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Table of Contents

April 3, 2007; 104 (14)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Micromechanical control of cell-cell interactions

Homogenization of river dynamics by dams

Substrate specificity of a phosphodiesterase

Hepatitis C virus dependent on lipoproteins

Lipid deficiency and natural killer T cells (A)

Lipid deficiency and natural killer T cells (B)

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down arrow THIS WEEK IN PNAS

down arrow COMMENTARIES

down arrow PHYSICAL SCIENCES
    Applied Physical Sciences
    Chemistry
    Environmental Sciences
    Geophysics
    Physics

down arrow BIOLOGICAL SCIENCES
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Psychology
    Sustainability Science

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up arrow THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 5705-5706. [Full Text] [PDF]  

up arrow COMMENTARIES

Daniel E. Schindler
Fish extinctions and ecosystem functioning in tropical ecosystems
PNAS 2007 104: 5707-5708; published online before print March 28 2007, 10.1073/pnas.0700426104 [Extract] [Full Text] [PDF]  
* See companion article on page 4461 in issue 11 of volume 104

Zev Rosenwaks and Kristin Bendikson
Further evidence of the safety of assisted reproductive technologies
PNAS 2007 104: 5709-5710; published online before print March 28 2007, 10.1073/pnas.0701316104 [Extract] [Full Text] [PDF]  
* See companion article on page 5085 in issue 12 of volume 104

Peter B. Moyle and Jeffrey F. Mount
Homogenous rivers, homogenous faunas
PNAS 2007 104: 5711-5712; published online before print March 28 2007, 10.1073/pnas.0701457104 [Extract] [Full Text] [PDF]  
* See companion article on page 5732

Mitchell Kronenberg and Laurent Gapin
Natural killer T cells: Know thyself
PNAS 2007 104: 5713-5714; published online before print March 27 2007, 10.1073/pnas.0701493104 [Extract] [Full Text] [Figures Only] [PDF]  
* See companion article on page 5971
* See companion article on page 5977

up arrow PHYSICAL SCIENCES

Applied Physical Sciences

Elliot E. Hui and Sangeeta N. Bhatia
From the Cover: Micromechanical control of cell–cell interactions
PNAS 2007 104: 5722-5726; published online before print March 27 2007, 10.1073/pnas.0608660104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chemistry

Yusheng Zhao, Hongwu Xu, Luke L. Daemen, Konstantin Lokshin, Kimberly T. Tait, Wendy L. Mao, Junhua Luo, Robert P. Currier, and Donald D. Hickmott
High-pressure/low-temperature neutron scattering of gas inclusion compounds: Progress and prospects
PNAS 2007 104: 5727-5731; published online before print March 26 2007, 10.1073/pnas.0610332104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Ruhong Zhou, Maria Eleftheriou, Ajay K. Royyuru, and Bruce J. Berne
Destruction of long-range interactions by a single mutation in lysozyme
PNAS 2007 104: 5824-5829; published online before print March 26 2007, 10.1073/pnas.0701249104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Environmental Sciences

N. LeRoy Poff, Julian D. Olden, David M. Merritt, and David M. Pepin
From the Cover: Homogenization of regional river dynamics by dams and global biodiversity implications
PNAS 2007 104: 5732-5737; published online before print March 12 2007, 10.1073/pnas.0609812104 [Abstract] [Full Text] [Figures Only] [PDF]  
* See Commentary on page 5711

John W. Williams, Stephen T. Jackson, and John E. Kutzbach
Projected distributions of novel and disappearing climates by 2100 AD
PNAS 2007 104: 5738-5742; published online before print March 27 2007, 10.1073/pnas.0606292104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joseph R. McConnell, Alberto J. Aristarain, J. Ryan Banta, P. Ross Edwards, and Jefferson C. Simões
20th-Century doubling in dust archived in an Antarctic Peninsula ice core parallels climate change and desertification in South America
PNAS 2007 104: 5743-5748; published online before print March 26 2007, 10.1073/pnas.0607657104 [Abstract] [Full Text] [Figures Only] [PDF]  

Geophysics

Lennard A. Fisk and George Gloeckler
Thermodynamic constraints on stochastic acceleration in compressional turbulence
PNAS 2007 104: 5749-5754; published online before print March 21 2007, 10.1073/pnas.0700881104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Physics

