COMMENTARIES

Peter Tattersall

The persistence of alien genomes
PNAS 2000 97: 6239-6241. [Extract] [Full Text] [PDF]

Eric C. Holland

Glioblastoma multiforme: The terminator
PNAS 2000 97: 6242-6244. [Extract] [Full Text] [PDF]

Neil M. Nathanson

A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away
PNAS 2000 97: 6245-6247. [Extract] [Full Text] [PDF]

Mary F. Lyon

LINE-1 elements and X chromosome inactivation: A function for "junk" DNA?
PNAS 2000 97: 6248-6249. [Extract] [Full Text] [PDF]

Jonathan F. Wendel and Susan R. Wessler

Retrotransposon-mediated genome evolution on a local ecological scale
PNAS 2000 97: 6250-6252. [Extract] [Full Text] [PDF]

PHYSICAL SCIENCES
Applied Mathematics

Anton P. Kast

Optimal prediction of stiff oscillatory mechanics
PNAS 2000 97: 6253-6257. [Abstract] [TeX] [PDF]

Alessandro Sarti, Ravi Malladi, and James A. Sethian

Subjective surfaces: A method for completing missing boundaries
PNAS 2000 97: 6258-6263; published online before print May 23 2000, 10.1073/pnas.110135797 [Abstract] [Full Text] [PDF]

Applied Physical Sciences

Hisashi Hayashi, Noboru Watanabe, Yasuo Udagawa, and C.-C. Kao

The complete optical spectrum of liquid water measured by inelastic x-ray scattering
PNAS 2000 97: 6264-6266; published online before print May 30 2000, 10.1073/pnas.110572097 [Abstract] [Full Text] [PDF]

Luna B. Leopold

Temperature profiles and bathymetry of some high mountain lakes
PNAS 2000 97: 6267-6270. [Abstract] [Full Text] [PDF]

Chemistry

Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel

Synthetic receptors as models for alkali metal cation- binding sites in proteins
PNAS 2000 97: 6271-6276. [Abstract] [Full Text] [PDF]

Oleg Galkin and Peter G. Vekilov

Control of protein crystal nucleation around the metastable liquid-liquid phase boundary
PNAS 2000 97: 6277-6281; published online before print May 23 2000, 10.1073/pnas.110000497 [Abstract] [Full Text] [PDF]

Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins PNAS 2000 97: 6298-6305. [Abstract] [Full Text] [PDF]

Emanuele Paci and Martin Karplus

Unfolding proteins by external forces and temperature: The importance of topology and energetics
PNAS 2000 97: 6521-6526; published online before print May 23 2000, 10.1073/pnas.100124597 [Abstract] [Full Text] [PDF]

Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus

Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor
PNAS 2000 97: 6908-6913. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Physics

Piotr E. Marszalek, William J. Greenleaf, Hongbin Li, Andres F. Oberhauser, and Julio M. Fernandez

Atomic force microscopy captures quantized plastic deformation in gold nanowires
PNAS 2000 97: 6282-6286. [Abstract] [Full Text] [PDF]

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
Applied Biological Sciences

Sharon Lafferty Doty, Tanya Q. Shang, Angela M. Wilson, Jeff Tangen, Aram D. Westergreen, Lee A. Newman, Stuart E. Strand, and Milton P. Gordon

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1
PNAS 2000 97: 6287-6291. [Abstract] [Full Text] [PDF]

Biochemistry

Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel

Synthetic receptors as models for alkali metal cation- binding sites in proteins
PNAS 2000 97: 6271-6276. [Abstract] [Full Text] [PDF]

David E. Benson, Michael S. Wisz, and Homme W. Hellinga

Rational design of nascent metalloenzymes
PNAS 2000 97: 6292-6297. [Abstract] [Full Text] [PDF] [Supplemental Data]

Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins PNAS 2000 97: 6298-6305. [Abstract] [Full Text] [PDF]

Flavia Todone, Robert O. J. Weinzierl, Peter Brick, and Silvia Onesti

Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target
PNAS 2000 97: 6306-6310. [Abstract] [Full Text] [PDF]

Adelinda Yee, Valerie Booth, Akil Dharamsi, Asaph Engel, Aled M. Edwards, and Cheryl H. Arrowsmith

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum
PNAS 2000 97: 6311-6315. [Abstract] [Full Text] [PDF]

Cameron D. Mackereth, Cheryl H. Arrowsmith, Aled M. Edwards, and Lawrence P. McIntosh

