COMMENTARIES

Shimon Weiss

Shattering the diffraction limit of light: A revolution in fluorescence microscopy?
PNAS 2000 97: 8747-8749. [Full Text] [PDF]  

N. A. Mitchison and L. R. Wedderburn

B cells in autoimmunity
PNAS 2000 97: 8750-8751. [Full Text] [PDF]  

COLLOQUIUM:
Virulence and Defense in Host-Pathogen Interactions: Common Features Between Plants and Animals

Noel Keen, Brian Staskawicz, John Mekalanos, Frederick Ausubel, and R. James Cook

INTRODUCTION. Pathogens and hosts: The dance is the same, the couples are different
PNAS 2000 97: 8752-8753. [Full Text] [PDF]  

Jorge E. Galán and Daoguo Zhou

Striking a balance: Modulation of the actin cytoskeleton by Salmonella
PNAS 2000 97: 8754-8761. [Abstract] [Full Text] [PDF]  

Steven R. Herron, Jacques A. E. Benen, Robert D. Scavetta, Jaap Visser, and Frances Jurnak

Structure and function of pectic enzymes: Virulence factors of plant pathogens
PNAS 2000 97: 8762-8769. [Abstract] [Full Text] [PDF]  

Alan Collmer, Jorge L. Badel, Amy O. Charkowski, Wen-Ling Deng, Derrick E. Fouts, Adela R. Ramos, Amos H. Rehm, Deborah M. Anderson, Olaf Schneewind, Karin van Dijk, and James R. Alfano

Pseudomonas syringae Hrp type III secretion system and effector proteins
PNAS 2000 97: 8770-8777. [Abstract] [Full Text] [PDF]  

Guy R. Cornelis

Molecular and cell biology aspects of plague
PNAS 2000 97: 8778-8783. [Abstract] [Full Text] [PDF]  

Michael Marino, Laurence Braun, Pascale Cossart, and Partho Ghosh

A framework for interpreting the leucine-rich repeats of the Listeria internalins
PNAS 2000 97: 8784-8788. [Abstract] [Full Text] [PDF]  

Matthew R. Parsek and E. Peter Greenberg

Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms
PNAS 2000 97: 8789-8793. [Abstract] [Full Text] [PDF]  

Silke Kügler, Tricia Schurtz Sebghati, Linda Groppe Eissenberg, and William E. Goldman

Phenotypic variation and intracellular parasitism by Histoplasma capsulatum
PNAS 2000 97: 8794-8798. [Abstract] [Full Text] [PDF]  

B. A. Vallance and B. B. Finlay

Exploitation of host cells by enteropathogenic Escherichia coli
PNAS 2000 97: 8799-8806. [Abstract] [Full Text] [PDF]  

Mark S. Dixon, Catherine Golstein, Colwyn M. Thomas, Erik A. van der Biezen, and Jonathan D. G. Jones

Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2
PNAS 2000 97: 8807-8814. [Abstract] [Full Text] [PDF]  

Laurence G. Rahme, Frederick M. Ausubel, Hui Cao, Eliana Drenkard, Boyan C. Goumnerov, Gee W. Lau, Shalina Mahajan-Miklos, Julia Plotnikova, Man-Wah Tan, John Tsongalis, Cynthia L. Walendziewicz, and Ronald G. Tompkins

Plants and animals share functionally common bacterial virulence factors
PNAS 2000 97: 8815-8821. [Abstract] [Full Text] [PDF]  

Gerald B. Pier

Role of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infections
PNAS 2000 97: 8822-8828. [Abstract] [Full Text] [PDF]  

Matthew A. Mulvey, Joel D. Schilling, Juan J. Martinez, and Scott J. Hultgren From the Cover: Bad bugs and beleaguered bladders: Interplay between uropathogenic Escherichia coli and innate host defenses PNAS 2000 97: 8829-8835. [Abstract] [Full Text] [PDF]

Adam J. Bogdanove and Gregory B. Martin

AvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomato
PNAS 2000 97: 8836-8840. [Abstract] [Full Text] [PDF]  

Carl Nathan and Michael U. Shiloh

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
PNAS 2000 97: 8841-8848. [Abstract] [Full Text] [PDF] [Supplemental Table]  

