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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 3171-3172. [Full Text] [PDF]  

COMMENTARIES

Michael R. Norman

Modulated pairs in superconducting cuprates
PNAS 2008 105: 3173-3174; published online on February 27, 2008, 10.1073/pnas.0800433105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 3203

Stephen Shennan

Canoes and cultural evolution
PNAS 2008 105: 3175-3176; published online on February 27, 2008, 10.1073/pnas.0800666105 [Extract] [Full Text] [PDF]  
See companion article on page 3416

Jonathan P. Stoye and Melvyn W. Yap

Chance favors a prepared genome
PNAS 2008 105: 3177-3178; published online on February 25, 2008, 10.1073/pnas.0800667105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 3557
See companion article on page 3563
See companion article on page 3569

PHYSICAL SCIENCES

Applied Mathematics

Z. V. Guo and L. Mahadevan

Limbless undulatory propulsion on land
PNAS 2008 105: 3179-3184; published online on February 28, 2008, 10.1073/pnas.0705442105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chemistry

Lorna Dougan, Gang Feng, Hui Lu, and Julio M. Fernandez

Solvent molecules bridge the mechanical unfolding transition state of a protein
PNAS 2008 105: 3185-3190; published online on February 27, 2008, 10.1073/pnas.0706075105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Engineering

Max Chabert and Jean-Louis Viovy

Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells
PNAS 2008 105: 3191-3196; published online on March 3, 2008, 10.1073/pnas.0708321105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Amit Agrawal, Rajesh Deo, Geoffrey D. Wang, May D. Wang, and Shuming Nie Nanometer-scale mapping and single-molecule detection with color-coded nanoparticle probes PNAS 2008 105: 3298-3303; published online on February 27, 2008, 10.1073/pnas.0712351105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Geology

Kathleen A. McFadden, Jing Huang, Xuelei Chu, Ganqing Jiang, Alan J. Kaufman, Chuanming Zhou, Xunlai Yuan, and Shuhai Xiao

Pulsed oxidation and biological evolution in the Ediacaran Doushantuo Formation
PNAS 2008 105: 3197-3202; published online on February 25, 2008, 10.1073/pnas.0708336105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physics

Statistics

SOCIAL SCIENCES

Anthropology

Psychology

Sarah Whittle, Marie B. H. Yap, Murat Yücel, Alex Fornito, Julian G. Simmons, Anna Barrett, Lisa Sheeber, and Nicholas B. Allen

Prefrontal and amygdala volumes are related to adolescents' affective behaviors during parent–adolescent interactions
PNAS 2008 105: 3652-3657; published online on February 25, 2008, 10.1073/pnas.0709815105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

BIOLOGICAL SCIENCES

Anthropology

Applied Biological Sciences

Koh Amano, Yasunori Chiba, Yoshiko Kasahara, Yukinari Kato, Mika Kato Kaneko, Atsushi Kuno, Hiromi Ito, Kazuo Kobayashi, Jun Hirabayashi, Yoshifumi Jigami, and Hisashi Narimatsu

Engineering of mucin-type human glycoproteins in yeast cells
PNAS 2008 105: 3232-3237; published online on February 22, 2008, 10.1073/pnas.0710412105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Pallavi Ghosh, Lori A. Bibb, and Graham F. Hatfull

Two-step site selection for serine-integrase-mediated excision: DNA-directed integrase conformation and central dinucleotide proofreading
PNAS 2008 105: 3238-3243; published online on February 25, 2008, 10.1073/pnas.0711649105 [Abstract] [Full Text] [Figures Only] [PDF]  

Sven N. Hobbie, Christian M. Bruell, Subramanian Akshay, Sarath K. Kalapala, Dmitry Shcherbakov, and Erik C. Böttger

Mitochondrial deafness alleles confer misreading of the genetic code
PNAS 2008 105: 3244-3249; published online on February 28, 2008, 10.1073/pnas.0707265105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sofya Kuznetsova, Gerhild Zauner, Thijs J. Aartsma, Hans Engelkamp, Nikos Hatzakis, Alan E. Rowan, Roeland J. M. Nolte, Peter C. M. Christianen, and Gerard W. Canters

The enzyme mechanism of nitrite reductase studied at single-molecule level
PNAS 2008 105: 3250-3255; published online on February 26, 2008, 10.1073/pnas.0707736105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Adrian W. R. Serohijos, Tamás Hegedus, Andrei A. Aleksandrov, Lihua He, Liying Cui, Nikolay V. Dokholyan, and John R. Riordan

Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
PNAS 2008 105: 3256-3261; published online on February 27, 2008, 10.1073/pnas.0800254105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elisabeth Stafflinger, Karina K. Hansen, Frank Hauser, Martina Schneider, Giuseppe Cazzamali, Michael Williamson, and Cornelis J. P. Grimmelikhuijzen

Cloning and identification of an oxytocin/vasopressin-like receptor and its ligand from insects
PNAS 2008 105: 3262-3267; published online on March 3, 2008, 10.1073/pnas.0710897105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Arthur D. Tinoco, Cynthia W. Peterson, Baldo Lucchese, Robert P. Doyle, and Ann M. Valentine

On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis
PNAS 2008 105: 3268-3273; published online on February 20, 2008, 10.1073/pnas.0705037105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chikako Suzuki, Robert G. Garces, Katherine A. Edmonds, Sebastian Hiller, Sven G. Hyberts, Assen Marintchev, and Gerhard Wagner

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
PNAS 2008 105: 3274-3279; published online on February 22, 2008, 10.1073/pnas.0712235105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joanne I. Yeh, Unmesh Chinte, and Shoucheng Du Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism PNAS 2008 105: 3280-3285; published online on February 22, 2008, 10.1073/pnas.0712331105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Markos Koutmos, Robert Pejchal, Theresa M. Bomer, Rowena G. Matthews, Janet L. Smith, and Martha L. Ludwig

Metal active site elasticity linked to activation of homocysteine in methionine synthases
PNAS 2008 105: 3286-3291; published online on February 22, 2008, 10.1073/pnas.0709960105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shanil P. Haugen, Wilma Ross, Michele Manrique, and Richard L. Gourse

Fine structure of the promoter– region 1.2 interaction
PNAS 2008 105: 3292-3297; published online on February 19, 2008, 10.1073/pnas.0709513105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Z. V. Guo and L. Mahadevan

Limbless undulatory propulsion on land
PNAS 2008 105: 3179-3184; published online on February 28, 2008, 10.1073/pnas.0705442105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Amit Agrawal, Rajesh Deo, Geoffrey D. Wang, May D. Wang, and Shuming Nie Nanometer-scale mapping and single-molecule detection with color-coded nanoparticle probes PNAS 2008 105: 3298-3303; published online on February 27, 2008, 10.1073/pnas.0712351105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Thierry Emonet and Philippe Cluzel

Relationship between cellular response and behavioral variability in bacterial chemotaxis
PNAS 2008 105: 3304-3309; published online on February 25, 2008, 10.1073/pnas.0705463105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jorge E. Contreras, Deepa Srikumar, and Miguel Holmgren

Gating at the selectivity filter in cyclic nucleotide-gated channels
PNAS 2008 105: 3310-3314; published online on February 20, 2008, 10.1073/pnas.0709809105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sandra J. Greive, Steven E. Weitzel, Jim P. Goodarzi, Lisa J. Main, Zvi Pasman, and Peter H. von Hippel

Monitoring RNA transcription in real time by using surface plasmon resonance
PNAS 2008 105: 3315-3320; published online on February 25, 2008, 10.1073/pnas.0712074105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Haipeng Gong and George D. Rose Assessing the solvent-dependent surface area of unfolded proteins using an ensemble model PNAS 2008 105: 3321-3326; published online on February 27, 2008, 10.1073/pnas.0712240105 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Cell Biology

Max Chabert and Jean-Louis Viovy

Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells
PNAS 2008 105: 3191-3196; published online on March 3, 2008, 10.1073/pnas.0708321105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

G. Valentin Börner, Aekam Barot, and Nancy Kleckner

Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis
PNAS 2008 105: 3327-3332; published online on February 27, 2008, 10.1073/pnas.0711864105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Louis C. Dore, Julio D. Amigo, Camila O. dos Santos, Zhe Zhang, Xiaowu Gai, John W. Tobias, Duonan Yu, Alyssa M. Klein, Christine Dorman, Weisheng Wu, Ross C. Hardison, Barry H. Paw, and Mitchell J. Weiss

