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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 4771-4772. [Full Text] [PDF]  

COMMENTARIES

James C. Wang

Unlocking and opening a DNA gate
PNAS 2007 104: 4773-4774; published online before print March 15 2007, 10.1073/pnas.0701070104 [Extract] [Full Text] [PDF]  
See companion article on page 4840

Scott E. Miller

DNA barcoding and the renaissance of taxonomy
PNAS 2007 104: 4775-4776; published online before print March 15 2007, 10.1073/pnas.0700466104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4967

Bruce R. Conklin

New tools to build synthetic hormonal pathways
PNAS 2007 104: 4777-4778; published online before print March 12 2007, 10.1073/pnas.0700913104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 5163

PROFILES

Nick Zagorski

Profile of Monica G. Turner
PNAS 2007 104: 4779-4781; published online before print March 12 2007, 10.1073/pnas.0701264104 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Stanca M. Ciupe, Ruy M. Ribeiro, Patrick W. Nelson, Geoffrey Dusheiko, and Alan S. Perelson

The role of cells refractory to productive infection in acute hepatitis B viral dynamics
PNAS 2007 104: 5050-5055; published online before print March 14 2007, 10.1073/pnas.0603626104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Applied Physical Sciences

Chemistry

Ivan Buchvarov, Qiang Wang, Milen Raytchev, Anton Trifonov, and Torsten Fiebig

Electronic energy delocalization and dissipation in single- and double-stranded DNA
PNAS 2007 104: 4794-4797; published online before print March 12 2007, 10.1073/pnas.0606757104 [Abstract] [Full Text] [Figures Only] [PDF]  

Marcel O. Vlad, Federico Morán, Vlad T. Popa, Stefan E. Szedlacsek, and John Ross

Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics
PNAS 2007 104: 4798-4803; published online before print March 14 2007, 10.1073/pnas.0700397104 [Abstract] [Full Text] [PDF]  

Maciej Haranczyk, Maciej Gutowski, Xiang Li, and Kit H. Bowen

Bound anionic states of adenine
PNAS 2007 104: 4804-4807; published online before print March 12 2007, 10.1073/pnas.0609982104 [Abstract] [Full Text] [Figures Only] [PDF]  

Richard L. Julius, Omar K. Farha, Janet Chiang, L. Jeanne Perry, and M. Frederick Hawthorne

Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores
PNAS 2007 104: 4808-4813; published online before print March 13 2007, 10.1073/pnas.0700316104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas Durek, Vladimir Yu. Torbeev, and Stephen B. H. Kent

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme
PNAS 2007 104: 4846-4851; published online before print March 8 2007, 10.1073/pnas.0610630104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Environmental Sciences

Ranga B. Myneni, Wenze Yang, Ramakrishna R. Nemani, Alfredo R. Huete, Robert E. Dickinson, Yuri Knyazikhin, Kamel Didan, Rong Fu, Robinson I. Negrón Juárez, Sasan S. Saatchi, Hirofumi Hashimoto, Kazuhito Ichii, Nikolay V. Shabanov, Bin Tan, Piyachat Ratana, Jeffrey L. Privette, Jeffrey T. Morisette, Eric F. Vermote, David P. Roy, Robert E. Wolfe, Mark A. Friedl, Steven W. Running, Petr Votava, Nazmi El-Saleous, Sadashiva Devadiga, Yin Su, and Vincent V. Salomonson Large seasonal swings in leaf area of Amazon rainforests PNAS 2007 104: 4820-4823; published online before print March 13 2007, 10.1073/pnas.0611338104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Physics

Sustainability Science

SOCIAL SCIENCES

Anthropology

Greger Larson, Thomas Cucchi, Masakatsu Fujita, Elizabeth Matisoo-Smith, Judith Robins, Atholl Anderson, Barry Rolett, Matthew Spriggs, Gaynor Dolman, Tae-Hun Kim, Nguyen Thi Dieu Thuy, Ettore Randi, Moira Doherty, Rokus Awe Due, Robert Bollt, Tony Djubiantono, Bion Griffin, Michiko Intoh, Emile Keane, Patrick Kirch, Kuang-Ti Li, Michael Morwood, Lolita M. Pedriña, Philip J. Piper, Ryan J. Rabett, Peter Shooter, Gert Van den Bergh, Eric West, Stephen Wickler, Jing Yuan, Alan Cooper, and Keith Dobney

Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania
PNAS 2007 104: 4834-4839; published online before print March 14 2007, 10.1073/pnas.0607753104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Psychology

Simon Kirby, Mike Dowman, and Thomas L. Griffiths

Innateness and culture in the evolution of language
PNAS 2007 104: 5241-5245; published online before print March 12 2007, 10.1073/pnas.0608222104 [Abstract] [Full Text] [Figures Only] [PDF]  

Kerri L. Johnson and Louis G. Tassinary

Compatibility of basic social perceptions determines perceived attractiveness
PNAS 2007 104: 5246-5251; published online before print March 13 2007, 10.1073/pnas.0608181104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sustainability Science

BIOLOGICAL SCIENCES

Anthropology

Greger Larson, Thomas Cucchi, Masakatsu Fujita, Elizabeth Matisoo-Smith, Judith Robins, Atholl Anderson, Barry Rolett, Matthew Spriggs, Gaynor Dolman, Tae-Hun Kim, Nguyen Thi Dieu Thuy, Ettore Randi, Moira Doherty, Rokus Awe Due, Robert Bollt, Tony Djubiantono, Bion Griffin, Michiko Intoh, Emile Keane, Patrick Kirch, Kuang-Ti Li, Michael Morwood, Lolita M. Pedriña, Philip J. Piper, Ryan J. Rabett, Peter Shooter, Gert Van den Bergh, Eric West, Stephen Wickler, Jing Yuan, Alan Cooper, and Keith Dobney

Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania
PNAS 2007 104: 4834-4839; published online before print March 14 2007, 10.1073/pnas.0607753104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

R. Derike Smiley, Tammy R. L. Collins, Gordon G. Hammes, and Tao-Shih Hsieh

Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II
PNAS 2007 104: 4840-4845; published online before print March 14 2007, 10.1073/pnas.0700342104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  
See Commentary on page 4773

Thomas Durek, Vladimir Yu. Torbeev, and Stephen B. H. Kent

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme
PNAS 2007 104: 4846-4851; published online before print March 8 2007, 10.1073/pnas.0610630104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Young-Soo Kwon, Ivan Garcia-Bassets, Kasey R. Hutt, Christine S. Cheng, Mingjie Jin, Dongyan Liu, Chris Benner, Dong Wang, Zhen Ye, Marina Bibikova, Jian-Bing Fan, Lingxun Duan, Christopher K. Glass, Michael G. Rosenfeld, and Xiang-Dong Fu Sensitive ChIP-DSL technology reveals an extensive estrogen receptor -binding program on human gene promoters PNAS 2007 104: 4852-4857; published online before print March 14 2007, 10.1073/pnas.0700715104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Christy Rani R. Grace, Marilyn H. Perrin, Jozsef Gulyas, Michael R. DiGruccio, Jeffrey P. Cantle, Jean E. Rivier, Wylie W. Vale, and Roland Riek

Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand
PNAS 2007 104: 4858-4863; published online before print March 12 2007, 10.1073/pnas.0700682104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jian Zhu, Tsuyoshi Egawa, Syun-Ru Yeh, Linda Yu, and Chang-An Yu

Simultaneous reduction of iron–sulfur protein and cytochrome b_L during ubiquinol oxidation in cytochrome bc₁ complex
PNAS 2007 104: 4864-4869; published online before print March 13 2007, 10.1073/pnas.0607812104 [Abstract] [Full Text] [Figures Only] [PDF]  

Ilana Braunstein, Shirly Miniowitz, Yakir Moshe, and Avram Hershko

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint
PNAS 2007 104: 4870-4875; published online before print March 13 2007, 10.1073/pnas.0700523104 [Abstract] [Full Text] [Figures Only] [PDF]  

Ryan T. Fuchs, Frank J. Grundy, and Tina M. Henkin

S-adenosylmethionine directly inhibits binding of 30S ribosomal subunits to the S_MK box translational riboswitch RNA
PNAS 2007 104: 4876-4880; published online before print March 9 2007, 10.1073/pnas.0609956104 [Abstract] [Full Text] [Figures Only] [PDF]  

Lucas H. Horan and Harry F. Noller

Intersubunit movement is required for ribosomal translocation
PNAS 2007 104: 4881-4885; published online before print March 8 2007, 10.1073/pnas.0700762104 [Abstract] [Full Text] [Figures Only] [PDF]  