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum
PNAS 2000 97: 6316-6321. [Abstract] [Full Text] [PDF]

Bruno P. Klaholz, André Mitschler, Makonen Belema, C. Zusi, and Dino Moras

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRAR
PNAS 2000 97: 6322-6327. [Abstract] [Full Text] [PDF] [Supplemental Figure]

George Minasov, Marianna Teplova, George C. Stewart, Eugene V. Koonin, Wayne F. Anderson, and Martin Egli

Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP
PNAS 2000 97: 6328-6333. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Gilda Tachedjian, Hans-Erik G. Aronson, and Stephen P. Goff

Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase
PNAS 2000 97: 6334-6339. [Abstract] [Full Text] [PDF]

Mary K. Bennett and Timothy F. Osborne

Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo
PNAS 2000 97: 6340-6344. [Abstract] [Full Text] [PDF]

Ernst Schönbrunn, Susanne Eschenburg, Karolin Luger, Wolfgang Kabsch, and Nikolaus Amrhein

Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA
PNAS 2000 97: 6345-6349; published online before print May 23 2000, 10.1073/pnas.120120397 [Abstract] [Full Text] [PDF]

Alexandros D. Polydorides, Hirotaka J. Okano, Yolanda Y. L. Yang, Giovanni Stefani, and Robert B. Darnell

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
PNAS 2000 97: 6350-6355; published online before print May 30 2000, 10.1073/pnas.110128397 [Abstract] [Full Text] [PDF]

Lijun Zhao, Arthur G. Cox, Jan A. Ruzicka, Ajita A. Bhat, Weiqing Zhang, and Ethan Will Taylor

Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase
PNAS 2000 97: 6356-6361. [Abstract] [Full Text] [PDF]

Tibor Farkas, Klara Kitajka, Elfrieda Fodor, István Csengeri, Eila Lahdes, Young K. Yeo, Zoltán Krasznai, and John E. Halver

Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates
PNAS 2000 97: 6362-6366; published online before print May 23 2000, 10.1073/pnas.120157297 [Abstract] [Full Text] [PDF]

Christian H. Haering, Toru M. Nakamura, Peter Baumann, and Thomas R. Cech

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe
PNAS 2000 97: 6367-6372; published online before print May 30 2000, 10.1073/pnas.130187397 [Abstract] [Full Text] [PDF]

Kwang S. Kim, Kyung Seok Oh, and Jin Yong Lee

Catalytic role of enzymes: Short strong H-bond-induced partial proton shuttles and charge redistributions
PNAS 2000 97: 6373-6378. [Abstract] [Full Text] [PDF]

Jianming Xu, Lan Liao, Guang Ning, Hiromi Yoshida-Komiya, Chuxia Deng, and Bert W. O'Malley

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
PNAS 2000 97: 6379-6384; published online before print May 23 2000, 10.1073/pnas.120166297 [Abstract] [Full Text] [PDF]

Matteo Negroni and Henri Buc

Copy-choice recombination by reverse transcriptases: Reshuffling of genetic markers mediated by RNA chaperones
PNAS 2000 97: 6385-6390; published online before print May 30 2000, 10.1073/pnas.120520497 [Abstract] [Full Text] [PDF]

Antonio A. Postigo and Douglas C. Dean

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
PNAS 2000 97: 6391-6396. [Abstract] [Full Text] [PDF]

Natalia G. Denissova, Celio Pouponnot, Jianyin Long, Dongming He, and Fang Liu

Transforming growth factor -inducible independent binding of SMAD to the Smad7 promoter
PNAS 2000 97: 6397-6402; published online before print May 23 2000, 10.1073/pnas.090099297 [Abstract] [Full Text] [PDF]

Jay A. White, Heather Ramshaw, Mohammed Taimi, Wayne Stangle, Anqi Zhang, Stephanie Everingham, Shelly Creighton, Shui-Pang Tam, Glenville Jones, and Martin Petkovich

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
PNAS 2000 97: 6403-6408; published online before print May 23 2000, 10.1073/pnas.120161397 [Abstract] [Full Text] [PDF]

Tanya T. Paull and Martin Gellert

A mechanistic basis for Mre11-directed DNA joining at microhomologies
PNAS 2000 97: 6409-6414; published online before print May 23 2000, 10.1073/pnas.110144297 [Abstract] [Full Text] [PDF]

Yanan Feng and Stanley N. Cohen

Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly(A) polymerase I
PNAS 2000 97: 6415-6420; published online before print May 23 2000, 10.1073/pnas.120173797 [Abstract] [Full Text] [PDF]

