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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 1775-1776. [Full Text] [PDF]  

COMMENTARIES

Jeeyon Jeong and Mary Lou Guerinot

Biofortified and bioavailable: The gold standard for plant-based diets
PNAS 2008 105: 1777-1778; published online on February 6, 2008, 10.1073/pnas.0712330105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 1431 in issue 5 of volume 105

Robert M. Glaeser

Macromolecular structures without crystals
PNAS 2008 105: 1779-1780; published online on February 6, 2008, 10.1073/pnas.0800032105 [Extract] [Full Text] [PDF]  
See companion article on page 1867

Evan H. DeLucia, Clare L. Casteel, Paul D. Nabity, and Bridget F. O'Neill

Insects take a bigger bite out of plants in a warmer, higher carbon dioxide world
PNAS 2008 105: 1781-1782; published online on February 6, 2008, 10.1073/pnas.0712056105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 1960

PERSPECTIVES

Timothy M. Lenton, Hermann Held, Elmar Kriegler, Jim W. Hall, Wolfgang Lucht, Stefan Rahmstorf, and Hans Joachim Schellnhuber Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Tipping elements in the Earth's climate system PNAS 2008 105: 1786-1793; published online on February 7, 2008, 10.1073/pnas.0705414105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

PROFILES

Kaspar Mossman

Profile of Hans Joachim Schellnhuber
PNAS 2008 105: 1783-1785; published online on February 6, 2008, 10.1073/pnas.0800554105 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Chemistry

Anatoliy N. Sokolov, Dale C. Swenson, and Leonard R. MacGillivray

Conformational polymorphism in a heteromolecular single crystal leads to concerted movement akin to collective rack-and-pinion gears at the molecular level
PNAS 2008 105: 1794-1797; published online on February 1, 2008, 10.1073/pnas.0706117105 [Abstract] [Full Text] [Figures Only] [PDF]  

Yongxia Zhang, Kadir Aslan, Michael J. R. Previte, and Chris D. Geddes

Plasmonic engineering of singlet oxygen generation
PNAS 2008 105: 1798-1802; published online on February 5, 2008, 10.1073/pnas.0709501105 [Abstract] [Full Text] [Figures Only] [PDF]  

Liviu M. Mirica and Judith P. Klinman The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase PNAS 2008 105: 1814-1819; published online on January 31, 2008, 10.1073/pnas.0711626105 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Mathematics

Peter W. Jones, Mauro Maggioni, and Raanan Schul

Manifold parametrizations by eigenfunctions of the Laplacian and heat kernels
PNAS 2008 105: 1803-1808; published online on February 7, 2008, 10.1073/pnas.0710175104 [Abstract] [Full Text] [Figures Only] [PDF]  

Physics

Sustainability Science

BIOLOGICAL SCIENCES

Biochemistry

Hyock Joo Kwon, Thomas A. Lagace, Markey C. McNutt, Jay D. Horton, and Johann Deisenhofer Molecular basis for LDL receptor recognition by PCSK9 PNAS 2008 105: 1820-1825; published online on February 4, 2008, 10.1073/pnas.0712064105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Brian P. Anton, Lana Saleh, Jack S. Benner, Elisabeth A. Raleigh, Simon Kasif, and Richard J. Roberts RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli PNAS 2008 105: 1826-1831; published online on February 5, 2008, 10.1073/pnas.0708608105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Prafull S. Gandhi, Zhiwei Chen, F. Scott Mathews, and Enrico Di Cera

Structural identification of the pathway of long-range communication in an allosteric enzyme
PNAS 2008 105: 1832-1837; published online on February 4, 2008, 10.1073/pnas.0710894105 [Abstract] [Full Text] [Figures Only] [PDF]  

Jieyi Wang, Lora A. Tucker, Jason Stavropoulos, Qian Zhang, Yi-Chun Wang, Gail Bukofzer, Amanda Niquette, Jonathan A. Meulbroek, David M. Barnes, Jianwei Shen, Jennifer Bouska, Cherrie Donawho, George S. Sheppard, and Randy L. Bell

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor
PNAS 2008 105: 1838-1843; published online on February 5, 2008, 10.1073/pnas.0708766105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Matthew P. Blakeley, Federico Ruiz, Raul Cachau, Isabelle Hazemann, Flora Meilleur, Andre Mitschler, Stephan Ginell, Pavel Afonine, Oscar N. Ventura, Alexandra Cousido-Siah, Michael Haertlein, Andrzej Joachimiak, Dean Myles, and Alberto Podjarny

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase
PNAS 2008 105: 1844-1848; published online on February 4, 2008, 10.1073/pnas.0711659105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lulu Huang, Lou Massa, and Jerome Karle

The kernel energy method of quantum mechanical approximation carried to fourth-order terms
PNAS 2008 105: 1849-1854; published online on February 4, 2008, 10.1073/pnas.0711297105 [Abstract] [Full Text] [PDF] [Supporting Information]  

Boriana Marintcheva, Assen Marintchev, Gerhard Wagner, and Charles C. Richardson

Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface
PNAS 2008 105: 1855-1860; published online on January 31, 2008, 10.1073/pnas.0711919105 [Abstract] [Full Text] [Figures Only] [PDF]  

Anthony A. Nuara, Leigh J. Walter, Naomi J. Logsdon, Sung Il Yoon, Brandi C. Jones, Jill M. Schriewer, R. Mark Buller, and Mark R. Walter

Structure and mechanism of IFN- antagonism by an orthopoxvirus IFN--binding protein
PNAS 2008 105: 1861-1866; published online on February 5, 2008, 10.1073/pnas.0705753105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Jesko Koehnke, Xiangshu Jin, Elaine C. Budreck, Shoshana Posy, Peter Scheiffele, Barry Honig, and Lawrence Shapiro

Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2
PNAS 2008 105: 1873-1878; published online on February 4, 2008, 10.1073/pnas.0711701105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yulia Pushkar, Junko Yano, Kenneth Sauer, Alain Boussac, and Vittal K. Yachandra

Structural changes in the Mn₄Ca cluster and the mechanism of photosynthetic water splitting
PNAS 2008 105: 1879-1884; published online on February 4, 2008, 10.1073/pnas.0707092105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Qing Peng and Hongbin Li

Atomic force microscopy reveals parallel mechanical unfolding pathways of T4 lysozyme: Evidence for a kinetic partitioning mechanism
PNAS 2008 105: 1885-1890; published online on February 6, 2008, 10.1073/pnas.0706775105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jorge A. Vila, Yelena A. Arnautova, and Harold A. Scheraga

Use of ¹³C chemical shifts for accurate determination of β-sheet structures in solution
PNAS 2008 105: 1891-1896; published online on February 4, 2008, 10.1073/pnas.0711022105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Matti Nykter, Nathan D. Price, Maximino Aldana, Stephen A. Ramsey, Stuart A. Kauffman, Leroy E. Hood, Olli Yli-Harja, and Ilya Shmulevich

Gene expression dynamics in the macrophage exhibit criticality
PNAS 2008 105: 1897-1900; published online on February 4, 2008, 10.1073/pnas.0711525105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Raymond Pfau, Alexandros Tzatsos, Sotirios C. Kampranis, Oksana B. Serebrennikova, Susan E. Bear, and Philip N. Tsichlis

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
PNAS 2008 105: 1907-1912; published online on February 4, 2008, 10.1073/pnas.0711865105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tomás Helikar, John Konvalina, Jack Heidel, and Jim A. Rogers

Emergent decision-making in biological signal transduction networks
PNAS 2008 105: 1913-1918; published online on February 4, 2008, 10.1073/pnas.0705088105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zhao-Qiu Wu and Xiaoqi Liu

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing
PNAS 2008 105: 1919-1924; published online on February 4, 2008, 10.1073/pnas.0712063105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Adriane Regina Todeschini, Jose Nilson Dos Santos, Kazuko Handa, and Sen-itiroh Hakomori

Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway
PNAS 2008 105: 1925-1930; published online on February 6, 2008, 10.1073/pnas.0709619104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Olivier C. Pertz, Yingchun Wang, Feng Yang, Wei Wang, Laurie J. Gay, Marina A. Gristenko, Therese R. Clauss, David J. Anderson, Tao Liu, Kenneth J. Auberry, David G. Camp, II, Richard D. Smith, and Richard L. Klemke

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network
PNAS 2008 105: 1931-1936; published online on February 1, 2008, 10.1073/pnas.0706545105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nicole Baptiste-Okoh, Anthony M. Barsotti, and Carol Prives

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis
PNAS 2008 105: 1937-1942; published online on January 31, 2008, 10.1073/pnas.0711800105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alexandra Are, Linda Aronsson, Shugui Wang, Gediminas Greicius, Yuan Kun Lee, Jan-Åke Gustafsson, Sven Pettersson, and Velmurugesan Arulampalam

Enterococcus faecalis from newborn babies regulate endogenous PPAR activity and IL-10 levels in colonic epithelial cells
PNAS 2008 105: 1943-1948; published online on January 30, 2008, 10.1073/pnas.0711734105 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Tatsuya Kobayashi, Jun Lu, Bradley S. Cobb, Stephen J. Rodda, Andrew P. McMahon, Ernestina Schipani, Matthias Merkenschlager, and Henry M. Kronenberg

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
PNAS 2008 105: 1949-1954; published online on January 31, 2008, 10.1073/pnas.0707900105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Frances A. High, Min Min Lu, Warren S. Pear, Kathleen M. Loomes, Klaus H. Kaestner, and Jonathan A. Epstein

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
PNAS 2008 105: 1955-1959; published online on February 1, 2008, 10.1073/pnas.0709663105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Ryan R. Rykaczewski and David M. Checkley, Jr

Influence of ocean winds on the pelagic ecosystem in upwelling regions
PNAS 2008 105: 1965-1970; published online on February 4, 2008, 10.1073/pnas.0711777105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Michael P. Perring, Lars O. Hedin, Simon A. Levin, Megan McGroddy, and Claire de Mazancourt

Increased plant growth from nitrogen addition should conserve phosphorus in terrestrial ecosystems
PNAS 2008 105: 1971-1976; published online on February 1, 2008, 10.1073/pnas.0711618105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Spencer T. Behmer and Anthony Joern

Coexisting generalist herbivores occupy unique nutritional feeding niches
PNAS 2008 105: 1977-1982; published online on January 31, 2008, 10.1073/pnas.0711870105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Evolution

M. J. E. Charpentier, R. C. Van Horn, J. Altmann, and S. C. Alberts

Paternal effects on offspring fitness in a multimale primate society
PNAS 2008 105: 1988-1992; published online on February 4, 2008, 10.1073/pnas.0711219105 [Abstract] [Full Text] [Figures Only] [PDF]  

G. W. Moy, S. A. Springer, S. L. Adams, W. J. Swanson, and V. D. Vacquier

Extraordinary intraspecific diversity in oyster sperm bindin
PNAS 2008 105: 1993-1998; published online on February 11, 2008, 10.1073/pnas.0711862105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

De-Hua Lai, Hassan Hashimi, Zhao-Rong Lun, Francisco J. Ayala, and Julius Lukes

Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
PNAS 2008 105: 1999-2004; published online on February 1, 2008, 10.1073/pnas.0711799105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Wesley D. Swingley, Min Chen, Patricia C. Cheung, Amber L. Conrad, Liza C. Dejesa, Jicheng Hao, Barbara M. Honchak, Lauren E. Karbach, Ahmet Kurdoglu, Surobhi Lahiri, Stephen D. Mastrian, Hideaki Miyashita, Lawrence Page, Pushpa Ramakrishna, Soichirou Satoh, W. Matthew Sattley, Yuichiro Shimada, Heather L. Taylor, Tatsuya Tomo, Tohru Tsuchiya, Zi T. Wang, Jason Raymond, Mamoru Mimuro, Robert E. Blankenship, and Jeffrey W. Touchman

Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina
PNAS 2008 105: 2005-2010; published online on February 5, 2008, 10.1073/pnas.0709772105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Maria I. Lioudyno, J. Ashot Kozak, Aubin Penna, Olga Safrina, Shenyuan L. Zhang, Debasish Sen, Jack Roos, Kenneth A. Stauderman, and Michael D. Cahalan

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
PNAS 2008 105: 2011-2016; published online on February 4, 2008, 10.1073/pnas.0706122105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kate Claycombe, Louis E. King, and Pamela J. Fraker

A role for leptin in sustaining lymphopoiesis and myelopoiesis
PNAS 2008 105: 2017-2021; published online on February 4, 2008, 10.1073/pnas.0712053105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Ling Xue, Hector Nolla, Akira Suzuki, Tak W. Mak, and Astar Winoto

Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
PNAS 2008 105: 2022-2027; published online on February 4, 2008, 10.1073/pnas.0712059105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mark D. Trottier, Matthew M. Newsted, Louis E. King, and Pamela J. Fraker

Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function
PNAS 2008 105: 2028-2033; published online on February 4, 2008, 10.1073/pnas.0712003105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nicole L. La Gruta, Paul G. Thomas, Andrew I. Webb, Michelle A. Dunstone, Tania Cukalac, Peter C. Doherty, Anthony W. Purcell, Jamie Rossjohn, and Stephen J. Turner

Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8⁺ T cell response to cognate viral peptides
PNAS 2008 105: 2034-2039; published online on January 31, 2008, 10.1073/pnas.0711682102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brantley R. Herrin, Matthew N. Alder, Kenneth H. Roux, Christina Sina, Götz R. A. Ehrhardt, Jeremy A. Boydston, Charles L. Turnbough, Jr, and Max D. Cooper Structure and specificity of lamprey monoclonal antibodies PNAS 2008 105: 2040-2045; published online on January 31, 2008, 10.1073/pnas.0711619105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Medical Sciences

Max Corbett, Willy M. Bogers, Jonathan L. Heeney, Stefan Gerber, Christian Genin, Arnaud Didierlaurent, Herman Oostermeijer, Rob Dubbes, Gerco Braskamp, Stéphanie Lerondel, Carmen E. Gomez, Mariano Esteban, Ralf Wagner, Ivanella Kondova, Petra Mooij, Sunita Balla-Jhagjhoorsingh, Niels Beenhakker, Gerrit Koopman, Sjoerd van der Burg, Jean-Pierre Kraehenbuhl, and Alain Le Pape

Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic
PNAS 2008 105: 2046-2051; published online on February 11, 2008, 10.1073/pnas.0705191105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Francesco Fornai, Patrizia Longone, Luisa Cafaro, Olga Kastsiuchenka, Michela Ferrucci, Maria Laura Manca, Gloria Lazzeri, Alida Spalloni, Natascia Bellio, Paola Lenzi, Nicola Modugno, Gabriele Siciliano, Ciro Isidoro, Luigi Murri, Stefano Ruggieri, and Antonio Paparelli Lithium delays progression of amyotrophic lateral sclerosis PNAS 2008 105: 2052-2057; published online on February 4, 2008, 10.1073/pnas.0708022105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Daniel P. Wermeling, Stan L. Banks, David A. Hudson, Harvinder S. Gill, Jyoti Gupta, Mark R. Prausnitz, and Audra L. Stinchcomb From the Cover: Microneedles permit transdermal delivery of a skin-impermeant medication to humans PNAS 2008 105: 2058-2063; published online on February 4, 2008, 10.1073/pnas.0710355105 [Abstract] [Full Text] [Figures Only] [PDF]

Ming Du, Xiaoli Liu, Ellen M. Welch, Samit Hirawat, Stuart W. Peltz, and David M. Bedwell

PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
PNAS 2008 105: 2064-2069; published online on February 6, 2008, 10.1073/pnas.0711795105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cai-Hong Yun, Kristen E. Mengwasser, Angela V. Toms, Michele S. Woo, Heidi Greulich, Kwok-Kin Wong, Matthew Meyerson, and Michael J. Eck

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
PNAS 2008 105: 2070-2075; published online on January 28, 2008, 10.1073/pnas.0709662105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Su-Jiang Zhang, Li-Yuan Ma, Qiu-Hua Huang, Guo Li, Bai-Wei Gu, Xiao-Dong Gao, Jing-Yi Shi, Yue-Ying Wang, Li Gao, Xun Cai, Rui-Bao Ren, Jiang Zhu, Zhu Chen, and Sai-Juan Chen

Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia
PNAS 2008 105: 2076-2081; published online on February 4, 2008, 10.1073/pnas.0711824105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Fredrik Johansson, Farah Kramer, Shelley Barnhart, Jenny E. Kanter, Tomas Vaisar, Rachel D. Merrill, Linda Geng, Kazuhiro Oka, Lawrence Chan, Alan Chait, Jay W. Heinecke, and Karin E. Bornfeldt

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
PNAS 2008 105: 2082-2087; published online on February 5, 2008, 10.1073/pnas.0709958105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Paul G. Matteson, Jigar Desai, Ron Korstanje, Gloria Lazar, Tanya E. Borsuk, Jarod Rollins, Sindhuja Kadambi, Jamie Joseph, Taslima Rahman, Jason Wink, Rym Benayed, Beverly Paigen, and James H. Millonig The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development PNAS 2008 105: 2088-2093; published online on February 4, 2008, 10.1073/pnas.0705657105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hyun-Jin Kim, Xiaotang Fan, Chiara Gabbi, Konstantin Yakimchuk, Paolo Parini, Margaret Warner, and Jan-Åke Gustafsson

Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia
PNAS 2008 105: 2094-2099; published online on January 31, 2008, 10.1073/pnas.0711599105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Vincent Vieillard, Roger Le Grand, Jean Dausset, and Patrice Debré

A vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques
PNAS 2008 105: 2100-2104; published online on January 30, 2008, 10.1073/pnas.0711629105 [Abstract] [Full Text] [Figures Only] [PDF]  

Olga Klezovitch, Michael Risk, Ilsa Coleman, Jared M. Lucas, Manda Null, Lawrence D. True, Peter S. Nelson, and Valeri Vasioukhin

A causal role for ERG in neoplastic transformation of prostate epithelium
PNAS 2008 105: 2105-2110; published online on February 1, 2008, 10.1073/pnas.0711711105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jian-Fu Chen, Elizabeth P. Murchison, Ruhang Tang, Thomas E. Callis, Mariko Tatsuguchi, Zhongliang Deng, Mauricio Rojas, Scott M. Hammond, Michael D. Schneider, Craig H. Selzman, Gerhard Meissner, Cam Patterson, Gregory J. Hannon, and Da-Zhi Wang

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
PNAS 2008 105: 2111-2116; published online on February 6, 2008, 10.1073/pnas.0710228105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Min Li, Baohong Wang, Menghui Zhang, Mattias Rantalainen, Shengyue Wang, Haokui Zhou, Yan Zhang, Jian Shen, Xiaoyan Pang, Meiling Zhang, Hua Wei, Yu Chen, Haifeng Lu, Jian Zuo, Mingming Su, Yunping Qiu, Wei Jia, Chaoni Xiao, Leon M. Smith, Shengli Yang, Elaine Holmes, Huiru Tang, Guoping Zhao, Jeremy K. Nicholson, Lanjuan Li, and Liping Zhao

Symbiotic gut microbes modulate human metabolic phenotypes
PNAS 2008 105: 2117-2122; published online on February 5, 2008, 10.1073/pnas.0712038105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

James E. Futse, Kelly A. Brayton, Michael J. Dark, Donald P. Knowles, Jr., and Guy H. Palmer Superinfection as a driver of genomic diversification in antigenically variant pathogens PNAS 2008 105: 2123-2127; published online on February 5, 2008, 10.1073/pnas.0710333105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Henning Seedorf, W. Florian Fricke, Birgit Veith, Holger Brüggemann, Heiko Liesegang, Axel Strittmatter, Marcus Miethke, Wolfgang Buckel, Julia Hinderberger, Fuli Li, Christoph Hagemeier, Rudolf K. Thauer, and Gerhard Gottschalk The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features PNAS 2008 105: 2128-2133; published online on January 24, 2008, 10.1073/pnas.0711093105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Roland Hatzenpichler, Elena V. Lebedeva, Eva Spieck, Kilian Stoecker, Andreas Richter, Holger Daims, and Michael Wagner A moderately thermophilic ammonia-oxidizing crenarchaeote from a hot spring PNAS 2008 105: 2134-2139; published online on February 4, 2008, 10.1073/pnas.0708857105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Erika Assarsson, Jason A. Greenbaum, Magnus Sundström, Lana Schaffer, Jennifer A. Hammond, Valerie Pasquetto, Carla Oseroff, R. Curtis Hendrickson, Elliot J. Lefkowitz, David C. Tscharke, John Sidney, Howard M. Grey, Steven R. Head, Bjoern Peters, and Alessandro Sette Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes PNAS 2008 105: 2140-2145; published online on February 1, 2008, 10.1073/pnas.0711573105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

David Hasenöhrl, Tania Lombo, Vladimir Kaberdin, Paola Londei, and Udo Bläsi

Translation initiation factor a/eIF2(-) counteracts 5' to 3' mRNA decay in the archaeon Sulfolobus solfataricus
PNAS 2008 105: 2146-2150; published online on February 1, 2008, 10.1073/pnas.0708894105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Andrew Derome, Christian Hoischen, Malte Bussiek, Ruth Grady, Malgorzata Adamczyk, Barbara Keedzierska, Stephan Diekmann, Daniela Barillà, and Finbarr Hayes

Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium
PNAS 2008 105: 2151-2156; published online on February 1, 2008, 10.1073/pnas.0704681105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Xiaoqun Zhang, Per E. Andren, Paul Greengard, and Per Svenningsson

Evidence for a role of the 5-HT_1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism
PNAS 2008 105: 2163-2168; published online on February 6, 2008, 10.1073/pnas.0711839105 [Abstract] [Full Text] [Figures Only] [PDF]  

Hongmei Li, Yingbei Chen, Adrienne F. Jones, Richard H. Sanger, Leon P. Collis, Richard Flannery, Ewan C. McNay, Tingxi Yu, Robert Schwarzenbacher, Blaise Bossy, Ella Bossy-Wetzel, Michael V. L. Bennett, Marc Pypaert, John A. Hickman, Peter J. S. Smith, J. Marie Hardwick, and Elizabeth A. Jonas

Bcl-x_L induces Drp1-dependent synapse formation in cultured hippocampal neurons
PNAS 2008 105: 2169-2174; published online on February 4, 2008, 10.1073/pnas.0711647105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mitsuko Hayashi, Andrea Raimondi, Eileen O'Toole, Summer Paradise, Chiara Collesi, Ottavio Cremona, Shawn M. Ferguson, and Pietro De Camilli Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons PNAS 2008 105: 2175-2180; published online on February 4, 2008, 10.1073/pnas.0712171105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Saul L. Miller, Kim Celone, Kristina DePeau, Eli Diamond, Bradford C. Dickerson, Dorene Rentz, Maija Pihlajamäki, and Reisa A. Sperling

Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation
PNAS 2008 105: 2181-2186; published online on January 31, 2008, 10.1073/pnas.0706818105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zhenjun Tan, Hang Hu, Z. Josh Huang, and Ariel Agmon

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