555103 [Abstract] [Full Text] [Figures Only] [PDF]  

Giovanni Ferrari, Giuseppe Pintucci, Graziano Seghezzi, Kevin Hyman, Aubrey C. Galloway, and Paolo Mignatti

VEGF, a prosurvival factor, acts in concert with TGF-1 to induce endothelial cell apoptosis
PNAS 2006 103: 17260-17265; published online before print November 6 2006, 10.1073/pnas.0605556103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Shuibing Chen, Jeong Tae Do, Qisheng Zhang, Shuyuan Yao, Feng Yan, Eric C. Peters, Hans R. Schöler, Peter G. Schultz, and Sheng Ding

Self-renewal of embryonic stem cells by a small molecule
PNAS 2006 103: 17266-17271; published online before print November 6 2006, 10.1073/pnas.0608156103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Li Zhang, Ji Li, Lawrence H. Young, and Michael J. Caplan

AMP-activated protein kinase regulates the assembly of epithelial tight junctions
PNAS 2006 103: 17272-17277; published online before print November 6 2006, 10.1073/pnas.0608531103 [Abstract] [Full Text] [Figures Only] [PDF]  

Keiko Horiuchi, Michihisa Umetani, Takashi Minami, Hiroto Okayama, Shinji Takada, Masayuki Yamamoto, Hiroyuki Aburatani, Patrick C. Reid, David E. Housman, Takao Hamakubo, and Tatsuhiko Kodama Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA PNAS 2006 103: 17278-17283; published online before print November 6 2006, 10.1073/pnas.0608357103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Developmental Biology

Xiaoqun Wang, Nan Yang, Etsuko Uno, Robert G. Roeder, and Su Guo

A subunit of the mediator complex regulates vertebrate neuronal development
PNAS 2006 103: 17284-17289; published online before print November 6 2006, 10.1073/pnas.0605414103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Evolution

Jeheskel Shoshani, Robert C. Walter, Michael Abraha, Seife Berhe, Pascal Tassy, William J. Sanders, Gary H. Marchant, Yosief Libsekal, Tesfalidet Ghirmai, and Dietmar Zinner

A proboscidean from the late Oligocene of Eritrea, a "missing link" between early Elephantiformes and Elephantimorpha, and biogeographic implications
PNAS 2006 103: 17296-17301; published online before print November 3 2006, 10.1073/pnas.0603689103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendices]  

Jan E. Aagaard, Xianhua Yi, Michael J. MacCoss, and Willie J. Swanson

Rapidly evolving zona pellucida domain proteins are a major component of the vitelline envelope of abalone eggs
PNAS 2006 103: 17302-17307; published online before print November 3 2006, 10.1073/pnas.0603125103 [Abstract] [Full Text] [Figures Only] [PDF]  

Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson

Cognitive cladistics and cultural override in Hominid spatial cognition
PNAS 2006 103: 17568-17573; published online before print November 1 2006, 10.1073/pnas.0607999103 [Abstract] [Full Text] [Figures Only] [PDF]  

Genetics

Nicolai Peschel, Shobi Veleri, and Ralf Stanewsky

Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock
PNAS 2006 103: 17313-17318; published online before print October 26 2006, 10.1073/pnas.0606675103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 17583

Elisabeth Kugelberg, Eric Kofoid, Andrew B. Reams, Dan I. Andersson, and John R. Roth Multiple pathways of selected gene amplification during adaptive mutation PNAS 2006 103: 17319-17324; published online before print November 2 2006, 10.1073/pnas.0608309103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text] OPEN ACCESS ARTICLE

Federica Marini, Tiziana Nardo, Michele Giannattasio, Mario Minuzzo, Miria Stefanini, Paolo Plevani, and Marco Muzi Falconi

DNA nucleotide excision repair-dependent signaling to checkpoint activation
PNAS 2006 103: 17325-17330; published online before print November 6 2006, 10.1073/pnas.0605446103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Weichang Yu, Jonathan C. Lamb, Fangpu Han, and James A. Birchler

Telomere-mediated chromosomal truncation in maize
PNAS 2006 103: 17331-17336; published online before print November 3 2006, 10.1073/pnas.0605750103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Long-Cheng Li, Steven T. Okino, Hong Zhao, Deepa Pookot, Robert F. Place, Shinji Urakami, Hideki Enokida, and Rajvir Dahiya

Small dsRNAs induce transcriptional activation in human cells
PNAS 2006 103: 17337-17342; published online before print November 3 2006, 10.1073/pnas.0607015103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Ayuko Sato, Melissa M. Linehan, and Akiko Iwasaki

Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
PNAS 2006 103: 17343-17348; published online before print November 3 2006, 10.1073/pnas.0605102103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jiri Kohoutek, Dalibor Blazek, and B. Matija Peterlin

Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
PNAS 2006 103: 17349-17354; published online before print November 6 2006, 10.1073/pnas.0603079103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Songdong Meng, Debu Tripathy, Sanjay Shete, Raheela Ashfaq, Hossein Saboorian, Barbara Haley, Eugene Frenkel, David Euhus, Marilyn Leitch, Cynthia Osborne, Edward Clifford, Steve Perkins, Peter Beitsch, Amanullah Khan, Larry Morrison, Dorothee Herlyn, Leon W. M. M. Terstappen, Nancy Lane, Jianqiang Wang, and Jonathan Uhr

uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues
PNAS 2006 103: 17361-17365; published online before print November 1 2006, 10.1073/pnas.0608113103 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 17073

Daniela Sanges, Antonella Comitato, Roberta Tammaro, and Valeria Marigo

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors
PNAS 2006 103: 17366-17371; published online before print November 6 2006, 10.1073/pnas.0606276103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Bruce L. Levine, Laurent M. Humeau, Jean Boyer, Rob-Roy MacGregor, Tessio Rebello, Xiaobin Lu, Gwendolyn K. Binder, Vladimir Slepushkin, Franck Lemiale, John R. Mascola, Frederic D. Bushman, Boro Dropulic, and Carl H. June Gene transfer in humans using a conditionally replicating lentiviral vector PNAS 2006 103: 17372-17377; published online before print November 7 2006, 10.1073/pnas.0608138103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Min Xie, Dou Zhang, Jason R. B. Dyck, Yi Li, Hui Zhang, Masae Morishima, Douglas L. Mann, George E. Taffet, Antonio Baldini, Dirar S. Khoury, and Michael D. Schneider

A pivotal role for endogenous TGF--activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
PNAS 2006 103: 17378-17383; published online before print November 3 2006, 10.1073/pnas.0604708103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Babak Oskouian, Prathap Sooriyakumaran, Alexander D. Borowsky, Angelina Crans, Lisa Dillard-Telm, Yuen Yee Tam, Padmavathi Bandhuvula, and Julie D. Saba

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
PNAS 2006 103: 17384-17389; published online before print November 7 2006, 10.1073/pnas.0600050103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Seok-Geun Lee, Zao-Zhong Su, Luni Emdad, Devanand Sarkar, and Paul B. Fisher

Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
PNAS 2006 103: 17390-17395; published online before print November 6 2006, 10.1073/pnas.0608386103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zhijun Du, Katrina Podsypanina, Shixia Huang, Amanda McGrath, Michael J. Toneff, Ekaterina Bogoslovskaia, Xiaomei Zhang, Ricardo C. Moraes, Michele Fluck, D. Craig Allred, Michael T. Lewis, Harold E. Varmus, and Yi Li Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models PNAS 2006 103: 17396-17401; published online before print November 7 2006, 10.1073/pnas.0608607103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]