Daniel F. Klessig, Jörg Durner, Robert Noad, Duroy A. Navarre, David Wendehenne, Dhirendra Kumar, Jun Ma Zhou, Jyoti Shah, Shuqun Zhang, Pradeep Kachroo, Youssef Trifa, Dominique Pontier, Eric Lam, and Herman Silva

Nitric oxide and salicylic acid signaling in plant defense
PNAS 2000 97: 8849-8855. [Abstract] [Full Text] [PDF]  

Robert E. W. Hancock and Monisha G. Scott

The role of antimicrobial peptides in animal defenses
PNAS 2000 97: 8856-8861. [Abstract] [Full Text] [PDF]  

Johannes Stratmann, Justin Scheer, and Clarence A. Ryan

Suramin inhibits initiation of defense signaling by systemin, chitosan, and a -glucan elicitor in suspension-cultured Lycopersicon peruvianum cells
PNAS 2000 97: 8862-8867. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Chemistry

Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes

Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
PNAS 2000 97: 8868-8873; published online before print July 25, 2000, 10.1073/pnas.160259697 [Abstract] [Full Text] [PDF]  

Thomas Loerting and Klaus R. Liedl

Toward elimination of discrepancies between theory and experiment: The rate constant of the atmospheric conversion of SO₃ to H₂SO₄
PNAS 2000 97: 8874-8878. [Abstract] [Full Text] [PDF]  

Roman F. Nalewajski and Robert G. Parr

Information theory, atoms in molecules, and molecular similarity
PNAS 2000 97: 8879-8882. [Abstract] [Full Text] [PDF]  

Engineering

Michael E. Phelps INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Positron emission tomography provides molecular imaging of biological processes PNAS 2000 97: 9226-9233. [Abstract] [Full Text] [PDF]

SOCIAL SCIENCES
Social Sciences

Brian Skyrms and Robin Pemantle INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: A dynamic model of social network formation PNAS 2000 97: 9340-9346. [Abstract] [TeX] [PDF]

BIOLOGICAL SCIENCES
Biochemistry

Hassan Mziaut, George Korza, and Juris Ozols

The N terminus of microsomal 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation
PNAS 2000 97: 8883-8888. [Abstract] [Full Text] [PDF]  

Christian Ungermann, Albert Price, and William Wickner

A new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of docking
PNAS 2000 97: 8889-8891; published online before print July 25, 2000, 10.1073/pnas.160269997 [Abstract] [Full Text] [PDF]  

Joel R. Hoskins, Satyendra K. Singh, Michael R. Maurizi, and Sue Wickner

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP
PNAS 2000 97: 8892-8897. [Abstract] [Full Text] [PDF]  

Satyendra K. Singh, Regis Grimaud, Joel R. Hoskins, Sue Wickner, and Michael R. Maurizi

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP
PNAS 2000 97: 8898-8903. [Abstract] [Full Text] [PDF]  

Mario Cinquanta, Alessandra C. Rovescalli, Christine A. Kozak, and Marshall Nirenberg

Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos
PNAS 2000 97: 8904-8909. [Abstract] [Full Text] [PDF]  

Gregory S. Taylor, Tomohiko Maehama, and Jack E. Dixon INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate PNAS 2000 97: 8910-8915; published online before print July 18, 2000, 10.1073/pnas.160255697 [Abstract] [Full Text] [PDF]

Penny J. Beuning and Karin Musier-Forsyth

Hydrolytic editing by a class II aminoacyl-tRNA synthetase
PNAS 2000 97: 8916-8920. [Abstract] [Full Text] [PDF]  

David I. Roper, Trevor Huyton, Alexei Vagin, and Guy Dodson

The molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of D-alanyl-D-lactate ligase (VanA)
PNAS 2000 97: 8921-8925; published online before print July 25, 2000, 10.1073/pnas.150116497 [Abstract] [Full Text] [PDF]  

Alonzo D. Garcia, L. Aravind, Eugene V. Koonin, and Bernard Moss

Bacterial-type DNA Holliday junction resolvases in eukaryotic viruses
PNAS 2000 97: 8926-8931; published online before print July 11, 2000, 10.1073/pnas.150238697 [Abstract] [Full Text] [PDF]  

