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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 12583-12584. [Full Text] [PDF]  

COMMENTARIES

Jonathan A. Foley, Chad Monfreda, Navin Ramankutty, and David Zaks

Our share of the planetary pie
PNAS 2007 104: 12585-12586; published online on July 23, 2007, 10.1073/pnas.0705190104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 12942

SPECIAL FEATURE

Introductory Perspectives

Robert J. Silbey

Single-Molecule Chemistry and Biology Special Feature: Introduction to the Special Feature on Single-Molecule Chemistry and Biology
PNAS 2007 104: 12595; published online on July 30, 2007, 10.1073/pnas.0705693104 [Extract] [Full Text] [PDF]  

Perspectives

W. E. Moerner

Single-molecule Chemistry and Biology Special Feature: New directions in single-molecule imaging and analysis
PNAS 2007 104: 12596-12602; published online on July 30, 2007, 10.1073/pnas.0610081104 [Abstract] [Full Text] [Figures Only] [PDF]  

Maarten B. J. Roeffaers, Gert De Cremer, Hiroshi Uji-i, Benîot Muls, Bert F. Sels, Pierre A. Jacobs, Frans C. De Schryver, Dirk E. De Vos, and Johan Hofkens

From the Cover: Single-molecule Chemistry And Biology Special Feature: Single-molecule fluorescence spectroscopy in (bio)catalysis
PNAS 2007 104: 12603-12609; published online on July 30, 2007, 10.1073/pnas.0610755104 [Abstract] [Full Text] [Figures Only] [PDF]  

Research Articles

Guobin Luo, Mina Wang, William H. Konigsberg, and X. Sunney Xie

Single-molecule Chemistry and Biology Special Feature: Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase
PNAS 2007 104: 12610-12615; published online on July 18, 2007, 10.1073/pnas.0700920104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tom Vosch, Yasuko Antoku, Jung-Cheng Hsiang, Chris I. Richards, Jose I. Gonzalez, and Robert M. Dickson

Single-molecule Chemistry and Biology Special Feature: Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores
PNAS 2007 104: 12616-12621; published online on May 22, 2007, 10.1073/pnas.0610677104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Adam E. Cohen and W. E. Moerner

Single-molecule Chemistry and Biology Special Feature: Principal-components analysis of shape fluctuations of single DNA molecules
PNAS 2007 104: 12622-12627; published online on May 11, 2007, 10.1073/pnas.0610396104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Rob Zondervan, Florian Kulzer, Gregorius C. G. Berkhout, and Michel Orrit

Single-molecule Chemistry and Biology Special Feature: Local viscosity of supercooled glycerol near T_g probed by rotational diffusion of ensembles and single dye molecules
PNAS 2007 104: 12628-12633; published online on May 8, 2007, 10.1073/pnas.0610521104 [Abstract] [Full Text] [Figures Only] [PDF]  

Shixin Liu, Gregory Bokinsky, Nils G. Walter, and Xiaowei Zhuang

Single-molecule Chemistry and Biology Special Feature: Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic "fingerprinting"
PNAS 2007 104: 12634-12639; published online on May 11, 2007, 10.1073/pnas.0610597104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Devdoot S. Majumdar, Irina Smirnova, Vladimir Kasho, Eyal Nir, Xiangxu Kong, Shimon Weiss, and H. Ronald Kaback

Single-molecule Chemistry and Biology Special Feature: Single-molecule FRET reveals sugar-induced conformational dynamics in LacY
PNAS 2007 104: 12640-12645; published online on May 14, 2007, 10.1073/pnas.0700969104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ibrahim Cisse, Burak Okumus, Chirlmin Joo, and Taekjip Ha

Single-molecule Chemistry and Biology Special Feature: Fueling protein–DNA interactions inside porous nanocontainers
PNAS 2007 104: 12646-12650; published online on June 11, 2007, 10.1073/pnas.0610673104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yining Zeng, Hsiao-Wei Liu, Christy F. Landes, Yoen Joo Kim, Xiaojing Ma, Yongjin Zhu, Karin Musier-Forsyth, and Paul F. Barbara

Single-molecule Chemistry and Biology Special Feature: Probing nucleation, reverse annealing, and chaperone function along the reaction path of HIV-1 single-strand transfer
PNAS 2007 104: 12651-12656; published online on June 19, 2007, 10.1073/pnas.0700350104 [Abstract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Jonathan Weare

Efficient Monte Carlo sampling by parallel marginalization
PNAS 2007 104: 12657-12662; published online on July 19, 2007, 10.1073/pnas.0705418104 [Abstract] [Full Text] [Figures Only] [PDF]  

Kevin F. Murphy, Gábor Balázsi, and James J. Collins Combinatorial promoter design for engineering noisy gene expression PNAS 2007 104: 12726-12731; published online on July 24, 2007, 10.1073/pnas.0608451104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Chemistry

Guobin Luo, Mina Wang, William H. Konigsberg, and X. Sunney Xie

Single-molecule Chemistry and Biology Special Feature: Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase
PNAS 2007 104: 12610-12615; published online on July 18, 2007, 10.1073/pnas.0700920104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tom Vosch, Yasuko Antoku, Jung-Cheng Hsiang, Chris I. Richards, Jose I. Gonzalez, and Robert M. Dickson

Single-molecule Chemistry and Biology Special Feature: Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores
PNAS 2007 104: 12616-12621; published online on May 22, 2007, 10.1073/pnas.0610677104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Physics

Adam E. Cohen and W. E. Moerner

Single-molecule Chemistry and Biology Special Feature: Principal-components analysis of shape fluctuations of single DNA molecules
PNAS 2007 104: 12622-12627; published online on May 11, 2007, 10.1073/pnas.0610396104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Rob Zondervan, Florian Kulzer, Gregorius C. G. Berkhout, and Michel Orrit

Single-molecule Chemistry and Biology Special Feature: Local viscosity of supercooled glycerol near T_g probed by rotational diffusion of ensembles and single dye molecules
PNAS 2007 104: 12628-12633; published online on May 8, 2007, 10.1073/pnas.0610521104 [Abstract] [Full Text] [Figures Only] [PDF]  

Statistics

Q. K. Beg, A. Vazquez, J. Ernst, M. A. de Menezes, Z. Bar-Joseph, A.-L. Barabási, and Z. N. Oltvai

Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity
PNAS 2007 104: 12663-12668; published online on July 24, 2007, 10.1073/pnas.0609845104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Psychology

Gordon Binsted, Kyle Brownell, Zofia Vorontsova, Matthew Heath, and Deborah Saucier

Visuomotor system uses target features unavailable to conscious awareness
PNAS 2007 104: 12669-12672; published online on July 23, 2007, 10.1073/pnas.0702307104 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Biochemistry

Guobin Luo, Mina Wang, William H. Konigsberg, and X. Sunney Xie

Single-molecule Chemistry and Biology Special Feature: Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase
PNAS 2007 104: 12610-12615; published online on July 18, 2007, 10.1073/pnas.0700920104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

David E. Prosser, Martin Kaufmann, Brendan O'Leary, Valarie Byford, and Glenville Jones

Single A326G mutation converts human CYP24A1 from 25-OH-D₃-24-hydroxylase into -23-hydroxylase, generating 1,25-(OH)₂D₃-26,23-lactone
PNAS 2007 104: 12673-12678; published online on July 23, 2007, 10.1073/pnas.0702093104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chun-Te Wu, Saleh Altuwaijri, William A. Ricke, Shu-Pin Huang, Shuyuan Yeh, Caixia Zhang, Yuanjie Niu, Meng-Ying Tsai, and Chawnshang Chang

Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor
PNAS 2007 104: 12679-12684; published online on July 25, 2007, 10.1073/pnas.0704940104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] [Online Correction for SI Fig. 8]  

Y. Paul Chang, Ganggang Wang, Vladimir Bermudez, Jerard Hurwitz, and Xiaojiang S. Chen

Crystal structure of the GINS complex and functional insights into its role in DNA replication
PNAS 2007 104: 12685-12690; published online on July 25, 2007, 10.1073/pnas.0705558104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tsai-Yu Tzeng, Chi-Hua Lee, Li-Wei Chan, and C.-K. James Shen

Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1
PNAS 2007 104: 12691-12696; published online on July 25, 2007, 10.1073/pnas.0705534104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kenneth Segers, Olivier Sperandio, Markus Sack, Rainer Fischer, Maria A. Miteva, Jan Rosing, Gerry A. F. Nicolaes, and Bruno O. Villoutreix

Design of protein–membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V
PNAS 2007 104: 12697-12702; published online on July 23, 2007, 10.1073/pnas.0701051104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tobin J. Dickerson, Kathleen M. McKenzie, Amanda S. Hoyt, Malcolm R. Wood, Kim D. Janda, Sydney B. Brenner, and Richard A. Lerner

Phage escape libraries for checkmate analysis
PNAS 2007 104: 12703-12708; published online on July 23, 2007, 10.1073/pnas.0705362104 [Abstract] [Full Text] [Figures Only] [PDF]  

Anna Pluciennik and Paul Modrich From the Cover: Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair PNAS 2007 104: 12709-12713; published online on July 9, 2007, 10.1073/pnas.0705129104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE   See Commentary on page 12953

Hirofumi Onishi and Manuel F. Morales A closer look at energy transduction in muscle PNAS 2007 104: 12714-12719; published online on July 18, 2007, 10.1073/pnas.0705525104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Gregory Yakovlev, Torsten Reda, and Judy Hirst Reevaluating the relationship between EPR spectra and enzyme structure for the iron–sulfur clusters in NADH:quinone oxidoreductase PNAS 2007 104: 12720-12725; published online on July 19, 2007, 10.1073/pnas.0705593104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Biophysics

Adam E. Cohen and W. E. Moerner

Single-molecule Chemistry and Biology Special Feature: Principal-components analysis of shape fluctuations of single DNA molecules
PNAS 2007 104: 12622-12627; published online on May 11, 2007, 10.1073/pnas.0610396104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shixin Liu, Gregory Bokinsky, Nils G. Walter, and Xiaowei Zhuang

Single-molecule Chemistry and Biology Special Feature: Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic "fingerprinting"
PNAS 2007 104: 12634-12639; published online on May 11, 2007, 10.1073/pnas.0610597104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Devdoot S. Majumdar, Irina Smirnova, Vladimir Kasho, Eyal Nir, Xiangxu Kong, Shimon Weiss, and H. Ronald Kaback

Single-molecule Chemistry and Biology Special Feature: Single-molecule FRET reveals sugar-induced conformational dynamics in LacY
PNAS 2007 104: 12640-12645; published online on May 14, 2007, 10.1073/pnas.0700969104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ibrahim Cisse, Burak Okumus, Chirlmin Joo, and Taekjip Ha

Single-molecule Chemistry and Biology Special Feature: Fueling protein–DNA interactions inside porous nanocontainers
PNAS 2007 104: 12646-12650; published online on June 11, 2007, 10.1073/pnas.0610673104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yining Zeng, Hsiao-Wei Liu, Christy F. Landes, Yoen Joo Kim, Xiaojing Ma, Yongjin Zhu, Karin Musier-Forsyth, and Paul F. Barbara

Single-molecule Chemistry and Biology Special Feature: Probing nucleation, reverse annealing, and chaperone function along the reaction path of HIV-1 single-strand transfer
PNAS 2007 104: 12651-12656; published online on June 19, 2007, 10.1073/pnas.0700350104 [Abstract] [Full Text] [Figures Only] [PDF]  

Q. K. Beg, A. Vazquez, J. Ernst, M. A. de Menezes, Z. Bar-Joseph, A.-L. Barabási, and Z. N. Oltvai

Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity
PNAS 2007 104: 12663-12668; published online on July 24, 2007, 10.1073/pnas.0609845104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kevin F. Murphy, Gábor Balázsi, and James J. Collins Combinatorial promoter design for engineering noisy gene expression PNAS 2007 104: 12726-12731; published online on July 24, 2007, 10.1073/pnas.0608451104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sune Danø, Mads Find Madsen, and Preben Graae Sørensen

Quantitative characterization of cell synchronization in yeast
PNAS 2007 104: 12732-12736; published online on July 25, 2007, 10.1073/pnas.0702560104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Trevor Huyton, Jian-Guo Zhang, Cindy S. Luo, Mei-Zhen Lou, Douglas J. Hilton, Nicos A. Nicola, and Thomas P. J. Garrett

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor
PNAS 2007 104: 12737-12742; published online on July 24, 2007, 10.1073/pnas.0705577104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ronen Benjamine Kopito and Michael Elbaum

Reversibility in nucleocytoplasmic transport
PNAS 2007 104: 12743-12748; published online on July 23, 2007, 10.1073/pnas.0702690104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Virgiliu Botan, Ellen H. G. Backus, Rolf Pfister, Alessandro Moretto, Marco Crisma, Claudio Toniolo, Phuong H. Nguyen, Gerhard Stock, and Peter Hamm

Energy transport in peptide helices
PNAS 2007 104: 12749-12754; published online on July 23, 2007, 10.1073/pnas.0701762104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neal Crampton, Masatoshi Yokokawa, David T. F. Dryden, J. Michael Edwardson, Desirazu N. Rao, Kunio Takeyasu, Shige H. Yoshimura, and Robert M. Henderson

Fast-scan atomic force microscopy reveals that the type III restriction enzyme EcoP15I is capable of DNA translocation and looping
PNAS 2007 104: 12755-12760; published online on July 23, 2007, 10.1073/pnas.0700483104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Lucy R. Forrest, Sotiria Tavoulari, Yuan-Wei Zhang, Gary Rudnick, and Barry Honig

Identification of a chloride ion binding site in Na⁺/Cl^–-dependent transporters
PNAS 2007 104: 12761-12766; published online on July 24, 2007, 10.1073/pnas.0705600104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anna Diller, Esha Roy, Peter Gast, Hans J. van Gorkom, Huub J. M. de Groot, Clemens Glaubitz, Gunnar Jeschke, Jörg Matysik, and A. Alia

¹⁵N photochemically induced dynamic nuclear polarization magic-angle spinning NMR analysis of the electron donor of photosystem II
PNAS 2007 104: 12767-12771; published online on July 24, 2007, 10.1073/pnas.0701763104 [Abstract] [Full Text] [Figures Only] [PDF]  

John J. Dwyer, Karen L. Wilson, Donna K. Davison, Stephanie A. Freel, Jennifer E. Seedorff, Stephen A. Wring, Nicolai A. Tvermoes, Thomas J. Matthews, Michael L. Greenberg, and Mary K. Delmedico

Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus
PNAS 2007 104: 12772-12777; published online on July 19, 2007, 10.1073/pnas.0701478104 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Frederick A. Derheimer, Heather M. O'Hagan, Heather M. Krueger, Sheela Hanasoge, Michelle T. Paulsen, and Mats Ljungman

RPA and ATR link transcriptional stress to p53
PNAS 2007 104: 12778-12783; published online on July 6, 2007, 10.1073/pnas.0705317104 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 13213

Sunny Y. Wong, Herbert Haack, Joseph L. Kissil, Marc Barry, Roderick T. Bronson, Steven S. Shen, Charles A. Whittaker, Denise Crowley, and Richard O. Hynes Protein 4.1B suppresses prostate cancer progression and metastasis PNAS 2007 104: 12784-12789; published online on July 18, 2007, 10.1073/pnas.0705499104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Colin Rae, Susana Langa, Steven J. Tucker, and David J. MacEwan

Elevated NF-B responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis
PNAS 2007 104: 12790-12795; published online on July 23, 2007, 10.1073/pnas.0701437104 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Peter D. Gluckman, Karen A. Lillycrop, Mark H. Vickers, Anthony B. Pleasants, Emma S. Phillips, Alan S. Beedle, Graham C. Burdge, and Mark A. Hanson

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
PNAS 2007 104: 12796-12800; published online on July 23, 2007, 10.1073/pnas.0705667104 [Abstract] [Full Text] [Figures Only] [PDF]  

Evolution

Radek Szklarczyk, Jaap Heringa, Sergei Kosakovsky Pond, and Anton Nekrutenko

Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function
PNAS 2007 104: 12807-12812; published online on July 24, 2007, 10.1073/pnas.0703238104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Taro Tsujimura, Akito Chinen, and Shoji Kawamura

Identification of a locus control region for quadruplicated green-sensitive opsin genes in zebrafish
PNAS 2007 104: 12813-12818; published online on July 23, 2007, 10.1073/pnas.0704061104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Eugenia N. Andreyeva, Tatyana D. Kolesnikova, Olga V. Demakova, Maria Mendez-Lago, Galina V. Pokholkova, Elena S. Belyaeva, Fabrizio Rossi, Patrizio Dimitri, Alfredo Villasante, and Igor F. Zhimulev

High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants
PNAS 2007 104: 12819-12824; published online on July 18, 2007, 10.1073/pnas.0704690104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Wu Wei, John H. McCusker, Richard W. Hyman, Ted Jones, Ye Ning, Zhiwei Cao, Zhenglong Gu, Dan Bruno, Molly Miranda, Michelle Nguyen, Julie Wilhelmy, Caridad Komp, Raquel Tamse, Xiaojing Wang, Peilin Jia, Philippe Luedi, Peter J. Oefner, Lior David, Fred S. Dietrich, Yixue Li, Ronald W. Davis, and Lars M. Steinmetz Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789 PNAS 2007 104: 12825-12830; published online on July 25, 2007, 10.1073/pnas.0701291104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Xiaoyue Zhao, Anthony Leotta, Vlad Kustanovich, Clara Lajonchere, Daniel H. Geschwind, Kiely Law, Paul Law, Shanping Qiu, Catherine Lord, Jonathan Sebat, Kenny Ye, and Michael Wigler A unified genetic theory for sporadic and inherited autism PNAS 2007 104: 12831-12836; published online on July 25, 2007, 10.1073/pnas.0705803104 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Kunle Odunsi, Feng Qian, Junko Matsuzaki, Paulette Mhawech-Fauceglia, Christopher Andrews, Eric W. Hoffman, Linda Pan, Gerd Ritter, Jeannine Villella, Bridget Thomas, Kerry Rodabaugh, Shashikant Lele, Protul Shrikant, Lloyd J. Old, and Sacha Gnjatic

Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
PNAS 2007 104: 12837-12842; published online on July 25, 2007, 10.1073/pnas.0703342104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gionata Cavadini, Saskia Petrzilka, Philipp Kohler, Corinne Jud, Irene Tobler, Thomas Birchler, and Adriano Fontana From the Cover: TNF- suppresses the expression of clock genes by interfering with E-box-mediated transcription PNAS 2007 104: 12843-12848; published online on July 23, 2007, 10.1073/pnas.0701466104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Milan Fiala, Philip T. Liu, Araceli Espinosa-Jeffrey, Mark J. Rosenthal, George Bernard, John M. Ringman, James Sayre, Laura Zhang, Justin Zaghi, Sheila Dejbakhsh, Ben Chiang, James Hui, Michelle Mahanian, Anita Baghaee, Pamela Hong, and John Cashman

Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin
PNAS 2007 104: 12849-12854; published online on July 24, 2007, 10.1073/pnas.0701267104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Donna L. Pedicord, Dietmar Seiffert, and Yuval Blat

Feedback activation of factor XI by thrombin does not occur in plasma
PNAS 2007 104: 12855-12860; published online on July 25, 2007, 10.1073/pnas.0705566104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joseph T. Rodgers and Pere Puigserver

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
PNAS 2007 104: 12861-12866; published online on July 23, 2007, 10.1073/pnas.0702509104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Paul H. Huang, Akitake Mukasa, Rudy Bonavia, Ryan A. Flynn, Zachary E. Brewer, Webster K. Cavenee, Frank B. Furnari, and Forest M. White

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
PNAS 2007 104: 12867-12872; published online on July 23, 2007, 10.1073/pnas.0705158104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Akihiko Urayama, Jeffrey H. Grubb, William A. Banks, and William S. Sly

Epinephrine enhances lysosomal enzyme delivery across the blood–brain barrier by up-regulation of the mannose 6-phosphate receptor
PNAS 2007 104: 12873-12878; published online on July 23, 2007, 10.1073/pnas.0705611104 [Abstract] [Full Text] [Figures Only] [PDF]  

Markus Loeffler, Gaelle Le'Negrate, Maryla Krajewska, and John C. Reed

Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth
PNAS 2007 104: 12879-12883; published online on July 24, 2007, 10.1073/pnas.0701959104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Glenn Randall, Maryline Panis, Jacob D. Cooper, Timothy L. Tellinghuisen, Karen E. Sukhodolets, Sebastien Pfeffer, Markus Landthaler, Pablo Landgraf, Sherry Kan, Brett D. Lindenbach, Minchen Chien, David B. Weir, James J. Russo, Jingyue Ju, Michael J. Brownstein, Robert Sheridan, Chris Sander, Mihaela Zavolan, Thomas Tuschl, and Charles M. Rice

Cellular cofactors affecting hepatitis C virus infection and replication
PNAS 2007 104: 12884-12889; published online on July 6, 2007, 10.1073/pnas.0704894104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 13215

Amir Abdollahi, Christian Schwager, Jörg Kleeff, Irene Esposito, Sophie Domhan, Peter Peschke, Kai Hauser, Philip Hahnfeldt, Lynn Hlatky, Jürgen Debus, Jeffrey M. Peters, Helmut Friess, Judah Folkman, and Peter E. Huber Transcriptional network governing the angiogenic switch in human pancreatic cancer PNAS 2007 104: 12890-12895; published online on July 24, 2007, 10.1073/pnas.0705505104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Microbiology

Alexandre Bougdour and Susan Gottesman

ppGpp regulation of RpoS degradation via anti-adaptor protein IraP
PNAS 2007 104: 12896-12901; published online on July 19, 2007, 10.1073/pnas.0705561104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gert C. Segers, Xuemin Zhang, Fuyou Deng, Qihong Sun, and Donald L. Nuss

Evidence that RNA silencing functions as an antiviral defense mechanism in fungi
PNAS 2007 104: 12902-12906; published online on July 23, 2007, 10.1073/pnas.0702500104 [Abstract] [Full Text] [Figures Only] [PDF]  

K. Sjöström, C. Blomberg, J. Fernebro, J. Dagerhamn, E. Morfeldt, M. A. Barocchi, S. Browall, M. Moschioni, M. Andersson, F. Henriques, B. Albiger, Rino Rappuoli, S. Normark, and B. Henriques-Normark Clonal success of piliated penicillin nonsusceptible pneumococci PNAS 2007 104: 12907-12912; published online on July 20, 2007, 10.1073/pnas.0705589104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Neuroscience

Gordon Binsted, Kyle Brownell, Zofia Vorontsova, Matthew Heath, and Deborah Saucier

Visuomotor system uses target features unavailable to conscious awareness
PNAS 2007 104: 12669-12672; published online on July 23, 2007, 10.1073/pnas.0702307104 [Abstract] [Full Text] [Figures Only] [PDF]  

Erna A. van Niekerk, Dianna E. Willis, Jay H. Chang, Kerstin Reumann, Tilman Heise, and Jeffery L. Twiss

Sumoylation in axons triggers retrograde transport of the RNA-binding protein La
PNAS 2007 104: 12913-12918; published online on July 23, 2007, 10.1073/pnas.0611562104 [Abstract] [Full Text] [Figures Only] [PDF]  

Amaya Miquelajauregui, Tom Van de Putte, Alexander Polyakov, Anjana Nityanandam, Sridhar Boppana, Eve Seuntjens, Anton Karabinos, Yujiro Higashi, Danny Huylebroeck, and Victor Tarabykin Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation PNAS 2007 104: 12919-12924; published online on July 20, 2007, 10.1073/pnas.0609863104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Shail K. Sharma and Marshall Nirenberg

Silencing of genes in cultured Drosophila neurons by RNA interference
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