COMMENTARIES

Thomas J. Wandless

A confederacy of bunches: Fundamentals and applications of a self-associating protein
PNAS 2000 97: 6921-6923; published online before print June 13, 2000, 10.1073/pnas.110149697 [Full Text] [PDF]  

Diana J. Laird, Anthony W. De Tomaso, Max D. Cooper, and Irving L. Weissman From the Cover: 50 million years of chordate evolution: Seeking the origins of adaptive immunity PNAS 2000 97: 6924-6926. [Full Text] [PDF]

Jaume Bertranpetit

Genome, diversity, and origins: The Y chromosome as a storyteller
PNAS 2000 97: 6927-6929. [Full Text] [PDF]  

Richard P. Phipps

Atherosclerosis: The emerging role of inflammation and the CD40-CD40 ligand system
PNAS 2000 97: 6930-6932. [Full Text] [PDF]  

Sebastian Joyce

Natural T cells: Cranking up the immune system by prompt cytokine secretion
PNAS 2000 97: 6933-6935. [Full Text] [PDF]  

Frederick S. Southwick

Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells
PNAS 2000 97: 6936-6938. [Full Text] [PDF]  

Allen F. Ryan

Protection of auditory receptors and neurons: Evidence for interactive damage
PNAS 2000 97: 6939-6940. [Full Text] [PDF]  

COLLOQUIUM:
Variation and evolution in plants and microorganisms

Francisco J. Ayala, Walter M. Fitch, and Michael T. Clegg

Variation and evolution in plants and microorganisms: Toward a new synthesis 50 years after Stebbins
PNAS 2000 97: 6941-6944. [Full Text] [PDF]  

Peter H. Raven

G. Ledyard Stebbins (1906-2000): An appreciation
PNAS 2000 97: 6945-6946. [Full Text] [PDF]  

J. William Schopf

Solution to Darwin's dilemma: Discovery of the missing Precambrian record of life
PNAS 2000 97: 6947-6953. [Abstract] [Full Text] [PDF]  

Lynn Margulis, Michael F. Dolan, and Ricardo Guerrero

The chimeric eukaryote: Origin of the nucleus from the karyomastigont in amitochondriate protists
PNAS 2000 97: 6954-6959. [Abstract] [Full Text] [PDF]  

Jeffrey D. Palmer, Keith L. Adams, Yangrae Cho, Christopher L. Parkinson, Yin-Long Qiu, and Keming Song

Dynamic evolution of plant mitochondrial genomes: Mobile genes and introns and highly variable mutation rates
PNAS 2000 97: 6960-6966. [Abstract] [Full Text] [PDF]  

Andrés Moya, Santiago F. Elena, Alma Bracho, Rosario Miralles, and Eladio Barrio

The evolution of RNA viruses: A population genetics view
PNAS 2000 97: 6967-6973. [Abstract] [Full Text] [PDF]  

Robin M. Bush, Catherine B. Smith, Nancy J. Cox, and Walter M. Fitch

Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution
PNAS 2000 97: 6974-6980. [Abstract] [Full Text] [PDF]  

Bruce R. Levin and Carl T. Bergstrom

Bacteria are different: Observations, interpretations, speculations, and opinions about the mechanisms of adaptive evolution in prokaryotes
PNAS 2000 97: 6981-6985. [Abstract] [Full Text] [PDF]  

Larry Simpson, Otavio H. Thiemann, Nicholas J. Savill, Juan D. Alfonzo, and D. A. Maslov

Evolution of RNA editing in trypanosome mitochondria
PNAS 2000 97: 6986-6993. [Abstract] [Full Text] [PDF]  

Stephen M. Rich and Francisco J. Ayala

Population structure and recent evolution of Plasmodium falciparum
PNAS 2000 97: 6994-7001. [Abstract] [Full Text] [PDF]  

Nina Fedoroff

Transposons and genome evolution in plants
PNAS 2000 97: 7002-7007. [Abstract] [Full Text] [PDF]  

Brandon S. Gaut, Maud Le Thierry d'Ennequin, Andrew S. Peek, and Mark C. Sawkins

Maize as a model for the evolution of plant nuclear genomes
PNAS 2000 97: 7008-7015. [Abstract] [Full Text] [PDF]  

Michael T. Clegg and Mary L. Durbin

Flower color variation: A model for the experimental study of evolution
PNAS 2000 97: 7016-7023. [Abstract] [Full Text] [PDF]  

Barbara A. Schaal and Kenneth M. Olsen

Gene genealogies and population variation in plants
PNAS 2000 97: 7024-7029. [Abstract] [Full Text] [PDF]  