E. Eisenberg and A. Baram
Estimation of critical exponents from cluster coefficients and the application of this estimation to hard spheres
PNAS 2007 104: 5755-5758; published online before print March 26 2007, 10.1073/pnas.0700778104 [Abstract] [Full Text] [Figures Only] [PDF]  

up arrow BIOLOGICAL SCIENCES

Biochemistry

Santina Bruzzone, Iliana Moreschi, Cesare Usai, Lucrezia Guida, Gianluca Damonte, Annalisa Salis, Sonia Scarfì, Enrico Millo, Antonio De Flora, and Elena Zocchi
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger
PNAS 2007 104: 5759-5764; published online before print March 26 2007, 10.1073/pnas.0609379104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Oyetunji A. Toogun, Will Zeiger, and Brian C. Freeman
The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation
PNAS 2007 104: 5765-5770; published online before print March 26 2007, 10.1073/pnas.0701442104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ami S. Bhatt, Alana Welm, Christopher J. Farady, Maximiliano Vásquez, Keith Wilson, and Charles S. Craik
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway
PNAS 2007 104: 5771-5776; published online before print March 27 2007, 10.1073/pnas.0606514104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Tsunehiro Mizushima, Yukiko Yoshida, Taichi Kumanomidou, Yuko Hasegawa, Atsuo Suzuki, Takashi Yamane, and Keiji Tanaka
Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase
PNAS 2007 104: 5777-5781; published online before print March 26 2007, 10.1073/pnas.0610312104 [Abstract] [Full Text] [Figures Only] [PDF]  

Huanchen Wang, Yudong Liu, Jing Hou, Meiyan Zheng, Howard Robinson, and Hengming Ke
From the Cover: Structural insight into substrate specificity of phosphodiesterase 10
PNAS 2007 104: 5782-5787; published online before print March 26 2007, 10.1073/pnas.0700279104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Robert J. C. Gilbert, Yulya Gordiyenko, Tobias von der Haar, Andreas F.-P. Sonnen, Gregor Hofmann, Maria Nardelli, David I. Stuart, and John E. G. McCarthy
Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex
PNAS 2007 104: 5788-5793; published online before print March 26 2007, 10.1073/pnas.0606880104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Catherine M. Eakin, Michael J. MacCoss, Gregory L. Finney, and Rachel E. Klevit
Estrogen receptor {alpha} is a putative substrate for the BRCA1 ubiquitin ligase
PNAS 2007 104: 5794-5799; published online before print March 28 2007, 10.1073/pnas.0610887104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Mihoko Takahashi, Youhei Kondou, and Chikashi Toyoshima
Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
PNAS 2007 104: 5800-5805; published online before print March 26 2007, 10.1073/pnas.0700979104 [Abstract] [Full Text] [Figures Only] [PDF]  

Nicholas P. Robinson and Stephen D. Bell
Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes
PNAS 2007 104: 5806-5811; published online before print March 28 2007, 10.1073/pnas.0700206104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Elenita I. Kanin, Ryan T. Kipp, Charles Kung, Matthew Slattery, Agnes Viale, Steven Hahn, Kevan M. Shokat, and Aseem Z. Ansari
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis
PNAS 2007 104: 5812-5817; published online before print March 28 2007, 10.1073/pnas.0611505104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

M. Duane Smith and Richard A. Collins
Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme
PNAS 2007 104: 5818-5823; published online before print March 26 2007, 10.1073/pnas.0608864104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Ruhong Zhou, Maria Eleftheriou, Ajay K. Royyuru, and Bruce J. Berne
Destruction of long-range interactions by a single mutation in lysozyme
PNAS 2007 104: 5824-5829; published online before print March 26 2007, 10.1073/pnas.0701249104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas M. Hansen, S. Nader S. Reihani, Lene B. Oddershede, and Michael A. Sørensen
Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting
PNAS 2007 104: 5830-5835; published online before print March 27 2007, 10.1073/pnas.0608668104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Cell Biology

R. Nicholas Laribee, Yoichiro Shibata, Douglas P. Mersman, Sean R. Collins, Patrick Kemmeren, Assen Roguev, Jonathan S. Weissman, Scott D. Briggs, Nevan J. Krogan, and Brian D. Strahl
CCR4/NOT complex associates with the proteasome and regulates histone methylation
PNAS 2007 104: 5836-5841; published online before print March 26 2007, 10.1073/pnas.0607996104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiang Zhou, J. Ramesh Babu, Susana da Silva, Qing Shu, Isabella A. Graef, Tim Oliver, Toshifumi Tomoda, Tomomi Tani, Marie W. Wooten, and Fan Wang
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
PNAS 2007 104: 5842-5847; published online before print March 26 2007, 10.1073/pnas.0701402104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hua Huang, Fang Sun, David M. Owen, Weiping Li, Yan Chen, Michael Gale, Jr., and Jin Ye
From the Cover: Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
PNAS 2007 104: 5848-5853; published online before print March 21 2007, 10.1073/pnas.0700760104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Seth DeBolt, Ryan Gutierrez, David W. Ehrhardt, Carlos V. Melo, Loretta Ross, Sean R. Cutler, Christopher Somerville, and Dario Bonetta
Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement
PNAS 2007 104: 5854-5859; published online before print March 27 2007, 10.1073/pnas.0700789104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alejandro Wolf-Yadlin, Sampsa Hautaniemi, Douglas A. Lauffenburger, and Forest M. White
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
PNAS 2007 104: 5860-5865; published online before print March 26 2007, 10.1073/pnas.0608638104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Qingchang Meng, Suresh K. Rayala, Anupama E. Gururaj, Amjad H. Talukder, Bert W. O'Malley, and Rakesh Kumar
Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1
PNAS 2007 104: 5866-5871; published online before print March 26 2007, 10.1073/pnas.0701065104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tanya Tolmachova, Magnus Åbrink, Clare E. Futter, Kalwant S. Authi, and Miguel C. Seabra
Rab27b regulates number and secretion of platelet dense granules
PNAS 2007 104: 5872-5877; published online before print March 23 2007, 10.1073/pnas.0609879104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Michelle B. Bowie, David G. Kent, Brad Dykstra, Kristen D. McKnight, Lindsay McCaffrey, Pamela A. Hoodless, and Connie J. Eaves
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties
PNAS 2007 104: 5878-5882; published online before print March 22 2007, 10.1073/pnas.0700460104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE  

Yoshitaka Nakayama, Kenta Fujiu, Masahiro Sokabe, and Kenjiro Yoshimura
Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas
PNAS 2007 104: 5883-5888; published online before print March 26 2007, 10.1073/pnas.0609996104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Prashant Prabhat, Zhuo Gan, Jerry Chao, Sripad Ram, Carlos Vaccaro, Steven Gibbons, Raimund J. Ober, and E. Sally Ward
Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy
PNAS 2007 104: 5889-5894; published online before print March 23 2007, 10.1073/pnas.0700337104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Barbara Stecca, Christophe Mas, Virginie Clement, Marie Zbinden, Rafael Correa, Vincent Piguet, Friedrich Beermann, and Ariel Ruiz i Altaba
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
PNAS 2007 104: 5895-5900; published online before print March 28 2007, 10.1073/pnas.0700776104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Yuying Wang, Ricardo M. Zayas, Tingxia Guo, and Phillip A. Newmark
nanos function is essential for development and regeneration of planarian germ cells
PNAS 2007 104: 5901-5906; published online before print March 21 2007, 10.1073/pnas.0609708104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hung Ping Shih, Michael K. Gross, and Chrissa Kioussi
Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch
PNAS 2007 104: 5907-5912; published online before print March 23 2007, 10.1073/pnas.0701122104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Sang-Yeob Yeo and Ajay B. Chitnis
Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord
PNAS 2007 104: 5913-5918; published online before print March 26 2007, 10.1073/pnas.0607062104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Chiharu Kimura-Yoshida, E. Tian, Hiroshi Nakano, Saori Amazaki, Kayo Shimokawa, Janet Rossant, Shinichi Aizawa, and Isao Matsuo
Crucial roles of Foxa2 in mouse anterior–posterior axis polarization via regulation of anterior visceral endoderm-specific genes
PNAS 2007 104: 5919-5924; published online before print March 26 2007, 10.1073/pnas.0607779104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ecology

N. LeRoy Poff, Julian D. Olden, David M. Merritt, and David M. Pepin
From the Cover: Homogenization of regional river dynamics by dams and global biodiversity implications
PNAS 2007 104: 5732-5737; published online before print March 12 2007, 10.1073/pnas.0609812104 [Abstract] [Full Text] [Figures Only] [PDF]  
* See Commentary on page 5711

John W. Williams, Stephen T. Jackson, and John E. Kutzbach
Projected distributions of novel and disappearing climates by 2100 AD
PNAS 2007 104: 5738-5742; published online before print March 27 2007, 10.1073/pnas.0606292104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Holger Kreft and Walter Jetz
Global patterns and determinants of vascular plant diversity
PNAS 2007 104: 5925-5930; published online before print March 22 2007, 10.1073/pnas.0608361104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Allison Kolpas, Jeff Moehlis, and Ioannis G. Kevrekidis
Coarse-grained analysis of stochasticity-induced switching between collective motion states
PNAS 2007 104: 5931-5935; published online before print March 27 2007, 10.1073/pnas.0608270104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Scott V. Edwards, Liang Liu, and Dennis K. Pearl
High-resolution species trees without concatenation
PNAS 2007 104: 5936-5941; published online before print March 28 2007, 10.1073/pnas.0607004104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Online Correction to SI Materials and Methods]  

David Crews, Andrea C. Gore, Timothy S. Hsu, Nygerma L. Dangleben, Michael Spinetta, Timothy Schallert, Matthew D. Anway, and Michael K. Skinner
Transgenerational epigenetic imprints on mate preference
PNAS 2007 104: 5942-5946; published online before print March 26 2007, 10.1073/pnas.0610410104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movie]  

Genetics

Arjumand Ghazi, Sivan Henis-Korenblit, and Cynthia Kenyon
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
PNAS 2007 104: 5947-5952; published online before print March 28 2007, 10.1073/pnas.0700638104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ahmad Besaratinia, Sang-in Kim, Steven E. Bates, and Gerd P. Pfeifer
Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C
PNAS 2007 104: 5953-5958; published online before print March 26 2007, 10.1073/pnas.0610534104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Pablo Tamayo, Daniel Scanfeld, Benjamin L. Ebert, Michael A. Gillette, Charles W. M. Roberts, and Jill P. Mesirov
Metagene projection for cross-platform, cross-species characterization of global transcriptional states
PNAS 2007 104: 5959-5964; published online before print March 27 2007, 10.1073/pnas.0701068104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Masahiro Terasawa, Hideyuki Ogawa, Yasumasa Tsukamoto, Miki Shinohara, Katsuhiko Shirahige, Nancy Kleckner, and Tomoko Ogawa
Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation
PNAS 2007 104: 5965-5970; published online before print March 23 2007, 10.1073/pnas.0611490104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Anneliese O. Speak, Mariolina Salio, David C. A. Neville, Josette Fontaine, David A. Priestman, Nick Platt, Tanya Heare, Terry D. Butters, Raymond A. Dwek, Francois Trottein, Mark A. Exley, Vincenzo Cerundolo, and Frances M. Platt
From the Cover: Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals
PNAS 2007 104: 5971-5976; published online before print March 19 2007, 10.1073/pnas.0607285104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  
* See Commentary on page 5713

Stefan Porubsky, Anneliese O. Speak, Bruno Luckow, Vincenzo Cerundolo, Frances M. Platt, and Hermann-Josef Gröne
From the Cover: Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency
PNAS 2007 104: 5977-5982; published online before print March 19 2007, 10.1073/pnas.0611139104 [Abstract] [Full Text] [Figures Only] [PDF]  
* See Commentary on page 5713

Yusuke Mimura, Yuka Mimura-Kimura, Katie Doores, Denise Golgher, Benjamin G. Davis, Raymond A. Dwek, Pauline M. Rudd, and Tim Elliott
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing
PNAS 2007 104: 5983-5988; published online before print March 26 2007, 10.1073/pnas.0701307104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anna M. Keller, Tom A. Groothuis, Elise A. M. Veraar, Marije Marsman, Lucas Maillette de Buy Wenniger, Hans Janssen, Jacques Neefjes, and Jannie Borst
Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules
PNAS 2007 104: 5989-5994; published online before print March 26 2007, 10.1073/pnas.0700946104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Alina Maloyan, James Gulick, Charles G. Glabe, Rakez Kayed, and Jeffrey Robbins
Exercise reverses preamyloid oligomer and prolongs survival in {alpha}B-crystallin-based desmin-related cardiomyopathy
PNAS 2007 104: 5995-6000; published online before print March 26 2007, 10.1073/pnas.0609202104 [Abstract] [Full Text] [Figures Only] [PDF]  

Glen D. Raffel, Thomas Mercher, Hirokazu Shigematsu, Ifor R. Williams, Dana E. Cullen, Koichi Akashi, Olivier A. Bernard, and D. Gary Gilliland
Ott1(Rbm15) has pleiotropic roles in hematopoietic development
PNAS 2007 104: 6001-6006; published online before print March 21 2007, 10.1073/pnas.0609041104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Liutao Du, Julianne M. Pollard, and Richard A. Gatti
Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides
PNAS 2007 104: 6007-6012; published online before print March 26 2007, 10.1073/pnas.0608616104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Shotaro Suzuki, Candice M. Brown, Christopher D. Dela Cruz, Enhua Yang, David A. Bridwell, and Phyllis M. Wise
Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
PNAS 2007 104: 6013-6018; published online before print March 26 2007, 10.1073/pnas.0610394104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Roberto Rocchi, Hiroaki Kimura, Shey-Cherng Tzou, Koichi Suzuki, Noel R. Rose, Aldo Pinchera, Paul W. Ladenson, and Patrizio Caturegli
Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
PNAS 2007 104: 6019-6024; published online before print March 26 2007, 10.1073/pnas.0701319104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jan M. Pestka, Mirjam B. Zeisel, Edith Bläser, Peter Schürmann, Birke Bartosch, Francois-Loïc Cosset, Arvind H. Patel, Helga Meisel, Jens Baumert, Sergei Viazov, Kay Rispeter, Hubert E. Blum, Michael Roggendorf, and Thomas F. Baumert
Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
PNAS 2007 104: 6025-6030; published online before print March 28 2007, 10.1073/pnas.0607026104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Sylvie Alonso, Kevin Pethe, David G. Russell, and Georgiana E. Purdy
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
PNAS 2007 104: 6031-6036; published online before print March 26 2007, 10.1073/pnas.0700036104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

David S. Weiss, Anna Brotcke, Thomas Henry, Jeffrey J. Margolis, Kaman Chan, and Denise M. Monack
In vivo negative selection screen identifies genes required for Francisella virulence
PNAS 2007 104: 6037-6042; published online before print March 26 2007, 10.1073/pnas.0609675104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Thomas Kuhlman, Zhongge Zhang, Milton H. Saier, Jr., and Terence Hwa
Combinatorial transcriptional control of the lactose operon of Escherichia coli
PNAS 2007 104: 6043-6048; published online before print March 21 2007, 10.1073/pnas.0606717104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kay D. Bidle, Liti Haramaty, Joana Barcelos e Ramos, and Paul Falkowski
Viral activation and recruitment of metacaspases in the unicellular coccolithophore, Emiliania huxleyi
PNAS 2007 104: 6049-6054; published online before print March 28 2007, 10.1073/pnas.0701240104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Neuroscience

Paul J. Kammermeier and Paul F. Worley
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
PNAS 2007 104: 6055-6060; published online before print March 26 2007, 10.1073/pnas.0608991104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mary M. Lunzer, Ajay Yekkirala, Robert P. Hebbel, and Philip S. Portoghese
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia
PNAS 2007 104: 6061-6065; published online before print March 26 2007, 10.1073/pnas.0700295104 [Abstract] [Full Text] [Figures Only] [PDF]  

Longnian Lin, Guifen Chen, Hui Kuang, Dong Wang, and Joe Z. Tsien
Neural encoding of the concept of nest in the mouse brain
PNAS 2007 104: 6066-6071; published online before print March 27 2007, 10.1073/pnas.0701106104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marjatta Son, Krishna Puttaparthi, Hibiki Kawamata, Bhagya Rajendran, Philip J. Boyer, Giovanni Manfredi, and Jeffrey L. Elliott
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology
PNAS 2007 104: 6072-6077; published online before print March 26 2007, 10.1073/pnas.0610923104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ying Shen, Koji Kishimoto, David J. Linden, and Adam Sapirstein
Cytosolic phospholipase A2 alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment
PNAS 2007 104: 6078-6083; published online before print March 26 2007, 10.1073/pnas.0605427104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Pharmacology

Jeremy D. Heidel, Zhongping Yu, Joanna Yi-Ching Liu, Shyam M. Rele, Yongchao Liang, Ryan K. Zeidan, Douglas J. Kornbrust, and Mark E. Davis
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
PNAS 2007 104: 5715-5721; published online before print March 22 2007, 10.1073/pnas.0701458104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Psychology

William T. Swaney, James P. Curley, Frances A. Champagne, and Eric B. Keverne
Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice
PNAS 2007 104: 6084-6089; published online before print March 26 2007, 10.1073/pnas.0609471104 [Abstract] [Full Text] [Figures Only] [PDF]  

Sustainability Science

N. LeRoy Poff, Julian D. Olden, David M. Merritt, and David M. Pepin
From the Cover: Homogenization of regional river dynamics by dams and global biodiversity implications
PNAS 2007 104: 5732-5737; published online before print March 12 2007, 10.1073/pnas.0609812104 [Abstract] [Full Text] [Figures Only] [PDF]  
* See Commentary on page 5711

up arrow CORRECTIONS

Correction for Moehle et al., Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases [Full Text] [PDF]  

Correction for Manuelidis et al., Cells infected with scrapie and Creutzfeldt–Jakob disease agents produce intracellular 25-nm virus-like particles [Full Text] [PDF]  

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