EDITORIAL

Diane M. Sullenberger, Kenneth R. Fulton, and Nicholas R. Cozzarelli

Redesign of PNAS: New Covers for the Journal
PNAS 1999 96: 1. [Full Text] [PDF]  

COMMENTARIES

Frank C. P. Holstege and Richard A. Young

Transcriptional regulation: Contending with complexity
PNAS 1999 96: 2-4. [Full Text] [PDF]  

Jack D. Keene

Why is Hu where? Shuttling of early-response-gene messenger RNA subsets
PNAS 1999 96: 5-7. [Full Text] [PDF]  

Peter Kareiva

Coevolutionary arms races: Is victory possible?
PNAS 1999 96: 8-10. [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Physical Sciences

Hou-Pu Chou, Charles Spence, Axel Scherer, and Stephen Quake

A microfabricated device for sizing and sorting DNA molecules
PNAS 1999 96: 11-13. [Abstract] [Full Text] [PDF]  

Engineering

Andre Marziali, Thomas D. Willis, and Ronald W. Davis

An arrayable flow-through microcentrifuge for high-throughput instrumentation
PNAS 1999 96: 61-66. [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES
Anthropology

Salvador Moyà-Solà, Meike Köhler, and Lorenzo Rook

Evidence of hominid-like precision grip capability in the hand of the Miocene ape Oreopithecus
PNAS 1999 96: 313-317. [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES
Applied Biological Sciences

Tomonori Nakai, Naoto Tonouchi, Teruko Konishi, Yukiko Kojima, Takayasu Tsuchida, Fumihiro Yoshinaga, Fukumi Sakai, and Takahisa Hayashi

Enhancement of cellulose production by expression of sucrose synthase in Acetobacter xylinum
PNAS 1999 96: 14-18. [Abstract] [Full Text] [PDF]  

Richard C. Miller, Gerhard Randers-Pehrson, Charles R. Geard, Eric J. Hall, and David J. Brenner

The oncogenic transforming potential of the passage of single  particles through mammalian cell nuclei
PNAS 1999 96: 19-22. [Abstract] [Full Text] [PDF]  

Biochemistry

James J.-D. Hsieh, Sifang Zhou, Lin Chen, David B. Young, and S. Diane Hayward

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
PNAS 1999 96: 23-28. [Abstract] [Full Text] [PDF]  

Lisa D. Belmont, Albina Orlova, David G. Drubin, and Edward H. Egelman

A change in actin conformation associated with filament instability after P_i release
PNAS 1999 96: 29-34. [Abstract] [Full Text] [PDF] [Supplementary Figures]  

Anne Puustinen and Mårten Wikström

Proton exit from the heme-copper oxidase of Escherichia coli
PNAS 1999 96: 35-37. [Abstract] [Full Text] [PDF]  

Scott J. Garforth, Thomas A. Ceska, Dietrich Suck, and Jon R. Sayers

Mutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endoand exonucleolytic cleavage
PNAS 1999 96: 38-43. [Abstract] [Full Text] [PDF]  

Gerard M. Lacourciere and Thressa C. Stadtman

Catalytic properties of selenophosphate synthetases: Comparison of the selenocysteine-containing enzyme from Haemophilus influenzae with the corresponding cysteine-containing enzyme from Escherichia coli
PNAS 1999 96: 44-48. [Abstract] [Full Text] [PDF]  

Simos Simeonidis, Deborah Stauber, Guoying Chen, Wayne A. Hendrickson, and Dimitris Thanos

Mechanisms by which IB proteins control NF-B activity
PNAS 1999 96: 49-54. [Abstract] [Full Text] [PDF]  

J. F. Uhrig, T.-R. Soellick, C. J. Minke, C. Philipp, J.-W. Kellmann, and P. H. Schreier

Homotypic interaction and multimerization of nucleocapsid protein of tomato spotted wilt tospovirus: Identification and characterization of two interacting domains
PNAS 1999 96: 55-60. [Abstract] [Full Text] [PDF]  