David Dilcher

Toward a new synthesis: Major evolutionary trends in the angiosperm fossil record
PNAS 2000 97: 7030-7036. [Abstract] [Full Text] [PDF]  

Kent E. Holsinger

Reproductive systems and evolution in vascular plants
PNAS 2000 97: 7037-7042. [Abstract] [Full Text] [PDF]  

Norman C. Ellstrand and Kristina A. Schierenbeck

Hybridization as a stimulus for the evolution of invasiveness in plants?
PNAS 2000 97: 7043-7050. [Abstract] [Full Text] [PDF]  

Pamela S. Soltis and Douglas E. Soltis

The role of genetic and genomic attributes in the success of polyploids
PNAS 2000 97: 7051-7057. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Physical Sciences

Jan T. Frohn, Helmut F. Knapp, and Andreas Stemmer

True optical resolution beyond the Rayleigh limit achieved by standing wave illumination
PNAS 2000 97: 7232-7236; published online before print June 6, 2000, 10.1073/pnas.130181797 [Abstract] [Full Text] [PDF]  

Chemistry

Philippe Vayron, Pierre-Yves Renard, Frédéric Taran, Christophe Créminon, Yveline Frobert, Jacques Grassi, and Charles Mioskowski

Toward antibody-catalyzed hydrolysis of organophosphorus poisons
PNAS 2000 97: 7058-7063. [Abstract] [Full Text] [PDF] [Supplemental Text]  

Donald E. Brooks, Charles A. Haynes, Doina Hritcu, Bradley M. Steels, and Werner Müller

Size exclusion chromatography does not require pores
PNAS 2000 97: 7064-7067; published online before print June 13, 2000, 10.1073/pnas.120129097 [Abstract] [Full Text] [PDF]  

Statistics

T. W. Anderson

The asymptotic distribution of canonical correlations and variates in cointegrated models
PNAS 2000 97: 7068-7073. [Abstract] [TeX] [PDF]  

SOCIAL SCIENCES
Anthropology

Michael P. Richards, Paul B. Pettitt, Erik Trinkaus, Fred H. Smith, Maja Paunovi, and Ivor Karavani From the Cover: Neanderthal diet at Vindija and Neanderthal predation: The evidence from stable isotopes PNAS 2000 97: 7663-7666; published online before print June 13, 2000, 10.1073/pnas.120178997 [Abstract] [Full Text] [PDF]

Economic Sciences

T. W. Anderson

The asymptotic distribution of canonical correlations and variates in cointegrated models
PNAS 2000 97: 7068-7073. [Abstract] [TeX] [PDF]  

BIOLOGICAL SCIENCES
Applied Biological Sciences

Víctor Sánchez-Cordero and Enrique Martínez-Meyer

Museum specimen data predict crop damage by tropical rodents
PNAS 2000 97: 7074-7077; published online before print June 6, 2000, 10.1073/pnas.110489897 [Abstract] [Full Text] [PDF]  

Rebecca Ing, Zhong Su, Marilyn E. Scott, and Kristine G. Koski

Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice
PNAS 2000 97: 7078-7083. [Abstract] [Full Text] [PDF]  

Biochemistry

Viara P. Grantcharova, David S. Riddle, and David Baker

Long-range order in the src SH3 folding transition state
PNAS 2000 97: 7084-7089. [Abstract] [Full Text] [PDF]  

Irina Artsimovitch and Robert Landick

Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals
PNAS 2000 97: 7090-7095. [Abstract] [Full Text] [PDF]  

Carl T. Rollins, Victor M. Rivera, Derek N. Woolfson, Terence Keenan, Marcos Hatada, Susan E. Adams, Lawrence J. Andrade, David Yaeger, Marie Rose van Schravendijk, Dennis A. Holt, Michael Gilman, and Tim Clackson

A ligand-reversible dimerization system for controlling protein-protein interactions
PNAS 2000 97: 7096-7101; published online before print June 13, 2000, 10.1073/pnas.100101997 [Abstract] [Full Text] [PDF]  

Tiemen van der Heide and Bert Poolman

Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane
PNAS 2000 97: 7102-7106. [Abstract] [Full Text] [PDF]  

William E. Royer Jr., Kristen Strand, Marin van Heel, and Wayne A. Hendrickson

Structural hierarchy in erythrocruorin, the giant respiratory assemblage of annelids
PNAS 2000 97: 7107-7111. [Abstract] [Full Text] [PDF]  

Laurence M. Brill, Rashmi S. Nunn, Theodore W. Kahn, Mark Yeager, and Roger N. Beachy

Recombinant tobacco mosaic virus movement protein is an RNA-binding, -helical membrane protein
PNAS 2000 97: 7112-7117; published online before print June 6, 2000, 10.1073/pnas.130187897 [Abstract] [Full Text] [PDF]  

Suofu Qin, Earl R. Stadtman, and P. Boon Chock

Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells
PNAS 2000 97: 7118-7123; published online before print June 6, 2000, 10.1073/pnas.130198197 [Abstract] [Full Text] [PDF]  

Jia-Lun Wang, Dongxiang Liu, Zhi-Jia Zhang, Simei Shan, Xiaobing Han, Srinivasa M. Srinivasula, Carlo M. Croce, Emad S. Alnemri, and Ziwei Huang

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
PNAS 2000 97: 7124-7129. [Abstract] [Full Text] [PDF]  

Sheldon Park, Motonari Uesugi, and Gregory L. Verdine

A second calcineurin binding site on the NFAT regulatory domain
PNAS 2000 97: 7130-7135. [Abstract] [Full Text] [PDF]  

Alberto Danielli, Thanasis G. Loukeris, Marie Lagueux, Hans-Michael Müller, Adam Richman, and Fotis C. Kafatos

A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae
PNAS 2000 97: 7136-7141. [Abstract] [Full Text] [PDF]  

Suman Mukhopadhyay and Dhruba K. Chattoraj

Replication-induced transcription of an autorepressed gene: The replication initiator gene of plasmid P1
PNAS 2000 97: 7142-7147; published online before print June 6, 2000, 10.1073/pnas.130189497 [Abstract] [Full Text] [PDF]  

Johan Paulsson, Otto G. Berg, and Måns Ehrenberg

Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation
PNAS 2000 97: 7148-7153; published online before print June 13, 2000, 10.1073/pnas.110057697 [Abstract] [Full Text] [PDF]  

Nathan L. Mata, Jian Weng, and Gabriel H. Travis

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration
PNAS 2000 97: 7154-7159; published online before print June 13, 2000, 10.1073/pnas.130110497 [Abstract] [Full Text] [PDF]  

Erich F. Greiner, Jutta Kirfel, Holger Greschik, Dongya Huang, Peter Becker, Josef P. Kapfhammer, and Roland Schüle

Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor
PNAS 2000 97: 7160-7165. [Abstract] [Full Text] [PDF]  

SiDe Li, Barbara Aufiero, R. Louis Schiltz, and Martin J. Walsh

Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP
PNAS 2000 97: 7166-7171; published online before print June 13, 2000, 10.1073/pnas.130028697 [Abstract] [Full Text] [PDF]  

Brian A. Lewis, Tae-Kyung Kim, and Stuart H. Orkin

A downstream element in the human -globin promoter: Evidence of extended sequence-specific transcription factor IID contacts
PNAS 2000 97: 7172-7177; published online before print June 6, 2000, 10.1073/pnas.120181197 [Abstract] [Full Text] [PDF]  

Tomohiro Kotani, Ken-ichi Banno, Mitsuhiko Ikura, Alan G. Hinnebusch, Yoshihiro Nakatani, Masashi Kawaichi, and Tetsuro Kokubo

A role of transcriptional activators as antirepressors for the autoinhibitory activity of TATA box binding of transcription factor IID
PNAS 2000 97: 7178-7183; published online before print June 13, 2000, 10.1073/pnas.120074297 [Abstract] [Full Text] [PDF]  

Enrique Castaño, Petra Gross, Zhengxin Wang, Robert G. Roeder, and Thomas Oelgeschläger

The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts
PNAS 2000 97: 7184-7189; published online before print June 13, 2000, 10.1073/pnas.140202297 [Abstract] [Full Text] [PDF]  

Xiangwu Nou and Robert J. Kadner

Adenosylcobalamin inhibits ribosome binding to btuB RNA
PNAS 2000 97: 7190-7195; published online before print June 13, 2000, 10.1073/pnas.130013897 [Abstract] [Full Text] [PDF]  

Frank Salinas and Stephen J. Benkovic

Characterization of bacteriophage T4-coordinated leading- and lagging-strand synthesis on a minicircle substrate
PNAS 2000 97: 7196-7201. [Abstract] [Full Text] [PDF]  

Yu-Der Wen, Valentina Perissi, Lena M. Staszewski, Wen-Ming Yang, Anna Krones, Christopher K. Glass, Michael G. Rosenfeld, and Edward Seto

The histone deacetylase-3 complex contains nuclear receptor corepressors
PNAS 2000 97: 7202-7207. [Abstract] [Full Text] [PDF]  

William T. Self and Thressa C. Stadtman

Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized
PNAS 2000 97: 7208-7213. [Abstract] [Full Text] [PDF]  

Jens Tyedmers, Monika Lerner, Christiane Bies, Johanna Dudek, Markus H. Skowronek, Ingrid G. Haas, Nicole Heim, Wolfgang Nastainczyk, Jörg Volkmer, and Richard Zimmermann

Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes
PNAS 2000 97: 7214-7219. [Abstract] [Full Text] [PDF]  

Biophysics

Lisa J. Lapidus, William A. Eaton, and James Hofrichter

Measuring the rate of intramolecular contact formation in polypeptides
PNAS 2000 97: 7220-7225. [Abstract] [Full Text] [PDF]  

M. Linari, G. Piazzesi, I. Dobbie, N. Koubassova, M. Reconditi, T. Narayanan, O. Diat, M. Irving, and V. Lombardi From the Cover: Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers PNAS 2000 97: 7226-7231. [Abstract] [Full Text] [PDF]

Jan T. Frohn, Helmut F. Knapp, and Andreas Stemmer

True optical resolution beyond the Rayleigh limit achieved by standing wave illumination
PNAS 2000 97: 7232-7236; published online before print June 6, 2000, 10.1073/pnas.130181797 [Abstract] [Full Text] [PDF]  

M. F. Garcia-Parajo, G. M. J. Segers-Nolten, J.-A. Veerman, J. Greve, and N. F. van Hulst

Real-time light-driven dynamics of the fluorescence emission in single green fluorescent protein molecules
PNAS 2000 97: 7237-7242. [Abstract] [Full Text] [PDF]  

Kengo Adachi, Ryohei Yasuda, Hiroyuki Noji, Hiroyasu Itoh, Yoshie Harada, Masasuke Yoshida, and Kazuhiko Kinosita Jr.

Stepping rotation of F₁-ATPase visualized through angle-resolved single-fluorophore imaging
PNAS 2000 97: 7243-7247; published online before print June 6, 2000, 10.1073/pnas.120174297 [Abstract] [Full Text] [PDF]  

Olivier Lambert, Lucienne Letellier, William M. Gelbart, and Jean-Louis Rigaud

DNA delivery by phage as a strategy for encapsulating toroidal condensates of arbitrary size into liposomes
PNAS 2000 97: 7248-7253; published online before print June 6, 2000, 10.1073/pnas.130187297 [Abstract] [Full Text] [PDF]  

D. K. Klimov and D. Thirumalai

Native topology determines force-induced unfolding pathways in globular proteins
PNAS 2000 97: 7254-7259. [Abstract] [Full Text] [PDF]  

Cell Biology

Valérie Baubet, Hervé Le Mouellic, Anthony K. Campbell, Estelle Lucas-Meunier, Philippe Fossier, and Philippe Brûlet

Chimeric green fluorescent protein-aequorin as bioluminescent Ca²⁺ reporters at the single-cell level
PNAS 2000 97: 7260-7265. [Abstract] [Full Text] [PDF]  

Kinya Yoda, Satoshi Ando, Setsuo Morishita, Kenichi Houmura, Keiji Hashimoto, Kunio Takeyasu, and Tuneko Okazaki

Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro
PNAS 2000 97: 7266-7271; published online before print June 6, 2000, 10.1073/pnas.130189697 [Abstract] [Full Text] [PDF]  

Toshiaki Yujiri, Margaret Ware, Christian Widmann, Ryan Oyer, David Russell, Edward Chan, Yuzuru Zaitsu, Penny Clarke, Kenneth Tyler, Yoshitomo Oka, Gary R. Fanger, Peter Henson, and Gary L. Johnson

MEK kinase 1 gene disruption alters cell migration and c-Jun NH₂-terminal kinase regulation but does not cause a measurable defect in NF-B activation
PNAS 2000 97: 7272-7277; published online before print June 13, 2000, 10.1073/pnas.130176697 [Abstract] [Full Text] [PDF]  

Joe F. Lau, Jean-Patrick Parisien, and Curt M. Horvath

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors
PNAS 2000 97: 7278-7283. [Abstract] [Full Text] [PDF]  

Tatsuya Nakamura, Janna Blechman, Shinichiro Tada, Tanya Rozovskaia, Takahiro Itoyama, Florencia Bullrich, Alexander Mazo, Carlo M. Croce, Benjamin Geiger, and Eli Canaani

huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions
PNAS 2000 97: 7284-7289. [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Tsuyoshi Akagi, Tomoyuki Shishido, Kazutaka Murata, and Hidesaburo Hanafusa

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation
PNAS 2000 97: 7290-7295; published online before print June 13, 2000, 10.1073/pnas.140210297 [Abstract] [Full Text] [PDF]  

Inaam A. Nakchbandi, Eleanor E. Weir, Karl L. Insogna, William M. Philbrick, and Arthur E. Broadus

Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade
PNAS 2000 97: 7296-7300; published online before print May 30, 2000, 10.1073/pnas.110553397 [Abstract] [Full Text] [PDF]  

Shengkan Jin, Sebastian Martinek, Woo S. Joo, Jennifer R. Wortman, Nebojsa Mirkovic, Andrej Sali, Mark D. Yandell, Nikola P. Pavletich, Michael W. Young, and Arnold J. Levine

Identification and characterization of a p53 homologue in Drosophila melanogaster
PNAS 2000 97: 7301-7306. [Abstract] [Full Text] [PDF]  

R. Kip Guy

Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
PNAS 2000 97: 7307-7312. [Abstract] [Full Text] [PDF]  

Mary O. Carayannopoulos, Maggie M.-Y. Chi, Ying Cui, Joyce M. Pingsterhaus, Robert A. McKnight, Mike Mueckler, Sherin U. Devaskar, and Kelle H. Moley

GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst
PNAS 2000 97: 7313-7318. [Abstract] [Full Text] [PDF]  

Christina A. M. Jamieson and Keith R. Yamamoto

Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling
PNAS 2000 97: 7319-7324. [Abstract] [Full Text] [PDF]  

Developmental Biology

Harriett E. Smith-Somerville, John K. Hardman, Russell Timkovich, William J. Ray, Karen E. Rose, Phillip E. Ryals, Sandra H. Gibbons, and Howard E. Buhse Jr.

A complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoan
PNAS 2000 97: 7325-7330. [Abstract] [Full Text] [PDF]  

Antonio Baonza, Fernando Roch, and Enrique Martín-Blanco

DER signaling restricts the boundaries of the wing field during Drosophila development
PNAS 2000 97: 7331-7335. [Abstract] [Full Text] [PDF]  

Maria Venihaki, Allison Carrigan, Pieter Dikkes, and Joseph A. Majzoub

Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency
PNAS 2000 97: 7336-7341. [Abstract] [Full Text] [PDF]  

Dashzeveg Bayarsaihan and Frank H. Ruddle

Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix-loop-helix domains
PNAS 2000 97: 7342-7347. [Abstract] [Full Text] [PDF]  

Nancy Fossett, Qian Zhang, Kathleen Gajewski, Cheol Yong Choi, Yongsok Kim, and Robert A. Schulz

The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo
PNAS 2000 97: 7348-7353. [Abstract] [Full Text] [PDF]  

Evolution

Peidong Shen, Frank Wang, Peter A. Underhill, Claudia Franco, Wei-Hsien Yang, Adriane Roxas, Raphael Sung, Alice A. Lin, Richard W. Hyman, Douglas Vollrath, Ronald W. Davis, L. Luca Cavalli-Sforza, and Peter J. Oefner

Population genetic implications from sequence variation in four Y chromosome genes
PNAS 2000 97: 7354-7359. [Abstract] [Full Text] [PDF]  

Russell Thomson, Jonathan K. Pritchard, Peidong Shen, Peter J. Oefner, and Marcus W. Feldman

Recent common ancestry of human Y chromosomes: Evidence from DNA sequence data
PNAS 2000 97: 7360-7365. [Abstract] [Full Text] [PDF]  

Shozo Yokoyama, F. Bernhard Radlwimmer, and Nathan S. Blow

Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change
PNAS 2000 97: 7366-7371. [Abstract] [Full Text] [PDF]  

Jun-ichi Tomizawa

Derivation of the relationship between neutral mutation and fixation solely from the definition of selective neutrality
PNAS 2000 97: 7372-7375. [Abstract] [Full Text] [PDF]  

Genetics

Quang Hien Le, Stephen Wright, Zhihui Yu, and Thomas Bureau

Transposon diversity in Arabidopsis thaliana
PNAS 2000 97: 7376-7381. [Abstract] [Full Text] [PDF]  

J. Keith Joung, Elizabeth I. Ramm, and Carl O. Pabo

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions
PNAS 2000 97: 7382-7387; published online before print June 13, 2000, 10.1073/pnas.110149297 [Abstract] [Full Text] [PDF]  

John E. J. Rasko, Jean-Luc Battini, Leonid Kruglyak, David R. Cox, and A. Dusty Miller

Precise gene localization by phenotypic assay of radiation hybrid cells
PNAS 2000 97: 7388-7392; published online before print June 13, 2000, 10.1073/pnas.130200097 [Abstract] [Full Text] [PDF]  

V. G. Godoy and M. S. Fox

Transposon stability and a role for conjugational transfer in adaptive mutability
PNAS 2000 97: 7393-7398; published online before print June 6, 2000, 10.1073/pnas.130186597 [Abstract] [Full Text] [PDF]  

