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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 4241-4242. [Full Text] [PDF]  

COMMENTARIES

Alexander J. Ninfa

Regulation of carbon and nitrogen metabolism: Adding regulation of ion channels and another second messenger to the mix
PNAS 2007 104: 4243-4244; published online before print March 7 2007, 10.1073/pnas.0700325104 [Extract] [Full Text] [PDF]  
See companion article on page 4124 in issue 10 of volume 104

Guillermina Lozano and Richard R. Behringer

New mouse models of cancer: Single-cell knockouts
PNAS 2007 104: 4245-4246; published online before print March 5 2007, 10.1073/pnas.0700173104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4495
See companion article on page 4501

John Z. Kiss

Where's the water? Hydrotropism in plants
PNAS 2007 104: 4247-4248; published online before print March 12 2007, 10.1073/pnas.0700846104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4724

PHYSICAL SCIENCES

Applied Mathematics

Gurinder Singh Atwal, Gareth L. Bond, Sally Metsuyanim, Moshe Papa, Eitan Friedman, Tal Distelman-Menachem, Edna Ben Asher, Doron Lancet, David A. Ross, John Sninsky, Tomas J. White, Arnold J. Levine, and Ronit Yarden

Haplotype structure and selection of the MDM2 oncogene in humans
PNAS 2007 104: 4524-4529; published online before print March 5 2007, 10.1073/pnas.0610998104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Environmental Sciences

SOCIAL SCIENCES

Anthropology

BIOLOGICAL SCIENCES

Anthropology

Applied Biological Sciences

Anubhav Arora, Itzhak Hakim, Joy Baxter, Ruben Rathnasingham, Ravi Srinivasan, Daniel A. Fletcher, and Samir Mitragotri

Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
PNAS 2007 104: 4255-4260; published online before print March 6 2007, 10.1073/pnas.0700182104 [Abstract] [Full Text] [Figures Only] [PDF]  

Biochemistry

Lulu Huang, Lou Massa, and Jerome Karle

Drug target interaction energies by the kernel energy method in aminoglycoside drugs and ribosomal A site RNA targets
PNAS 2007 104: 4261-4266; published online before print March 1 2007, 10.1073/pnas.0610533104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Christian Castro, Eric Smidansky, Kenneth R. Maksimchuk, Jamie J. Arnold, Victoria S. Korneeva, Matthias Götte, William Konigsberg, and Craig E. Cameron

Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
PNAS 2007 104: 4267-4272; published online before print March 5 2007, 10.1073/pnas.0608952104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas Chertemps, Line Duportets, Carole Labeur, Ryu Ueda, Kuniaki Takahashi, Kaoru Saigo, and Claude Wicker-Thomas

A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster
PNAS 2007 104: 4273-4278; published online before print March 6 2007, 10.1073/pnas.0608142104 [Abstract] [Full Text] [Figures Only] [PDF]  

Dmitry A. Rodionov, Oleg V. Kurnasov, Boguslaw Stec, Yan Wang, Mary F. Roberts, and Andrei L. Osterman

Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate
PNAS 2007 104: 4279-4284; published online before print March 2 2007, 10.1073/pnas.0609279104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shinsuke Muto, Miki Senda, Yusuke Akai, Lui Sato, Toru Suzuki, Ryozo Nagai, Toshiya Senda, and Masami Horikoshi Relationship between the structure of SET/TAF-I/INHAT and its histone chaperone activity PNAS 2007 104: 4285-4290; published online before print March 6 2007, 10.1073/pnas.0603762104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Chen Davidovich, Anat Bashan, Tamar Auerbach-Nevo, Rachel D. Yaggie, Richard R. Gontarek, and Ada Yonath Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity PNAS 2007 104: 4291-4296; published online before print March 8 2007, 10.1073/pnas.0700041104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Liang Guo, Aidong Han, Darren L. Bates, Jue Cao, and Lin Chen

Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains
PNAS 2007 104: 4297-4302; published online before print March 5 2007, 10.1073/pnas.0608041104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Filippo Mancia, Susan Brenner-Morton, Risa Siegel, Zahra Assur, Yonghua Sun, Ira Schieren, Monica Mendelsohn, Richard Axel, and Wayne A. Hendrickson

Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor
PNAS 2007 104: 4303-4308; published online before print March 6 2007, 10.1073/pnas.0700301104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Fusheng Guo and Sankar Adhya

Spiral structure of Escherichia coli HU provides foundation for DNA supercoiling
PNAS 2007 104: 4309-4314; published online before print March 5 2007, 10.1073/pnas.0611686104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Masaki Nojiri, Yong Xie, Tsuyoshi Inoue, Takahiko Yamamoto, Hiroyoshi Matsumura, Kunishige Kataoka, Deligeer, Kazuya Yamaguchi, Yasushi Kai, and Shinnichiro Suzuki

Structure and function of a hexameric copper-containing nitrite reductase
PNAS 2007 104: 4315-4320; published online before print March 5 2007, 10.1073/pnas.0609195104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lori Buetow, Terry K. Smith, Alice Dawson, Stewart Fyffe, and William N. Hunter Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis PNAS 2007 104: 4321-4326; published online before print March 5 2007, 10.1073/pnas.0606356104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Vladimir V. Bulygin and Yakov M. Milgrom

Studies of nucleotide binding to the catalytic sites of Escherichia coli Y331W-F₁-ATPase using fluorescence quenching
PNAS 2007 104: 4327-4331; published online before print March 5 2007, 10.1073/pnas.0700078104 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

Juwen Shen, Jian Zhang, Xiaomin Luo, Weiliang Zhu, Kunqian Yu, Kaixian Chen, Yixue Li, and Hualiang Jiang

Predicting protein–protein interactions based only on sequences information
PNAS 2007 104: 4337-4341; published online before print March 5 2007, 10.1073/pnas.0607879104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alexander Negoda, Mo Xian, and Rosetta N. Reusch

Insight into the selectivity and gating functions of Streptomyces lividans KcsA
PNAS 2007 104: 4342-4346; published online before print March 6 2007, 10.1073/pnas.0700495104 [Abstract] [Full Text] [Figures Only] [PDF]  

Tong Liu, Steven T. Whitten, and Vincent J. Hilser

Functional residues serve a dominant role in mediating the cooperativity of the protein ensemble
PNAS 2007 104: 4347-4352; published online before print March 5 2007, 10.1073/pnas.0607132104 [Abstract] [Full Text] [Figures Only] [PDF]  

Dmitri Ivanov, Oleg V. Tsodikov, Jeremy Kasanov, Tom Ellenberger, Gerhard Wagner, and Tucker Collins

Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
PNAS 2007 104: 4353-4358; published online before print March 5 2007, 10.1073/pnas.0609477104 [Abstract] [Full Text] [Figures Only] [PDF]  

Peter C. M. van Zijl, Craig K. Jones, Jimin Ren, Craig R. Malloy, and A. Dean Sherry

MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST)
PNAS 2007 104: 4359-4364; published online before print March 5 2007, 10.1073/pnas.0700281104 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Ralph S. Pero, Michael T. Borchers, Karsten Spicher, Sergei I. Ochkur, Lyudmila Sikora, Savita P. Rao, Hiam Abdala-Valencia, Katie R. O'Neill, Huahao Shen, Michael P. McGarry, Nancy A. Lee, Joan M. Cook-Mills, P. Sriramarao, Melvin I. Simon, Lutz Birnbaumer, and James J. Lee

G_i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
PNAS 2007 104: 4371-4376; published online before print March 7 2007, 10.1073/pnas.0700185104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jens Fielitz, Eva van Rooij, Jeffrey A. Spencer, John M. Shelton, Shuaib Latif, Roel van der Nagel, Svetlana Bezprozvannaya, Leon de Windt, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson

Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction
PNAS 2007 104: 4377-4382; published online before print March 2 2007, 10.1073/pnas.0611726104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mark E. Burkard, Catherine L. Randall, Stéphane Larochelle, Chao Zhang, Kevan M. Shokat, Robert P. Fisher, and Prasad V. Jallepalli

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
PNAS 2007 104: 4383-4388; published online before print March 6 2007, 10.1073/pnas.0701140104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Stephanie J. Leuenroth, Dayne Okuhara, Joseph D. Shotwell, Glen S. Markowitz, Zhiheng Yu, Stefan Somlo, and Craig M. Crews

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
PNAS 2007 104: 4389-4394; published online before print March 6 2007, 10.1073/pnas.0700499104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Fan Zhang, Jason H. Pomerantz, George Sen, Adam T. Palermo, and Helen M. Blau

Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons
PNAS 2007 104: 4395-4400; published online before print March 7 2007, 10.1073/pnas.0700181104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

James A. Timmons, Kristian Wennmalm, Ola Larsson, Tomas B. Walden, Timo Lassmann, Natasa Petrovic, D. Lee Hamilton, Ruth E. Gimeno, Claes Wahlestedt, Keith Baar, Jan Nedergaard, and Barbara Cannon Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages PNAS 2007 104: 4401-4406; published online before print March 5 2007, 10.1073/pnas.0610615104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Christian Zuber, James H. Cormier, Bruno Guhl, Roger Santimaria, Daniel N. Hebert, and Jürgen Roth EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites PNAS 2007 104: 4407-4412; published online before print March 6 2007, 10.1073/pnas.0700154104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Xiaoqing Liu, Oleg V. Bulgakov, Keith N. Darrow, Basil Pawlyk, Michael Adamian, M. Charles Liberman, and Tiansen Li

Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells
PNAS 2007 104: 4413-4418; published online before print March 5 2007, 10.1073/pnas.0610950104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Oliver Strobel, Yuval Dor, Amy Stirman, Amanda Trainor, Carlos Fernández-del Castillo, Andrew L. Warshaw, and Sarah P. Thayer cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo PNAS 2007 104: 4419-4424; published online before print March 7 2007, 10.1073/pnas.0605248104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jörg Moelleken, Jörg Malsam, Matthew J. Betts, Ali Movafeghi, Ingeborg Reckmann, Ingrid Meissner, Andrea Hellwig, Robert B. Russell, Thomas Söllner, Britta Brügger, and Felix T. Wieland

Differential localization of coatomer complex isoforms within the Golgi apparatus
PNAS 2007 104: 4425-4430; published online before print March 7 2007, 10.1073/pnas.0611360104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alain Beliveau, Ekaterina Bassett, Alvin T. Lo, James Garbe, Miguel A. Rubio, Mina J. Bissell, Judith Campisi, and Paul Yaswen

p53-dependent integration of telomere and growth factor deprivation signals
PNAS 2007 104: 4431-4436; published online before print March 5 2007, 10.1073/pnas.0700260104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Developmental Biology

Elena Vasyutina, Diana C. Lenhard, Hagen Wende, Bettina Erdmann, Jonathan A. Epstein, and Carmen Birchmeier RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells PNAS 2007 104: 4443-4448; published online before print March 7 2007, 10.1073/pnas.0610647104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Dachun Wang, David L. Haviland, Alan R. Burns, Eva Zsigmond, and Rick A. Wetsel

A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells
PNAS 2007 104: 4449-4454; published online before print March 2 2007, 10.1073/pnas.0700052104 [Abstract] [Full Text] [Figures Only] [PDF]  

Sophia H. L. George, Marina Gertsenstein, Kristina Vintersten, Ella Korets-Smith, John Murphy, Mary E. Stevens, Jody J. Haigh, and Andras Nagy

