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THIS WEEK IN PNAS

In This Issue
PNAS 2007 104: 3017-3018. [Full Text] [PDF]  

COMMENTARIES

Herbert Y. Meltzer

Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden
PNAS 2007 104: 3019-3020; published online before print February 20 2007, 10.1073/pnas.0700090104 [Extract] [Full Text] [PDF]  
See companion article on page 3456

Daniel H. Sandweiss

Small is big: The microfossil perspective on human–plant interaction
PNAS 2007 104: 3021-3022; published online before print February 23 2007, 10.1073/pnas.0700225104 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 3651

PROFILES

Bijal P. Trivedi

Profile of Joseph R. Ecker
PNAS 2007 104: 3023-3025; published online before print February 21 2007, 10.1073/pnas.0607124104 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Chemistry

G. K. Surya Prakash, Habiba Vaghoo, Chiradeep Panja, Vijayalakshmi Surampudi, Roman Kultyshev, Thomas Mathew, and George A. Olah

Effect of carbonates/phosphates as nucleophilic catalysts in dimethylformamide for efficient cyanosilylation of aldehydes and ketones
PNAS 2007 104: 3026-3030; published online before print February 22 2007, 10.1073/pnas.0611309104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Engineering

Environmental Sciences

SOCIAL SCIENCES

Anthropology

Julio Mercader, Huw Barton, Jason Gillespie, Jack Harris, Steven Kuhn, Robert Tyler, and Christophe Boesch

4,300-Year-old chimpanzee sites and the origins of percussive stone technology
PNAS 2007 104: 3043-3048; published online before print February 20 2007, 10.1073/pnas.0607909104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Paul Mellars, Brad Gravina, and Christopher Bronk Ramsey

Confirmation of Neanderthal/modern human interstratification at the Chatelperronian type-site
PNAS 2007 104: 3657-3662; published online before print February 21 2007, 10.1073/pnas.0608053104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

A. M. Thibodeau, D. J. Killick, J. Ruiz, J. T. Chesley, K. Deagan, J. M. Cruxent, and W. Lyman

The strange case of the earliest silver extraction by European colonists in the New World
PNAS 2007 104: 3663-3666; published online before print February 21 2007, 10.1073/pnas.0607297104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sustainability Science

BIOLOGICAL SCIENCES

Anthropology

Julio Mercader, Huw Barton, Jason Gillespie, Jack Harris, Steven Kuhn, Robert Tyler, and Christophe Boesch

4,300-Year-old chimpanzee sites and the origins of percussive stone technology
PNAS 2007 104: 3043-3048; published online before print February 20 2007, 10.1073/pnas.0607909104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Ruth Dickau, Anthony J. Ranere, and Richard G. Cooke From the Cover: Starch grain evidence for the preceramic dispersals of maize and root crops into tropical dry and humid forests of Panama PNAS 2007 104: 3651-3656; published online before print February 21 2007, 10.1073/pnas.0611605104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 3021

Applied Biological Sciences

James A. Cooper, Jr., Janmeet S. Sahota, W. Jay Gorum, II, Janell Carter, Stephen B. Doty, and Cato T. Laurencin

Biomimetic tissue-engineered anterior cruciate ligament replacement
PNAS 2007 104: 3049-3054; published online before print February 20 2007, 10.1073/pnas.0608837104 [Abstract] [Full Text] [Figures Only] [PDF]  

Erica A. Moehle, Jeremy M. Rock, Ya-Li Lee, Yann Jouvenot, Russell C. DeKelver, Philip D. Gregory, Fyodor D. Urnov, and Michael C. Holmes Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases PNAS 2007 104: 3055-3060; published online before print February 20 2007, 10.1073/pnas.0611478104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Biochemistry

Lingang Zhang, Simon Kasif, and and Charles R. Cantor

Quantifying DNA–protein binding specificities by using oligonucleotide mass tags and mass spectroscopy
PNAS 2007 104: 3061-3066; published online before print February 20 2007, 10.1073/pnas.0611075104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sigrun M. Gustafsdottir, Joerg Schlingemann, Alvaro Rada-Iglesias, Edith Schallmeiner, Masood Kamali-Moghaddam, Claes Wadelius, and Ulf Landegren

In vitro analysis of DNA–protein interactions by proximity ligation
PNAS 2007 104: 3067-3072; published online before print February 20 2007, 10.1073/pnas.0611229104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Grazyna B. Seiffert, G. Matthias Ullmann, Albrecht Messerschmidt, Bernhard Schink, Peter M. H. Kroneck, and Oliver Einsle

Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase
PNAS 2007 104: 3073-3077. [Abstract] [Full Text] [Figures Only] [PDF]  

Gabrielle J. Grundy, Joanne E. Hesse, and Martin Gellert

Requirements for DNA hairpin formation by RAG1/2
PNAS 2007 104: 3078-3083; published online before print February 16 2007, 10.1073/pnas.0611293104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tomonobu Toyomasu, Mai Tsukahara, Akane Kaneko, Rie Niida, Wataru Mitsuhashi, Tohru Dairi, Nobuo Kato, and Takeshi Sassa

Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
PNAS 2007 104: 3084-3088; published online before print February 20 2007, 10.1073/pnas.0608426104 [Abstract] [Full Text] [Figures Only] [PDF]  

Ana Luísa Carvalho, Fernando M. V. Dias, Tibor Nagy, José A. M. Prates, Mark R. Proctor, Nicola Smith, Edward A. Bayer, Gideon J. Davies, Luís M. A. Ferreira, Maria J. Romão, Carlos M. G. A. Fontes, and Harry J. Gilbert

Evidence for a dual binding mode of dockerin modules to cohesins
PNAS 2007 104: 3089-3094; published online before print February 20 2007, 10.1073/pnas.0611173104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Steven A. Beasley, Ventzislava A. Hristova, and Gary S. Shaw From the Cover: Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease PNAS 2007 104: 3095-3100. [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Ronald S. Ullers, Debbie Ang, Françoise Schwager, Costa Georgopoulos, and Pierre Genevaux

Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli
PNAS 2007 104: 3101-3106; published online before print February 20 2007, 10.1073/pnas.0608232104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Begoña García-Álvarez, Guillermo de Cárcer, Sonia Ibañez, Elisabeth Bragado-Nilsson, and Guillermo Montoya

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
PNAS 2007 104: 3107-3112; published online before print February 16 2007, 10.1073/pnas.0609131104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ville O. Paavilainen, Maarit Hellman, Emmanuèle Helfer, Miia Bovellan, Arto Annila, Marie-France Carlier, Perttu Permi, and Pekka Lappalainen

Structural basis and evolutionary origin of actin filament capping by twinfilin
PNAS 2007 104: 3113-3118; published online before print February 20 2007, 10.1073/pnas.0608725104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yakov Kipnis, Niv Papo, Gilad Haran, and Amnon Horovitz

Concerted ATP-induced allosteric transitions in GroEL facilitate release of protein substrate domains in an all-or-none manner
PNAS 2007 104: 3119-3124; published online before print February 21 2007, 10.1073/pnas.0700070104 [Abstract] [Full Text] [Figures Only] [PDF]  

Susan M. Hanson, Eugenia V. Gurevich, Sergey A. Vishnivetskiy, Mohamed R. Ahmed, Xiufeng Song, and Vsevolod V. Gurevich

Each rhodopsin molecule binds its own arrestin
PNAS 2007 104: 3125-3128; published online before print February 20 2007, 10.1073/pnas.0610886104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jian Zhu, Kodetham Gopinath, Ayaluru Murali, Guanghui Yi, S. Diane Hayward, Heng Zhu, and Cheng Kao

RNA-binding proteins that inhibit RNA virus infection
PNAS 2007 104: 3129-3134; published online before print February 20 2007, 10.1073/pnas.0611617104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Gloria Levicán, Assaf Katz, Merly de Armas, Harold Núñez, and Omar Orellana

Regulation of a glutamyl-tRNA synthetase by the heme status
PNAS 2007 104: 3135-3140; published online before print February 20 2007, 10.1073/pnas.0611611104 [Abstract] [Full Text] [Figures Only] [PDF]  

Alexandre Ambrogelly, Sarath Gundllapalli, Stephanie Herring, Carla Polycarpo, Carina Frauer, and Dieter Söll

Pyrrolysine is not hardwired for cotranslational insertion at UAG codons
PNAS 2007 104: 3141-3146; published online before print February 20 2007, 10.1073/pnas.0611634104 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

Yan Chen and Joachim D. Müller

Determining the stoichiometry of protein heterocomplexes in living cells with fluorescence fluctuation spectroscopy
PNAS 2007 104: 3147-3152; published online before print February 16 2007, 10.1073/pnas.0606557104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jeong-Yong Suh, Junji Iwahara, and G. Marius Clore

Intramolecular domain–domain association/dissociation and phosphoryl transfer in the mannitol transporter of Escherichia coli are not coupled
PNAS 2007 104: 3153-3158; published online before print February 21 2007, 10.1073/pnas.0609103104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Chenghang Zong, Corey J. Wilson, Tongye Shen, Pernilla Wittung-Stafshede, Steven L. Mayo, and Peter G. Wolynes

Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin
PNAS 2007 104: 3159-3164; published online before print February 14 2007, 10.1073/pnas.0611149104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tobias Baumgart, Adam T. Hammond, Prabuddha Sengupta, Samuel T. Hess, David A. Holowka, Barbara A. Baird, and Watt W. Webb

Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles
PNAS 2007 104: 3165-3170; published online before print February 21 2007, 10.1073/pnas.0611357104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jung-Chi Liao, James A. Spudich, David Parker, and Scott L. Delp

Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways
PNAS 2007 104: 3171-3176; published online before print February 21 2007, 10.1073/pnas.0611519104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Christopher M. Summa and Michael Levitt Near-native structure refinement using in vacuo energy minimization PNAS 2007 104: 3177-3182; published online before print February 20 2007, 10.1073/pnas.0611593104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Michael Levitt Growth of novel protein structural data PNAS 2007 104: 3183-3188; published online before print February 20 2007, 10.1073/pnas.0611678104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Cell Biology

Daniel W. Young, Mohammad Q. Hassan, Xiao-Qing Yang, Mario Galindo, Amjad Javed, Sayyed K. Zaidi, Paul Furcinitti, David Lapointe, Martin Montecino, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2
PNAS 2007 104: 3189-3194; published online before print February 20 2007, 10.1073/pnas.0611419104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Melanie D. Ohi, Liping Ren, Joseph S. Wall, Kathleen L. Gould, and Thomas Walz

Structural characterization of the fission yeast U5.U2/U6 spliceosome complex
PNAS 2007 104: 3195-3200; published online before print February 20 2007, 10.1073/pnas.0611591104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Fuminobu Kuroda, Joel Moss, and Martha Vaughan

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1
PNAS 2007 104: 3201-3206; published online before print February 21 2007, 10.1073/pnas.0611696104 [Abstract] [Full Text] [Figures Only] [PDF]  

Jose M. Polo, Przemyslaw Juszczynski, Stefano Monti, Leandro Cerchietti, Kenny Ye, John M. Greally, Margaret Shipp, and Ari Melnick

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas
PNAS 2007 104: 3207-3212; published online before print February 20 2007, 10.1073/pnas.0611399104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Koji Ikegami, Robb L. Heier, Midori Taruishi, Hiroshi Takagi, Masahiro Mukai, Shuichi Shimma, Shu Taira, Ken Hatanaka, Nobuhiro Morone, Ikuko Yao, Patrick K. Campbell, Shigeki Yuasa, Carsten Janke, Grant R. MacGregor, and Mitsutoshi Setou Loss of -tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function PNAS 2007 104: 3213-3218; published online before print February 20 2007, 10.1073/pnas.0611547104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Developmental Biology

I. B. Lobov, R. A. Renard, N. Papadopoulos, N. W. Gale, G. Thurston, G. D. Yancopoulos, and S. J. Wiegand

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
PNAS 2007 104: 3219-3224; published online before print February 12 2007, 10.1073/pnas.0611206104 [Abstract] [Full Text] [Figures Only] [PDF]  

Steven Suchting, Catarina Freitas, Ferdinand le Noble, Rui Benedito, Christiane Bréant, Antonio Duarte, and Anne Eichmann

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
PNAS 2007 104: 3225-3230; published online before print February 12 2007, 10.1073/pnas.0611177104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Bryan T. Phillips, Ambrose R. Kidd, III, Ryan King, Jeff Hardin, and Judith Kimble Reciprocal asymmetry of SYS-1/-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans PNAS 2007 104: 3231-3236; published online before print February 12 2007, 10.1073/pnas.0611507104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Qing Lin, Qi Chen, Lan Lin, Sheryl Smith, and Jumin Zhou

Promoter targeting sequence mediates enhancer interference in the Drosophila embryo
PNAS 2007 104: 3237-3242; published online before print February 16 2007, 10.1073/pnas.0605730104 [Abstract] [Full Text] [Figures Only] [PDF]  

Melissa G. Dominguez, Virginia C. Hughes, Li Pan, Mary Simmons, Christopher Daly, Keith Anderson, Irene Noguera-Troise, Andrew J. Murphy, David M. Valenzuela, Samuel Davis, Gavin Thurston, George D. Yancopoulos, and Nicholas W. Gale Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis PNAS 2007 104: 3243-3248; published online before print February 21 2007, 10.1073/pnas.0611510104 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Fabian Rentzsch, Corina Guder, Dirk Vocke, Bert Hobmayer, and Thomas W. Holstein

An ancient chordin-like gene in organizer formation of Hydra
PNAS 2007 104: 3249-3254; published online before print February 20 2007, 10.1073/pnas.0604501104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Maranke I. Koster, Daisy Dai, Barbara Marinari, Yuji Sano, Antonio Costanzo, Michael Karin, and Dennis R. Roop

p63 induces key target genes required for epidermal morphogenesis
PNAS 2007 104: 3255-3260; published online before print February 20 2007, 10.1073/pnas.0611376104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Margaret E. McLaughlin, Genevieve M. Kruger, Kelly L. Slocum, Denise Crowley, Norman A. Michaud, Jennifer Huang, Margaret Magendantz, and Tyler Jacks The Nf2 tumor suppressor regulates cell–cell adhesion during tissue fusion PNAS 2007 104: 3261-3266; published online before print February 20 2007, 10.1073/pnas.0700044104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Ecology

J. E. Houlahan, D. J. Currie, K. Cottenie, G. S. Cumming, S. K. M. Ernest, C. S. Findlay, S. D. Fuhlendorf, U. Gaedke, P. Legendre, J. J. Magnuson, B. H. McArdle, E. H. Muldavin, D. Noble, R. Russell, R. D. Stevens, T. J. Willis, I. P. Woiwod, and S. M. Wondzell From the Cover: Compensatory dynamics are rare in natural ecological communities PNAS 2007 104: 3273-3277; published online before print February 21 2007, 10.1073/pnas.0603798104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]

P. Jordano, C. García, J. A. Godoy, and J. L. García-Castaño

Differential contribution of frugivores to complex seed dispersal patterns
PNAS 2007 104: 3278-3282; published online before print February 20 2007, 10.1073/pnas.0606793104 [Abstract] [Full Text] [Figures Only] [PDF]  

Evolution

Christian R. Landry, Cristian I. Castillo-Davis, Atsushi Ogura, Jun S. Liu, and Daniel L. Hartl

Systems-level analysis and evolution of the phototransduction network in Drosophila
PNAS 2007 104: 3283-3288; published online before print February 20 2007, 10.1073/pnas.0611402104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Peter L. Morrell and Michael T. Clegg

Genetic evidence for a second domestication of barley (Hordeum vulgare) east of the Fertile Crescent
PNAS 2007 104: 3289-3294; published online before print February 21 2007, 10.1073/pnas.0611377104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Heather M. Hines, James H. Hunt, Timothy K. O'Connor, Joseph J. Gillespie, and Sydney A. Cameron

Multigene phylogeny reveals eusociality evolved twice in vespid wasps
PNAS 2007 104: 3295-3299; published online before print February 21 2007, 10.1073/pnas.0610140104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Matthew A. Saunders, Han Liang, and Wen-Hsiung Li

Human polymorphism at microRNAs and microRNA target sites
PNAS 2007 104: 3300-3305; published online before print February 20 2007, 10.1073/pnas.0611347104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Luis Gómez-Alpizar, Ignazio Carbone, and Jean Beagle Ristaino

An Andean origin of Phytophthora infestans inferred from mitochondrial and nuclear gene genealogies
PNAS 2007 104: 3306-3311; published online before print February 21 2007, 10.1073/pnas.0611479104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Johannes Bischof, Robert K. Maeda, Monika Hediger, François Karch, and Konrad Basler

An optimized transgenesis system for Drosophila using germ-line-specific C31 integrases
PNAS 2007 104: 3312-3317; published online before print February 22 2007, 10.1073/pnas.0611511104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ho-Ming Chen, Yi-Hang Li, and Shu-Hsing Wu

Bioinformatic prediction and experimental validation of a microRNA-directed tandem trans-acting siRNA cascade in Arabidopsis
PNAS 2007 104: 3318-3323; published online before print February 20 2007, 10.1073/pnas.0611119104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gregory S. Yochum, Shannon McWeeney, Veena Rajaraman, Ryan Cleland, Sandra Peters, and Richard H. Goodman

Serial analysis of chromatin occupancy identifies -catenin target genes in colorectal carcinoma cells
PNAS 2007 104: 3324-3329; published online before print February 21 2007, 10.1073/pnas.0611576104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Frank Batista, Daniel Vaiman, Jean Dausset, Marc Fellous, and Reiner A. Veitia

Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics
PNAS 2007 104: 3330-3335; published online before print February 20 2007, 10.1073/pnas.0611326104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Bénédicte Duriez, Philippe Duquesnoy, Estelle Escudier, Anne-Marie Bridoux, Denise Escalier, Isabelle Rayet, Elisabeth Marcos, Anne-Marie Vojtek, Jean-François Bercher, and Serge Amselem

A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia
PNAS 2007 104: 3336-3341; published online before print February 20 2007, 10.1073/pnas.0611405104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brooke H. Miller, Erin L. McDearmon, Satchidananda Panda, Kevin R. Hayes, Jie Zhang, Jessica L. Andrews, Marina P. Antoch, John R. Walker, Karyn A. Esser, John B. Hogenesch, and Joseph S. Takahashi Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation PNAS 2007 104: 3342-3347; published online before print February 20 2007, 10.1073/pnas.0611724104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Brian C. Thomas, Lakshmi Rapaka, Eric Lyons, Brent Pedersen, and Michael Freeling

Arabidopsis intragenomic conserved noncoding sequence
PNAS 2007 104: 3348-3353; published online before print February 14 2007, 10.1073/pnas.0611574104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

A. Vasilescu, Y. Terashima, M. Enomoto, S. Heath, V. Poonpiriya, H. Gatanaga, H. Do, G. Diop, T. Hirtzig, P. Auewarakul, D. Lauhakirti, T. Sura, P. Charneau, S. Marullo, A. Therwath, S. Oka, S. Kanegasaki, M. Lathrop, K. Matsushima, J.-F. Zagury, and F. Matsuda

A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1⁺ patients
PNAS 2007 104: 3354-3359; published online before print February 21 2007, 10.1073/pnas.0611670104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Junzo Hamanishi, Masaki Mandai, Masashi Iwasaki, Taku Okazaki, Yoshimasa Tanaka, Ken Yamaguchi, Toshihiro Higuchi, Haruhiko Yagi, Kenji Takakura, Nagahiro Minato, Tasuku Honjo, and Shingo Fujii

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer
PNAS 2007 104: 3360-3365; published online before print February 21 2007, 10.1073/pnas.0611533104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Martin Rowe, Britt Glaunsinger, Daphne van Leeuwen, Jianmin Zuo, David Sweetman, Don Ganem, Jaap Middeldorp, Emmanuel J. H. J. Wiertz, and Maaike E. Ressing

Host shutoff during productive Epstein–Barr virus infection is mediated by BGLF5 and may contribute to immune evasion
PNAS 2007 104: 3366-3371; published online before print February 21 2007, 10.1073/pnas.0611128104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sinead M. Miggin, Eva Pålsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas Golenbock, Katherine A. Fitzgerald, and Luke A. J. O'Neill

NF-B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
PNAS 2007 104: 3372-3377; published online before print February 20 2007, 10.1073/pnas.0608100104 [Abstract] [Full Text] [Figures Only] [PDF]  

Derin B. Keskin, David S. J. Allan, Basya Rybalov, Milena M. Andzelm, Joel N. H. Stern, Hernan D. Kopcow, Louise A. Koopman, and Jack L. Strominger

TGF promotes conversion of CD16⁺ peripheral blood NK cells into CD16^– NK cells with similarities to decidual NK cells
PNAS 2007 104: 3378-3383; published online before print February 20 2007, 10.1073/pnas.0611098104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thierry Walzer, Mathieu Bléry, Julie Chaix, Nicolas Fuseri, Lionel Chasson, Scott H. Robbins, Sébastien Jaeger, Pascale André, Laurent Gauthier, Laurent Daniel, Karine Chemin, Yannis Morel, Marc Dalod, Jean Imbert, Michel Pierres, Alessandro Moretta, François Romagné, and Eric Vivier

Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
PNAS 2007 104: 3384-3389; published online before print February 20 2007, 10.1073/pnas.0609692104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Audrey Kinter, Jonathan McNally, Lindsey Riggin, Robert Jackson, Gregg Roby, and Anthony S. Fauci

Suppression of HIV-specific T cell activity by lymph node CD25⁺ regulatory T cells from HIV-infected individuals
PNAS 2007 104: 3390-3395; published online before print February 21 2007, 10.1073/pnas.0611423104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Elena Martinelli, Claudia Cicala, Donald Van Ryk, Diana J. Goode, Katilyn Macleod, James Arthos, and Anthony S. Fauci

HIV-1 gp120 inhibits TLR9-mediated activation and IFN- secretion in plasmacytoid dendritic cells
PNAS 2007 104: 3396-3401; published online before print February 20 2007, 10.1073/pnas.0611353104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Hideyuki Yanai, Hui-min Chen, Takayuki Inuzuka, Seiji Kondo, Tak W. Mak, Akinori Takaoka, Kenya Honda, and Tadatsugu Taniguchi

Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
PNAS 2007 104: 3402-3407; published online before print February 20 2007, 10.1073/pnas.0611559104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Medical Sciences

Maaike A. Riedijk, Barbara Stoll, Shaji Chacko, Henk Schierbeek, Agneta L. Sunehag, Johannes B. van Goudoever, and Douglas G. Burrin

Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract
PNAS 2007 104: 3408-3413; published online before print February 21 2007, 10.1073/pnas.0607965104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Nathan D. Price, Jonathan Trent, Adel K. El-Naggar, David Cogdell, Ellen Taylor, Kelly K. Hunt, Raphael E. Pollock, Leroy Hood, Ilya Shmulevich, and Wei Zhang

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas
PNAS 2007 104: 3414-3419; published online before print February 21 2007, 10.1073/pnas.0611373104 [Abstract] [Full Text] [Figures Only] [PDF]  

Kathleen Caron, John Hagaman, Toshio Nishikimi, Hyung-Suk Kim, and Oliver Smithies Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males PNAS 2007 104: 3420-3425; published online before print February 20 2007, 10.1073/pnas.0611365104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text] OPEN ACCESS ARTICLE

Tsuyoshi Kashima, Nishta Rao, and James L. Manley

An intronic element contributes to splicing repression in spinal muscular atrophy
PNAS 2007 104: 3426-3431; published online before print February 16 2007, 10.1073/pnas.0700343104 [Abstract] [Full Text] [Figures Only] [PDF]  

Mitsuo Kato, Jane Zhang, Mei Wang, Linda Lanting, Hang Yuan, John J. Rossi, and Rama Natarajan

MicroRNA-192 in diabetic kidney glomeruli and its function in TGF--induced collagen expression via inhibition of E-box repressors
PNAS 2007 104: 3432-3437; published online before print February 20 2007, 10.1073/pnas.0611192104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Eliseo A. Eugenin, Jessie E. King, Avindra Nath, Tina M. Calderon, R. Suzanne Zukin, Michael V. L. Bennett, and Joan W. Berman

HIV-tat induces formation of an LRP–PSD-95– NMDAR–nNOS complex that promotes apoptosis in neurons and astrocytes
PNAS 2007 104: 3438-3443; published online before print February 21 2007, 10.1073/pnas.0611699104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael H. Radke, Jun Peng, Yiming Wu, Mark McNabb, O. Lynne Nelson, Henk Granzier, and Michael Gotthardt

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
PNAS 2007 104: 3444-3449; published online before print February 20 2007, 10.1073/pnas.0608543104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anne M. Curtis, Yan Cheng, Shiv Kapoor, Dermot Reilly, Tom S. Price, and Garret A. FitzGerald Circadian variation of blood pressure and the vascular response to asynchronous stress PNAS 2007 104: 3450-3455; published online before print February 20 2007, 10.1073/pnas.0611680104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sangwon F. Kim, Alex S. Huang, Adele M. Snowman, Cory Teuscher, and Solomon H. Snyder From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase PNAS 2007 104: 3456-3459; published online before print February 20 2007, 10.1073/pnas.0611417104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 3019

Mitsunobu R. Kano, Younsoo Bae, Caname Iwata, Yasuyuki Morishita, Masakazu Yashiro, Masako Oka, Tomoko Fujii, Akiyoshi Komuro, Kunihiko Kiyono, Michio Kaminishi, Kosei Hirakawa, Yasuyoshi Ouchi, Nobuhiro Nishiyama, Kazunori Kataoka, and Kohei Miyazono Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF- signaling PNAS 2007 104: 3460-3465; published online before print February 16 2007, 10.1073/pnas.0611660104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Liliana Soroceanu, Samir Kharbanda, Ruihuan Chen, Robert H. Soriano, Ken Aldape, Anjan Misra, Jiping Zha, William F. Forrest, Janice M. Nigro, Zora Modrusan, Burt G. Feuerstein, and Heidi S. Phillips Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma PNAS 2007 104: 3466-3471; published online before print February 20 2007, 10.1073/pnas.0611271104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jacques J. Laschet, Irène Kurcewicz, Frédéric Minier, Suzanne Trottier, Jamila Khallou-Laschet, Jacques Louvel, Sylvain Gigout, Baris Turak, Arnaud Biraben, Jean-Marie Scarabin, Bertrand Devaux, Patrick Chauvel, and René Pumain

Dysfunction of GABA_A receptor glycolysis-dependent modulation in human partial epilepsy
PNAS 2007 104: 3472-3477; published online before print February 20 2007, 10.1073/pnas.0606451104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hans-Peter Gerber, Xiumin Wu, Lanlan Yu, Christian Wiesmann, Xiao Huan Liang, Chingwei V. Lee, Germaine Fuh, Christine Olsson, Lisa Damico, David Xie, Y. Gloria Meng, Johnny Gutierrez, Racquel Corpuz, Bing Li, Linda Hall, Linda Rangell, Ron Ferrando, Henry Lowman, Franklin Peale, and Napoleone Ferrara

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
PNAS 2007 104: 3478-3483; published online before print February 20 2007, 10.1073/pnas.0611492104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]