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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 397-398. [Full Text] [PDF]  

COMMENTARIES

Ronald E. Viola

The impact of structural biology on neurobiology
PNAS 2007 104: 399-400. [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 456

Raquel L. Lieberman and Michael S. Wolfe

Membrane-embedded protease poses for photoshoot
PNAS 2007 104: 401-402. [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 462

PERSPECTIVES

Jie Shen and Raymond J. Kelleher, III

The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
PNAS 2007 104: 403-409; published online before print December 29 2006, 10.1073/pnas.0608332104 [Abstract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Applied Physical Sciences

Francesco Mallamace, Matteo Broccio, Carmelo Corsaro, Antonio Faraone, Domenico Majolino, Valentina Venuti, Li Liu, Chung-Yuan Mou, and Sow-Hsin Chen

Evidence of the existence of the low-density liquid phase in supercooled, confined water
PNAS 2007 104: 424-428; published online before print December 27 2006, 10.1073/pnas.0607138104 [Abstract] [Full Text] [Figures Only] [PDF]  

Chemistry

Valérie C. Pierre, Jens T. Kaiser, and Jacqueline K. Barton

Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
PNAS 2007 104: 429-434; published online before print December 28 2006, 10.1073/pnas.0610170104 [Abstract] [Full Text] [Figures Only] [PDF]  

Patrick M. Hare, Carlos E. Crespo-Hernández, and Bern Kohler

Internal conversion to the electronic ground state occurs via two distinct pathways for pyrimidine bases in aqueous solution
PNAS 2007 104: 435-440; published online before print December 29 2006, 10.1073/pnas.0608055104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Silvia N. López, I. Ayelen Ramallo, Manuel Gonzalez Sierra, Susana A. Zacchino, and Ricardo L. E. Furlan

Chemically engineered extracts as an alternative source of bioactive natural product-like compounds
PNAS 2007 104: 441-444; published online before print December 27 2006, 10.1073/pnas.0608438104 [Abstract] [Full Text] [Figures Only] [PDF]  

Environmental Sciences

Geology

Achim Brauer, Judy R. M. Allen, Jens Mingram, Peter Dulski, Sabine Wulf, and Brian Huntley

Evidence for last interglacial chronology and environmental change from Southern Europe
PNAS 2007 104: 450-455; published online before print January 3 2007, 10.1073/pnas.0603321104 [Abstract] [Full Text] [Figures Only] [PDF]  

Geophysics

SOCIAL SCIENCES

Anthropology

Dustin J. Penn and Ken R. Smith

Differential fitness costs of reproduction between the sexes
PNAS 2007 104: 553-558; published online before print December 27 2006, 10.1073/pnas.0609301103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

BIOLOGICAL SCIENCES

Biochemistry

Valérie C. Pierre, Jens T. Kaiser, and Jacqueline K. Barton

Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
PNAS 2007 104: 429-434; published online before print December 28 2006, 10.1073/pnas.0610170104 [Abstract] [Full Text] [Figures Only] [PDF]  

Eduard Bitto, Craig A. Bingman, Gary E. Wesenberg, Jason G. McCoy, and George N. Phillips, Jr. From the Cover: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease PNAS 2007 104: 456-461; published online before print December 28 2006, 10.1073/pnas.0607817104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]   See Commentary on page 399

Adam Ben-Shem, Deborah Fass, and Eitan Bibi

Structural basis for intramembrane proteolysis by rhomboid serine proteases
PNAS 2007 104: 462-466; published online before print December 26 2006, 10.1073/pnas.0609773104 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 401

Valerie E. Pye, Fabienne Beuron, Catherine A. Keetch, Ciaran McKeown, Carol V. Robinson, Hemmo H. Meyer, Xiaodong Zhang, and Paul S. Freemont Structural insights into the p97-Ufd1-Npl4 complex PNAS 2007 104: 467-472; published online before print January 3 2007, 10.1073/pnas.0603408104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Farhad Forouhar, J. L. Ross Anderson, Christopher G. Mowat, Sergey M. Vorobiev, Arif Hussain, Mariam Abashidze, Chiara Bruckmann, Sarah J. Thackray, Jayaraman Seetharaman, Todd Tucker, Rong Xiao, Li-Chung Ma, Li Zhao, Thomas B. Acton, Gaetano T. Montelione, Stephen K. Chapman, and Liang Tong

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase
PNAS 2007 104: 473-478; published online before print December 29 2006, 10.1073/pnas.0610007104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

King Pan Ng, Gary Potikyan, Rupert O. V. Savene, Christopher T. Denny, Vladimir N. Uversky, and Kevin A. W. Lee

Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
PNAS 2007 104: 479-484; published online before print January 3 2007, 10.1073/pnas.0607007104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Katsumi Imada, Tohru Minamino, Aiko Tahara, and Keiichi Namba