Frédéric Beaudoin, Louise V. Michaelson, Sandra J. Hey, Mervyn J. Lewis, Peter R. Shewry, Olga Sayanova, and Johnathan A. Napier

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway
PNAS 2000 97: 6421-6426; published online before print May 30 2000, 10.1073/pnas.110140197 [Abstract] [Full Text] [PDF]

Yi Zhang, Eric C. Griffith, Julien Sage, Tyler Jacks, and Jun O. Liu

Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21^WAF1/CIP1
PNAS 2000 97: 6427-6432. [Abstract] [Full Text] [PDF]

Jean-Luc Desseyn, Kimberly A. Burton, and G. Stanley McKnight

Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development
PNAS 2000 97: 6433-6438. [Abstract] [Full Text] [PDF]

Tomoyuki Shishido, Tsuyoshi Akagi, Toru Ouchi, Maria-Magdalena Georgescu, Wallace Y. Langdon, and Hidesaburo Hanafusa

The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation
PNAS 2000 97: 6439-6444; published online before print May 30 2000, 10.1073/pnas.060030697 [Abstract] [Full Text] [PDF]

Astria D. Ferrão-Gonzales, Sandro O. Souto, Jerson L. Silva, and Débora Foguel

The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state
PNAS 2000 97: 6445-6450. [Abstract] [Full Text] [PDF]

Felix Rohdich, Juraithip Wungsintaweekul, Wolfgang Eisenreich, Gerald Richter, Christoph A. Schuhr, Stefan Hecht, Meinhart H. Zenk, and Adelbert Bacher

Biosynthesis of terpenoids: 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana
PNAS 2000 97: 6451-6456. [Abstract] [Full Text] [PDF]

Timothy R. Hughes, Rodney G. Weilbaecher, Monika Walterscheid, and Victoria Lundblad

Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
PNAS 2000 97: 6457-6462. [Abstract] [Full Text] [PDF]

W. Todd Lowther, Nathan Brot, Herbert Weissbach, John F. Honek, and Brian W. Matthews

Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase
PNAS 2000 97: 6463-6468. [Abstract] [Full Text] [PDF]

Kenji Furuya, Richard J. Milchak, Kathleen M. Schegg, Jinrui Zhang, Stephen S. Tobe, Geoffrey M. Coast, and David A. Schooley

Cockroach diuretic hormones: Characterization of a calcitonin-like peptide in insects
PNAS 2000 97: 6469-6474. [Abstract] [Full Text] [PDF]

Jochen Kuper, Tracy Palmer, Ralf R. Mendel, and Günter Schwarz

Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization
PNAS 2000 97: 6475-6480; published online before print May 23 2000, 10.1073/pnas.110568497 [Abstract] [Full Text] [PDF]

Miguel R. Campanero, Monica I. Armstrong, and Erik K. Flemington

CpG methylation as a mechanism for the regulation of E2F activity
PNAS 2000 97: 6481-6486; published online before print May 23 2000, 10.1073/pnas.100340697 [Abstract] [Full Text] [PDF]

Anders Dahlqvist, Ulf Ståhl, Marit Lenman, Antoni Banas, Michael Lee, Line Sandager, Hans Ronne, and Sten Stymne

Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
PNAS 2000 97: 6487-6492; published online before print May 30 2000, 10.1073/pnas.120067297 [Abstract] [Full Text] [PDF]

Sandra E. Nicholson, David De Souza, Louis J. Fabri, Jason Corbin, Tracy A. Willson, Jian-Guo Zhang, Anabel Silva, Maria Asimakis, Alison Farley, Andrew D. Nash, Donald Metcalf, Douglas J. Hilton, Nicos A. Nicola, and Manuel Baca

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
PNAS 2000 97: 6493-6498; published online before print May 30 2000, 10.1073/pnas.100135197 [Abstract] [Full Text] [PDF]

James C. Clemens, Carolyn A. Worby, Nancy Simonson-Leff, Marco Muda, Tomohiko Maehama, Brian A. Hemmings, and Jack E. Dixon

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
PNAS 2000 97: 6499-6503; published online before print May 23 2000, 10.1073/pnas.110149597 [Abstract] [Full Text] [PDF]

Julia K. Karow, Angelos Constantinou, Ji-Liang Li, Stephen C. West, and Ian D. Hickson

The Bloom's syndrome gene product promotes branch migration of Holliday junctions
PNAS 2000 97: 6504-6508; published online before print May 23 2000, 10.1073/pnas.100448097 [Abstract] [Full Text] [PDF]

