COMMENTARIES

Ann M. Stock

A nonlinear stimulus-response relation in bacterial chemotaxis
PNAS 1999 96: 10945-10947. [Full Text] [PDF]  

Jerry Kaplan

Friedreich's ataxia is a mitochondrial disorder
PNAS 1999 96: 10948-10949. [Full Text] [PDF]  

Mason W. Freeman

Effluxed lipids: Tangier Island's latest export
PNAS 1999 96: 10950-10952. [Full Text] [PDF]  

Charles J. Lowenstein

NO news is good news
PNAS 1999 96: 10953-10954. [Full Text] [PDF]  

COLLOQUIUM:
Papers from a NAS Colloquium on Proteolytic Processing and Physiological Regulation

Hans Neurath

Proteolytic enzymes, past and future
PNAS 1999 96: 10962-10963. [Abstract] [Full Text] [PDF]  

Guy S. Salvesen and Vishva M. Dixit

Caspase activation: The induced-proximity model
PNAS 1999 96: 10964-10967. [Abstract] [Full Text] [PDF]  

Amir R. Khan, Nina Khazanovich-Bernstein, Ernst M. Bergmann, and Michael N. G. James

Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors
PNAS 1999 96: 10968-10975. [Abstract] [Full Text] [PDF]  

Michael Groll, Wolfgang Heinemeyer, Sibylle Jäger, Tobias Ullrich, Matthias Bochtler, Dieter H. Wolf, and Robert Huber

The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
PNAS 1999 96: 10976-10983. [Abstract] [Full Text] [PDF]  

Christian P. Sommerhoff, Wolfram Bode, Pedro J. B. Pereira, Milton T. Stubbs, Jörg Stürzebecher, Gerd P. Piechottka, Gabriele Matschiner, and Andreas Bergner

The structure of the human II-tryptase tetramer: Fo(u)r better or worse
PNAS 1999 96: 10984-10991. [Abstract] [Full Text] [PDF]  

Naoyuki Fuse, Tapan Maiti, Baolin Wang, Jeffery A. Porter, Traci M. Tanaka Hall, Daniel J. Leahy, and Philip A. Beachy

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
PNAS 1999 96: 10992-10999. [Abstract] [Full Text] [PDF]  

D. A. Matthews, P. S. Dragovich, S. E. Webber, S. A. Fuhrman, A. K. Patick, L. S. Zalman, T. F. Hendrickson, R. A. Love, T. J. Prins, J. T. Marakovits, R. Zhou, J. Tikhe, C. E. Ford, J. W. Meador, R. A. Ferre, E. L. Brown, S. L. Binford, M. A. Brothers, D. M. DeLisle, and S. T. Worland

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
PNAS 1999 96: 11000-11007. [Abstract] [Full Text] [PDF]  

Erin L. Cunningham, Sheila S. Jaswal, Julie L. Sohl, and David A. Agard

Kinetic stability as a mechanism for protease longevity
PNAS 1999 96: 11008-11014. [Abstract] [Full Text] [PDF]  

Paul M. Selzer, Sabine Pingel, Ivy Hsieh, Bernhard Ugele, Victor J. Chan, Juan C. Engel, Matthew Bogyo, David G. Russell, Judy A. Sakanari, and James H. McKerrow

Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
PNAS 1999 96: 11015-11022. [Abstract] [Full Text] [PDF]  

Shaun R. Coughlin

How the protease thrombin talks to cells
PNAS 1999 96: 11023-11027. [Abstract] [Full Text] [PDF]  

Ivan A. D. Lessard and Christopher T. Walsh

VanX, a bacterial D-alanyl-D-alanine dipeptidase: Resistance, immunity, or survival function?
PNAS 1999 96: 11028-11032. [Abstract] [Full Text] [PDF]  

Arthur L. Horwich, Eilika U. Weber-Ban, and Daniel Finley

Chaperone rings in protein folding and degradation
PNAS 1999 96: 11033-11040. [Abstract] [Full Text] [PDF]  

Michael S. Brown and Joseph L. Goldstein

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
PNAS 1999 96: 11041-11048. [Abstract] [Full Text] [PDF]  

Sukanto Sinha and Ivan Lieberburg

Cellular mechanisms of -amyloid production and secretion
PNAS 1999 96: 11049-11053. [Abstract] [Full Text] [PDF]  