Developmental and adult phenotyping directly from mutant embryonic stem cells
PNAS 2007 104: 4455-4460; published online before print March 2 2007, 10.1073/pnas.0609277104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Environmental Sciences

Evolution

Bingye Xue, Alejandro P. Rooney, Masaki Kajikawa, Norihiro Okada, and Wendell L. Roelofs

Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion
PNAS 2007 104: 4467-4472; published online before print March 5 2007, 10.1073/pnas.0700422104 [Abstract] [Full Text] [Figures Only] [PDF]  

Robert G. Wallace, HoangMinh HoDac, Richard H. Lathrop, and Walter M. Fitch

A statistical phylogeography of influenza A H5N1
PNAS 2007 104: 4473-4478; published online before print March 7 2007, 10.1073/pnas.0700435104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jeffrey P. Hoover and Scott K. Robinson

Retaliatory mafia behavior by a parasitic cowbird favors host acceptance of parasitic eggs
PNAS 2007 104: 4479-4483; published online before print March 5 2007, 10.1073/pnas.0609710104 [Abstract] [Full Text] [Figures Only] [PDF]  

Wyatt W. Anderson, Yong-Kyu Kim, and Patricia Adair Gowaty

Experimental constraints on mate preferences in Drosophila pseudoobscura decrease offspring viability and fitness of mated pairs
PNAS 2007 104: 4484-4488; published online before print March 6 2007, 10.1073/pnas.0611152104 [Abstract] [Full Text] [Figures Only] [PDF]  

In-Geol Choi and Sung-Hou Kim Global extent of horizontal gene transfer PNAS 2007 104: 4489-4494; published online before print March 7 2007, 10.1073/pnas.0611557104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Genetics

Wei Wang, Madhuri Warren, and Allan Bradley From the Cover: Induced mitotic recombination of p53 in vivo PNAS 2007 104: 4501-4505; published online before print March 5 2007, 10.1073/pnas.0607953104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 4245

Carmine Settembre, Ida Annunziata, Carmine Spampanato, Daniela Zarcone, Gilda Cobellis, Edoardo Nusco, Ester Zito, Carlo Tacchetti, Maria Pia Cosma, and Andrea Ballabio Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency PNAS 2007 104: 4506-4511; published online before print March 6 2007, 10.1073/pnas.0700382104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Bridget M. Riley, M. Adela Mansilla, Jinghong Ma, Sandra Daack-Hirsch, Brion S. Maher, Lisa M. Raffensperger, Erilynn T. Russo, Alexandre R. Vieira, Catherine Dodé, Moosa Mohammadi, Mary L. Marazita, and Jeffrey C. Murray Impaired FGF signaling contributes to cleft lip and palate PNAS 2007 104: 4512-4517; published online before print March 6 2007, 10.1073/pnas.0607956104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Shan Zha, Frederick W. Alt, Hwei-Ling Cheng, James W. Brush, and Gang Li

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
PNAS 2007 104: 4518-4523; published online before print March 7 2007, 10.1073/pnas.0611734104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Gurinder Singh Atwal, Gareth L. Bond, Sally Metsuyanim, Moshe Papa, Eitan Friedman, Tal Distelman-Menachem, Edna Ben Asher, Doron Lancet, David A. Ross, John Sninsky, Tomas J. White, Arnold J. Levine, and Ronit Yarden

Haplotype structure and selection of the MDM2 oncogene in humans
PNAS 2007 104: 4524-4529; published online before print March 5 2007, 10.1073/pnas.0610998104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Haijin Meng, Iset Vera, Nam Che, Xuping Wang, Susanna S. Wang, Leslie Ingram-Drake, Eric E. Schadt, Thomas A. Drake, and Aldons J. Lusis

Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
PNAS 2007 104: 4530-4535; published online before print March 6 2007, 10.1073/pnas.0607620104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiaoyu Zhang, Ian R. Henderson, Cheng Lu, Pamela J. Green, and Steven E. Jacobsen Role of RNA polymerase IV in plant small RNA metabolism PNAS 2007 104: 4536-4541; published online before print March 5 2007, 10.1073/pnas.0611456104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Yang Yang, James W. Tung, Eliver E. B. Ghosn, Leonard A. Herzenberg, and Leonore A. Herzenberg