Andre Marziali, Thomas D. Willis, and Ronald W. Davis

An arrayable flow-through microcentrifuge for high-throughput instrumentation
PNAS 1999 96: 61-66. [Abstract] [Full Text] [PDF]  

Lawrence C. Myers, Claes M. Gustafsson, Kathleen C. Hayashibara, Patrick O. Brown, and Roger D. Kornberg

Mediator protein mutations that selectively abolish activated transcription
PNAS 1999 96: 67-72. [Abstract] [Full Text] [PDF]  

Hirock J. Datta, Ghan Shyam Khatri, and Deepak Bastia

Mechanism of recruitment of DnaB helicase to the replication origin of the plasmid pSC101
PNAS 1999 96: 73-78. [Abstract] [Full Text] [PDF]  

Jochen Buck, Meeghan L. Sinclair, Lissy Schapal, Martin J. Cann, and Lonny R. Levin

Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
PNAS 1999 96: 79-84. [Abstract] [Full Text] [PDF]  

Philipp Khaitovich, Alexander S. Mankin, Rachel Green, Laura Lancaster, and Harry F. Noller

Characterization of functionally active subribosomal particles from Thermus aquaticus
PNAS 1999 96: 85-90. [Abstract] [Full Text] [PDF]  

Maria Antonietta Zanta, Pascale Belguise-Valladier, and Jean-Paul Behr

Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
PNAS 1999 96: 91-96. [Abstract] [Full Text] [PDF]  

Edna S. Kaneshiro, Zunika Amit, Mardie M. Swonger, George P. Kreishman, Elwood E. Brooks, Mara Kreishman, Koka Jayasimhulu, Edward J. Parish, Hang Sun, Stephen A. Kizito, and David H. Beach

Pneumocysterol [(24Z)-ethylidenelanost-8-en-3-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: Structural identity and chemical synthesis
PNAS 1999 96: 97-102. [Abstract] [Full Text] [PDF]  

Biophysics

Hou-Pu Chou, Charles Spence, Axel Scherer, and Stephen Quake

A microfabricated device for sizing and sorting DNA molecules
PNAS 1999 96: 11-13. [Abstract] [Full Text] [PDF]  

B. Yu, M. Blaber, A. M. Gronenborn, G. M. Clore, and D. L. D. Caspar

Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography
PNAS 1999 96: 103-108. [Abstract] [Full Text] [PDF]  

Cell Biology

Yang Xu, Mike A. Singer, and Susan Lindquist

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90
PNAS 1999 96: 109-114. [Abstract] [Full Text] [PDF]  

Vladimir Rodionov, Elena Nadezhdina, and Gary Borisy

Centrosomal control of microtubule dynamics
PNAS 1999 96: 115-120. [Abstract] [Full Text] [PDF]  

Peter Csutora, Zhengchang Su, Hak Yong Kim, Andrej Bugrim, Kyle W. Cunningham, Richard Nuccitelli, Joel E. Keizer, Michael R. Hanley, J. Edwin Blalock, and Richard B. Marchase

Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores
PNAS 1999 96: 121-126. [Abstract] [Full Text] [PDF]  

J. Patrick Condreay, Sam M. Witherspoon, William C. Clay, and Thomas A. Kost

Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector
PNAS 1999 96: 127-132. [Abstract] [Full Text] [PDF]  

J. E. Fisher, M. J. Rogers, J. M. Halasy, S. P. Luckman, D. E. Hughes, P. J. Masarachia, G. Wesolowski, R. G. G. Russell, G. A. Rodan, and A. A. Reszka

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
PNAS 1999 96: 133-138. [Abstract] [Full Text] [PDF]  

Masahiro Aoki, Andreas Hecht, Ulrich Kruse, Rolf Kemler, and Peter K. Vogt

Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1
PNAS 1999 96: 139-144. [Abstract] [Full Text] [PDF]  