Toshihiko Takeuchi, Marc A. Shuman, and Charles S. Craik

Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue
PNAS 1999 96: 11054-11061. [Abstract] [Full Text] [PDF]  

FROM THE ACADEMY

Introduction to Chinese-American Frontiers of Science
PNAS 1999 96: 11062. [Full Text] [PDF]  

Wendy L. Freedman and Long Long Feng

Determination of the Hubble constant
PNAS 1999 96: 11063-11064. [Abstract] [Full Text] [PDF]  

Weicheng Shen and Tieniu Tan

Automated biometrics-based personal identification
PNAS 1999 96: 11065-11066. [Full Text] [PDF]  

Laura F. Landweber

Testing ancient RNA-protein interactions
PNAS 1999 96: 11067-11068. [Abstract] [Full Text] [PDF]  

Z. Zhang

Crystal growth
PNAS 1999 96: 11069-11070. [Full Text] [PDF]  

Hui-Jun Wang, Ren-He Zhang, Julie Cole, and Francisco Chavez

El Niño and the related phenomenon Southern Oscillation (ENSO): The largest signal in interannual climate variation
PNAS 1999 96: 11071-11072. [Abstract] [Full Text] [PDF]  

Xuchu Weng, Yu-Shin Ding, and Nora D. Volkow

Imaging the functioning human brain
PNAS 1999 96: 11073-11074. [Abstract] [Full Text] [PDF]  

Chunli Bai, Chen Wang, X. Sunney Xie, and Peter G. Wolynes

Single molecule physics and chemistry
PNAS 1999 96: 11075-11076. [Abstract] [Full Text] [PDF]  

PERSPECTIVES

Robert A. Berner

Atmospheric oxygen over Phanerozoic time
PNAS 1999 96: 10955-10957. [Abstract] [Full Text] [PDF]  

Tae-Wook Chun and Anthony S. Fauci

Latent reservoirs of HIV: Obstacles to the eradication of virus
PNAS 1999 96: 10958-10961. [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Physical Sciences

Peijun Cong, Ahmad Dehestani, Robert Doolen, Daniel M. Giaquinta, Shenheng Guan, Victor Markov, Damodara Poojary, Kyle Self, Howard Turner, and W. Henry Weinberg

Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system
PNAS 1999 96: 11077-11080. [Abstract] [Full Text] [PDF]  

Chemistry

Xiaopeng Wang, Linda J. Krebs, Mohammed Al-Nuri, Haridas E. Pudavar, Saswati Ghosal, Charles Liebow, Attila A. Nagy, Andrew V. Schally, and Paras N. Prasad

A chemically labeled cytotoxic agent: Two-photon fluorophore for optical tracking of cellular pathway in chemotherapy
PNAS 1999 96: 11081-11084. [Abstract] [Full Text] [PDF]  

Ralf Metzler, Joseph Klafter, and Joshua Jortner

Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems
PNAS 1999 96: 11085-11089. [Abstract] [Full Text] [PDF]  

Victor Muñoz and William A. Eaton

A simple model for calculating the kinetics of protein folding from three-dimensional structures
PNAS 1999 96: 11311-11316. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Geophysics

Dan M. Davis and Lynn R. Sykes

Geologic constraints on clandestine nuclear testing in South Asia
PNAS 1999 96: 11090-11095. [Abstract] [Full Text] [PDF]  

Mathematics

William Arveson

The curvature of a Hilbert module over [z₁, ... , z_d]
PNAS 1999 96: 11096-11099. [Abstract] [TeX] [PDF]  

Physics

P. Lavalle, P. Schaaf, M. Ostafin, J.-C. Voegel, and B. Senger

Extended random sequential adsorption model of irreversible deposition processes: From simulations to experiments
PNAS 1999 96: 11100-11105. [Abstract] [Full Text] [PDF]  

Statistics

Zhidong Bai, Calyampudi R. Rao, Yuehua Wu, Mei-Mei Zen, and Lincheng Zhao

The simultaneous estimation of the number of signals and frequencies of multiple sinusoids when some observations are missing: I. Asymptotics
PNAS 1999 96: 11106-11110. [Abstract] [TeX] [PDF]  