A GATA-1-regulated microRNA locus essential for erythropoiesis
PNAS 2008 105: 3333-3338; published online on February 26, 2008, 10.1073/pnas.0712312105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Liping Sun, Julie S. Trausch-Azar, Louis J. Muglia, and Alan L. Schwartz

Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism
PNAS 2008 105: 3339-3344; published online on February 22, 2008, 10.1073/pnas.0800165105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Venkataramana K. Sidhaye, Kelly S. Schweitzer, Michael J. Caterina, Larissa Shimoda, and Landon S. King

Shear stress regulates aquaporin-5 and airway epithelial barrier function
PNAS 2008 105: 3345-3350; published online on February 27, 2008, 10.1073/pnas.0712287105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zi Zhao Lieu, John G. Lock, Luke A. Hammond, Nicole L. La Gruta, Jennifer L. Stow, and Paul A. Gleeson

A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo
PNAS 2008 105: 3351-3356; published online on February 28, 2008, 10.1073/pnas.0800137105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Philip Ian Padilla, Marina Uhart, Gustavo Pacheco-Rodriguez, Brenda A. Peculis, Joel Moss, and Martha Vaughan

Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin
PNAS 2008 105: 3357-3361; published online on February 21, 2008, 10.1073/pnas.0712387105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ru-hang Tang, Xi-Long Zheng, Thomas E. Callis, William E. Stansfield, Jiayin He, Albert S. Baldwin, Da-Zhi Wang, and Craig H. Selzman

Myocardin inhibits cellular proliferation by inhibiting NF-B(p65)-dependent cell cycle progression
PNAS 2008 105: 3362-3367; published online on February 22, 2008, 10.1073/pnas.0705842105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiaofeng Zheng, Sarah Linke, José M. Dias, Xiaowei Zheng, Katarina Gradin, Tristan P. Wallis, Brett R. Hamilton, Maria Gustafsson, Jorge L. Ruas, Sarah Wilkins, Rebecca L. Bilton, Kerstin Brismar, Murray L. Whitelaw, Teresa Pereira, Jeffrey J. Gorman, Johan Ericson, Daniel J. Peet, Urban Lendahl, and Lorenz Poellinger

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
PNAS 2008 105: 3368-3373; published online on February 25, 2008, 10.1073/pnas.0711591105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

In Hye Lee, Liu Cao, Raul Mostoslavsky, David B. Lombard, Jie Liu, Nicholas E. Bruns, Maria Tsokos, Frederick W. Alt, and Toren Finkel

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
PNAS 2008 105: 3374-3379; published online on February 22, 2008, 10.1073/pnas.0712145105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alok S. Shah, Sara L. Farmen, Thomas O. Moninger, Thomas R. Businga, Michael P. Andrews, Kevin Bugge, Charles C. Searby, Darryl Nishimura, Kim A. Brogden, Joel N. Kline, Val C. Sheffield, and Michael J. Welsh Loss of Bardet–Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia PNAS 2008 105: 3380-3385; published online on February 25, 2008, 10.1073/pnas.0712327105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Patricia Valencia, Anusha P. Dias, and Robin Reed

Splicing promotes rapid and efficient mRNA export in mammalian cells
PNAS 2008 105: 3386-3391; published online on February 20, 2008, 10.1073/pnas.0800250105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Myung Soo Cho, Young-Eun Lee, Ji Young Kim, Seungsoo Chung, Yoon Hee Cho, Dae-Sung Kim, Sang-Moon Kang, Haksup Lee, Myung-Hwa Kim, Jeong-Hoon Kim, Joong Woo Leem, Sun Kyung Oh, Young Min Choi, Dong-Youn Hwang, Jin Woo Chang, and Dong-Wook Kim

Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells
PNAS 2008 105: 3392-3397; published online on February 27, 2008, 10.1073/pnas.0712359105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jia Sheng Hu, Linda T. Doan, D. Spencer Currle, Michelle Paff, Justin Y. Rheem, Rachel Schreyer, Benoit Robert, and Edwin S. Monuki

Border formation in a Bmp gradient reduced to single dissociated cells
PNAS 2008 105: 3398-3403; published online on February 21, 2008, 10.1073/pnas.0709100105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Katherine M. Thibault and James H. Brown Impact of an extreme climatic event on community assembly PNAS 2008 105: 3410-3415; published online on February 26, 2008, 10.1073/pnas.0712282105 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Evolution