Seung-Je Cho, Myong Gyong Lee, Jin Kuk Yang, Jae Young Lee, Hyun Kyu Song, and Se Won Suh

Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family
PNAS 2000 97: 8932-8937; published online before print July 25, 2000, 10.1073/pnas.160270897 [Abstract] [Full Text] [PDF]  

Adam B. Weinglass and H. Ronald Kaback

The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion
PNAS 2000 97: 8938-8943; published online before print July 4, 2000, 10.1073/pnas.140224497 [Abstract] [Full Text] [PDF]  

Todd A. Naumann and William S. Reznikoff

Trans catalysis in Tn5 transposition
PNAS 2000 97: 8944-8949; published online before print July 25, 2000, 10.1073/pnas.160107997 [Abstract] [Full Text] [PDF]  

Gregory A. Weiss, Colin K. Watanabe, Alan Zhong, Audrey Goddard, and Sachdev S. Sidhu

Rapid mapping of protein functional epitopes by combinatorial alanine scanning
PNAS 2000 97: 8950-8954; published online before print July 25, 2000, 10.1073/pnas.160252097 [Abstract] [Full Text] [PDF]  

Alessandro Michienzi, Laurence Cagnon, Ingrid Bahner, and John J. Rossi

Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA
PNAS 2000 97: 8955-8960. [Abstract] [Full Text] [PDF]  

Hong Ye and Hao Wu

Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry
PNAS 2000 97: 8961-8966; published online before print July 25, 2000, 10.1073/pnas.160241997 [Abstract] [Full Text] [PDF]  

Zsofia Palfi, Stephan Lücke, Hans-Werner Lahm, William S. Lane, Volker Kruft, Elisabeth Bragado-Nilsson, Bertrand Séraphin, and Albrecht Bindereif

The spliceosomal snRNP core complex of Trypanosoma brucei: Cloning and functional analysis reveals seven Sm protein constituents
PNAS 2000 97: 8967-8972; published online before print July 18, 2000, 10.1073/pnas.150236097 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Michael Gmachl, Christian Gieffers, Alexandre V. Podtelejnikov, Matthias Mann, and Jan-Michael Peters

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
PNAS 2000 97: 8973-8978. [Abstract] [Full Text] [PDF]  

Marina Ramírez-Alvarado, Jane S. Merkel, and Lynne Regan

A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro
PNAS 2000 97: 8979-8984; published online before print July 25, 2000, 10.1073/pnas.150091797 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Alexandra Dace, Li Zhao, Kyung Soo Park, T. Furuno, N. Takamura, M. Nakanishi, Brian L. West, John A. Hanover, and Sheue-yann Cheng

Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
PNAS 2000 97: 8985-8990; published online before print July 25, 2000, 10.1073/pnas.160257997 [Abstract] [Full Text] [PDF]  

Tammie C. Yeh, Elisabetta Dondi, Gilles Uzé, and Sandra Pellegrini

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon- signaling
PNAS 2000 97: 8991-8996; published online before print July 25, 2000, 10.1073/pnas.160130297 [Abstract] [Full Text] [PDF]  

Ronglan Zheng, Rodolfo Ghirlando, Myung Soo Lee, Kiyoshi Mizuuchi, Michael Krause, and Robert Craigie

Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
PNAS 2000 97: 8997-9002; published online before print July 25, 2000, 10.1073/pnas.150240197 [Abstract] [Full Text] [PDF]  

Zhongjun Luo, Margaret A. Macris, A. Fawad Faruqi, and Peter M. Glazer

High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells
PNAS 2000 97: 9003-9008; published online before print July 18, 2000, 10.1073/pnas.160004997 [Abstract] [Full Text] [PDF]  

Christopher J. Schwartz, Ouliana Djaman, James A. Imlay, and Patricia J. Kiley

The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli
PNAS 2000 97: 9009-9014; published online before print July 25, 2000, 10.1073/pnas.160261497 [Abstract] [Full Text] [PDF]  

Sherry M. Carty, Aaron C. Goldstrohm, Carles Suñé, Mariano A. Garcia-Blanco, and Arno L. Greenleaf

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II
PNAS 2000 97: 9015-9020; published online before print July 25, 2000, 10.1073/pnas.160266597 [Abstract] [Full Text] [PDF]  

Biophysics

Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes

Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
PNAS 2000 97: 8868-8873; published online before print July 25, 2000, 10.1073/pnas.160259697 [Abstract] [Full Text] [PDF]  

G. Marius Clore

Accurate and rapid docking of protein-protein complexes on the basis of intermolecular nuclear Overhauser enhancement data and dipolar couplings by rigid body minimization
PNAS 2000 97: 9021-9025. [Abstract] [Full Text] [PDF]  

David G. Myszka, Raymond W. Sweet, Preston Hensley, Michael Brigham-Burke, Peter D. Kwong, Wayne A. Hendrickson, Richard Wyatt, Joseph Sodroski, and Michael L. Doyle

Energetics of the HIV gp120-CD4 binding reaction
PNAS 2000 97: 9026-9031. [Abstract] [Full Text] [PDF]  

George S. Attard, Richard H. Templer, Wendy S. Smith, Alan N. Hunt, and Suzanne Jackowski

Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress
PNAS 2000 97: 9032-9036; published online before print July 25, 2000, 10.1073/pnas.160260697 [Abstract] [Full Text] [PDF]  

J. Satulovsky, M. A. Carignano, and I. Szleifer

Kinetic and thermodynamic control of protein adsorption
PNAS 2000 97: 9037-9041; published online before print July 25, 2000, 10.1073/pnas.150236197 [Abstract] [Full Text] [PDF]  

Cell Biology

Sandrine Cariou, Jeffrey C. H. Donovan, W. M. Flanagan, Andrea Milic, Nandita Bhattacharya, and Joyce M. Slingerland

Down-regulation of p21^WAF1/CIP1 or p27^Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
PNAS 2000 97: 9042-9046; published online before print July 25, 2000, 10.1073/pnas.160016897 [Abstract] [Full Text] [PDF]  

Joke G. Orsel, Paul M. Sincock, Jeffrey P. Krise, and Suzanne R. Pfeffer

Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein
PNAS 2000 97: 9047-9051; published online before print July 25, 2000, 10.1073/pnas.160251397 [Abstract] [Full Text] [PDF]  

Leena Hajra, Andrew I. Evans, Mian Chen, Sharon J. Hyduk, Tucker Collins, and Myron I. Cybulsky

The NF-B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
PNAS 2000 97: 9052-9057. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Peter E. Light, Christopher Bladen, Robert J. Winkfein, Michael P. Walsh, and Robert J. French

Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels
PNAS 2000 97: 9058-9063; published online before print July 25, 2000, 10.1073/pnas.160068997 [Abstract] [Full Text] [PDF]  

Benjamin Boettner, Eve-Ellen Govek, Justin Cross, and Linda Van Aelst

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin
PNAS 2000 97: 9064-9069. [Abstract] [Full Text] [PDF]  

Paola Massari, Yu Ho, and Lee M. Wetzler

Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis
PNAS 2000 97: 9070-9075. [Abstract] [Full Text] [PDF]  

Hajime Yano, Hiroshi Uchida, Teruo Iwasaki, Mutsuko Mukai, Hitoshi Akedo, Kuniaki Nakamura, Shigeru Hashimoto, and Hisataka Sabe

Paxillin  and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation
PNAS 2000 97: 9076-9081. [Abstract] [Full Text] [PDF]  

Richard K. Bruick

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
PNAS 2000 97: 9082-9087. [Abstract] [Full Text] [PDF]  

Lori Lommel, Miriam E. Bucheli, and Kevin S. Sweder

Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndrome
PNAS 2000 97: 9088-9092; published online before print July 18, 2000, 10.1073/pnas.150130197 [Abstract] [Full Text] [PDF]  

Developmental Biology

Jin-Hua Han, Si Hyoung Lee, Yue-Qing Tan, Ellen K. LeMosy, and Carl Hashimoto

Gastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo
PNAS 2000 97: 9093-9097. [Abstract] [Full Text] [PDF]  

Bryan Julien, A. Dale Kaiser, and Anthony Garza

Spatial control of cell differentiation in Myxococcus xanthus
PNAS 2000 97: 9098-9103. [Abstract] [Full Text] [PDF]  

I. I. Slukvin, D. P. Lunn, D. I. Watkins, and T. G. Golos

Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey
PNAS 2000 97: 9104-9109. [Abstract] [Full Text] [PDF]  

Evolution

William Swenson, David Sloan Wilson, and Roberta Elias From the Cover: Artificial ecosystem selection PNAS 2000 97: 9110-9114; published online before print July 11, 2000, 10.1073/pnas.150237597 [Abstract] [Full Text] [PDF]

Mats Dynesius and Roland Jansson

Evolutionary consequences of changes in species' geographical distributions driven by Milankovitch climate oscillations
PNAS 2000 97: 9115-9120. [Abstract] [Full Text] [PDF]  

Hsin-Mei Ku, Todd Vision, Jiping Liu, and Steven D. Tanksley

Comparing sequenced segments of the tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss creates a network of synteny
PNAS 2000 97: 9121-9126; published online before print July 25, 2000, 10.1073/pnas.160271297 [Abstract] [Full Text] [PDF]  

Genetics

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood III, Kevin G. Becker, and Minoru S. H. Ko

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray
PNAS 2000 97: 9127-9132. [Abstract] [Full Text] [PDF]  

Anjanette M. Searfoss and Reed B. Wickner

3' poly(A) is dispensable for translation
PNAS 2000 97: 9133-9137. [Abstract] [Full Text] [PDF]  

Margarita Flores, Patrick Mavingui, Xavier Perret, William J. Broughton, David Romero, Georgina Hernández, Guillermo Dávila, and Rafael Palacios

Prediction, identification, and artificial selection of DNA rearrangements in Rhizobium: Toward a natural genomic design
PNAS 2000 97: 9138-9143. [Abstract] [Full Text] [PDF]  

Vladimir Kokoza, Abduelaziz Ahmed, Wen-Long Cho, Nijole Jasinskiene, Anthony A. James, and Alexander Raikhel

Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti
PNAS 2000 97: 9144-9149; published online before print July 25, 2000, 10.1073/pnas.160258197 [Abstract] [Full Text] [PDF]  

David W. Emery, Evangelia Yannaki, Julie Tubb, and George Stamatoyannopoulos

A chromatin insulator protects retrovirus vectors from chromosomal position effects
PNAS 2000 97: 9150-9155; published online before print July 25, 2000, 10.1073/pnas.160159597 [Abstract] [Full Text] [PDF]  

Immunology

Hong-Bing Shu and Holly Johnson

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
PNAS 2000 97: 9156-9161; published online before print July 25, 2000, 10.1073/pnas.160213497 [Abstract] [Full Text] [PDF]  

Manuela Cota, Manuela Mengozzi, Elisa Vicenzi, Paola Panina-Bordignon, Francesco Sinigaglia, Pietro Transidico, Silvano Sozzani, Alberto Mantovani, and Guido Poli

Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine
PNAS 2000 97: 9162-9167; published online before print July 25, 2000, 10.1073/pnas.160359197 [Abstract] [Full Text] [PDF]  

Medical Sciences

Arndt Borkhardt, Stig Bojesen, Oskar A. Haas, Uta Fuchs, Dominique Bartelheimer, Ivan F. Loncarevic, Rainer M. Bohle, Jochen Harbott, Reinald Repp, Ulrich Jaeger, Susanne Viehmann, Traudl Henn, Petra Korth, Dirk Scharr, and Fritz Lampert

The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q
PNAS 2000 97: 9168-9173; published online before print July 25, 2000, 10.1073/pnas.150079597 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Donald Metcalf, Ladina Di Rago, Sandra Mifsud, Lynne Hartley, and Warren S. Alexander

The development of fatal myocarditis and polymyositis in mice heterozygous for IFN- and lacking the SOCS-1 gene
PNAS 2000 97: 9174-9179; published online before print July 25, 2000, 10.1073/pnas.160255197 [Abstract] [Full Text] [PDF]  

Naoual Benali, Pierre Cordelier, Denis Calise, Philippe Pagès, Philippe Rochaix, Attila Nagy, Jean-Pierre Estève, Parviz M. Pour, Andrew V. Schally, Nicole Vaysse, Christiane Susini, and Louis Buscail

Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238
PNAS 2000 97: 9180-9185; published online before print July 18, 2000, 10.1073/pnas.130196697 [Abstract] [Full Text] [PDF]  

Mindy Tsai, Jochen Wedemeyer, Soula Ganiatsas, See-Ying Tam, Leonard I. Zon, and Stephen J. Galli

In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo
PNAS 2000 97: 9186-9190; published online before print July 25, 2000, 10.1073/pnas.160254997 [Abstract] [Full Text] [PDF]  

Jeffrey S. Schechner, Anjali K. Nath, Lian Zheng, Martin S. Kluger, Christopher C. W. Hughes, M. Rocio Sierra-Honigmann, Marc I. Lorber, George Tellides, Michael Kashgarian, Alfred L. M. Bothwell, and Jordan S. Pober

In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
PNAS 2000 97: 9191-9196; published online before print July 11, 2000, 10.1073/pnas.150242297 [Abstract] [Full Text] [PDF]  

Thomas Meyer, Michaela Kneissel, Jean Mariani, and Brigitte Fournier

In vitro and in vivo evidence for orphan nuclear receptor ROR function in bone metabolism
PNAS 2000 97: 9197-9202; published online before print July 18, 2000, 10.1073/pnas.150246097 [Abstract] [Full Text] [PDF]  

Kerstin Koetz, Ewa Bryl, Kay Spickschen, W. Michael O'Fallon, Jörg J. Goronzy, and Cornelia M. Weyand

T cell homeostasis in patients with rheumatoid arthritis
PNAS 2000 97: 9203-9208. [Abstract] [Full Text] [PDF]  

Kanneboyina Nagaraju, Nina Raben, Lisa Loeffler, Tomasina Parker, Paul J. Rochon, Eunice Lee, Carol Danning, Ryuichi Wada, Cynthia Thompson, Gul Bahtiyar, Joseph Craft, Rob Hooft van Huijsduijnen, and Paul Plotz From the Cover: Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies PNAS 2000 97: 9209-9214. [Abstract] [Full Text] [PDF]

P. J. Moos, K. Edes, and F. A. Fitzpatrick

Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
PNAS 2000 97: 9215-9220; published online before print July 25, 2000, 10.1073/pnas.160241897 [Abstract] [Full Text] [PDF]  

Zhiwei Hu and Alan Garen

Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy
PNAS 2000 97: 9221-9225. [Abstract] [Full Text] [PDF]  

Michael E. Phelps INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Positron emission tomography provides molecular imaging of biological processes PNAS 2000 97: 9226-9233. [Abstract] [Full Text] [PDF]

Henrik J. Ditzel, Yasufumi Masaki, Heidi Nielsen, Lauge Farnaes, and Dennis R. Burton

Cloning and expression of a novel human antibody-antigen pair associated with Felty's syndrome
PNAS 2000 97: 9234-9239. [Abstract] [Full Text] [PDF]  

Microbiology

Evan T. Saulino, Esther Bullitt, and Scott J. Hultgren

Snapshots of usher-mediated protein secretion and ordered pilus assembly
PNAS 2000 97: 9240-9245; published online before print July 25, 2000, 10.1073/pnas.160070497 [Abstract] [Full Text] [PDF]  

Leendert W. Hamoen, Aske F. Van Werkhoven, Gerard Venema, and David Dubnau

The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis
PNAS 2000 97: 9246-9251; published online before print July 25, 2000, 10.1073/pnas.160010597 [Abstract] [Full Text] [PDF]  

Keith M. Haan and Richard Longnecker

Coreceptor restriction within the HLA-DQ locus for Epstein-Barr virus infection
PNAS 2000 97: 9252-9257; published online before print July 25, 2000, 10.1073/pnas.160171697 [Abstract] [Full Text] [PDF]  

Gerald F. Späth, Linda Epstein, Ben Leader, Steven M. Singer, Herbert A. Avila, Salvatore J. Turco, and Stephen M. Beverley

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
PNAS 2000 97: 9258-9263; published online before print July 25, 2000, 10.1073/pnas.160257897 [Abstract] [Full Text] [PDF]  

Neurobiology

Bret N. Smith, Bruce W. Banfield, Cynthia A. Smeraski, Christine L. Wilcox, F. Edward Dudek, Lynn W. Enquist, and Gary E. Pickard

Pseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits
PNAS 2000 97: 9264-9269. [Abstract] [Full Text] [PDF]  