SOCIAL SCIENCES
Psychology

Erik Blaser, George Sperling, and Zhong-Lin Lu

Measuring the amplification of attention
PNAS 1999 96: 11681-11686. [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES
Applied Biological Sciences

Mark A. Lovich and Elazer R. Edelman

Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo
PNAS 1999 96: 11111-11116. [Abstract] [Full Text] [PDF]  

Vibha Srivastava, Olin D. Anderson, and David W. Ow

Single-copy transgenic wheat generated through the resolution of complex integration patterns
PNAS 1999 96: 11117-11121. [Abstract] [Full Text] [PDF]  

Paul Zuck, Zhege Lao, Stephen Skwish, J. Fraser Glickman, Ke Yang, Jonathan Burbaum, and James Inglese

Ligand-receptor binding measured by laser-scanning imaging
PNAS 1999 96: 11122-11127. [Abstract] [Full Text] [PDF]  

Carmen Vaquero, Markus Sack, John Chandler, Jürgen Drossard, Flora Schuster, Michael Monecke, Stefan Schillberg, and Rainer Fischer

Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
PNAS 1999 96: 11128-11133. [Abstract] [Full Text] [PDF]  

Biochemistry

Graeme C. M. Smith, Robert B. Cary, Nicholas D. Lakin, Byron C. Hann, Soo-Hwang Teo, David J. Chen, and Stephen P. Jackson

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
PNAS 1999 96: 11134-11139. [Abstract] [Full Text] [PDF]  

Aileen Soriano and Robert P. Hausinger

GTP-dependent activation of urease apoprotein in complex with the UreD, UreF, and UreG accessory proteins
PNAS 1999 96: 11140-11144. [Abstract] [Full Text] [PDF]  

James J. Havranek and Pehr B. Harbury

Tanford-Kirkwood electrostatics for protein modeling
PNAS 1999 96: 11145-11150. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Norbert Sträter, Lee Sun, E. R. Kantrowitz, and William N. Lipscomb

A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase
PNAS 1999 96: 11151-11155. [Abstract] [Full Text] [PDF]  

Pushkar Sharma, Monica Sharma, Niranjana D. Amin, R. Wayne Albers, and Harish C. Pant

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation
PNAS 1999 96: 11156-11160. [Abstract] [Full Text] [PDF]  

Haiching Ma and Trevor M. Penning

Conversion of mammalian 3-hydroxysteroid dehydrogenase to 20-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins
PNAS 1999 96: 11161-11166. [Abstract] [Full Text] [PDF]  

Livio Pellizzoni, Bernard Charroux, and Gideon Dreyfuss

SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins
PNAS 1999 96: 11167-11172. [Abstract] [Full Text] [PDF]  

Hong-Chiang Chang, Hiroshi Miyamoto, Padma Marwah, Henry Lardy, Shuyuan Yeh, Ko-En Huang, and Chawnshang Chang

Suppression of ⁵-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells
PNAS 1999 96: 11173-11177. [Abstract] [Full Text] [PDF]  

Adam B. Weinglass and H. Ronald Kaback

Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli
PNAS 1999 96: 11178-11182. [Abstract] [Full Text] [PDF]  

Alexander A. Szewczak, Lori Ortoleva-Donnelly, Maris V. Zivarts, Adegboyega K. Oyelere, Alexei V. Kazantsev, and Scott A. Strobel

An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site
PNAS 1999 96: 11183-11188. [Abstract] [Full Text] [PDF]  

Henrik Andersen, Daniel L. Greenberg, Kazuo Fujikawa, Wenfeng Xu, Dominic W. Chung, and Earl W. Davie

Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity
PNAS 1999 96: 11189-11193. [Abstract] [Full Text] [PDF]  

Christian Ungermann, William Wickner, and Zuoyu Xu

Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion
PNAS 1999 96: 11194-11199. [Abstract] [Full Text] [PDF]  

Daniel A. Pomeranz Krummel and Sidney Altman

Verification of phylogenetic predictions in vivo and the importance of the tetraloop motif in a catalytic RNA
PNAS 1999 96: 11200-11205. [Abstract] [Full Text] [PDF]  