Division and differentiation of natural antibody-producing cells in mouse spleen
PNAS 2007 104: 4542-4546; published online before print March 7 2007, 10.1073/pnas.0700001104 [Abstract] [Full Text] [Figures Only] [PDF]  

Kondala R. Atkuri, Leonard A. Herzenberg, Anna-Kaisa Niemi, Tina Cowan, and Leonore A. Herzenberg

Importance of culturing primary lymphocytes at physiological oxygen levels
PNAS 2007 104: 4547-4552; published online before print March 5 2007, 10.1073/pnas.0611732104 [Abstract] [Full Text] [Figures Only] [PDF]  

Zacarias Garcia, Emmanuelle Pradelli, Susanna Celli, Hélène Beuneu, Aurélie Simon, and Philippe Bousso

Competition for antigen determines the stability of T cell–dendritic cell interactions during clonal expansion
PNAS 2007 104: 4553-4558; published online before print March 2 2007, 10.1073/pnas.0610019104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Monita Poudyal, Sabrina Rosa, Anahid E. Powell, Maria Moreno, Stephen L. Dellaporta, Leo W. Buss, and Fadi G. Lakkis

Embryonic chimerism does not induce tolerance in an invertebrate model organism
PNAS 2007 104: 4559-4564; published online before print March 5 2007, 10.1073/pnas.0608696104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Paola Agnellini, Petra Wolint, Manuela Rehr, Julia Cahenzli, Urs Karrer, and Annette Oxenius Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection PNAS 2007 104: 4565-4570; published online before print March 7 2007, 10.1073/pnas.0610335104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Bin Li, Arabinda Samanta, Xiaomin Song, Kathryn T. Iacono, Kathryn Bembas, Ran Tao, Samik Basu, James L. Riley, Wayne W. Hancock, Yuan Shen, Sandra J. Saouaf, and Mark I. Greene

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
PNAS 2007 104: 4571-4576; published online before print March 7 2007, 10.1073/pnas.0700298104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Shan Liao, Kevin Bentley, Marielle Lebrun, Werner Lesslauer, Frank H. Ruddle, and Nancy H. Ruddle

Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules
PNAS 2007 104: 4577-4582; published online before print March 5 2007, 10.1073/pnas.0700334104 [Abstract] [Full Text] [Figures Only] [PDF]  

Irina Gavanescu, Benedikt Kessler, Hidde Ploegh, Christophe Benoist, and Diane Mathis

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
PNAS 2007 104: 4583-4587; published online before print March 6 2007, 10.1073/pnas.0700259104 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Cornelius Miething, Rebekka Grundler, Claudia Mugler, Simone Brero, Josef Hoepfl, Jochen Geigl, Michael R. Speicher, Oliver Ottmann, Christian Peschel, and Justus Duyster Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment PNAS 2007 104: 4594-4599; published online before print March 5 2007, 10.1073/pnas.0604716104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Bryan L. Krock, Joseph Bilotta, and Brian D. Perkins Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia PNAS 2007 104: 4600-4605; published online before print March 5 2007, 10.1073/pnas.0605818104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Microbiology

Lixin Zhang, Kezhi Yan, Yu Zhang, Ren Huang, Jiang Bian, Chuansen Zheng, Haixiang Sun, Zhihui Chen, Nuo Sun, Rong An, Fangui Min, Weibo Zhao, Ying Zhuo, Jianlan You, Yongjie Song, Zhenyan Yu, Zhiheng Liu, Keqian Yang, Hong Gao, Huanqin Dai, Xiaoli Zhang, Jian Wang, Chengzhang Fu, Gang Pei, Jintao Liu, Si Zhang, Michael Goodfellow, Yuanying Jiang, Jun Kuai, Guochun Zhou, and Xiaoping Chen