Deborah S. Rogers and Paul R. Ehrlich From the Cover: Natural selection and cultural rates of change PNAS 2008 105: 3416-3420; published online on February 19, 2008, 10.1073/pnas.0711802105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE   See Commentary on page 3175

Amro Zayed and Charles W. Whitfield

A genome-wide signature of positive selection in ancient and recent invasive expansions of the honey bee Apis mellifera
PNAS 2008 105: 3421-3426; published online on February 25, 2008, 10.1073/pnas.0800107105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cindy Martens, Klaas Vandepoele, and Yves Van de Peer

Whole-genome analysis reveals molecular innovations and evolutionary transitions in chromalveolate species
PNAS 2008 105: 3427-3432; published online on February 25, 2008, 10.1073/pnas.0712248105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Maria Costantini and Giorgio Bernardi

Replication timing, chromosomal bands, and isochores
PNAS 2008 105: 3433-3437; published online on February 27, 2008, 10.1073/pnas.0710587105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Yousin Suh, Gil Atzmon, Mi-Ook Cho, David Hwang, Bingrong Liu, Daniel J. Leahy, Nir Barzilai, and Pinchas Cohen Functionally significant insulin-like growth factor I receptor mutations in centenarians PNAS 2008 105: 3438-3442; published online on March 3, 2008, 10.1073/pnas.0705467105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Thomas D. Barber, Kirk McManus, Karen W. Y. Yuen, Marcelo Reis, Giovanni Parmigiani, Dong Shen, Irene Barrett, Yasaman Nouhi, Forrest Spencer, Sanford Markowitz, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer, and Philip Hieter

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
PNAS 2008 105: 3443-3448; published online on February 25, 2008, 10.1073/pnas.0712384105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elena Torban, Anne-Marie Patenaude, Severine Leclerc, Staci Rakowiecki, Susan Gauthier, Gregor Andelfinger, Douglas J. Epstein, and Philippe Gros

Genetic interaction between members of the Vangl family causes neural tube defects in mice
PNAS 2008 105: 3449-3454; published online on February 22, 2008, 10.1073/pnas.0712126105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Catherine A. Brownstein, Felix Adler, Carol Nelson-Williams, Junko Iijima, Peining Li, Akihiro Imura, Yo-ichi Nabeshima, Miguel Reyes-Mugica, Thomas O. Carpenter, and Richard P. Lifton A translocation causing increased -Klotho level results in hypophosphatemic rickets and hyperparathyroidism PNAS 2008 105: 3455-3460; published online on February 28, 2008, 10.1073/pnas.0712361105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Ramamurthy Mani, Robert P. St.Onge, John L. Hartman, IV, Guri Giaever, and Frederick P. Roth Defining genetic interaction PNAS 2008 105: 3461-3466; published online on February 27, 2008, 10.1073/pnas.0712255105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Roman Gonitel, Hilary Moffitt, Kirupa Sathasivam, Ben Woodman, Peter J. Detloff, Richard L. M. Faull, and Gillian P. Bates DNA instability in postmitotic neurons PNAS 2008 105: 3467-3472; published online on February 25, 2008, 10.1073/pnas.0800048105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Christoph Schoen, Jochen Blom, Heike Claus, Anja Schramm-Glück, Petra Brandt, Tobias Müller, Alexander Goesmann, Biju Joseph, Sebastian Konietzny, Oliver Kurzai, Corinna Schmitt, Torben Friedrich, Burkhard Linke, Ulrich Vogel, and Matthias Frosch Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis PNAS 2008 105: 3473-3478; published online on February 27, 2008, 10.1073/pnas.0800151105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Panayotis Verginis, Katherine A. McLaughlin, Kai W. Wucherpfennig, Harald von Boehmer, and Irina Apostolou

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression
PNAS 2008 105: 3479-3484; published online on February 25, 2008, 10.1073/pnas.0800149105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hye Mee Joo, Yuxia He, and Mark Y. Sangster

Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia
PNAS 2008 105: 3485-3490; published online on February 25, 2008, 10.1073/pnas.0800003105 [Abstract] [Full Text] [Figures Only] [PDF]  

Aude De Gassart, Voahirana Camosseto, Jacques Thibodeau, Maurizio Ceppi, Nadia Catalan, Philippe Pierre, and Evelina Gatti

