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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 2027-2028. [Full Text] [PDF]  

COMMENTARIES

Jacob Klein

Probing the interactions of proteins and nanoparticles
PNAS 2007 104: 2029-2030; published online before print February 6 2007, 10.1073/pnas.0611610104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2050

Venkat Gopalan

Uniformity amid diversity in RNase P
PNAS 2007 104: 2031-2032; published online before print February 7 2007, 10.1073/pnas.0611193104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2062

Alan Bird

How to keep photoreceptors alive
PNAS 2007 104: 2033-2034; published online before print February 6 2007, 10.1073/pnas.0611014104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2425

PHYSICAL SCIENCES

Chemistry

Juewen Liu, Andrea K. Brown, Xiangli Meng, Donald M. Cropek, Jonathan D. Istok, David B. Watson, and Yi Lu

A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity
PNAS 2007 104: 2056-2061; published online before print February 6 2007, 10.1073/pnas.0607875104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sharon Rozovsky and Ann E. McDermott Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase PNAS 2007 104: 2080-2085; published online before print February 7 2007, 10.1073/pnas.0608876104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sean D. Taverna, Beatrix M. Ueberheide, Yifan Liu, Alan J. Tackett, Robert L. Diaz, Jeffrey Shabanowitz, Brian T. Chait, Donald F. Hunt, and C. David Allis

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini
PNAS 2007 104: 2086-2091; published online before print February 6 2007, 10.1073/pnas.0610993104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jason C. Crack, Jeffrey Green, Myles R. Cheesman, Nick E. Le Brun, and Andrew J. Thomson

Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR
PNAS 2007 104: 2092-2097; published online before print January 31 2007, 10.1073/pnas.0609514104 [Abstract] [Full Text] [Figures Only] [PDF]  

Beat Fierz, Helmut Satzger, Christopher Root, Peter Gilch, Wolfgang Zinth, and Thomas Kiefhaber Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale PNAS 2007 104: 2163-2168; published online before print February 6 2007, 10.1073/pnas.0611087104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Young C. Kim, Mårten Wikström, and Gerhard Hummer

Kinetic models of redox-coupled proton pumping
PNAS 2007 104: 2169-2174; published online before print February 7 2007, 10.1073/pnas.0611114104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

An Chi, Curtis Huttenhower, Lewis Y. Geer, Joshua J. Coon, John E. P. Syka, Dina L. Bai, Jeffrey Shabanowitz, Daniel J. Burke, Olga G. Troyanskaya, and Donald F. Hunt

Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry
PNAS 2007 104: 2193-2198; published online before print February 7 2007, 10.1073/pnas.0607084104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Online Correction for SI Table 2]  

Physics

Changbong Hyeon and José N. Onuchic

Internal strain regulates the nucleotide binding site of the kinesin leading head
PNAS 2007 104: 2175-2180; published online before print February 7 2007, 10.1073/pnas.0610939104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

BIOLOGICAL SCIENCES

Biochemistry

Ema Kikovska, Staffan G. Svärd, and Leif A. Kirsebom From the Cover: Eukaryotic RNase P RNA mediates cleavage in the absence of protein PNAS 2007 104: 2062-2067; published online before print February 6 2007, 10.1073/pnas.0607326104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]   See Commentary on page 2031

Gelin Wang, Libin Shang, Anthony W. G. Burgett, Patrick G. Harran, and Xiaodong Wang Diazonamide toxins reveal an unexpected function for ornithine -amino transferase in mitotic cell division PNAS 2007 104: 2068-2073; published online before print February 7 2007, 10.1073/pnas.0610832104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Noelle S. Williams, Anthony W. G. Burgett, Ashley S. Atkins, Xiaodong Wang, Patrick G. Harran, and Steven L. McKnight Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity PNAS 2007 104: 2074-2079; published online before print February 7 2007, 10.1073/pnas.0611340104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sharon Rozovsky and Ann E. McDermott Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase PNAS 2007 104: 2080-2085; published online before print February 7 2007, 10.1073/pnas.0608876104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sean D. Taverna, Beatrix M. Ueberheide, Yifan Liu, Alan J. Tackett, Robert L. Diaz, Jeffrey Shabanowitz, Brian T. Chait, Donald F. Hunt, and C. David Allis

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini
PNAS 2007 104: 2086-2091; published online before print February 6 2007, 10.1073/pnas.0610993104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jason C. Crack, Jeffrey Green, Myles R. Cheesman, Nick E. Le Brun, and Andrew J. Thomson

Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR
PNAS 2007 104: 2092-2097; published online before print January 31 2007, 10.1073/pnas.0609514104 [Abstract] [Full Text] [Figures Only] [PDF]  

Yongcheng Wang and Ya Ha

Open-cap conformation of intramembrane protease GlpG
PNAS 2007 104: 2098-2102; published online before print February 2 2007, 10.1073/pnas.0611080104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yunsun Nam, Piotr Sliz, Warren S. Pear, Jon C. Aster, and Stephen C. Blacklow

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
PNAS 2007 104: 2103-2108; published online before print February 6 2007, 10.1073/pnas.0611092104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mohamad A. Abbani, Christie V. Papagiannis, My D. Sam, Duilio Cascio, Reid C. Johnson, and Robert T. Clubb

Structure of the cooperative Xis–DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly
PNAS 2007 104: 2109-2114; published online before print February 7 2007, 10.1073/pnas.0607820104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Giedrius Sasnauskas, Bernard A. Connolly, Stephen E. Halford, and Virginijus Siksnys Site-specific DNA transesterification catalyzed by a restriction enzyme PNAS 2007 104: 2115-2120; published online before print January 31 2007, 10.1073/pnas.0608689104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Randall J. DeJong, Lisa M. Miller, Alvaro Molina-Cruz, Lalita Gupta, Sanjeev Kumar, and Carolina Barillas-Mury

Reactive oxygen species detoxification by catalase is a major determinant of fecundity in the mosquito Anopheles gambiae
PNAS 2007 104: 2121-2126; published online before print February 6 2007, 10.1073/pnas.0608407104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Julius SternJohn, Sanchita Hati, Paul G. Siliciano, and Karin Musier-Forsyth

Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain
PNAS 2007 104: 2127-2132; published online before print February 5 2007, 10.1073/pnas.0611110104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Leo T. O. Lee, Francis K. Y. Siu, Janice K. V. Tam, Ivy T. Y. Lau, Anderson O. L. Wong, Marie C. M. Lin, Hubert Vaudry, and Billy K. C. Chow

Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates
PNAS 2007 104: 2133-2138; published online before print February 5 2007, 10.1073/pnas.0611008104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Susan Parrish, Wolfgang Resch, and Bernard Moss Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression PNAS 2007 104: 2139-2144; published online before print February 5 2007, 10.1073/pnas.0611685104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Eun Sun Park, Wayne A. Fenton, and Arthur L. Horwich Disulfide formation as a probe of folding in GroEL–GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones PNAS 2007 104: 2145-2150; published online before print February 5 2007, 10.1073/pnas.0610989104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Mario Meng-Chiang Kuo, Kent A. Baker, Lee Wong, and Senyon Choe

Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity
PNAS 2007 104: 2151-2156; published online before print February 7 2007, 10.1073/pnas.0609085104 [Abstract] [Full Text] [Figures Only] [PDF]  

Alfred Hausladen, Ruslan Rafikov, Michael Angelo, David J. Singel, Evgeny Nudler, and Jonathan S. Stamler

Assessment of nitric oxide signals by triiodide chemiluminescence
PNAS 2007 104: 2157-2162; published online before print February 7 2007, 10.1073/pnas.0611191104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Young C. Kim, Mårten Wikström, and Gerhard Hummer

Kinetic models of redox-coupled proton pumping
PNAS 2007 104: 2169-2174; published online before print February 7 2007, 10.1073/pnas.0611114104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Changbong Hyeon and José N. Onuchic

Internal strain regulates the nucleotide binding site of the kinesin leading head
PNAS 2007 104: 2175-2180; published online before print February 7 2007, 10.1073/pnas.0610939104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Matthew J. Footer, Jacob W. J. Kerssemakers, Julie A. Theriot, and Marileen Dogterom

Direct measurement of force generation by actin filament polymerization using an optical trap
PNAS 2007 104: 2181-2186; published online before print February 2 2007, 10.1073/pnas.0607052104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Keith D. Connaghan-Jones, Aaron F. Heneghan, Michael T. Miura, and David L. Bain