Clare R. Ozawa, Jill J. Ho, David J. Tsai, Dora Y. Ho, and Robert M. Sapolsky

Neuroprotective potential of a viral vector system induced by a neurological insult
PNAS 2000 97: 9270-9275; published online before print July 25, 2000, 10.1073/pnas.160503997 [Abstract] [Full Text] [PDF]  

Gregory J. Popken, William E. Bunney Jr., Steven G. Potkin, and Edward G. Jones

Subnucleus-specific loss of neurons in medial thalamus of schizophrenics
PNAS 2000 97: 9276-9280; published online before print July 25, 2000, 10.1073/pnas.150243397 [Abstract] [Full Text] [PDF]  

Alexander Ploghaus, Irene Tracey, Stuart Clare, Joseph S. Gati, J. Nicholas P. Rawlins, and Paul M. Matthews

Learning about pain: The neural substrate of the prediction error for aversive events
PNAS 2000 97: 9281-9286; published online before print July 25, 2000, 10.1073/pnas.160266497 [Abstract] [Full Text] [PDF]  

Jian Feng, Zhen Yan, Adriana Ferreira, Kazuhito Tomizawa, Jason A. Liauw, Min Zhuo, Patrick B. Allen, Charles C. Ouimet, and Paul Greengard

Spinophilin regulates the formation and function of dendritic spines
PNAS 2000 97: 9287-9292. [Abstract] [Full Text] [PDF]  

Joyce H. Hurley, Anne L. Cahill, Kevin P. M. Currie, and Aaron P. Fox

The role of dynamic palmitoylation in Ca²⁺ channel inactivation
PNAS 2000 97: 9293-9298; published online before print July 18, 2000, 10.1073/pnas.160589697 [Abstract] [Full Text] [PDF]  

Weiming Xia, William J. Ray, Beth L. Ostaszewski, Talat Rahmati, W. Taylor Kimberly, Michael S. Wolfe, Jimin Zhang, Alison M. Goate, and Dennis J. Selkoe

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid -protein generation
PNAS 2000 97: 9299-9304. [Abstract] [Full Text] [PDF]  

Pharmacology

Maria Paola Mascia, James R. Trudell, and R. Adron Harris

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
PNAS 2000 97: 9305-9310; published online before print July 25, 2000, 10.1073/pnas.160128797 [Abstract] [Full Text] [PDF]  

Chang-Seon Myung and James C. Garrison

Role of C-terminal domains of the G protein  subunit in the activation of effectors
PNAS 2000 97: 9311-9316. [Abstract] [Full Text] [PDF]  

Physiology

Kathleen E. Bethin, Sherri K. Vogt, and Louis J. Muglia

Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
PNAS 2000 97: 9317-9322. [Abstract] [Full Text] [PDF]  

Plant Biology

Steven J. Clough, Kevin A. Fengler, I-ching Yu, Bernadette Lippok, Roger K. Smith Jr., and Andrew F. Bent

The Arabidopsis dnd1 "defense, no death" gene encodes a mutated cyclic nucleotide-gated ion channel
PNAS 2000 97: 9323-9328; published online before print July 18, 2000, 10.1073/pnas.150005697 [Abstract] [Full Text] [PDF]  

Michael A. Birkett, Colin A. M. Campbell, Keith Chamberlain, Emilio Guerrieri, Alastair J. Hick, Janet L. Martin, Michaela Matthes, Johnathan A. Napier, Jan Pettersson, John A. Pickett, Guy M. Poppy, Eleanor M. Pow, Barry J. Pye, Lesley E. Smart, George H. Wadhams, Lester J. Wadhams, and Christine M. Woodcock

New roles for cis-jasmone as an insect semiochemical and in plant defense
PNAS 2000 97: 9329-9334; published online before print July 18, 2000, 10.1073/pnas.160241697 [Abstract] [Full Text] [PDF]  

Population Biology

Simon I. Hay, Monica F. Myers, Donald S. Burke, David W. Vaughn, Timothy Endy, Nisalak Ananda, G. Dennis Shanks, Robert W. Snow, and David J. Rogers

Etiology of interepidemic periods of mosquito-borne disease
PNAS 2000 97: 9335-9339. [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for vol. 97, p. 3100 [Full Text]  

Correction for vol. 96, p. 8819 [Full Text]