Barbara C. Osmond, Charles A. Specht, and Phillips W. Robbins

Chitin synthase III: Synthetic lethal mutants and "stress related" chitin synthesis that bypasses the CSD3/CHS6 localization pathway
PNAS 1999 96: 11206-11210. [Abstract] [Full Text] [PDF]  

Michael W. West, Weixun Wang, Jennifer Patterson, Joseph D. Mancias, James R. Beasley, and Michael H. Hecht

De novo amyloid proteins from designed combinatorial libraries
PNAS 1999 96: 11211-11216. [Abstract] [Full Text] [PDF]  

Michele Sabbah, Delphine Courilleau, Jan Mester, and Gerard Redeuilh

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element
PNAS 1999 96: 11217-11222. [Abstract] [Full Text] [PDF]  

Manon Couture, Syun-Ru Yeh, Beatrice A. Wittenberg, Jonathan B. Wittenberg, Yannick Ouellet, Denis L. Rousseau, and Michel Guertin

A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis
PNAS 1999 96: 11223-11228. [Abstract] [Full Text] [PDF]  

Everett C. Pesci, Jared B. J. Milbank, James P. Pearson, Susan McKnight, Andrew S. Kende, E. Peter Greenberg, and Barbara H. Iglewski

Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
PNAS 1999 96: 11229-11234. [Abstract] [Full Text] [PDF]  

Axel Nohturfft, Russell A. DeBose-Boyd, Sigrid Scheek, Joseph L. Goldstein, and Michael S. Brown

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
PNAS 1999 96: 11235-11240. [Abstract] [Full Text] [PDF]  

Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien

Circular permutation and receptor insertion within green fluorescent proteins
PNAS 1999 96: 11241-11246. [Abstract] [Full Text] [PDF]  

Rivka L. Isaacson, Alan G. Weeds, and Alan R. Fersht

Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type
PNAS 1999 96: 11247-11252. [Abstract] [Full Text] [PDF]  

LeAnn L. Lindsay, Joy C. Yang, and Jerry L. Hedrick

Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease
PNAS 1999 96: 11253-11258. [Abstract] [Full Text] [PDF]  

Alison Bermingham and Peter L. Collins

The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription
PNAS 1999 96: 11259-11264. [Abstract] [Full Text] [PDF]  

Biophysics

Pei Zhou, James Chou, Roberto Sanchez Olea, Junying Yuan, and Gerhard Wagner

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
PNAS 1999 96: 11265-11270. [Abstract] [Full Text] [PDF]  

Martin A. Bopp, Alexander Sytnik, Tina D. Howard, Richard J. Cogdell, and Robin M. Hochstrasser

The dynamics of structural deformations of immobilized single light-harvesting complexes
PNAS 1999 96: 11271-11276. [Abstract] [Full Text] [PDF]  

Torsten Strunz, Krisztina Oroszlan, Rolf Schäfer, and Hans-Joachim Güntherodt

Dynamic force spectroscopy of single DNA molecules
PNAS 1999 96: 11277-11282. [Abstract] [Full Text] [PDF]  

Yongzhang Luo and Robert L. Baldwin

The 28-111 disulfide bond constrains the -lactalbumin molten globule and weakens its cooperativity of folding
PNAS 1999 96: 11283-11287. [Abstract] [Full Text] [PDF]  

Mariano Carrion-Vazquez, Piotr E. Marszalek, Andres F. Oberhauser, and Julio M. Fernandez

Atomic force microscopy captures length phenotypes in single proteins
PNAS 1999 96: 11288-11292. [Abstract] [Full Text] [PDF]  

M. P. Morrissey and E. I. Shakhnovich

Evidence for the role of PrP^C helix 1 in the hydrophilic seeding of prion aggregates
PNAS 1999 96: 11293-11298. [Abstract] [Full Text] [PDF]  

Oxana V. Galzitskaya and Alexei V. Finkelstein

A theoretical search for folding/unfolding nuclei in three-dimensional protein structures
PNAS 1999 96: 11299-11304. [Abstract] [Full Text] [PDF]  

E. Alm and D. Baker

Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures
PNAS 1999 96: 11305-11310. [Abstract] [Full Text] [PDF]  

Victor Muñoz and William A. Eaton

A simple model for calculating the kinetics of protein folding from three-dimensional structures
PNAS 1999 96: 11311-11316. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cell Biology