Thermodynamic analysis of progesterone receptor–promoter interactions reveals a molecular model for isoform-specific function
PNAS 2007 104: 2187-2192; published online before print February 2 2007, 10.1073/pnas.0608848104 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

An Chi, Curtis Huttenhower, Lewis Y. Geer, Joshua J. Coon, John E. P. Syka, Dina L. Bai, Jeffrey Shabanowitz, Daniel J. Burke, Olga G. Troyanskaya, and Donald F. Hunt

Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry
PNAS 2007 104: 2193-2198; published online before print February 7 2007, 10.1073/pnas.0607084104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Online Correction for SI Table 2]  

Henrik Molina, David M. Horn, Ning Tang, Suresh Mathivanan, and Akhilesh Pandey Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry PNAS 2007 104: 2199-2204; published online before print February 7 2007, 10.1073/pnas.0611217104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Laure Crabbe, Anna Jauch, Colleen M. Naeger, Heidi Holtgreve-Grez, and Jan Karlseder Telomere dysfunction as a cause of genomic instability in Werner syndrome PNAS 2007 104: 2205-2210; published online before print February 6 2007, 10.1073/pnas.0609410104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Dominique Promeneur, Yangjian Liu, Jorge Maciel, Peter Agre, Landon S. King, and Nirbhay Kumar

Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei
PNAS 2007 104: 2211-2216; published online before print February 6 2007, 10.1073/pnas.0610843104 [Abstract] [Full Text] [Figures Only] [PDF]  

Zhen Zhang, Kui Yang, Chin-Chuan Chen, Jason Feser, and Mingxia Huang

Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1
PNAS 2007 104: 2217-2222; published online before print February 2 2007, 10.1073/pnas.0611095104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jia-Jia Liu, Jianqing Ding, Chengbiao Wu, Prasanthi Bhagavatula, Bianxiao Cui, Steve Chu, William C. Mobley, and Yanmin Yang

Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport
PNAS 2007 104: 2223-2228; published online before print February 7 2007, 10.1073/pnas.0602222104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ben Wong, Shuai Chen, Jin-Ah Kwon, and Alexander Rich

Characterization of Z-DNA as a nucleosome-boundary element in yeast Saccharomyces cerevisiae
PNAS 2007 104: 2229-2234; published online before print February 6 2007, 10.1073/pnas.0611447104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jung-Chun Lin, Min Hsu, and Woan-Yuh Tarn

Cell stress modulates the function of splicing regulatory protein RBM4 in translation control
PNAS 2007 104: 2235-2240; published online before print February 6 2007, 10.1073/pnas.0611015104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Douglas B. Murray, Manfred Beckmann, and Hiroaki Kitano Regulation of yeast oscillatory dynamics PNAS 2007 104: 2241-2246; published online before print February 6 2007, 10.1073/pnas.0606677104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Lydia Finney, Suneeta Mandava, Lyann Ursos, Wen Zhang, Diane Rodi, Stefan Vogt, Daniel Legnini, Jorg Maser, Francis Ikpatt, Olufunmilayo I. Olopade, and David Glesne

X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis
PNAS 2007 104: 2247-2252; published online before print February 5 2007, 10.1073/pnas.0607238104 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Ximeng Liu, Katia J. Bruxvoort, Cassandra R. Zylstra, Jiarong Liu, Rachel Cichowski, Marie-Claude Faugere, Mary L. Bouxsein, Chao Wan, Bart O. Williams, and Thomas L. Clemens

Lifelong accumulation of bone in mice lacking Pten in osteoblasts
PNAS 2007 104: 2259-2264; published online before print February 7 2007, 10.1073/pnas.0604153104 [Abstract] [Full Text] [Figures Only] [PDF]  

Ecology

Evolution

Joshua A. Shapiro, Wei Huang, Chenhui Zhang, Melissa J. Hubisz, Jian Lu, David A. Turissini, Shu Fang, Hurng-Yi Wang, Richard R. Hudson, Rasmus Nielsen, Zhu Chen, and Chung-I Wu

Adaptive genic evolution in the Drosophila genomes
PNAS 2007 104: 2271-2276; published online before print February 6 2007, 10.1073/pnas.0610385104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ville Mustonen and Michael Lässig