Gisele Monteiro, Bruno B. Horta, Daniel Carvalho Pimenta, Ohara Augusto, and Luis E. S. Netto

Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C
PNAS 2007 104: 4886-4891; published online before print March 14 2007, 10.1073/pnas.0700481104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Ivan Buchvarov, Qiang Wang, Milen Raytchev, Anton Trifonov, and Torsten Fiebig

Electronic energy delocalization and dissipation in single- and double-stranded DNA
PNAS 2007 104: 4794-4797; published online before print March 12 2007, 10.1073/pnas.0606757104 [Abstract] [Full Text] [Figures Only] [PDF]  

Rae M. Robertson and Douglas E. Smith Strong effects of molecular topology on diffusion of entangled DNA molecules PNAS 2007 104: 4824-4827; published online before print March 13 2007, 10.1073/pnas.0700137104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Ahmad S. Khalil, Jorge M. Ferrer, Ricardo R. Brau, Stephen T. Kottmann, Christopher J. Noren, Matthew J. Lang, and Angela M. Belcher From the Cover: Single M13 bacteriophage tethering and stretching PNAS 2007 104: 4892-4897; published online before print March 13 2007, 10.1073/pnas.0605727104 [Abstract] [Full Text] [Figures Only] [PDF]

P. Barth, T. Alber, and P. B. Harbury

Accurate, conformation-dependent predictions of solvent effects on protein ionization constants
PNAS 2007 104: 4898-4903; published online before print March 14 2007, 10.1073/pnas.0700188104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

P.-G. de Gennes

Collective neuronal growth and self organization of axons
PNAS 2007 104: 4904-4906; published online before print March 12 2007, 10.1073/pnas.0609871104 [Abstract] [Full Text] [Figures Only] [PDF]  

Timothy O. Street, Christina M. Bradley, and Doug Barrick

Predicting coupling limits from an experimentally determined energy landscape
PNAS 2007 104: 4907-4912; published online before print March 14 2007, 10.1073/pnas.0608756104 [Abstract] [Full Text] [Figures Only] [PDF]  

Andres E. Leschziner, Anjanabha Saha, Jacqueline Wittmeyer, Yongli Zhang, Carlos Bustamante, Bradley R. Cairns, and Eva Nogales Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method PNAS 2007 104: 4913-4918; published online before print March 13 2007, 10.1073/pnas.0700706104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Xiaoyong Bao, Sung Chang Lee, Luis Reuss, and Guillermo A. Altenberg Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC PNAS 2007 104: 4919-4924; published online before print March 8 2007, 10.1073/pnas.0603154104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hongxing Lei, Chun Wu, Haiguang Liu, and Yong Duan

Folding free-energy landscape of villin headpiece subdomain from molecular dynamics simulations
PNAS 2007 104: 4925-4930; published online before print March 12 2007, 10.1073/pnas.0608432104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Ariel Solomon, Barak Akabayov, Anatoly Frenkel, Marcos E. Milla, and Irit Sagi

Key feature of the catalytic cycle of TNF- converting enzyme involves communication between distal protein sites and the enzyme catalytic core
PNAS 2007 104: 4931-4936; published online before print March 13 2007, 10.1073/pnas.0700066104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ju Li, George Lykotrafitis, Ming Dao, and Subra Suresh

Cytoskeletal dynamics of human erythrocyte
PNAS 2007 104: 4937-4942; published online before print March 12 2007, 10.1073/pnas.0700257104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sudha Dorairaj and Toby W. Allen

On the thermodynamic stability of a charged arginine side chain in a transmembrane helix
PNAS 2007 104: 4943-4948; published online before print March 13 2007, 10.1073/pnas.0610470104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Thomas Dechat, Takeshi Shimi, Stephen A. Adam, Antonio E. Rusinol, Douglas A. Andres, H. Peter Spielmann, Michael S. Sinensky, and Robert D. Goldman

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging
PNAS 2007 104: 4955-4960; published online before print March 14 2007, 10.1073/pnas.0700854104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kris Schauwaers, Karel De Gendt, Philippa T. K. Saunders, Nina Atanassova, Annemie Haelens, Leen Callewaert, Udo Moehren, Johannes V. Swinnen, Guido Verhoeven, Guy Verrijdt, and Frank Claessens

Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model
PNAS 2007 104: 4961-4966; published online before print March 12 2007, 10.1073/pnas.0610814104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