Biophysics

Steven S. Plotkin and José N. Onuchic

Investigation of routes and funnels in protein folding by free energy functional methods
PNAS 2000 97: 6509-6514. [Abstract] [Full Text] [PDF] [Supplemental Text]

Hervé Isambert and Eric D. Siggia

Modeling RNA folding paths with pseudoknots: Application to hepatitis delta virus ribozyme
PNAS 2000 97: 6515-6520; published online before print May 23 2000, 10.1073/pnas.110533697 [Abstract] [Full Text] [PDF]

Emanuele Paci and Martin Karplus

Unfolding proteins by external forces and temperature: The importance of topology and energetics
PNAS 2000 97: 6521-6526; published online before print May 23 2000, 10.1073/pnas.100124597 [Abstract] [Full Text] [PDF]

Hongbin Li, Andres F. Oberhauser, Susan B. Fowler, Jane Clarke, and Julio M. Fernandez

Atomic force microscopy reveals the mechanical design of a modular protein
PNAS 2000 97: 6527-6531; published online before print May 23 2000, 10.1073/pnas.120048697 [Abstract] [Full Text] [PDF]

Cell Biology

James L. McGrath, Eric A. Osborn, Yanik S. Tardy, C. Forbes Dewey, Jr., and John H. Hartwig

Regulation of the actin cycle in vivo by actin filament severing
PNAS 2000 97: 6532-6537; published online before print May 23 2000, 10.1073/pnas.100023397 [Abstract] [Full Text] [PDF]

Mamoru Ikemoto, Hiroyuki Arai, Dongdong Feng, Kazumi Tanaka, Junken Aoki, Naoshi Dohmae, Koji Takio, Hideki Adachi, Masafumi Tsujimoto, and Keizo Inoue

Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I
PNAS 2000 97: 6538-6543; published online before print May 30 2000, 10.1073/pnas.100114397 [Abstract] [Full Text] [PDF]

Elizabeth A. Sweeney, Gregory V. Priestley, Betty Nakamoto, Robert G. Collins, Arthur L. Beaudet, and Thalia Papayannopoulou

Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence
PNAS 2000 97: 6544-6549. [Abstract] [Full Text] [PDF]

Leonor Oliveira and Jean-Claude Drapier

Down-regulation of iron regulatory protein 1 gene expression by nitric oxide
PNAS 2000 97: 6550-6555; published online before print May 23 2000, 10.1073/pnas.120571797 [Abstract] [Full Text] [PDF]

Guillermo A. Yudowski, Riad Efendiev, Carlos H. Pedemonte, Adrian I. Katz, Per-Olof Berggren, and Alejandro M. Bertorello

Phosphoinositide-3 kinase binds to a proline-rich motif in the Na⁺,K⁺-ATPase  subunit and regulates its trafficking
PNAS 2000 97: 6556-6561; published online before print May 23 2000, 10.1073/pnas.100128297 [Abstract] [Full Text] [PDF]

Ecology

Daniel H. Monson, Daniel F. Doak, Brenda E. Ballachey, Ancel Johnson, and James L. Bodkin

Long-term impacts of the Exxon Valdez oil spill on sea otters, assessed through age-dependent mortality patterns
PNAS 2000 97: 6562-6567; published online before print May 23 2000, 10.1073/pnas.120163397 [Abstract] [Full Text] [PDF]

Thomas Eisner and Daniel J. Aneshansley

Defense by foot adhesion in a beetle (Hemisphaerota cyanea)
PNAS 2000 97: 6568-6573. [Abstract] [Full Text] [PDF]

Evolution

Richard Fortey

Olenid trilobites: The oldest known chemoautotrophic symbionts?
PNAS 2000 97: 6574-6578. [Abstract] [Full Text] [PDF]

Andreas Wagner

Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate
PNAS 2000 97: 6579-6584; published online before print May 23 2000, 10.1073/pnas.110147097 [Abstract] [Full Text] [PDF]

Franky Bossuyt and Michel C. Milinkovitch From the Cover: Convergent adaptive radiations in Madagascan and Asian ranid frogs reveal covariation between larval and adult traits PNAS 2000 97: 6585-6590. [Abstract] [Full Text] [PDF]

Reinhard Schröder, Christoph Eckert, Christian Wolff, and Diethard Tautz

Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum
PNAS 2000 97: 6591-6596; published online before print May 23 2000, 10.1073/pnas.100005497 [Abstract] [Full Text] [PDF]