Christian Gieffers, Beate H. Peters, Edgar R. Kramer, Carlos G. Dotti, and Jan-Michael Peters

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
PNAS 1999 96: 11317-11322. [Abstract] [Full Text] [PDF]  

Yashpal S. Kanwar, Anil Kumar, Qiwei Yang, Yufeng Tian, Jun Wada, Naoki Kashihara, and Elisabeth I. Wallner

Tubulointerstitial nephritis antigen: An extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development
PNAS 1999 96: 11323-11328. [Abstract] [Full Text] [PDF]  

Francoise Bernerd, Alain Sarasin, and Thierry Magnaldo

Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
PNAS 1999 96: 11329-11334. [Abstract] [Full Text] [PDF]  

Jocelyn H. Wright, Erlynda Munar, Damon R. Jameson, Paul R. Andreassen, Robert L. Margolis, Rony Seger, and Edwin G. Krebs

Mitogen-activated protein kinase kinase activity is required for the G₂/M transition of the cell cycle in mammalian fibroblasts
PNAS 1999 96: 11335-11340. [Abstract] [Full Text] [PDF]  

David A. Pearce, Carrie J. Carr, Biswadip Das, and Fred Sherman

Phenotypic reversal of the btn1 defects in yeast by chloroquine: A yeast model for Batten disease
PNAS 1999 96: 11341-11345. [Abstract] [Full Text] [PDF]  

Ravi Jasuja, Yu-Lin, David R. Trentham, and Shahid Khan

Response tuning in bacterial chemotaxis
PNAS 1999 96: 11346-11351. [Abstract] [Full Text] [PDF]  

Baltazar D. Aguda

A quantitative analysis of the kinetics of the G₂ DNA damage checkpoint system
PNAS 1999 96: 11352-11357. [Abstract] [Full Text] [PDF]  

Yukihiro Takahashi and Jonathan D. Smith

Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway
PNAS 1999 96: 11358-11363. [Abstract] [Full Text] [PDF]  

Kevin L. Lorick, Jane P. Jensen, Shengyun Fang, Albert M. Ong, Shigetsugu Hatakeyama, and Allan M. Weissman

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
PNAS 1999 96: 11364-11369. [Abstract] [Full Text] [PDF]  

Jonathan S. Rosenblum and Günter Blobel

Autoproteolysis in nucleoporin biogenesis
PNAS 1999 96: 11370-11375. [Abstract] [Full Text] [PDF]  

Developmental Biology

Tohru Tsukui, Javier Capdevila, Koji Tamura, Pilar Ruiz-Lozano, Concepción Rodriguez-Esteban, Sayuri Yonei-Tamura, Jorge Magallón, Roshantha A. S. Chandraratna, Kenneth Chien, Bruce Blumberg, Ronald M. Evans, and Juan Carlos Izpisúa Belmonte

Multiple left-right asymmetry defects in Shh^/ mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1
PNAS 1999 96: 11376-11381. [Abstract] [Full Text] [PDF]  

François Schweisguth

Dominant-negative mutation in the 2 and 6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
PNAS 1999 96: 11382-11386. [Abstract] [Full Text] [PDF]  

Ecology

R. B. Jackson, L. A. Moore, W. A. Hoffmann, W. T. Pockman, and C. R. Linder

Ecosystem rooting depth determined with caves and DNA
PNAS 1999 96: 11387-11392. [Abstract] [Full Text] [PDF]  

Evolution

Stewart T. Schultz, Michael Lynch, and John H. Willis

Spontaneous deleterious mutation in Arabidopsis thaliana
PNAS 1999 96: 11393-11398. [Abstract] [Full Text] [PDF]  

Wayne A. Van Voorhies and Samuel Ward

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
PNAS 1999 96: 11399-11403. [Abstract] [Full Text] [PDF]  

Genetics

A. Kazantsev, E. Preisinger, A. Dranovsky, D. Goldgaber, and D. Housman

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
PNAS 1999 96: 11404-11409. [Abstract] [Full Text] [PDF]  

Rainer Heuchel, Ansgar Berg, Michelle Tallquist, Karina Åhlén, Rolf K. Reed, Kristofer Rubin, Lena Claesson-Welsh, Carl-Henrik Heldin, and Philippe Soriano