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections
PNAS 2007 104: 4606-4611; published online before print March 5 2007, 10.1073/pnas.0609370104 [Abstract] [Full Text] [Figures Only] [PDF]  

Sune Lobedanz, Evert Bokma, Martyn F. Symmons, Eva Koronakis, Colin Hughes, and Vassilis Koronakis

A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
PNAS 2007 104: 4612-4617; published online before print March 5 2007, 10.1073/pnas.0610160104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Huan Zhang, Yubo Hou, Lilibeth Miranda, David A. Campbell, Nancy R. Sturm, Terry Gaasterland, and Senjie Lin

Spliced leader RNA trans-splicing in dinoflagellates
PNAS 2007 104: 4618-4623; published online before print March 2 2007, 10.1073/pnas.0700258104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Antonio DiGiandomenico, Jayasimha Rao, Katie Harcher, Tanweer S. Zaidi, Jason Gardner, Alice N. Neely, Gerald B. Pier, and Joanna B. Goldberg

Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections
PNAS 2007 104: 4624-4629; published online before print March 5 2007, 10.1073/pnas.0608657104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marc T. Facciotti, David J. Reiss, Min Pan, Amardeep Kaur, Madhavi Vuthoori, Richard Bonneau, Paul Shannon, Alok Srivastava, Samuel M. Donohoe, Leroy E. Hood, and Nitin S. Baliga

General transcription factor specified global gene regulation in archaea
PNAS 2007 104: 4630-4635; published online before print March 7 2007, 10.1073/pnas.0611663104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

David M. Raskin, Nicholas Judson, and John J. Mekalanos

Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae
PNAS 2007 104: 4636-4641; published online before print March 5 2007, 10.1073/pnas.0611650104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Neuroscience

Jennifer L. Warner-Schmidt and Ronald S. Duman

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
PNAS 2007 104: 4647-4652; published online before print March 5 2007, 10.1073/pnas.0610282104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Fred W. Wolf, Mark Eddison, Seonok Lee, William Cho, and Ulrike Heberlein

GSK-3/Shaggy regulates olfactory habituation in Drosophila
PNAS 2007 104: 4653-4657; published online before print March 6 2007, 10.1073/pnas.0700493104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Luis M. Valor, Paul Charlesworth, Lawrence Humphreys, Chris N. G. Anderson, and Seth G. N. Grant Network activity-independent coordinated gene expression program for synapse assembly PNAS 2007 104: 4658-4663; published online before print March 5 2007, 10.1073/pnas.0609071104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Ruifa Mi, Weiran Chen, and Ahmet Höke From the Cover: Pleiotrophin is a neurotrophic factor for spinal motor neurons PNAS 2007 104: 4664-4669; published online before print March 5 2007, 10.1073/pnas.0603243104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Elena Choleris, Steven R. Little, Jessica A. Mong, Sidharth V. Puram, Robert Langer, and Donald W. Pfaff

Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice
PNAS 2007 104: 4670-4675; published online before print March 5 2007, 10.1073/pnas.0700670104 [Abstract] [Full Text] [Figures Only] [PDF]  

E. Dong, A. Guidotti, D. R. Grayson, and E. Costa Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters PNAS 2007 104: 4676-4681; published online before print March 7 2007, 10.1073/pnas.0700529104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Yanhong Liao, Christian Erxleben, Eda Yildirim, Joel Abramowitz, David L. Armstrong, and Lutz Birnbaumer

Orai proteins interact with TRPC channels and confer responsiveness to store depletion
PNAS 2007 104: 4682-4687; published online before print March 7 2007, 10.1073/pnas.0611692104 [Abstract] [Full Text] [Figures Only] [PDF]  

Aaron M. Rozeboom, Huda Akil, and Audrey F. Seasholtz

Mineralocorticoid receptor overexpression in forebrain decreases anxiety-lik