Patricia M. Schulte, Hélène C. Glémet, Aline A. Fiebig, and Dennis A. Powers

Adaptive variation in lactate dehydrogenase-B gene expression: Role of a stress-responsive regulatory element
PNAS 2000 97: 6597-6602. [Abstract] [Full Text] [PDF]

Ruslan Kalendar, Jaakko Tanskanen, Sirkka Immonen, Eviatar Nevo, and Alan H. Schulman From the Cover: Genome evolution of wild barley (Hordeum spontaneum) by BARE-1 retrotransposon dynamics in response to sharp microclimatic divergence PNAS 2000 97: 6603-6607; published online before print May 23 2000, 10.1073/pnas.110587497 [Abstract] [Full Text] [PDF] [Supplemental Data]

D. V. Butruille and L. S. Boiteux

Selection-mutation balance in polysomic tetraploids: Impact of double reduction and gametophytic selection on the frequency and subchromosomal localization of deleterious mutations
PNAS 2000 97: 6608-6613; published online before print May 23 2000, 10.1073/pnas.100101097 [Abstract] [Full Text] [PDF]

Jessica Y. Leung, F. Ellis McKenzie, Adele M. Uglialoro, Pedro O. Flores-Villanueva, Barbara C. Sorkin, Edmond J. Yunis, Daniel L. Hartl, and Anne E. Goldfeld

Identification of phylogenetic footprints in primate tumor necrosis factor- promoters
PNAS 2000 97: 6614-6618. [Abstract] [Full Text] [PDF]

Genetics

George Dimopoulos, Thomas L. Casavant, Shereen Chang, Todd Scheetz, Chad Roberts, Micca Donohue, Jörg Schultz, Vladimir Benes, Peer Bork, Wilhelm Ansorge, Marcelo Bento Soares, and Fotis C. Kafatos

Anopheles gambiae pilot gene discovery project: Identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines
PNAS 2000 97: 6619-6624. [Abstract] [Full Text] [PDF]

Herman K. Edskes and Reed B. Wickner

A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein
PNAS 2000 97: 6625-6629; published online before print May 23 2000, 10.1073/pnas.120168697 [Abstract] [Full Text] [PDF]

David O. Ferguson, JoAnn M. Sekiguchi, Sandy Chang, Karen M. Frank, Yijie Gao, Ronald A. DePinho, and Frederick W. Alt

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
PNAS 2000 97: 6630-6633; published online before print May 23 2000, 10.1073/pnas.110152897 [Abstract] [Full Text] [PDF]

Jeffrey A. Bailey, Laura Carrel, Aravinda Chakravarti, and Evan E. Eichler From the Cover: Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis PNAS 2000 97: 6634-6639. [Abstract] [Full Text] [PDF] [Supplemental Tables]

Kirill A. Datsenko and Barry L. Wanner

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
PNAS 2000 97: 6640-6645; published online before print May 30 2000, 10.1073/pnas.120163297 [Abstract] [Full Text] [PDF]

Gregory J. McKenzie, Reuben S. Harris, Peter L. Lee, and Susan M. Rosenberg

The SOS response regulates adaptive mutation
PNAS 2000 97: 6646-6651; published online before print May 30 2000, 10.1073/pnas.120161797 [Abstract] [Full Text] [PDF]

Heladia Salgado, Gabriel Moreno-Hagelsieb, Temple F. Smith, and Julio Collado-Vides

Operons in Escherichia coli: Genomic analyses and predictions
PNAS 2000 97: 6652-6657; published online before print May 23 2000, 10.1073/pnas.110147297 [Abstract] [Full Text] [PDF]

Jeffrey S. Smith, Carrie Baker Brachmann, Ivana Celic, Margaret A. Kenna, Shabazz Muhammad, Vincent J. Starai, Jose L. Avalos, Jorge C. Escalante-Semerena, Charles Grubmeyer, Cynthia Wolberger, and Jef D. Boeke

A phylogenetically conserved NAD⁺-dependent protein deacetylase activity in the Sir2 protein family
PNAS 2000 97: 6658-6663. [Abstract] [Full Text] [PDF] [Supplemental Data]

Immunology

Lisa K. Petiniot, Zoë Weaver, Carrolee Barlow, Rhuna Shen, Michael Eckhaus, Seth M. Steinberg, Thomas Ried, Anthony Wynshaw-Boris, and Richard J. Hodes

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice
PNAS 2000 97: 6664-6669. [Abstract] [Full Text] [PDF]