Structural similarity between the flagellar type III ATPase FliI and F₁-ATPase subunits
PNAS 2007 104: 485-490; published online before print January 3 2007, 10.1073/pnas.0608090104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

H. Ronald Kaback, R. Dunten, S. Frillingos, P. Venkatesan, I. Kwaw, W. Zhang, and Natalia Ermolova

Site-directed alkylation and the alternating access model for LacY
PNAS 2007 104: 491-494; published online before print December 15 2006, 10.1073/pnas.0609968104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Biophysics

Luc Fetler, Evan R. Kantrowitz, and Patrice Vachette

Direct observation in solution of a preexisting structural equilibrium for a mutant of the allosteric aspartate transcarbamoylase
PNAS 2007 104: 495-500; published online before print January 3 2007, 10.1073/pnas.0607641104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Justin B. Kinney, Gasper Tkacik, and Curtis G. Callan, Jr.

Precise physical models of protein–DNA interaction from high-throughput data
PNAS 2007 104: 501-506; published online before print December 29 2006, 10.1073/pnas.0609908104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sam Hay, Michael J. Sutcliffe, and Nigel S. Scrutton

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
PNAS 2007 104: 507-512; published online before print January 3 2007, 10.1073/pnas.0608408104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Andrew D. Ferguson, Carlos A. Amezcua, Najeeb M. Halabi, Yogarany Chelliah, Michael K. Rosen, Rama Ranganathan, and Johann Deisenhofer Signal transduction pathway of TonB-dependent transporters PNAS 2007 104: 513-518; published online before print December 29 2006, 10.1073/pnas.0609887104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Frauke Baymann, Fabrice Giusti, Daniel Picot, and Wolfgang Nitschke

The c_i/b_H moiety in the b₆f complex studied by EPR: A pair of strongly interacting hemes
PNAS 2007 104: 519-524; published online before print January 3 2007, 10.1073/pnas.0606369104 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Ian K. Greaves, Danny Rangasamy, Patricia Ridgway, and David J. Tremethick

H2A.Z contributes to the unique 3D structure of the centromere
PNAS 2007 104: 525-530; published online before print December 28 2006, 10.1073/pnas.0607870104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Foster C. Gonsalves and David A. Weisblat

MAPK regulation of maternal and zygotic Notch transcript stability in early development
PNAS 2007 104: 531-536; published online before print January 3 2007, 10.1073/pnas.0609851104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Karin Schuster-Gossler, Ralf Cordes, and Achim Gossler

Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
PNAS 2007 104: 537-542; published online before print December 28 2006, 10.1073/pnas.0608281104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Environmental Sciences

Diane R. Elam, Caroline E. Ridley, Karen Goodell, and Norman C. Ellstrand Population size and relatedness affect fitness of a self-incompatible invasive plant PNAS 2007 104: 549-552; published online before print December 29 2006, 10.1073/pnas.0607306104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Evolution

Dustin J. Penn and Ken R. Smith

Differential fitness costs of reproduction between the sexes
PNAS 2007 104: 553-558; published online before print December 27 2006, 10.1073/pnas.0609301103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Chihiro Koike, Monica Uddin, Derek E. Wildman, Edward A. Gray, Massimo Trucco, Thomas E. Starzl, and Morris Goodman

Functionally important glycosyltransferase gain and loss during catarrhine primate emergence
PNAS 2007 104: 559-564; published online before print December 28 2006, 10.1073/pnas.0610012104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sonja Wedmann, Sven Bradler, and Jes Rust

The first fossil leaf insect: 47 million years of specialized cryptic morphology and behavior
PNAS 2007 104: 565-569; published online before print December 29 2006, 10.1073/pnas.0606937104 [Abstract] [Full Text] [Figures Only] [PDF]  

Immunology

Vincent Butty, Matt Roy, Pardis Sabeti, Whitney Besse, Christophe Benoist, and Diane Mathis

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes
PNAS 2007 104: 570-575; published online before print December 29 2006, 10.1073/pnas.0610124104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joshua D. Milner, Jerrold M. Ward, Andrea Keane-Myers, and William E. Paul Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease PNAS 2007 104: 576-581; published online before print January 3 2007, 10.1073/pnas.0610289104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Takeshi Saito, Reiko Hirai, Yueh-Ming Loo, David Owen, Cynthia L. Johnson, Sangita C. Sinha, Shizuo Akira, Takashi Fujita, and Michael Gale, Jr.

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
PNAS 2007 104: 582-587; published online before print December 26 2006, 10.1073/pnas.0606699104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Noriko Sato, Hiral J. Patel, Thomas A. Waldmann, and Yutaka Tagaya

The IL-15/IL-15R on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells
PNAS 2007 104: 588-593; published online before print January 3 2007, 10.1073/pnas.0610115104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Marinos Kallikourdis, Kristian G. Andersen, Katie A. Welch, and Alexander G. Betz

Alloantigen-enhanced accumulation of CCR5⁺ ‘effector’ regulatory T cells in the gravid uterus
PNAS 2007 104: 594-599; published online before print December 29 2006, 10.1073/pnas.0604268104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Medical Sciences

José Inzunza, Andrea Morani, Guojun Cheng, Margaret Warner, Julius Hreinsson, Jan-Åke Gustafsson, and Outi Hovatta

Ovarian wedge resection restores fertility in estrogen receptor knockout (ER^–/–) mice
PNAS 2007 104: 600-605; published online before print December 29 2006, 10.1073/pnas.0608951103 [Abstract] [Full Text] [Figures Only] [PDF]  

Fredrik Bäckhed, Peter A. Crawford, David O'Donnell, and Jeffrey I. Gordon Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor PNAS 2007 104: 606-611; published online before print January 3 2007, 10.1073/pnas.0605957104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Julie R. McMullen, Fatemeh Amirahmadi, Elizabeth A. Woodcock, Martina Schinke-Braun, Russell D. Bouwman, Kimberly A. Hewitt, Janelle P. Mollica, Li Zhang, Yunyu Zhang, Tetsuo Shioi, Antje Buerger, Seigo Izumo, Patrick Y. Jay, and Garry L. Jennings

Protective effects of exercise and phosphoinositide 3-kinase(p110) signaling in dilated and hypertrophic cardiomyopathy
PNAS 2007 104: 612-617; published online before print January 3 2007, 10.1073/pnas.0606663104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Wendy A. Woodward, Mercy S. Chen, Fariba Behbod, Maria P. Alfaro, Thomas A. Buchholz, and Jeffrey M. Rosen

WNT/-catenin mediates radiation resistance of mouse mammary progenitor cells
PNAS 2007 104: 618-623; published online before print January 3 2007, 10.1073/pnas.0606599104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Bettina Hartlieb, Tadeusz Muziol, Winfried Weissenhorn, and Stephan Becker

Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association
PNAS 2007 104: 624-629; published online before print January 3 2007, 10.1073/pnas.0606730104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoshiharu Yamaichi, Michael A. Fogel, and Matthew K. Waldor par genes and the pathology of chromosome loss in Vibrio cholerae PNAS 2007 104: 630-635; published online before print December 29 2006, 10.1073/pnas.0608341104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Neuroscience

Karl K. Szpunar, Jason M. Watson, and Kathleen B. McDermott Neural substrates of envisioning the future PNAS 2007 104: 642-647; published online before print January 3 2007, 10.1073/pnas.0610082104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Haydn M. Prosser, Allan Bradley, Johanna E. Chesham, Francis J. P. Ebling, Michael H. Hastings, and Elizabeth S. Maywood Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei PNAS 2007 104: 648-653; published online before print January 3 2007, 10.1073/pnas.0606884104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Asim J. Rashid, Christopher H. So, Michael M. C. Kong, Teresa Furtak, Mufida El-Ghundi, Regina Cheng, Brian F. O'Dowd, and Susan R. George

D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G_q/11 in the striatum
PNAS 2007 104: 654-659; published online before print December 28 2006, 10.1073/pnas.0604049104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tej K. Pareek, Jason Keller, Sashi Kesavapany, Nitin Agarwal, Rohini Kuner, Harish C. Pant, Michael J. Iadarola, Roscoe O. Brady, and Ashok B. Kulkarni Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1 PNAS 2007 104: 660-665; published online before print December 28 2006, 10.1073/pnas.0609916104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Physiology

María Isabel Niemeyer, Fernando D. González-Nilo, Leandro Zúñiga, Wendy González, L. Pablo Cid, and Francisco V. Sepúlveda

Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K⁺ channel
PNAS 2007 104: 666-671; published online before print December 29 2006, 10.1073/pnas.0606173104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Plant Biology

Christophe Laloi, Monika Stachowiak, Emilia Pers-Kamczyc, Ewelina Warzych, Irene Murgia, and Klaus Apel

Cross-talk between singlet oxygen- and hydrogen peroxide-dependent signaling of stress responses in Arabidopsis thaliana
PNAS 2007 104: 672-677; published online before print December 29 2006, 10.1073/pnas.0609063103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Katrin Philippar, Tina Geis, Iryna Ilkavets, Ulrike Oster, Serena Schwenkert, Jörg Meurer, and Jürgen Soll

Chloroplast biogenesis: The use of mutants to study the etioplast–chloroplast transition
PNAS 2007 104: 678-683; published online before print January 3 2007, 10.1073/pnas.0610062104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Politz et al., MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells [Full Text] [Figures Only] [PDF]  

Correction for Newton et al., A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion [Full Text] [Figures Only] [PDF]