Susan K. Amundsen, Andrew F. Taylor, and Gerald R. Smith

The RecD subunit of the Escherichia coli RecBCD enzyme inhibits RecA loading, homologous recombination, and DNA repair
PNAS 2000 97: 7399-7404; published online before print June 6, 2000, 10.1073/pnas.130192397 [Abstract] [Full Text] [PDF]  

Changshun Shao, Li Deng, Octavian Henegariu, Li Liang, Peter J. Stambrook, and Jay A. Tischfield

Chromosome instability contributes to loss of heterozygosity in mice lacking p53
PNAS 2000 97: 7405-7410. [Abstract] [Full Text] [PDF]  

Immunology

S. Brian Wilson, Sally C. Kent, Heidi F. Horton, Andrew A. Hill, Paul L. Bollyky, David A. Hafler, Jack L. Strominger, and Michael C. Byrne

Multiple differences in gene expression in regulatory V24JQ T cells from identical twins discordant for type I diabetes
PNAS 2000 97: 7411-7416; published online before print June 6, 2000, 10.1073/pnas.120161297 [Abstract] [Full Text] [PDF]  

Seikou Shintani, Janos Terzic, Akie Sato, Mirna Saraga-Babic, Colm O'hUigin, Herbert Tichy, and Jan Klein

Do lampreys have lymphocytes? The Spi evidence
PNAS 2000 97: 7417-7422; published online before print June 6, 2000, 10.1073/pnas.110505597 [Abstract] [Full Text] [PDF]  

Yuko Kawakami, Jiro Kitaura, Stephen E. Hartman, Clifford A. Lowell, Reuben P. Siraganian, and Toshiaki Kawakami

Regulation of protein kinase CI by two protein-tyrosine kinases, Btk and Syk
PNAS 2000 97: 7423-7428; published online before print June 13, 2000, 10.1073/pnas.120175097 [Abstract] [Full Text] [PDF]  

Uschi Braun, Klaus Rajewsky, and Roberta Pelanda

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes
PNAS 2000 97: 7429-7434; published online before print May 30, 2000, 10.1073/pnas.050578497 [Abstract] [Full Text] [PDF]  

Valerie Kouskoff, Georges Lacaud, Kathryn Pape, Marc Retter, and David Nemazee

B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection
PNAS 2000 97: 7435-7439; published online before print May 30, 2000, 10.1073/pnas.130182597 [Abstract] [Full Text] [PDF]  

Medical Sciences

Chinnaswamy Tiruppathi, Weihong Yan, Raudel Sandoval, Tabassum Naqvi, Alexey N. Pronin, Jeffery L. Benovic, and Asrar B. Malik

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells
PNAS 2000 97: 7440-7445. [Abstract] [Full Text] [PDF]  

Jonathan Kipnis, Eti Yoles, Ziv Porat, Avi Cohen, Felix Mor, Michael Sela, Irun R. Cohen, and Michal Schwartz

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies
PNAS 2000 97: 7446-7451. [Abstract] [Full Text] [PDF]  

Oliver Neuhaus, Cinthia Farina, Alexander Yassouridis, Heinz Wiendl, Florian Then Bergh, Tatjana Dose, Hartmut Wekerle, and Reinhard Hohlfeld

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells
PNAS 2000 97: 7452-7457. [Abstract] [Full Text] [PDF]  

U. Schönbeck, G. K. Sukhova, K. Shimizu, F. Mach, and P. Libby

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
PNAS 2000 97: 7458-7463. [Abstract] [Full Text] [PDF]  

Esther Lutgens, Kitty B. J. M. Cleutjens, Sylvia Heeneman, Victor E. Koteliansky, Linda C. Burkly, and Mat J. A. P. Daemen

Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype
PNAS 2000 97: 7464-7469. [Abstract] [Full Text] [PDF]  

Bakary S. Sylla, Kerry Murphy, Ellen Cahir-McFarland, William S. Lane, George Mosialos, and Elliott Kieff

The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62^dok (Dok1) and activates NF-B
PNAS 2000 97: 7470-7475; published online before print June 13, 2000, 10.1073/pnas.130193097 [Abstract] [Full Text] [PDF]  

Jan Wijnholds, Carla A. A. M. Mol, Liesbeth van Deemter, Marcel de Haas, George L. Scheffer, Frank Baas, Jos H. Beijnen, Rik J. Scheper, Sigrid Hatse, Erik De Clercq, Jan Balzarini, and Piet Borst

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
PNAS 2000 97: 7476-7481; published online before print June 6, 2000, 10.1073/pnas.120159197 [Abstract] [Full Text] [PDF]  

Clare E. Thomas, Gudrun Schiedner, Stefan Kochanek, Maria G. Castro, and Pedro R. Löwenstein