Laurence Morel, Byron P. Croker, Kim R. Blenman, Chandra Mohan, Guanling Huang, Gary Gilkeson, and Edward K. Wakeland

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
PNAS 2000 97: 6670-6675. [Abstract] [Full Text] [PDF]

Georgia Deliyannis, Jefferey S. Boyle, Jamie L. Brady, Lorena E. Brown, and Andrew M. Lew

A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge
PNAS 2000 97: 6676-6680; published online before print May 23 2000, 10.1073/pnas.120162497 [Abstract] [Full Text] [PDF]

Simon P. Hogan, Anil Mishra, Eric B. Brandt, Paul S. Foster, and Marc E. Rothenberg

A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
PNAS 2000 97: 6681-6686. [Abstract] [Full Text] [PDF] [Supplemental Figure]

Anne B. Satterthwaite, Fiona Willis, Prim Kanchanastit, David Fruman, Lewis C. Cantley, Cheryl D. Helgason, R. Keith Humphries, Clifford A. Lowell, Melvin Simon, Michael Leitges, Alexander Tarakhovsky, Thomas F. Tedder, Ralf Lesche, Hong Wu, and Owen N. Witte

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase
PNAS 2000 97: 6687-6692; published online before print May 30 2000, 10.1073/pnas.110146697 [Abstract] [Full Text] [PDF]

Medical Sciences

Karin Butz, Claudia Denk, Angela Ullmann, Martin Scheffner, and Felix Hoppe-Seyler

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
PNAS 2000 97: 6693-6697; published online before print May 30 2000, 10.1073/pnas.110538897 [Abstract] [Full Text] [PDF]

Frank Griscelli, Hong Li, Chiat Cheong, Paule Opolon, Annelise Bennaceur-Griscelli, Gilles Vassal, Jeannette Soria, Claudine Soria, He Lu, Michel Perricaudet, and Patrice Yeh

Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model
PNAS 2000 97: 6698-6703; published online before print May 23 2000, 10.1073/pnas.110134297 [Abstract] [Full Text] [PDF]

Yasmine Belkaid, Jesus G. Valenzuela, Shaden Kamhawi, Edgar Rowton, David L. Sacks, and José M. C. Ribeiro

Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly?
PNAS 2000 97: 6704-6709. [Abstract] [Full Text] [PDF]

Matthew S. Shive, Mariah L. Salloum, and James M. Anderson

Shear stress-induced apoptosis of adherent neutrophils: A mechanism for persistence of cardiovascular device infections
PNAS 2000 97: 6710-6715; published online before print May 23 2000, 10.1073/pnas.110463197 [Abstract] [Full Text] [PDF]

Ziying Yan, Yulong Zhang, Dongsheng Duan, and John F. Engelhardt From the Cover: Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy PNAS 2000 97: 6716-6721. [Abstract] [Full Text] [PDF]

Matthew A. Nugent, Helen M. Nugent, Renato V. Iozzo, Kristian Sanchack, and Elazer R. Edelman

Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia
PNAS 2000 97: 6722-6727. [Abstract] [Full Text] [PDF]

Todd C. Holmes, Sonsoles de Lacalle, Xing Su, Guosong Liu, Alexander Rich, and Shuguang Zhang

Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
PNAS 2000 97: 6728-6733. [Abstract] [Full Text] [PDF]

Zheng-Feng Yin, Zhong-Fu Huang, Jisong Cui, Ryan Fiehler, Nina Lasky, David Ginsburg, and George J. Broze, Jr.

Prothrombotic phenotype of protein Z deficiency
PNAS 2000 97: 6734-6738; published online before print May 30 2000, 10.1073/pnas.120081897 [Abstract] [Full Text] [PDF]

Volker Heiser, Eberhard Scherzinger, Annett Boeddrich, Eckhard Nordhoff, Rudi Lurz, Nancy Schugardt, Hans Lehrach, and Erich E. Wanker

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
PNAS 2000 97: 6739-6744; published online before print May 30 2000, 10.1073/pnas.110138997 [Abstract] [Full Text] [PDF]

Carl J. Friddle, Teiichiro Koga, Edward M. Rubin, and James Bristow

Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy
PNAS 2000 97: 6745-6750; published online before print May 30 2000, 10.1073/pnas.100127897 [Abstract] [Full Text] [PDF]

Gesine Hansen, S.-L. Catherine Jin, Dale T. Umetsu, and Marco Conti

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
PNAS 2000 97: 6751-6756. [Abstract] [Full Text] [PDF]

Florence Salomon-Nguyen, Véronique Della-Valle, Martine Mauchauffé, Maryvonne Busson-Le Coniat, Jacques Ghysdael, Roland Berger, and Olivier A. Bernard

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion
PNAS 2000 97: 6757-6762; published online before print May 30 2000, 10.1073/pnas.120162297 [Abstract] [Full Text] [PDF]

Joan S. Steffan, Aleksey Kazantsev, Olivera Spasic-Boskovic, Marilee Greenwald, Ya-Zhen Zhu, Heike Gohler, Erich E. Wanker, Gillian P. Bates, David E. Housman, and Leslie M. Thompson

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
PNAS 2000 97: 6763-6768; published online before print May 23 2000, 10.1073/pnas.100110097 [Abstract] [Full Text] [PDF]

M. F. Hammer, A. J. Redd, E. T. Wood, M. R. Bonner, H. Jarjanazi, T. Karafet, S. Santachiara-Benerecetti, A. Oppenheim, M. A. Jobling, T. Jenkins, H. Ostrer, and B. Bonné-Tamir

Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes
PNAS 2000 97: 6769-6774; published online before print May 9 2000, 10.1073/pnas.100115997 [Abstract] [Full Text] [PDF]

Shengkan Jin, Barbara Gorfajn, Glynn Faircloth, and Kathleen W. Scotto

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
PNAS 2000 97: 6775-6779. [Abstract] [Full Text] [PDF]

Mario Minuzzo, Sergio Marchini, Massimo Broggini, Glynn Faircloth, Maurizio D'Incalci, and Roberto Mantovani

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743
PNAS 2000 97: 6780-6784. [Abstract] [Full Text] [PDF]

Microbiology

Ann H. Reid, Thomas G. Fanning, Thomas A. Janczewski, and Jeffery K. Taubenberger

Characterization of the 1918 "Spanish" influenza virus neuraminidase gene
PNAS 2000 97: 6785-6790; published online before print May 23 2000, 10.1073/pnas.100140097 [Abstract] [Full Text] [PDF]

Smadar Levin-Zaidman, Daphna Frenkiel-Krispin, Eyal Shimoni, Ilana Sabanay, Sharon G. Wolf, and Abraham Minsky

Ordered intracellular RecA-DNA assemblies: A potential site of in vivo RecA-mediated activities
PNAS 2000 97: 6791-6796; published online before print May 30 2000, 10.1073/pnas.090532397 [Abstract] [Full Text] [PDF]

Efi G. Kokkotou, Jean-Louis Sankalé, Indu Mani, Aissatou Guèye-Ndiaye, David Schwartz, Myron E. Essex, Souleymane Mboup, and Phyllis J. Kanki

In vitro correlates of HIV-2-mediated HIV-1 protection
PNAS 2000 97: 6797-6802. [Abstract] [Full Text] [PDF]

Matthias Gromeier, Sylvie Lachmann, Myrna R. Rosenfeld, Philip H. Gutin, and Eckard Wimmer

Intergeneric poliovirus recombinants for the treatment of malignant glioma
PNAS 2000 97: 6803-6808. [Abstract] [Full Text] [PDF]

Neurobiology

James A. Bibb, Zhen Yan, Per Svenningsson, Gretchen L. Snyder, Vincent A. Pieribone, Atsuko Horiuchi, Angus C. Nairn, Anne Messer, and Paul Greengard

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
PNAS 2000 97: 6809-6814; published online before print May 30 2000, 10.1073/pnas.120166397 [Abstract] [Full Text] [PDF]

Yan Sun, Lily Yeh Jan, and Yuh Nung Jan

Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors
PNAS 2000 97: 6815-6819; published online before print May 23 2000, 10.1073/pnas.110154497 [Abstract] [Full Text] [PDF]

Arthur E. Warrington, Kunihiko Asakura, Allan J. Bieber, Bogoljub Ciric, Virginia Van Keulen, Srini V. Kaveri, Robert A. Kyle, Larry R. Pease, and Moses Rodriguez

Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis
PNAS 2000 97: 6820-6825. [Abstract] [Full Text] [PDF]

Simona Capsoni, Gabriele Ugolini, Alessandro Comparini, Francesca Ruberti, Nicoletta Berardi, and Antonino Cattaneo

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
PNAS 2000 97: 6826-6831. [Abstract] [Full Text] [PDF]

Merav Ahissar, Athanassios Protopapas, Miriam Reid, and Michael M. Merzenich

Auditory processing parallels reading abilities in adults
PNAS 2000 97: 6832-6837. [Abstract] [Full Text] [PDF]

Ingrid Bureau, Stéphane Dieudonné, Françoise Coussen, and Christophe Mulle

Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate
PNAS 2000 97: 6838-6843. [Abstract] [Full Text] [PDF]

Weimin Zhong, Ming-Ming Jiang, Marcus D. Schonemann, Juanito J. Meneses, Roger A. Pedersen, Lily Yeh Jan, and Yuh Nung Jan

Mouse numb is an essential gene involved in cortical neurogenesis
PNAS 2000 97: 6844-6849. [Abstract] [Full Text] [PDF]

Christine Saunders, Jasmine V. Ferrer, Lei Shi, Jiayun Chen, Gerald Merrill, Maria E. Lamb, L. M. Fredrik Leeb-Lundberg, Lucia Carvelli, Jonathan A. Javitch, and Aurelio Galli

Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism
PNAS 2000 97: 6850-6855; published online before print May 23 2000, 10.1073/pnas.110035297 [Abstract] [Full Text] [PDF]

Thomas Krucker, George R. Siggins, and Shelley Halpain

Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
PNAS 2000 97: 6856-6861; published online before print May 23 2000, 10.1073/pnas.100139797 [Abstract] [Full Text] [PDF]

Pharmacology

Bruce P. England, Palaniappan Balasubramanian, Iain Uings, Sue Bethell, Min-Jia Chen, Peter J. Schatz, Qun Yin, Yao-Fen Chen, Erik A. Whitehorn, Alexander Tsavaler, Christine L. Martens, Ronald W. Barrett, and Murray McKinnon

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor  chains
PNAS 2000 97: 6862-6867; published online before print May 23 2000, 10.1073/pnas.110053997 [Abstract] [Full Text] [PDF]

Physiology

Iori Ueki, Guck T. Ooi, Michel L. Tremblay, Kelley R. Hurst, Leon A. Bach, and Yves R. Boisclair

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system
PNAS 2000 97: 6868-6873; published online before print May 23 2000, 10.1073/pnas.120172697 [Abstract] [Full Text] [PDF]

Didier Marguet, Laurie Baggio, Takashi Kobayashi, Anne-Marie Bernard, Michel Pierres, Per F. Nielsen, Ulla Ribel, Takeshi Watanabe, Daniel J. Drucker, and Nicolai Wagtmann

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
PNAS 2000 97: 6874-6879; published online before print May 23 2000, 10.1073/pnas.120069197 [Abstract] [Full Text] [PDF]

Beat M. Jucker, Sylvie Dufour, Jianming Ren, Xueying Cao, Stephen F. Previs, Brian Underhill, Kevin S. Cadman, and Gerald I. Shulman

Assessment of mitochondrial energy coupling in vivo by ¹³C/³¹P NMR
PNAS 2000 97: 6880-6884; published online before print May 23 2000, 10.1073/pnas.120131997 [Abstract] [Full Text] [PDF]

T. E. DeCoursey, V. V. Cherny, W. Zhou, and L. L. Thomas

Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils
PNAS 2000 97: 6885-6889; published online before print May 23 2000, 10.1073/pnas.100047297 [Abstract] [Full Text] [PDF]

Plant Biology

Keith Saunders, Ian D. Bedford, Rob W. Briddon, Peter G. Markham, Sek Man Wong, and John Stanley

A unique virus complex causes Ageratum yellow vein disease
PNAS 2000 97: 6890-6895. [Abstract] [Full Text] [PDF]

Huazhong Shi, Manabu Ishitani, Cheolsoo Kim, and Jian-Kang Zhu

The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na⁺/H⁺ antiporter
PNAS 2000 97: 6896-6901; published online before print May 23 2000, 10.1073/pnas.120170197 [Abstract] [Full Text] [PDF]

Alice X. Li and John C. Steffens

An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein
PNAS 2000 97: 6902-6907; published online before print May 30 2000, 10.1073/pnas.110154197 [Abstract] [Full Text] [PDF]

Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus

Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor
PNAS 2000 97: 6908-6913. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Population Biology

Dan P. Toma, Guy Bloch, Darrell Moore, and Gene E. Robinson

Changes in period mRNA levels in the brain and division of labor in honey bee colonies
PNAS 2000 97: 6914-6919. [Abstract] [Full Text] [PDF]

CORRECTIONS

Correction for vol. 95, p. 12100 [Extract] [Full Text] [PDF]