Platelet-derived growth factor  receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
PNAS 1999 96: 11410-11415. [Abstract] [Full Text] [PDF]  

Ming Yang, Yi Hu, Muhammad Lodhi, W. Richard McCombie, and Hong Ma

The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation
PNAS 1999 96: 11416-11421. [Abstract] [Full Text] [PDF]  

T. Zhang, H. Xiong, L.-X. Kan, C.-K. Zhang, X.-F. Jiao, G. Fu, Q.-H. Zhang, L. Lu, J.-H. Tong, B.-W. Gu, M. Yu, J.-X. Liu, J. Licht, S. Waxman, A. Zelent, E. Chen, and S.-J. Chen

Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene
PNAS 1999 96: 11422-11427. [Abstract] [Full Text] [PDF]  

David J. Lampe, Brian J. Akerley, Eric J. Rubin, John J. Mekalanos, and Hugh M. Robertson

Hyperactive transposase mutants of the Himar1 mariner transposon
PNAS 1999 96: 11428-11433. [Abstract] [Full Text] [PDF]  

R. Ofir, A. C. C. Wong, H. E. McDermid, K. L. Skorecki, and S. Selig

Position effect of human telomeric repeats on replication timing
PNAS 1999 96: 11434-11439. [Abstract] [Full Text] [PDF]  

Robert J. D. Reid, Paola Fiorani, Mizuno Sugawara, and Mary-Ann Bjornsti

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
PNAS 1999 96: 11440-11445. [Abstract] [Full Text] [PDF]  

Immunology

J. Jay Boniface, Ziv Reich, Daniel S. Lyons, and Mark M. Davis

Thermodynamics of T cell receptor binding to peptide-MHC: Evidence for a general mechanism of molecular scanning
PNAS 1999 96: 11446-11451. [Abstract] [Full Text] [PDF]  

Stephen D. Robinson, Paul S. Frenette, Helen Rayburn, Marge Cummiskey, Mollie Ullman-Culleré, Denisa D. Wagner, and Richard O. Hynes

Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
PNAS 1999 96: 11452-11457. [Abstract] [Full Text] [PDF]  

Giorgio Senaldi, Brian C. Varnum, Ulla Sarmiento, Charlie Starnes, Jackson Lile, Sheila Scully, Jane Guo, Gary Elliott, Jennifer McNinch, Christine L. Shaklee, Daniel Freeman, Frank Manu, W. Scott Simonet, Thomas Boone, and Ming-Shi Chang

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
PNAS 1999 96: 11458-11463. [Abstract] [Full Text] [PDF]  

John R. McWhirter, Saskia T. C. Neuteboom, Edward V. Wancewicz, Brett P. Monia, James R. Downing, and Cornelis Murre

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
PNAS 1999 96: 11464-11469. [Abstract] [Full Text] [PDF]  

Jens Zerrahn, Ariane Volkmann, Mark C. Coles, Werner Held, Francois A. Lemonnier, and David H. Raulet

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells
PNAS 1999 96: 11470-11475. [Abstract] [Full Text] [PDF]  

Eduardo M. Sotomayor, Ivan Borrello, Erev Tubb, James P. Allison, and Hyam I. Levitsky

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
PNAS 1999 96: 11476-11481. [Abstract] [Full Text] [PDF]  

Medical Sciences

Cynthia McCoig, Gregory Van Dyke, Chin-Sheng Chou, Louis J. Picker, Octavio Ramilo, and Ellen S. Vitetta

An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro
PNAS 1999 96: 11482-11485. [Abstract] [Full Text] [PDF]  

Donald C. Shields, Kurt E. Schaecher, Takaomi C. Saido, and Naren L. Banik

A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
PNAS 1999 96: 11486-11491. [Abstract] [Full Text] [PDF]  

Raffaele Lodi, J. Mark Cooper, Jane L. Bradley, David Manners, Peter Styles, Doris J. Taylor, and Anthony H. V. Schapira

Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia
PNAS 1999 96: 11492-11495. [Abstract] [Full Text] [PDF]  

Ronit Lahav, Garrett Heffner, and Paul H. Patterson

An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
PNAS 1999 96: 11496-11500. [Abstract] [Full Text] [PDF]  

