Cover illustration

August 1, 2000; 97 (16)
Cover image expansion

Cover image: High-resolution freeze-dry/deep-etch electron micrograph showing piliated uropathogenic Escherichia coli (gold) tethered to the lumenal surface of a mouse bladder (blue). The bacterial pili attach to hexameric complexes of integral membrane proteins, known as uroplakins, which coat the bladder sur-face. See article by Mulvey et al., on pages 8829–8835 in this issue.