M. Alex Smith, D. Monty Wood, Daniel H. Janzen, Winnie Hallwachs, and Paul D. N. Hebert From the Cover: DNA barcodes affirm that 16 species of apparently generalist tropical parasitoid flies (Diptera, Tachinidae) are not all generalists PNAS 2007 104: 4967-4972; published online before print March 14 2007, 10.1073/pnas.0700050104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE   See Commentary on page 4775

Ingolf Steffan-Dewenter, Michael Kessler, Jan Barkmann, Merijn M. Bos, Damayanti Buchori, Stefan Erasmi, Heiko Faust, Gerhard Gerold, Klaus Glenk, S. Robbert Gradstein, Edi Guhardja, Marieke Harteveld, Dietrich Hertel, Patrick Höhn, Martin Kappas, Stefan Köhler, Christoph Leuschner, Miet Maertens, Rainer Marggraf, Sonja Migge-Kleian, Johanis Mogea, Ramadhaniel Pitopang, Matthias Schaefer, Stefan Schwarze, Simone G. Sporn, Andrea Steingrebe, Sri S. Tjitrosoedirdjo, Soekisman Tjitrosoemito, André Twele, Robert Weber, Lars Woltmann, Manfred Zeller, and Teja Tscharntke From the Cover: Tradeoffs between income, biodiversity, and ecosystem functioning during tropical rainforest conversion and agroforestry intensification PNAS 2007 104: 4973-4978; published online before print March 14 2007, 10.1073/pnas.0608409104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Gregory S. Gilbert and Campbell O. Webb

Phylogenetic signal in plant pathogen–host range
PNAS 2007 104: 4979-4983; published online before print March 14 2007, 10.1073/pnas.0607968104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Dataset]  

Graeme A. Forster and Christopher A. Gilligan

Optimizing the control of disease infestations at the landscape scale
PNAS 2007 104: 4984-4989; published online before print March 13 2007, 10.1073/pnas.0607900104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Karen M. Carney, Bruce A. Hungate, Bert G. Drake, and J. Patrick Megonigal Altered soil microbial community at elevated CO2 leads to loss of soil carbon PNAS 2007 104: 4990-4995; published online before print March 13 2007, 10.1073/pnas.0610045104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Evolution

Carolyn S. McBride

Rapid evolution of smell and taste receptor genes during host specialization in Drosophila sechellia
PNAS 2007 104: 4996-5001; published online before print March 9 2007, 10.1073/pnas.0608424104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kate F. Darling, Michal Kucera, and Christopher M. Wade

Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protist
PNAS 2007 104: 5002-5007; published online before print March 13 2007, 10.1073/pnas.0700520104 [Abstract] [Full Text] [Figures Only] [PDF]  

Simon Kirby, Mike Dowman, and Thomas L. Griffiths

Innateness and culture in the evolution of language
PNAS 2007 104: 5241-5245; published online before print March 12 2007, 10.1073/pnas.0608222104 [Abstract] [Full Text] [Figures Only] [PDF]  

Genetics

Marcel O. Vlad, Federico Morán, Vlad T. Popa, Stefan E. Szedlacsek, and John Ross

Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics
PNAS 2007 104: 4798-4803; published online before print March 14 2007, 10.1073/pnas.0700397104 [Abstract] [Full Text] [PDF]  

Ben E. Black, Melissa A. Brock, Sabrina Bédard, Virgil L. Woods, Jr., and Don W. Cleveland

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes
PNAS 2007 104: 5008-5013; published online before print March 13 2007, 10.1073/pnas.0700390104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Birgit Gerisch, Veerle Rottiers, Dongling Li, Daniel L. Motola, Carolyn L. Cummins, Hans Lehrach, David J. Mangelsdorf, and Adam Antebi A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling PNAS 2007 104: 5014-5019; published online before print March 14 2007, 10.1073/pnas.0700847104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hidenori Inaoka, Yutaka Fukuoka, and Isaac S. Kohane Evidence of spatially bound gene regulation in Mus musculus: Decreased gene expression proximal to microRNA genomic location PNAS 2007 104: 5020-5025; published online before print March 12 2007, 10.1073/pnas.0611078104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Glaucia C. Furtado, Tatjana Marinkovic, Andrea P. Martin, Alexandre Garin, Benjamin Hoch, Wolfgang Hubner, Benjamin K. Chen, Eric Genden, Mihaela Skobe, and Sergio A. Lira

Lymphotoxin receptor signaling is required for inflammatory lymphangiogenesis in the thyroid
PNAS 2007 104: 5026-5031; published online before print March 14 2007, 10.1073/pnas.0606697104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

E. D. Hawkins, M. L. Turner, M. R. Dowling, C. van Gend, and P. D. Hodgkin A model of immune regulation as a consequence of randomized lymphocyte division and death times PNAS 2007 104: 5032-5037; published online before print March 14 2007, 10.1073/pnas.0700026104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Qibin Leng, Qing Ge, Tam Nguyen, Herman N. Eisen, and Jianzhu Chen

Stage-dependent reactivity of thymocytes to self-peptide–MHC complexes
PNAS 2007 104: 5038-5043; published online before print March 14 2007, 10.1073/pnas.0700674104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Vladimir Hurgin, Daniela Novick, Ariel Werman, Charles A. Dinarello, and Menachem Rubinstein Antiviral and immunoregulatory activities of IFN- depend on constitutively expressed IL-1 PNAS 2007 104: 5044-5049; published online before print March 8 2007, 10.1073/pnas.0611608104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Medical Sciences

Stanca M. Ciupe, Ruy M. Ribeiro, Patrick W. Nelson, Geoffrey Dusheiko, and Alan S. Perelson

The role of cells refractory to productive infection in acute hepatitis B viral dynamics
PNAS 2007 104: 5050-5055; published online before print March 14 2007, 10.1073/pnas.0603626104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eduardo Lopez-Granados, Stephane T. Temmerman, Lynne Wu, James C. Reynolds, Dean Follmann, Shuying Liu, David L. Nelson, Frank Rauch, and Ashish Jain Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis PNAS 2007 104: 5056-5061; published online before print March 9 2007, 10.1073/pnas.0605715104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Kentaro Ide, Hui Wang, Hiroyuki Tahara, Jianxiang Liu, Xiaoying Wang, Toshimasa Asahara, Megan Sykes, Yong-Guang Yang, and Hideki Ohdan

Role for CD47-SIRP signaling in xenograft rejection by macrophages
PNAS 2007 104: 5062-5066; published online before print March 12 2007, 10.1073/pnas.0609661104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Paolo Lusso, Richard W. Crowley, Mauro S. Malnati, Clelia Di Serio, Maurilio Ponzoni, Angelique Biancotto, Phillip D. Markham, and Robert C. Gallo

Human herpesvirus 6A accelerates AIDS progression in macaques
PNAS 2007 104: 5067-5072; published online before print March 14 2007, 10.1073/pnas.0700929104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ingmar Meinecke, Antje Cinski, Anja Baier, Marvin A. Peters, Berno Dankbar, Aline Wille, Andreas Drynda, Heidi Mendoza, Renate E. Gay, Ronald T. Hay, Barbara Ink, Steffen Gay, and Thomas Pap

Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts
PNAS 2007 104: 5073-5078; published online before print March 14 2007, 10.1073/pnas.0608773104 [Abstract] [Full Text] [Figures Only] [PDF]  

John D. Phillips, Hector A. Bergonia, Christopher A. Reilly, Michael R. Franklin, and James P. Kushner A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda PNAS 2007 104: 5079-5084; published online before print March 9 2007, 10.1073/pnas.0700547104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Lee Caperton, Patricia Murphey, Yukiko Yamazaki, C. Alex McMahan, Christi A. Walter, Ryuzo Yanagimachi, and John R. McCarrey From the Cover: Assisted reproductive technologies do not alter mutation frequency or spectrum PNAS 2007 104: 5085-5090; published online before print March 2 2007, 10.1073/pnas.0611642104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE

Linda Yang, Lei Wang, Hartmut Geiger, Jose A. Cancelas, Jun Mo, and Yi Zheng

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
PNAS 2007 104: 5091-5096; published online before print March 12 2007, 10.1073/pnas.0610819104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