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases
PNAS 2000 97: 7482-7487; published online before print June 6, 2000, 10.1073/pnas.120474397 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Matthew L. Brown, M. P. Ramprasad, Patrick K. Umeda, Akira Tanaka, Yasushi Kobayashi, Teruo Watanabe, Hiroaki Shimoyamada, Wen-Lin Kuo, Ran Li, Ruiling Song, William A. Bradley, and Sandra H. Gianturco

A macrophage receptor for apolipoprotein B48: Cloning, expression, and atherosclerosis
PNAS 2000 97: 7488-7493; published online before print June 13, 2000, 10.1073/pnas.120184097 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Wenle Xia, Sydney Spector, Lys Hardy, Sumin Zhao, Alan Saluk, Lourdes Alemane, and Neil L. Spector

Tumor selective G₂/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine
PNAS 2000 97: 7494-7499. [Abstract] [Full Text] [PDF]  

Linda B. Moore, Bryan Goodwin, Stacey A. Jones, G. Bruce Wisely, Cosette J. Serabjit-Singh, Timothy M. Willson, Jon L. Collins, and Steven A. Kliewer

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
PNAS 2000 97: 7500-7502; published online before print June 13, 2000, 10.1073/pnas.130155097 [Abstract] [Full Text] [PDF]  

John H. Sampson, Laura E. Crotty, Samson Lee, Gary E. Archer, David M. Ashley, Carol J. Wikstrand, Laura P. Hale, Clayton Small, Glenn Dranoff, Allan H. Friedman, Henry S. Friedman, and Darell D. Bigner

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
PNAS 2000 97: 7503-7508; published online before print June 13, 2000, 10.1073/pnas.130166597 [Abstract] [Full Text] [PDF]  

Michael B. Reed, Sonia R. Caruana, Adrian H. Batchelor, Jennifer K. Thompson, Brendan S. Crabb, and Alan F. Cowman

Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion
PNAS 2000 97: 7509-7514. [Abstract] [Full Text] [PDF]  

Toshihiro Takenaka, Gary J. Murray, Gangjian Qin, Jane M. Quirk, Toshio Ohshima, Pankaj Qasba, Kelly Clark, Ashok B. Kulkarni, Roscoe O. Brady, and Jeffrey A. Medin

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells
PNAS 2000 97: 7515-7520; published online before print June 6, 2000, 10.1073/pnas.120177997 [Abstract] [Full Text] [PDF]  

Toshihiro Miyamoto, Irving L. Weissman, and Koichi Akashi

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
PNAS 2000 97: 7521-7526. [Abstract] [Full Text] [PDF]  

Microbiology

Maria Hammarstedt, Kristina Wallengren, Ketil Winther Pedersen, Norbert Roos, and Henrik Garoff

Minimal exclusion of plasma membrane proteins during retroviral envelope formation
PNAS 2000 97: 7527-7532; published online before print June 13, 2000, 10.1073/pnas.120051597 [Abstract] [Full Text] [PDF]  

Yoshio Yamaoka, Dong H. Kwon, and David Y. Graham

A M_r 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori
PNAS 2000 97: 7533-7538; published online before print June 13, 2000, 10.1073/pnas.130079797 [Abstract] [Full Text] [PDF]  

Edward A. Miao and Samuel I. Miller

A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium
PNAS 2000 97: 7539-7544. [Abstract] [Full Text] [PDF]  

Lishan Chen, Catherine M. Li, and Eugene W. Nester

Transferred DNA (T-DNA)-associated proteins of Agrobacterium tumefaciens are exported independently of virB
PNAS 2000 97: 7545-7550; published online before print June 13, 2000, 10.1073/pnas.120156997 [Abstract] [Full Text] [PDF]  

Neurobiology

Anthony P. Auger, Marc J. Tetel, and Margaret M. McCarthy

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior
PNAS 2000 97: 7551-7555. [Abstract] [Full Text] [PDF]  

Stephen L. Macknik, Susana Martinez-Conde, and Michael M. Haglund

The role of spatiotemporal edges in visibility and visual masking
PNAS 2000 97: 7556-7560; published online before print June 13, 2000, 10.1073/pnas.110142097 [Abstract] [Full Text] [PDF]  

Shu-ichi Okamoto, Dimitri Krainc, Katerina Sherman, and Stuart A. Lipton

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
PNAS 2000 97: 7561-7566; published online before print June 13, 2000, 10.1073/pnas.130502697 [Abstract] [Full Text] [PDF]  

Ningya Shi and William M. Pardridge

Noninvasive gene targeting to the brain
PNAS 2000 97: 7567-7572; published online before print June 6, 2000, 10.1073/pnas.130187497 [Abstract] [Full Text] [PDF]  