Adaptations to fluctuating selection in Drosophila
PNAS 2007 104: 2277-2282; published online before print February 7 2007, 10.1073/pnas.0607105104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Genetics

Satoko Arai, Katsuhisa Miyake, Renate Voit, Shino Nemoto, Edward K. Wakeland, Ingrid Grummt, and Toru Miyazaki Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1 PNAS 2007 104: 2289-2294; published online before print February 5 2007, 10.1073/pnas.0611167104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Elizabeth Pradel, Yun Zhang, Nathalie Pujol, Tohey Matsuyama, Cornelia I. Bargmann, and Jonathan J. Ewbank Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans PNAS 2007 104: 2295-2300; published online before print January 31 2007, 10.1073/pnas.0610281104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Michaela Gruber, Cheng-Jun Hu, Randall S. Johnson, Eric J. Brown, Brian Keith, and M. Celeste Simon

Acute postnatal ablation of Hif-2 results in anemia
PNAS 2007 104: 2301-2306; published online before print February 6 2007, 10.1073/pnas.0608382104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Richard Harrison, Balázs Papp, Csaba Pál, Stephen G. Oliver, and Daniela Delneri Plasticity of genetic interactions in metabolic networks of yeast PNAS 2007 104: 2307-2312; published online before print February 6 2007, 10.1073/pnas.0607153104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Dennis Hedgecock, Jing-Zhong Lin, Shannon DeCola, Christian D. Haudenschild, Eli Meyer, Donal T. Manahan, and Ben Bowen Transcriptomic analysis of growth heterosis in larval Pacific oysters (Crassostrea gigas) PNAS 2007 104: 2313-2318; published online before print February 2 2007, 10.1073/pnas.0610880104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Immunology

Yeny Martinez de la Torre, Chiara Buracchi, Elena M. Borroni, Jana Dupor, Raffaella Bonecchi, Manuela Nebuloni, Fabio Pasqualini, Andrea Doni, Eleonora Lauri, Chiara Agostinis, Roberta Bulla, Donald N. Cook, Bodduluri Haribabu, Pierluigi Meroni, Daniel Rukavina, Luca Vago, Francesco Tedesco, Annunciata Vecchi, Sergio A. Lira, Massimo Locati, and Alberto Mantovani

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6
PNAS 2007 104: 2319-2324; published online before print February 5 2007, 10.1073/pnas.0607514104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Peter A. Nigrovic, Bryce A. Binstadt, Paul A. Monach, Alyssa Johnsen, Michael Gurish, Yoichiro Iwakura, Christophe Benoist, Diane Mathis, and David M. Lee

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
PNAS 2007 104: 2325-2330; published online before print February 2 2007, 10.1073/pnas.0610852103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Medical Sciences

Yoshisuke Haruna, Naoki Kashihara, Minoru Satoh, Naruya Tomita, Tamehachi Namikoshi, Tamaki Sasaki, Toshihiko Fujimori, Ping Xie, and Yashpal S. Kanwar

Amelioration of progressive renal injury by genetic manipulation of Klotho gene
PNAS 2007 104: 2331-2336; published online before print February 7 2007, 10.1073/pnas.0611079104 [Abstract] [Full Text] [Figures Only] [PDF]  

Chunyan Zhang, Ivan Todorov, Chia-Lei Lin, Mark Atkinson, Fouad Kandeel, Stephen Forman, and Defu Zeng Elimination of insulitis and augmentation of islet cell regeneration via induction of chimerism in overtly diabetic NOD mice PNAS 2007 104: 2337-2342; published online before print January 31 2007, 10.1073/pnas.0611101104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

V. Uma Bai, Ahmed Kaseb, Sheela Tejwani, George W. Divine, Evelyn R. Barrack, Mani Menon, Arthur B. Pardee, and G. Prem-Veer Reddy

Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine
PNAS 2007 104: 2343-2348; published online before print February 5 2007, 10.1073/pnas.0610504104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jun Seita, Hideo Ema, Jun Ooehara, Satoshi Yamazaki, Yuko Tadokoro, Akiko Yamasaki, Koji Eto, Satoshi Takaki, Kiyoshi Takatsu, and Hiromitsu Nakauchi