Ardy van Helvoort, Arjan de Brouwer, Roelof Ottenhoff, Jos F. H. M. Brouwers, Jan Wijnholds, Jos H. Beijnen, Anita Rijneveld, Tom van der Poll, Martin A. van der Valk, Donné Majoor, Wim Voorhout, Karel W. A. Wirtz, Ronald P. J. Oude Elferink, and Piet Borst

Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces
PNAS 1999 96: 11501-11506. [Abstract] [Full Text] [PDF]  

Yiru Guo, W. Keith Jones, Yu-Ting Xuan, Xian-Liang Tang, Weike Bao, Wen-Jian Wu, Hui Han, Victor E. Laubach, Peipei Ping, Zequan Yang, Yumin Qiu, and Roberto Bolli

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
PNAS 1999 96: 11507-11512. [Abstract] [Full Text] [PDF]  

Moritake Higa, Yan-Ting Zhou, Mariella Ravazzola, Danielle Baetens, Lelio Orci, and Roger H. Unger

Troglitazone prevents mitochondrial alterations,  cell destruction, and diabetes in obese prediabetic rats
PNAS 1999 96: 11513-11518. [Abstract] [Full Text] [PDF]  

Barbara Krynska, Luis Del Valle, Sidney Croul, Jennifer Gordon, Christos D. Katsetos, Michele Carbone, Antonio Giordano, and Kamel Khalili

Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas
PNAS 1999 96: 11519-11524. [Abstract] [Full Text] [PDF]  

Ho-Jin Park and Jonas B. Galper

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor- signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase
PNAS 1999 96: 11525-11530. [Abstract] [Full Text] [PDF]  

Nathalie Scholler, Ning Fu, Yi Yang, Zhengmao Ye, Gary E. Goodman, Karl Erik Hellström, and Ingegerd Hellström

Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma
PNAS 1999 96: 11531-11536. [Abstract] [Full Text] [PDF]  

Yan Xiang and Bernard Moss

IL-18 binding and inhibition of interferon  induction by human poxvirus-encoded proteins
PNAS 1999 96: 11537-11542. [Abstract] [Full Text] [PDF]  

Peter M. C. Wong, Anthony Kang, Hong Chen, Quan Yuan, Peidong Fan, Barnet M. Sultzer, Yuet Wai Kan, and Siu-Wah Chung

Lps^d/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses
PNAS 1999 96: 11543-11548. [Abstract] [Full Text] [PDF]  

Ramy A. Arnaout, Alun L. Lloyd, Thomas R. O'Brien, James J. Goedert, John M. Leonard, and Martin A. Nowak

A simple relationship between viral load and survival time in HIV-1 infection
PNAS 1999 96: 11549-11553. [Abstract] [Full Text] [PDF]  

Microbiology

James E. Graham and Josephine E. Clark-Curtiss

Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)
PNAS 1999 96: 11554-11559. [Abstract] [Full Text] [PDF]  

Pierre-Emmanuel Lobert, Nicolas Escriou, Jean Ruelle, and Thomas Michiels

A coding RNA sequence acts as a replication signal in cardioviruses
PNAS 1999 96: 11560-11565. [Abstract] [Full Text] [PDF] [Supplemental Table 2]  

Sukhanya Jayachandra, Kenneth G. Low, Ai-En Thlick, Jin Yu, Paul D. Ling, Yuan Chang, and Patrick S. Moore

Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors
PNAS 1999 96: 11566-11571. [Abstract] [Full Text] [PDF]  

Gary L. Gallia, Nune Darbinian, Anna Tretiakova, Sameer A. Ansari, Jay Rappaport, John Brady, Margaret J. Wortman, Edward M. Johnson, and Kamel Khalili

Association of HIV-1 Tat with the cellular protein, Pur, is mediated by RNA
PNAS 1999 96: 11572-11577. [Abstract] [Full Text] [PDF]  

Francisco García-Del Portillo, M. Graciela Pucciarelli, and Josep Casadesús

DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity
PNAS 1999 96: 11578-11583. [Abstract] [Full Text] [PDF]  