J. E. Rash, W. A. Staines, T. Yasumura, D. Patel, C. S. Furman, G. L. Stelmack, and J. I. Nagy

Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43
PNAS 2000 97: 7573-7578. [Abstract] [Full Text] [PDF]  

Amelia J. Eisch, Michel Barrot, Christina A. Schad, David W. Self, and Eric J. Nestler

Opiates inhibit neurogenesis in the adult rat hippocampus
PNAS 2000 97: 7579-7584; published online before print June 6, 2000, 10.1073/pnas.120552597 [Abstract] [Full Text] [PDF]  

P. Charles, M. P. Hernandez, B. Stankoff, M. S. Aigrot, C. Colin, G. Rougon, B. Zalc, and C. Lubetzki

Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule
PNAS 2000 97: 7585-7590; published online before print June 6, 2000, 10.1073/pnas.100076197 [Abstract] [Full Text] [PDF]  

K. J. Friston and C. Büchel

Attentional modulation of effective connectivity from V2 to V5/MT in humans
PNAS 2000 97: 7591-7596. [Abstract] [Full Text] [PDF]  

Maoli Duan, Karin Agerman, Patrik Ernfors, and Barbara Canlon From the Cover: Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity PNAS 2000 97: 7597-7602. [Abstract] [Full Text] [PDF]

Dmitriy A. Yablonskiy, Joseph J. H. Ackerman, and Marcus E. Raichle

Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation
PNAS 2000 97: 7603-7608. [Abstract] [Full Text] [PDF]  

Daniel M. Skovronsky, Bin Zhang, Mei-Ping Kung, Hank F. Kung, John Q. Trojanowski, and Virginia M.-Y. Lee

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
PNAS 2000 97: 7609-7614. [Abstract] [Full Text] [PDF]  

Pharmacology

Charles Parnot, Sabine Bardin, Stéphanie Miserey-Lenkei, Denis Guedin, Pierre Corvol, and Eric Clauser

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay
PNAS 2000 97: 7615-7620; published online before print June 13, 2000, 10.1073/pnas.110142297 [Abstract] [Full Text] [PDF]  

Stacy E. Foran, Daniel B. Carr, Andrzej W. Lipkowski, Iwona Maszczynska, James E. Marchand, Aleksandra Misicka, Martin Beinborn, Alan S. Kopin, and Richard M. Kream

A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic
PNAS 2000 97: 7621-7626; published online before print June 13, 2000, 10.1073/pnas.130181897 [Abstract] [Full Text] [PDF]  

Physiology

Philippe Bijlenga, Jian-Hui Liu, Estelle Espinos, Charles-Antoine Haenggeli, Jacqueline Fischer-Lougheed, Charles R. Bader, and Laurent Bernheim

T-type 1H Ca²⁺ channels are involved in Ca²⁺ signaling during terminal differentiation (fusion) of human myoblasts
PNAS 2000 97: 7627-7632. [Abstract] [Full Text] [PDF]  

Plant Biology

Eva C. Ziegelhoffer, Leonard J. Medrano, and Elliot M. Meyerowitz

Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development
PNAS 2000 97: 7633-7638; published online before print June 6, 2000, 10.1073/pnas.130189397 [Abstract] [Full Text] [PDF]  

Susanne Oxenbøll Sørensen, Markus Pauly, Max Bush, Michael Skjøt, Maureen C. McCann, Bernhard Borkhardt, and Peter Ulvskov

Pectin engineering: Modification of potato pectin by in vivo expression of an endo-1,4--D-galactanase
PNAS 2000 97: 7639-7644; published online before print June 13, 2000, 10.1073/pnas.130568297 [Abstract] [Full Text] [PDF]  

Psychology

Corinna Haenschel, Torsten Baldeweg, Rodney J. Croft, Miles Whittington, and John Gruzelier

Gamma and beta frequency oscillations in response to novel auditory stimuli: A comparison of human electroencephalogram (EEG) data with in vitro models
PNAS 2000 97: 7645-7650; published online before print June 13, 2000, 10.1073/pnas.120162397 [Abstract] [Full Text] [PDF]  

Etienne Koechlin, Gregory Corrado, Pietro Pietrini, and Jordan Grafman

Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning
PNAS 2000 97: 7651-7656; published online before print June 13, 2000, 10.1073/pnas.130177397 [Abstract] [Full Text] [PDF]  

Aryeh Routtenberg, Isabel Cantallops, Sal Zaffuto, Peter Serrano, and Uk Namgung

Enhanced learning after genetic overexpression of a brain growth protein
PNAS 2000 97: 7657-7662. [Abstract] [Full Text] [PDF]