Hirotaka Kanuka, Shin Hisahara, Kazunobu Sawamoto, Shin-ichi Shoji, Hideyuki Okano, and Masayuki Miura

Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: Implicated mechanisms for caspase activation
PNAS 1999 96: 145-150. [Abstract] [Full Text] [PDF]  

Yao Xu, David W. Piston, and Carl Hirschie Johnson

A bioluminescence resonance energy transfer (BRET) system: Application to interacting circadian clock proteins
PNAS 1999 96: 151-156. [Abstract] [Full Text] [PDF]  

Developmental Biology

Edwin Gilland, Andrew L. Miller, Eric Karplus, Robert Baker, and Sarah E. Webb

Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation
PNAS 1999 96: 157-161. [Abstract] [Full Text] [PDF] [PNAS 96(1) Gilland Suppl. Data]  

Maria I. Morasso, Alexander Grinberg, Gertraud Robinson, Thomas D. Sargent, and Kathleen A. Mahon

Placental failure in mice lacking the homeobox gene Dlx3
PNAS 1999 96: 162-167. [Abstract] [Full Text] [PDF]  

Evolution

Adam D. Richman and Joshua R. Kohn

Self-incompatibility alleles from Physalis: Implications for historical inference from balanced genetic polymorphisms
PNAS 1999 96: 168-172. [Abstract] [Full Text] [PDF]  

Laura F. Landweber and Irina D. Pokrovskaya

Emergence of a dual-catalytic RNA with metal-specific cleavage and ligase activities: The spandrels of RNA evolution
PNAS 1999 96: 173-178. [Abstract] [Full Text] [PDF]  

Genetics

Peter W. Faber, Janet R. Alter, Marcy E. MacDonald, and Anne C. Hart

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
PNAS 1999 96: 179-184. [Abstract] [Full Text] [PDF]  

Immunology

Peter A. Bretscher

A two-step, two-signal model for the primary activation of precursor helper T cells
PNAS 1999 96: 185-190. [Abstract] [Full Text] [PDF]  

Yung Chang and Matthew L. Brown

Formation of coding joints in V(D)J recombination-inducible severe combined immune deficient pre-B cell lines
PNAS 1999 96: 191-196. [Abstract] [Full Text] [PDF]  

Cecelia I. Pearson, Anand M. Gautam, Ingrid C. Rulifson, Roland S. Liblau, and Hugh O. McDevitt

A small number of residues in the class II molecule I-A^u confer the ability to bind the myelin basic protein peptide Ac1-11
PNAS 1999 96: 197-202. [Abstract] [Full Text] [PDF]  

Medical Sciences

Norifumi Takeda, Masabumi Shibuya, and Yoshiro Maru

The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein
PNAS 1999 96: 203-207. [Abstract] [Full Text] [PDF]  

Woo-Shin Shim, James DiRenzo, James A. DeCaprio, Richard J. Santen, Myles Brown, and Meei-Huey Jeng

Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium
PNAS 1999 96: 208-213. [Abstract] [Full Text] [PDF]  

Yinhua Yu, Fengji Xu, Hongqi Peng, Xianjun Fang, Shulei Zhao, Yang Li, Bruce Cuevas, Wen-Lin Kuo, Joe W. Gray, Michael Siciliano, Gordon B. Mills, and Robert C. Bast Jr.

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas
PNAS 1999 96: 214-219. [Abstract] [Full Text] [PDF]  

Lynn A. Megeney, Boris Kablar, Robert L. S. Perry, Chuyan Ying, Linda May, and Michael A. Rudnicki

Severe cardiomyopathy in mice lacking dystrophin and MyoD
PNAS 1999 96: 220-225. [Abstract] [Full Text] [PDF]  

Hippokratis Kiaris and Andrew V. Schally

Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
PNAS 1999 96: 226-231. [Abstract] [Full Text] [PDF]  

Kevin D. Bunting, Kirsten J. Flynn, Janice M. Riberdy, Peter C. Doherty, and Brian P. Sorrentino

Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency
PNAS 1999 96: 232-237. [Abstract] [Full Text] [PDF]  

Akira Nakanishi, Lufeng Guan, Robert R. Kane, Harumi Kasamatsu, and M. Frederick Hawthorne

Toward a cancer therapy with boron-rich oligomeric phosphate diesters that target the cell nucleus
PNAS 1999 96: 238-241. [Abstract] [Full Text] [PDF]  

Microbiology

Kathryn E. Stockbauer, Loranne Magoun, Mengyao Liu, Eugene H. Burns Jr., Siddeswar Gubba, Sarah Renish, Xi Pan, Sarah C. Bodary, Elizabeth Baker, Jenifer Coburn, John M. Leong, and James M. Musser

A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins _v3 and _IIb3
PNAS 1999 96: 242-247. [Abstract] [Full Text] [PDF]  

Neurobiology

Ofer Wiser, Michael Trus, Ana Hernández, Erik Renström, Sebastian Barg, Patrik Rorsman, and Daphne Atlas

The voltage sensitive Lc-type Ca²⁺ channel is functionally coupled to the exocytotic machinery
PNAS 1999 96: 248-253. [Abstract] [Full Text] [PDF]  

Dafang Wu and William M. Pardridge

Neuroprotection with noninvasive neurotrophin delivery to the brain
PNAS 1999 96: 254-259. [Abstract] [Full Text] [PDF]  

Catherine Abbadie, Kate Skinner, Igor Mitrovic, and Allan I. Basbaum

Neurons in the dorsal column white matter of the spinal cord: Complex neuropil in an unexpected location
PNAS 1999 96: 260-265. [Abstract] [Full Text] [PDF]  

Pharmacology

Bethany A. Janowski, Michael J. Grogan, Stacey A. Jones, G. Bruce Wisely, Steven A. Kliewer, Elias J. Corey, and David J. Mangelsdorf

Structural requirements of ligands for the oxysterol liver X receptors LXR and LXR
PNAS 1999 96: 266-271. [Abstract] [Full Text] [PDF]  

B. F. McAdam, F. Catella-Lawson, I. A. Mardini, S. Kapoor, J. A. Lawson, and G. A. FitzGerald

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
PNAS 1999 96: 272-277. [Abstract] [Full Text] [PDF]  

Physiology

T. J. Soares, T. M. Coimbra, A. R. Martins, A. G. F. Pereira, E. C. Carnio, L. G. S. Branco, W. I. C. Albuquerque-Araujo, G. de Nucci, A. L. V. Favaretto, J. Gutkowska, S. M. McCann, and J. Antunes-Rodrigues

Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP
PNAS 1999 96: 278-283. [Abstract] [Full Text] [PDF]  

Plant Biology

Ruth C. Martin, Machteld C. Mok, and David W. S. Mok

Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus
PNAS 1999 96: 284-289. [Abstract] [Full Text] [PDF]  

Karin Schumacher, Thomas Schmitt, Mathias Rossberg, Gregor Schmitz, and Klaus Theres

The Lateral suppressor (Ls) gene of tomato encodes a new member of the VHIID protein family
PNAS 1999 96: 290-295. [Abstract] [Full Text] [PDF]  

Ming Luo, Pierre Bilodeau, Anna Koltunow, Elizabeth S. Dennis, W. James Peacock, and Abdul M. Chaudhury

Genes controlling fertilization-independent seed development in Arabidopsis thaliana
PNAS 1999 96: 296-301. [Abstract] [Full Text] [PDF]  

Ana Lucia Caicedo, Barbara A. Schaal, and Barbara N. Kunkel

Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana
PNAS 1999 96: 302-306. [Abstract] [Full Text] [PDF]  

Psychology

J. M. Kraft and D. H. Brainard

Mechanisms of color constancy under nearly natural viewing
PNAS 1999 96: 307-312. [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for vol. 93, p. 13256 [Full Text]  

Correction for vol. 95, p. 13278 [Full Text]