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
PNAS 2007 104: 2349-2354; published online before print February 6 2007, 10.1073/pnas.0606238104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lia Vassena, Michael Proschan, Anthony S. Fauci, and Paolo Lusso

Interleukin 7 reduces the levels of spontaneous apoptosis in CD4⁺ and CD8⁺ T cells from HIV-1-infected individuals
PNAS 2007 104: 2355-2360; published online before print February 6 2007, 10.1073/pnas.0610775104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Atsuyasu Sato, Toyohiro Hirai, Akihiro Imura, Naoko Kita, Akiko Iwano, Shigeo Muro, Yo-ichi Nabeshima, Bela Suki, and Michiaki Mishima

Morphological mechanism of the development of pulmonary emphysema in klotho mice
PNAS 2007 104: 2361-2365; published online before print February 6 2007, 10.1073/pnas.0607882104 [Abstract] [Full Text] [Figures Only] [PDF]  

Katrine Almind, Monia Manieri, William I. Sivitz, Saverio Cinti, and C. Ronald Kahn

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
PNAS 2007 104: 2366-2371; published online before print February 5 2007, 10.1073/pnas.0610416104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Microbiology

Elizabeth A. Shakhnovich, Deborah T. Hung, Emily Pierson, Kyungae Lee, and John J. Mekalanos

Virstatin inhibits dimerization of the transcriptional activator ToxT
PNAS 2007 104: 2372-2377; published online before print February 5 2007, 10.1073/pnas.0611643104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jun-ya Kato, Nobutaka Funa, Hidenori Watanabe, Yasuo Ohnishi, and Sueharu Horinouchi

Biosynthesis of -butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
PNAS 2007 104: 2378-2383; published online before print February 2 2007, 10.1073/pnas.0607472104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dzung B. Diep, Morten Skaugen, Zhian Salehian, Helge Holo, and Ingolf F. Nes

Common mechanisms of target cell recognition and immunity for class II bacteriocins
PNAS 2007 104: 2384-2389; published online before print February 6 2007, 10.1073/pnas.0608775104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Richard F. Collins, Konstantinos Beis, Changjiang Dong, Catherine H. Botting, Catherine McDonnell, Robert C. Ford, Bradley R. Clarke, Chris Whitfield, and James H. Naismith The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli PNAS 2007 104: 2390-2395; published online before print February 5 2007, 10.1073/pnas.0607763104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Yehuda Chowers, Joachim Kirschner, Nathan Keller, Iris Barshack, Simon Bar-Meir, Shai Ashkenazi, Rachel Schneerson, John Robbins, and Justen H. Passwell

O-Specific polysaccharide conjugate vaccine-induced IgG antibodies prevent invasion of Shigella into Caco-2 cells and may be curative
PNAS 2007 104: 2396-2401; published online before print February 7 2007, 10.1073/pnas.0610833104 [Abstract] [Full Text] [Figures Only] [PDF]  

G. N. Vemuri, M. A. Eiteman, J. E. McEwen, L. Olsson, and J. Nielsen

Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae
PNAS 2007 104: 2402-2407; published online before print February 7 2007, 10.1073/pnas.0607469104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jessica M. Walter, Derek Greenfield, Carlos Bustamante, and Jan Liphardt

Light-powering Escherichia coli with proteorhodopsin
PNAS 2007 104: 2408-2412; published online before print February 2 2007, 10.1073/pnas.0611035104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

C. Mark Fletcher, Michael J. Coyne, David L. Bentley, Otto F. Villa, and Laurie E. Comstock

Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem
PNAS 2007 104: 2413-2418; published online before print February 6 2007, 10.1073/pnas.0608797104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ioannis Eleftherianos, Sam Boundy, Susan A. Joyce, Shazia Aslam, James W. Marshall, Russell J. Cox, Thomas J. Simpson, David J. Clarke, Richard H. ffrench-Constant, and Stuart E. Reynolds

An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition
PNAS 2007 104: 2419-2424; published online before print February 6 2007, 10.1073/pnas.0610525104 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Alexander F. Jeans, Peter L. Oliver, Reuben Johnson, Marco Capogna, Jenny Vikman, Zoltán Molnár, Arran Babbs, Christopher J. Partridge, Albert Salehi, Martin Bengtsson, Lena Eliasson, Patrik Rorsman, and Kay E. Davies A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse PNAS 2007 104: 2431-2436; published online before print February 5 2007, 10.1073/pnas.0610222104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Yafell Serulle, Gerardo Morfini, Gustavo Pigino, Jorge E. Moreira, Mutsuyuki Sugimori, Scott T. Brady, and Rodolfo R. Llinás

1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKC enzymatic activities
PNAS 2007 104: 2437-2441; published online before print February 7 2007, 10.1073/pnas.0611227104 [Abstract] [Full Text] [Figures Only] [PDF]  

G. Morfini, G. Pigino, K. Opalach, Y. Serulle, J. E. Moreira, M. Sugimori, R. R. Llinás, and S. T. Brady

1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
PNAS 2007 104: 2442-2447; published online before print February 7 2007, 10.1073/pnas.0611231104 [Abstract] [Full Text] [Figures Only] [PDF]  

Gareth B. Miles, Robert Hartley, Andrew J. Todd, and Robert M. Brownstone Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion PNAS 2007 104: 2448-2453; published online before print February 7 2007, 10.1073/pnas.0611134104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Brian M. Wilson and Charles L. Cox

Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice
PNAS 2007 104: 2454-2459; published online before print February 7 2007, 10.1073/pnas.0610875104 [Abstract] [Full Text] [Figures Only] [PDF]  

Kyle T. Beggs, Kelly A. Glendining, Nicola M. Marechal, Vanina Vergoz, Ikumi Nakamura, Keith N. Slessor, and Alison R. Mercer

Queen pheromone modulates brain dopamine function in worker honey bees
PNAS 2007 104: 2460-2464; published online before print February 7 2007, 10.1073/pnas.0608224104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jean-Claude Dreher, Peter J. Schmidt, Philip Kohn, Daniella Furman, David Rubinow, and Karen Faith Berman

Menstrual cycle phase modulates reward-related neural function in women
PNAS 2007 104: 2465-2470; published online before print January 31 2007, 10.1073/pnas.0605569104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Weihong Lin, Robert Margolskee, Gerald Donnert, Stefan W. Hell, and Diego Restrepo

Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
PNAS 2007 104: 2471-2476; published online before print January 31 2007, 10.1073/pnas.0610201104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eun-Jin Yang, Brian T. Nasipak, and Darcy B. Kelley

Direct action of gonadotropin in brain integrates behavioral and reproductive functions
PNAS 2007 104: 2477-2482; published online before print February 6 2007, 10.1073/pnas.0608391104 [Abstract] [Full Text] [Figures Only] [PDF]  

Julie L. Lefebvre, Lili Jing, Sara Becaficco, Clara Franzini-Armstrong, and Michael Granato

Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation
PNAS 2007 104: 2483-2488; published online before print February 6 2007, 10.1073/pnas.0610822104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hanbing Lu, Zheng-Xiong Xi, Leah Gitajn, William Rea, Yihong Yang, and Elliot A. Stein

Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)
PNAS 2007 104: 2489-2494; published online before print February 7 2007, 10.1073/pnas.0606983104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Makoto Urushitani, Samer Abou Ezzi, and Jean-Pierre Julien Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis PNAS 2007 104: 2495-2500; published online before print February 2 2007, 10.1073/pnas.0606201104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sergei Musatov, Walter Chen, Donald W. Pfaff, Charles V. Mobbs, Xue-Jun Yang, Deborah J. Clegg, Michael G. Kaplitt, and Sonoko Ogawa

Silencing of estrogen receptor in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
PNAS 2007 104: 2501-2506; published online before print February 6 2007, 10.1073/pnas.0610787104 [Abstract] [Full Text] [Figures Only] [PDF]  

William V. Nikolic, Yun Bai, Demian Obregon, Huayan Hou, Takashi Mori, Jin Zeng, Jared Ehrhart, R. Douglas Shytle, Brian Giunta, Dave Morgan, Terrence Town, and Jun Tan

Transcutaneous -amyloid immunization reduces cerebral -amyloid deposits without T cell infiltration and microhemorrhage
PNAS 2007 104: 2507-2512; published online before print January 30 2007, 10.1073/pnas.0609377104