J. Roberto Trujillo, Rick Rogers, Ramon M. Molina, Fernando Dangond, Mary Fran McLane, Max Essex, and Joseph D. Brain Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor PNAS 2007 104: 5097-5102; published online before print March 14 2007, 10.1073/pnas.0611263104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jennifer P. Morton, Michelle E. Mongeau, David S. Klimstra, John P. Morris, Yie Chia Lee, Yoshiya Kawaguchi, Christopher V. E. Wright, Matthias Hebrok, and Brian C. Lewis Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis PNAS 2007 104: 5103-5108; published online before print March 19 2007, 10.1073/pnas.0701158104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Beek Y. Chin, Ge Jiang, Barbara Wegiel, Hong J. Wang, Theresa MacDonald, Xu Chen Zhang, David Gallo, Eva Cszimadia, Fritz H. Bach, Patty J. Lee, and Leo E. Otterbein Hypoxia-inducible factor 1 stabilization by carbon monoxide results in cytoprotective preconditioning PNAS 2007 104: 5109-5114; published online before print March 12 2007, 10.1073/pnas.0609611104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Francesco Dotta, Stefano Censini, Astrid G. S. van Halteren, Lorella Marselli, Matilde Masini, Sabrina Dionisi, Franco Mosca, Ugo Boggi, Andrea Onetti Muda, Stefano Del Prato, John F. Elliott, Antonello Covacci, Rino Rappuoli, Bart O. Roep, and Piero Marchetti

Coxsackie B4 virus infection of cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
PNAS 2007 104: 5115-5120; published online before print March 14 2007, 10.1073/pnas.0700442104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, and Zhao-Qing Luo

Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family
PNAS 2007 104: 5121-5126; published online before print March 14 2007, 10.1073/pnas.0611030104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jan Mrázek and Samuel Karlin

Distinctive features of large complex virus genomes and proteomes
PNAS 2007 104: 5127-5132; published online before print March 9 2007, 10.1073/pnas.0700429104 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Madhulika Jain, Christopher J. Petzold, Michael W. Schelle, Michael D. Leavell, Joseph D. Mougous, Carolyn R. Bertozzi, Julie A. Leary, and Jeffery S. Cox

Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
PNAS 2007 104: 5133-5138; published online before print March 8 2007, 10.1073/pnas.0610634104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kengo Kitadokoro, Shigeki Kamitani, Masayuki Miyazawa, Miyuki Hanajima-Ozawa, Aya Fukui, Masami Miyake, and Yasuhiko Horiguchi

Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin
PNAS 2007 104: 5139-5144; published online before print March 14 2007, 10.1073/pnas.0608197104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Christopher J. Alteri, Juan Xicohténcatl-Cortes, Sonja Hess, Guillermo Caballero-Olín, Jorge A. Girón, and Richard L. Friedman Mycobacterium tuberculosis produces pili during human infection PNAS 2007 104: 5145-5150; published online before print March 8 2007, 10.1073/pnas.0602304104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Shah M. Faruque, Vincent C. Tam, Nityananda Chowdhury, Pornphan Diraphat, Michelle Dziejman, John F. Heidelberg, John D. Clemens, John J. Mekalanos, and G. Balakrish Nair

Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage
PNAS 2007 104: 5151-5156; published online before print March 12 2007, 10.1073/pnas.0700365104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Apoorva Bhatt, Nagatoshi Fujiwara, Kiranmai Bhatt, Sudagar S. Gurcha, Laurent Kremer, Bing Chen, John Chan, Steven A. Porcelli, Kazuo Kobayashi, Gurdyal S. Besra, and William R. Jacobs, Jr.

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice
PNAS 2007 104: 5157-5162; published online before print March 12 2007, 10.1073/pnas.0608654104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Thomas T. G. Hahn, Bert Sakmann, and Mayank R. Mehta

Differential responses of hippocampal subfields to cortical up–down states
PNAS 2007 104: 5169-5174; published online before print March 12 2007, 10.1073/pnas.0700222104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Steven M. Chase and Eric D. Young

First-spike latency information in single neurons increases when referenced to population onset
PNAS 2007 104: 5175-5180; published online before print March 9 2007, 10.1073/pnas.0610368104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Rossella Ventura, Cristina Morrone, and Stefano Puglisi-Allegra Prefrontal/accumbal catecholamine system determines motivational salience attribution to both reward- and aversion-related stimuli PNAS 2007 104: 5181-5186; published online before print March 9 2007, 10.1073/pnas.0610178104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

W. Preston Few, Todd Scheuer, and William A. Catterall

Dopamine modulation of neuronal Na⁺ channels requires binding of A kinase-anchoring protein 15and PKA by a modified leucine zipper motif
PNAS 2007 104: 5187-5192; published online before print March 14 2007, 10.1073/pnas.0611619104 [Abstract] [Full Text] [Figures Only] [PDF]