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
PNAS 2008 105: 3491-3496; published online on February 27, 2008, 10.1073/pnas.0708874105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sascha Rutz, Marko Janke, Nadine Kassner, Thordis Hohnstein, Manuela Krueger, and Alexander Scheffold

Notch regulates IL-10 production by T helper 1 cells
PNAS 2008 105: 3497-3502; published online on February 21, 2008, 10.1073/pnas.0712102105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brian Zarnegar, Soh Yamazaki, Jeannie Q. He, and Genhong Cheng

Control of canonical NF-B activation through the NIK–IKK complex pathway
PNAS 2008 105: 3503-3508; published online on February 21, 2008, 10.1073/pnas.0707959105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marcella Fassò, Rebecca Waitz, Yafei Hou, Tae Rim, Norman M. Greenberg, Nilabh Shastri, Lawrence Fong, and James P. Allison

SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
PNAS 2008 105: 3509-3514; published online on February 26, 2008, 10.1073/pnas.0712269105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mihai G. Netea, Eli C. Lewis, Tania Azam, Leo A. B. Joosten, Jun Jaekal, Su-Young Bae, Charles A. Dinarello, and Soo-Hyun Kim

Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
PNAS 2008 105: 3515-3520; published online on February 22, 2008, 10.1073/pnas.0712381105 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Edward W. Blank, Po-Yin Wong, Rajkumar Lakshmanaswamy, Raphael Guzman, and Satyabrata Nandi

Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats
PNAS 2008 105: 3527-3532; published online on February 25, 2008, 10.1073/pnas.0710535105 [Abstract] [Full Text] [Figures Only] [PDF]  

Taku Yoshida, Fang Jiang, Tasuku Honjo, and Taku Okazaki

PD-1 deficiency reveals various tissue-specific autoimmunity by H-2^b and dose-dependent requirement of H-2^g7 for diabetes in NOD mice
PNAS 2008 105: 3533-3538; published online on February 25, 2008, 10.1073/pnas.0710951105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shaowei Li, Fumiko Takeuchi, Ji-an Wang, Qingyuan Fan, Toshi Komurasaki, Eric M. Billings, Gustavo Pacheco-Rodriguez, Joel Moss, and Thomas N. Darling

Mesenchymal–epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas
PNAS 2008 105: 3539-3544; published online on February 21, 2008, 10.1073/pnas.0712397105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brice Emanuelli, Delphine Eberlé, Ryo Suzuki, and C. Ronald Kahn

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
PNAS 2008 105: 3545-3550; published online on February 22, 2008, 10.1073/pnas.0712275105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ross F. Goldberg, William G. Austen, Jr., Xiaobo Zhang, Gitonga Munene, Golam Mostafa, Shaluk Biswas, Michael McCormack, Kyle R. Eberlin, John T. Nguyen, Hamit S. Tatlidede, H. Shaw Warren, Sonoko Narisawa, Jose L. Millán, and Richard A. Hodin

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition
PNAS 2008 105: 3551-3556; published online on February 21, 2008, 10.1073/pnas.0712140105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Cesar A. Virgen, Zerina Kratovac, Paul D. Bieniasz, and Theodora Hatziioannou From the Cover: Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species PNAS 2008 105: 3563-3568; published online on February 19, 2008, 10.1073/pnas.0709258105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 3177

Greg Brennan, Yury Kozyrev, and Shiu-Lok Hu From the Cover: TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis PNAS 2008 105: 3569-3574; published online on February 19, 2008, 10.1073/pnas.0709511105 [Abstract] [Full Text] [Figures Only] [PDF]   See Commentary on page 3177

Ivorlyne P. Greene, Eun-Young Lee, Natalie Prow, Brownhilda Ngwang, and Diane E. Griffin

Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection
PNAS 2008 105: 3575-3580; published online on February 22, 2008, 10.1073/pnas.0712390105 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Annalisa Buffo, Inmaculada Rite, Pratibha Tripathi, Alexandra Lepier, Dilek Colak, Ana-Paula Horn, Tetsuji Mori, and Magdalena Götz

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
PNAS 2008 105: 3581-3586; published online on February 25, 2008, 10.1073/pnas.0709002105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eric P. Meyer, Alexandra Ulmann-Schuler, Matthias Staufenbiel, and Thomas Krucker Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease PNAS 2008 105: 3587-3592; published online on February 27, 2008, 10.1073/pnas.0709788105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE<