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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 18345-18346. [Full Text] [PDF]  

COMMENTARIES

George Hinkal and Lawrence A. Donehower

Decline and fall of the tumor suppressor
PNAS 2007 104: 18347-18348; published online on November 12, 2007, 10.1073/pnas.0709330104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 16633 in issue 42 of volume 104

Mordecai P. Blaustein, Thomas H. Charpentier, and David J. Weber

Getting a grip on calcium regulation
PNAS 2007 104: 18349-18350; published online on November 14, 2007, 10.1073/pnas.0709008104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 18467

Edward C. Holmes

When HIV spread afar
PNAS 2007 104: 18351-18352; published online on November 14, 2007, 10.1073/pnas.0709179104 [Extract] [Full Text] [PDF]  
See companion article on page 18566

David Schimel

Carbon cycle conundrums
PNAS 2007 104: 18353-18354; published online on November 12, 2007, 10.1073/pnas.0709331104 [Extract] [Full Text] [PDF]  
See companion article on page 18866

PERSPECTIVES

Monita Y. M. Pau, John D. Lipscomb, and Edward I. Solomon

Substrate activation for O₂ reactions by oxidized metal centers in biology
PNAS 2007 104: 18355-18362; published online on November 14, 2007, 10.1073/pnas.0704191104 [Abstract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Silvia De Monte, Francesco d'Ovidio, Sune Danø, and Preben Graae Sørensen

Dynamical quorum sensing: Population density encoded in cellular dynamics
PNAS 2007 104: 18377-18381; published online on November 14, 2007, 10.1073/pnas.0706089104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Applied Physical Sciences

Graziano Vernizzi and Monica Olvera de la Cruz

Faceting ionic shells into icosahedra via electrostatics
PNAS 2007 104: 18382-18386; published online on November 14, 2007, 10.1073/pnas.0703431104 [Abstract] [Full Text] [Figures Only] [PDF]  

Francesco Mallamace, Caterina Branca, Matteo Broccio, Carmelo Corsaro, Chung-Yuan Mou, and Sow-Hsin Chen

The anomalous behavior of the density of water in the range 30 K < T < 373 K
PNAS 2007 104: 18387-18391; published online on November 13, 2007, 10.1073/pnas.0706504104 [Abstract] [Full Text] [Figures Only] [PDF]  

Shaffique Adam, E. H. Hwang, V. M. Galitski, and S. Das Sarma

A self-consistent theory for graphene transport
PNAS 2007 104: 18392-18397; published online on November 14, 2007, 10.1073/pnas.0704772104 [Abstract] [Full Text] [Figures Only] [PDF]  

Chemistry

Marcel O. Vlad, Alexandru Dan Corlan, Vlad T. Popa, and John Ross

On anti-portfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology
PNAS 2007 104: 18398-18403; published online on November 14, 2007, 10.1073/pnas.0708624104 [Abstract] [Full Text] [PDF]  

Luyuan Zhang, Lijuan Wang, Ya-Ting Kao, Weihong Qiu, Yi Yang, Oghaghare Okobiah, and Dongping Zhong From the Cover: Mapping hydration dynamics around a protein surface PNAS 2007 104: 18461-18466; published online on November 14, 2007, 10.1073/pnas.0707647104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Geology

Physics

Chuanwei Zhang, V. W. Scarola, Sumanta Tewari, and S. Das Sarma

Anyonic braiding in optical lattices
PNAS 2007 104: 18415-18420; published online on November 13, 2007, 10.1073/pnas.0709075104 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Economic Sciences

Kenneth J. Arrow, Alain Bensoussan, Qi Feng, and Suresh P. Sethi

Optimal savings and the value of population
PNAS 2007 104: 18421-18426; published online on November 5, 2007, 10.1073/pnas.0708030104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Wenbin Li, Qijian Song, Ronald H. Brlansky, and John S. Hartung

Genetic diversity of citrus bacterial canker pathogens preserved in herbarium specimens
PNAS 2007 104: 18427-18432; published online on November 12, 2007, 10.1073/pnas.0705590104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Applied Biological Sciences

Biochemistry

Adam W. Barb, Ling Jiang, Christian R. H. Raetz, and Pei Zhou

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
PNAS 2007 104: 18433-18438; published online on November 19, 2007, 10.1073/pnas.0709412104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

SunHwa Hong, Young-Wook Cho, Li-Rong Yu, Hong Yu, Timothy D. Veenstra, and Kai Ge

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
PNAS 2007 104: 18439-18444; published online on November 14, 2007, 10.1073/pnas.0707292104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Laure Yatime, Yves Mechulam, Sylvain Blanquet, and Emmanuelle Schmitt Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states PNAS 2007 104: 18445-18450; published online on November 13, 2007, 10.1073/pnas.0706784104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

R. E. Alcantara, C. Xu, T. G. Spiro, and V. Guallar

A quantum-chemical picture of hemoglobin affinity
PNAS 2007 104: 18451-18455; published online on November 14, 2007, 10.1073/pnas.0706026104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yasuko Noda, Barbara S. Berlett, Earl R. Stadtman, Angel Aponte, Meghan Morgan, and Rong-Fong Shen

Identification of enzymes and regulatory proteins in Escherichia coli that are oxidized under nitrogen, carbon, or phosphate starvation
PNAS 2007 104: 18456-18460; published online on November 14, 2007, 10.1073/pnas.0709368104 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

Gabriel Mercado Besserer, Michela Ottolia, Debora A. Nicoll, Vincent Chaptal, Duilio Cascio, Kenneth D. Philipson, and Jeff Abramson From the Cover: The second Ca2+-binding domain of the Na+–Ca2+ exchanger is essential for regulation: Crystal structures and mutational analysis PNAS 2007 104: 18467-18472; published online on October 25, 2007, 10.1073/pnas.0707417104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 18349

Pramodh Vallurupalli, D. Flemming Hansen, Elliott Stollar, Eva Meirovitch, and Lewis E. Kay

Measurement of bond vector orientations in invisible excited states of proteins
PNAS 2007 104: 18473-18477; published online on November 15, 2007, 10.1073/pnas.0708296104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hui Z. Mao and Joachim Weber

Identification of the _TP site in the x-ray structure of F₁-ATPase as the high-affinity catalytic site
PNAS 2007 104: 18478-18483; published online on November 14, 2007, 10.1073/pnas.0709322104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Akira Nakamura, Chieko Wada, and Kunio Miki

Structural basis for regulation of bifunctional roles in replication initiator protein
PNAS 2007 104: 18484-18489; published online on November 13, 2007, 10.1073/pnas.0705623104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nathalie Declerck, Laurent Bouillaut, Denis Chaix, Nathalie Rugani, Leyla Slamti, François Hoh, Didier Lereclus, and Stefan T. Arold

Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria
PNAS 2007 104: 18490-18495; published online on November 12, 2007, 10.1073/pnas.0704501104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Karunesh Arora and Charles L. Brooks, III

Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism
PNAS 2007 104: 18496-18501; published online on November 13, 2007, 10.1073/pnas.0706443104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Anuradha Pradhan, Que T. Lambert, and Gary W. Reuther

Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor
PNAS 2007 104: 18502-18507; published online on November 14, 2007, 10.1073/pnas.0702388104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Miriam Palacios-Callender, Veronica Hollis, Miriam Mitchison, Nanci Frakich, David Unitt, and Salvador Moncada Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation PNAS 2007 104: 18508-18513; published online on November 14, 2007, 10.1073/pnas.0709440104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Georgios T. Stathopoulos, Taylor P. Sherrill, Dong-Sheng Cheng, Robert M. Scoggins, Wei Han, Vasiliy V. Polosukhin, Linda Connelly, Fiona E. Yull, Barbara Fingleton, and Timothy S. Blackwell

Epithelial NF-B activation promotes urethane-induced lung carcinogenesis
PNAS 2007 104: 18514-18519; published online on November 13, 2007, 10.1073/pnas.0705316104 [Abstract] [Full Text] [Figures Only] [PDF] [Suppporting Text]  

Lindsay D. Rogers and Leonard J. Foster The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum PNAS 2007 104: 18520-18525; published online on November 15, 2007, 10.1073/pnas.0705801104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Yan Zhang and David C. Chan

Structural basis for recruitment of mitochondrial fission complexes by Fis1
PNAS 2007 104: 18526-18530; published online on November 12, 2007, 10.1073/pnas.0706441104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Developmental Biology

Alexandra Klaus, Yumiko Saga, Makoto M. Taketo, Eldad Tzahor, and Walter Birchmeier

Distinct roles of Wnt/-catenin and Bmp signaling during early cardiogenesis
PNAS 2007 104: 18531-18536; published online on November 13, 2007, 10.1073/pnas.0703113104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elena Zvaritch, Frederic Depreux, Natasha Kraeva, Ryan E. Loy, Sanjeewa A. Goonasekera, Simona Boncompagni, Alexander Kraev, Anthony O. Gramolini, Robert T. Dirksen, Clara Franzini-Armstrong, Christine E. Seidman, J. G. Seidman, and David H. MacLennan

An Ryr1^I4895T mutation abolishes Ca²⁺ release channel function and delays development in homozygous offspring of a mutant mouse line
PNAS 2007 104: 18537-18542; published online on November 14, 2007, 10.1073/pnas.0709312104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nanami Senoo-Matsuda and Laura A. Johnston Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc PNAS 2007 104: 18543-18548; published online on November 13, 2007, 10.1073/pnas.0709021104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jos Käfer, Takashi Hayashi, Athanasius F. M. Marée, Richard W. Carthew, and François Graner

Cell adhesion and cortex contractility determine cell patterning in the Drosophilaretina
PNAS 2007 104: 18549-18554; published online on November 14, 2007, 10.1073/pnas.0704235104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

J. Barlow, T. A. Gardner, I. S. Araujo, T. C. Ávila-Pires, A. B. Bonaldo, J. E. Costa, M. C. Esposito, L. V. Ferreira, J. Hawes, M. I. M. Hernandez, M. S. Hoogmoed, R. N. Leite, N. F. Lo-Man-Hung, J. R. Malcolm, M. B. Martins, L. A. M. Mestre, R. Miranda-Santos, A. L. Nunes-Gutjahr, W. L. Overal, L. Parry, S. L. Peters, M. A. Ribeiro-Junior, M. N. F. da Silva, C. da Silva Motta, and C. A. Peres

Quantifying the biodiversity value of tropical primary, secondary, and plantation forests
PNAS 2007 104: 18555-18560; published online on November 14, 2007, 10.1073/pnas.0703333104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

James E. Cloern, Alan D. Jassby, Janet K. Thompson, and Kathryn A. Hieb A cold phase of the East Pacific triggers new phytoplankton blooms in San Francisco Bay PNAS 2007 104: 18561-18565; published online on November 13, 2007, 10.1073/pnas.0706151104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Evolution

M. Thomas P. Gilbert, Andrew Rambaut, Gabriela Wlasiuk, Thomas J. Spira, Arthur E. Pitchenik, and Michael Worobey From the Cover: The emergence of HIV/AIDS in the Americas and beyond PNAS 2007 104: 18566-18570; published online on October 31, 2007, 10.1073/pnas.0705329104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE   See Commentary on page 18351

Mario Cáceres, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, Robert T. Sullivan, and James W. Thomas

A recurrent inversion on the eutherian X chromosome
PNAS 2007 104: 18571-18576; published online on November 14, 2007, 10.1073/pnas.0706604104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marta L. Wayne, Marina Telonis-Scott, Lisa M. Bono, Larry Harshman, Artyom Kopp, Sergey V. Nuzhdin, and Lauren M. McIntyre

Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster
PNAS 2007 104: 18577-18582; published online on November 14, 2007, 10.1073/pnas.0705441104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xinshu Xiao, Zefeng Wang, Minyoung Jang, and Christopher B. Burge

Coevolutionary networks of splicing cis-regulatory elements
PNAS 2007 104: 18583-18588; published online on November 12, 2007, 10.1073/pnas.0707349104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

V. L. Friesen, A. L. Smith, E. Gómez-Díaz, M. Bolton, R. W. Furness, J. González-Solís, and L. R. Monteiro

Sympatric speciation by allochrony in a seabird
PNAS 2007 104: 18589-18594; published online on November 15, 2007, 10.1073/pnas.0700446104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

A. M. Peattie and R. J. Full

Phylogenetic analysis of the scaling of wet and dry biological fibrillar adhesives
PNAS 2007 104: 18595-18600; published online on November 13, 2007, 10.1073/pnas.0707591104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Marcel O. Vlad, Alexandru Dan Corlan, Vlad T. Popa, and John Ross

On anti-portfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology
PNAS 2007 104: 18398-18403; published online on November 14, 2007, 10.1073/pnas.0708624104 [Abstract] [Full Text] [PDF]  

Susanne Wolfrum, Daniel Teupser, Marietta Tan, Kwan Y. Chen, and Jan L. Breslow The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-B target genes PNAS 2007 104: 18601-18606; published online on November 15, 2007, 10.1073/pnas.0709011104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE

Lisa M. Maier, David E. Anderson, Philip L. De Jager, Linda S. Wicker, and David A. Hafler

Allelic variant in CTLA4 alters T cell phosphorylation patterns
PNAS 2007 104: 18607-18612; published online on November 13, 2007, 10.1073/pnas.0706409104 [Abstract] [Full Text] [Figures Only] [PDF]  

Ting Wang, Jue Zeng, Craig B. Lowe, Robert G. Sellers, Sofie R. Salama, Min Yang, Shawn M. Burgess, Rainer K. Brachmann, and David Haussler Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53 PNAS 2007 104: 18613-18618; published online on November 14, 2007, 10.1073/pnas.0703637104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Tomoko Hayashi, Ji-Hun Mo, Xing Gong, Cyprian Rossetto, Angela Jang, Lucinda Beck, Gregory I. Elliott, Irina Kufareva, Ruben Abagyan, David H. Broide, Jongdae Lee, and Eyal Raz

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
PNAS 2007 104: 18619-18624; published online on November 14, 2007, 10.1073/pnas.0709261104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

F. Odoardi, N. Kawakami, W. E. F. Klinkert, H. Wekerle, and A. Flügel

Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease
PNAS 2007 104: 18625-18630; published online on November 13, 2007, 10.1073/pnas.0705033104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nicholas Funderburg, Michael M. Lederman, Zhimin Feng, Michael G. Drage, Julie Jadlowsky, Clifford V. Harding, Aaron Weinberg, and Scott F. Sieg Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2 PNAS 2007 104: 18631-18635; published online on November 15, 2007, 10.1073/pnas.0702130104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Supporting Figures] OPEN ACCESS ARTICLE

Medical Sciences

Min Li, Yuqing Zhang, Zijuan Liu, Uddalak Bharadwaj, Hao Wang, Xinwen Wang, Sheng Zhang, Juan P. Liuzzi, Shou-Mei Chang, Robert J. Cousins, William E. Fisher, F. Charles Brunicardi, Craig D. Logsdon, Changyi Chen, and Qizhi Yao

Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
PNAS 2007 104: 18636-18641; published online on November 14, 2007, 10.1073/pnas.0709307104 [Abstract] [Full Text] [Figures Only] [PDF]  

Donald Metcalf, Ian Majewski, Sandra Mifsud, Ladina Di Rago, and Warren S. Alexander

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1
PNAS 2007 104: 18642-18647; published online on November 13, 2007, 10.1073/pnas.0709625104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jean D. Boyer, Tara M. Robinson, Michele A. Kutzler, Gordon Vansant, David A. Hokey, Sanjeev Kumar, Rose Parkinson, Ling Wu, Maninder K. Sidhu, George N. Pavlakis, Barbara K. Felber, Charles Brown, Peter Silvera, Mark G. Lewis, Joseph Monforte, Thomas A. Waldmann, John Eldridge, and David B. Weiner

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid
PNAS 2007 104: 18648-18653; published online on November 13, 2007, 10.1073/pnas.0709198104 [Abstract] [Full Text] [Figures Only] [PDF]  

Lanlan Shen, Minoru Toyota, Yutaka Kondo, E Lin, Li Zhang, Yi Guo, Natalie Supunpong Hernandez, Xinli Chen, Saira Ahmed, Kazuo Konishi, Stanley R. Hamilton, and Jean-Pierre J. Issa

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
PNAS 2007 104: 18654-18659; published online on November 14, 2007, 10.1073/pnas.0704652104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shafaqat Ali, Michael Huber, Christian Kollewe, Stephan C. Bischoff, Werner Falk, and Michael U. Martin

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
PNAS 2007 104: 18660-18665; published online on November 14, 2007, 10.1073/pnas.0705939104 [Abstract] [Full Text] [Figures Only] [PDF]  

Hua Huang, Yan Chen, and Jin Ye Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E PNAS 2007 104: 18666-18670; published online on November 14, 2007, 10.1073/pnas.0708423104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Florian Hohla, Andrew V. Schally, Celia A. Kanashiro, Stefan Buchholz, Benjamin Baker, Chandrika Kannadka, Angelika Moder, Elmar Aigner, Christian Datz, and Gabor Halmos

Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt
PNAS 2007 104: 18671-18676; published online on November 14, 2007, 10.1073/pnas.0709455104 [Abstract] [Full Text] [Figures Only] [PDF]  

Minghui Xiang, Mingye Feng, Sabina Muend, and Rajini Rao

A human Na⁺/H⁺ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension
PNAS 2007 104: 18677-18681; published online on November 13, 2007, 10.1073/pnas.0707120104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tao Liu, Andrew E. L. Tee, Antonio Porro, Stewart A. Smith, Tanya Dwarte, Pei Yan Liu, Nunzio Iraci, Eric Sekyere, Michelle Haber, Murray D. Norris, Daniel Diolaiti, Giuliano Della Valle, Giovanni Perini, and Glenn M. Marshall

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis
PNAS 2007 104: 18682-18687; published online on November 14, 2007, 10.1073/pnas.0705524104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shengqiang Yu, Karl Hackmann, Jiangang Gao, Xiaobing He, Klaus Piontek, Miguel A. García-González, Luis F. Menezes, Hangxue Xu, Gregory G. Germino, Jian Zuo, and Feng Qian

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure
PNAS 2007 104: 18688-18693; published online on November 14, 2007, 10.1073/pnas.0708217104 [Abstract] [Full Text] [Figures Only] [PDF]  

Fabien Guidez, Sarah Parks, Henna Wong, Jelena V. Jovanovic, Ashley Mays, Amanda F. Gilkes, Kenneth I. Mills, Marie-Claude Guillemin, Robin M. Hobbs, Pier Paolo Pandolfi, Hugues de Thé, Ellen Solomon, and David Grimwade

RAR-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia
PNAS 2007 104: 18694-18699; published online on November 13, 2007, 10.1073/pnas.0704433104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Masanori Ono, Tetsuo Maruyama, Hirotaka Masuda, Takashi Kajitani, Takashi Nagashima, Toru Arase, Mamoru Ito, Kuniaki Ohta, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura, Hideyuki Okano, and Yumi Matsuzaki

Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells
PNAS 2007 104: 18700-18705; published online on November 14, 2007, 10.1073/pnas.0704472104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Rebecca N. Fong, Kwang-Seo Kim, Corinne Yoshihara, William B. Inwood, and Sydney Kustu

The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion
PNAS 2007 104: 18706-18711; published online on November 12, 2007, 10.1073/pnas.0709267104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yoko Eguchi, Junji Itou, Masatake Yamane, Ryo Demizu, Fumiyuki Yamato, Ario Okada, Hirotada Mori, Akinori Kato, and Ryutaro Utsumi

B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli
PNAS 2007 104: 18712-18717; published online on November 12, 2007, 10.1073/pnas.0705768104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Doina Atanasiu, J. Charles Whitbeck, Tina M. Cairns, Brigid Reilly, Gary H. Cohen, and Roselyn J. Eisenberg Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion PNAS 2007 104: 18718-18723; published online on November 14, 2007, 10.1073/pnas.0707452104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Frank S. De Silva, Whitney Lewis, Peter Berglund, Eugene V. Koonin, and Bernard Moss Poxvirus DNA primase PNAS 2007 104: 18724-18729; published online on November 13, 2007, 10.1073/pnas.0709276104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jun Xu, Charles W. Saunders, Ping Hu, Raymond A. Grant, Teun Boekhout, Eiko E. Kuramae, James W. Kronstad, Yvonne M. DeAngelis, Nancy L. Reeder, Kevin R. Johnstone, Meredith Leland, Angela M. Fieno, William M. Begley, Yiping Sun, Martin P. Lacey, Tanuja Chaudhary, Thomas Keough, Lien Chu, Russell Sears, Bo Yuan, and Thomas L. Dawson, Jr Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens PNAS 2007 104: 18730-18735; published online on November 13, 2007, 10.1073/pnas.0706756104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Neuroscience

Roberto C. Agís-Balboa, Graziano Pinna, Fabio Pibiri, Bashkim Kadriu, Erminio Costa, and Alessandro Guidotti

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice
PNAS 2007 104: 18736-18741; published online on November 14, 2007, 10.1073/pnas.0709419104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jianguo Fang, Tomohiro Nakamura, Dong-Hyung Cho, Zezong Gu, and Stuart A. Lipton

S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease
PNAS 2007 104: 18742-18747; published online on November 14, 2007, 10.1073/pnas.0705904104 [Abstract] [Full Text] [Figures Only] [PDF]  

Hossein Aleyasin, Maxime W. C. Rousseaux, Maryam Phillips, Raymond H. Kim, Ross J. Bland, Steve Callaghan, Ruth S. Slack, Matthew J. During, Tak W. Mak, and David S. Park

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage
PNAS 2007 104: 18748-18753; published online on November 14, 2007, 10.1073/pnas.0709379104 [Abstract] [Full Text] [Figures Only] [PDF]  

Anamitra Ghosh, Avik Roy, Xiaojuan Liu, Jeffrey H. Kordower, Elliott J. Mufson, Dean M. Hartley, Sankar Ghosh, R. Lee Mosley, Howard E. Gendelman, and Kalipada Pahan

Selective inhibition of NF-B activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
PNAS 2007 104: 18754-18759; published online on November 13, 2007, 10.1073/pnas.0704908104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

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PNAS 2007 104: 18766-18771; published online on November 12, 2007, 10.1073/pnas.0705618104 [Abstract] [Full Text] [Figures Only] [PDF]  

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