Ricardo Guerrero, Aaron Haselton, Mónica Solé, Andrew Wier, and Lynn Margulis

Titanospirillum velox: A huge, speedy, sulfur-storing spirillum from Ebro Delta microbial mats
PNAS 1999 96: 11584-11588. [Abstract] [Full Text] [PDF]  

Neurobiology

James A. Galbraith, Thomas S. Reese, Michelle L. Schlief, and Paul E. Gallant

Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon
PNAS 1999 96: 11589-11594. [Abstract] [Full Text] [PDF]  

I. Jill Karolyi, Heather L. Burrows, Tennore M. Ramesh, Masaharu Nakajima, J. Shonee Lesh, Eunju Seong, Sally A. Camper, and Audrey F. Seasholtz

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice
PNAS 1999 96: 11595-11600. [Abstract] [Full Text] [PDF]  

Todd M. Preuss, Huixin Qi, and Jon H. Kaas

Distinctive compartmental organization of human primary visual cortex
PNAS 1999 96: 11601-11606. [Abstract] [Full Text] [PDF]  

Zhen Yan, Jian Feng, Allen A. Fienberg, and Paul Greengard

D₂ dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
PNAS 1999 96: 11607-11612. [Abstract] [Full Text] [PDF]  

Gareth R. John, Eliana Scemes, Sylvia O. Suadicani, Judy S. H. Liu, Peter C. Charles, Sunhee C. Lee, David C. Spray, and Celia F. Brosnan

IL-1 differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels
PNAS 1999 96: 11613-11618. [Abstract] [Full Text] [PDF]  

Fiona Doetsch, Jose Manuel García-Verdugo, and Arturo Alvarez-Buylla

Regeneration of a germinal layer in the adult mammalian brain
PNAS 1999 96: 11619-11624. [Abstract] [Full Text] [PDF]  

Michael A. Conditt and Ferdinando A. Mussa-Ivaldi

Central representation of time during motor learning
PNAS 1999 96: 11625-11630. [Abstract] [Full Text] [PDF]  

R. Anne McKinney, Andreas Lüthi, Christine E. Bandtlow, Beat H. Gähwiler, and Scott M. Thompson

Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures
PNAS 1999 96: 11631-11636. [Abstract] [Full Text] [PDF]  

John L. Barbur, Lawrence Weiskrantz, and J. Alister Harlow

The unseen color aftereffect of an unseen stimulus: Insight from blindsight into mechanisms of color afterimages
PNAS 1999 96: 11637-11641. [Abstract] [Full Text] [PDF]  

Benno Roozendaal, Bichngoc T. Nguyen, Ann E. Power, and James L. McGaugh

Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
PNAS 1999 96: 11642-11647. [Abstract] [Full Text] [PDF]  

Pharmacology

H. C. Champion, T. J. Bivalacqua, A. L. Hyman, L. J. Ignarro, W. J. G. Hellstrom, and P. J. Kadowitz

Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat
PNAS 1999 96: 11648-11652. [Abstract] [Full Text] [PDF]  

Physiology

S. Sturiale, G. Barbara, B. Qiu, M. Figini, P. Geppetti, N. Gerard, C. Gerard, E. F. Grady, N. W. Bunnett, and S. M. Collins

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
PNAS 1999 96: 11653-11658. [Abstract] [Full Text] [PDF]  

Plant Biology

Jiqing Sai and Carl Hirschie Johnson

Different circadian oscillators control Ca²⁺ fluxes and Lhcb gene expression
PNAS 1999 96: 11659-11663. [Abstract] [Full Text] [PDF]  

Ursula Schiefthaler, Sureshkumar Balasubramanian, Patrick Sieber, David Chevalier, Ellen Wisman, and Kay Schneitz

Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana
PNAS 1999 96: 11664-11669. [Abstract] [Full Text] [PDF]  

D. Shelley Lupold, Angelina G. F. S. Caoile, and David B. Stern

Genomic context influences the activity of maize mitochondrial cox2 promoters
PNAS 1999 96: 11670-11675. [Abstract] [Full Text] [PDF]  

Prem L. Bhalla, Ines Swoboda, and Mohan B. Singh

Antisense-mediated silencing of a gene encoding a major ryegrass pollen allergen
PNAS 1999 96: 11676-11680. [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for vol. 96, p. 3160 [Full Text]