COMMENTARIES

Vincent M. Cassone

The self-same beat of time's wide wings
PNAS 2000 97: 11677-11679. [Full Text] [PDF]  

Ernesto Freire

Can allosteric regulation be predicted from structure?
PNAS 2000 97: 11680-11682. [Full Text] [PDF]  

Robert S. Kass and Candido Cabo

Channel structure and drug-induced cardiac arrhythmias
PNAS 2000 97: 11683-11684. [Full Text] [PDF]  

Michael Waring

Facilitating structural transitions in DNA
PNAS 2000 97: 11685-11687. [Full Text] [PDF]  

Steven R. Beissinger

Ecological mechanisms of extinction
PNAS 2000 97: 11688-11689. [Full Text] [PDF]  

COLLOQUIUM:
Papers from the National Academy of Sciences Colloquium on Auditory Neuroscience: Development, Transduction, and Integration

A. J. Hudspeth and Masakazu Konishi

INTRODUCTION -- Auditory neuroscience: Development, transduction, and integration
PNAS 2000 97: 11690-11691. [Abstract] [Full Text] [PDF]  

Mark Eddison, Isabelle Le Roux, and Julian Lewis

Notch signaling in the development of the inner ear: Lessons from Drosophila
PNAS 2000 97: 11692-11699. [Abstract] [Full Text] [PDF]  

John V. Brigande, Amy E. Kiernan, Xiaoying Gao, Laurie E. Iten, and Donna M. Fekete

Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
PNAS 2000 97: 11700-11706. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Raquel Cantos, Laura K. Cole, Dario Acampora, Antonio Simeone, and Doris K. Wu

Patterning of the mammalian cochlea
PNAS 2000 97: 11707-11713. [Abstract] [Full Text] [PDF]  

Jennifer S. Stone and Edwin W Rubel

Cellular studies of auditory hair cell regeneration in birds
PNAS 2000 97: 11714-11721. [Abstract] [Full Text] [PDF]  

Richard A. Baird, Miriam D. Burton, David S. Fashena, and Rebecca A. Naeger

Hair cell recovery in mitotically blocked cultures of the bullfrog saccule
PNAS 2000 97: 11722-11729. [Abstract] [Full Text] [PDF]  

Jeffrey R. Holt and David P. Corey

Two mechanisms for transducer adaptation in vertebrate hair cells
PNAS 2000 97: 11730-11735. [Abstract] [Full Text] [PDF]  

Geoffrey A. Manley

Cochlear mechanisms from a phylogenetic viewpoint
PNAS 2000 97: 11736-11743. [Abstract] [Full Text] [PDF]  

Mario A. Ruggero, S. Shyamla Narayan, Andrei N. Temchin, and Alberto Recio

Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: Comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla
PNAS 2000 97: 11744-11750. [Abstract] [Full Text] [PDF]  

K. E. Nilsen and I. J. Russell

The spatial and temporal representation of a tone on the guinea pig basilar membrane
PNAS 2000 97: 11751-11758. [Abstract] [Full Text] [PDF]  

Jonathan F. Ashmore, Gwénaëlle S. G. Géléoc, and Lene Harbott

Molecular mechanisms of sound amplification in the mammalian cochlea
PNAS 2000 97: 11759-11764. [Abstract] [Full Text] [PDF]  

A. J. Hudspeth, Y. Choe, A. D. Mehta, and P. Martin

Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells
PNAS 2000 97: 11765-11772. [Abstract] [Full Text] [PDF]  

Donata Oertel, Ramazan Bal, Stephanie M. Gardner, Philip H. Smith, and Philip X. Joris

Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus
PNAS 2000 97: 11773-11779. [Abstract] [Full Text] [PDF]  

Jane J. Yu and Eric D. Young

Linear and nonlinear pathways of spectral information transmission in the cochlear nucleus
PNAS 2000 97: 11780-11786. [Abstract] [Full Text] [PDF]  

José Luis Peña and Masakazu Konishi

Cellular mechanisms for resolving phase ambiguity in the owl's inferior colliculus
PNAS 2000 97: 11787-11792. [Abstract] [Full Text] [PDF]  

Jon H. Kaas and Troy A. Hackett

Subdivisions of auditory cortex and processing streams in primates
PNAS 2000 97: 11793-11799. [Abstract] [Full Text] [PDF]  

Josef P. Rauschecker and Biao Tian

Mechanisms and streams for processing of "what" and "where" in auditory cortex
PNAS 2000 97: 11800-11806. [Abstract] [Full Text] [PDF]  

Nobuo Suga, Enquan Gao, Yunfeng Zhang, Xiaofeng Ma, and John F. Olsen

The corticofugal system for hearing: Recent progress
PNAS 2000 97: 11807-11814. [Abstract] [Full Text] [PDF]  

Eric I. Knudsen, Weimin Zheng, and William M. DeBello

Traces of learning in the auditory localization pathway
PNAS 2000 97: 11815-11820. [Abstract] [Full Text] [PDF]  

Andrew J. King, Carl H. Parsons, and David R. Moore

Plasticity in the neural coding of auditory space in the mammalian brain
PNAS 2000 97: 11821-11828. [Abstract] [Full Text] [PDF]  

Gregg H. Recanzone

Spatial processing in the auditory cortex of the macaque monkey
PNAS 2000 97: 11829-11835. [Abstract] [Full Text] [PDF]  

Michele M. Solis, Michael S. Brainard, Neal A. Hessler, and Allison J. Doupe

Song selectivity and sensorimotor signals in vocal learning and production
PNAS 2000 97: 11836-11842. [Abstract] [Full Text] [PDF]  

Xiaoqin Wang

On cortical coding of vocal communication sounds in primates
PNAS 2000 97: 11843-11849. [Abstract] [Full Text] [PDF]  

Patricia K. Kuhl

A new view of language acquisition
PNAS 2000 97: 11850-11857. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Physical Sciences

William J. Trush, Scott M. McBain, and Luna B. Leopold

Attributes of an alluvial river and their relation to water policy and management
PNAS 2000 97: 11858-11863. [Abstract] [Full Text] [PDF]  

Chemistry

Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida

Atmospheric aerosols as prebiotic chemical reactors
PNAS 2000 97: 11864-11868; published online before print October 17, 2000, 10.1073/pnas.200366897 [Abstract] [Full Text] [PDF]  

David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
PNAS 2000 97: 11869-11874. [Abstract] [Full Text] [PDF]  

Geology

Nikolai V. Sobolev, Boris A. Fursenko, Sergei V. Goryainov, Jinfu Shu, Russell J. Hemley, Ho-kwang Mao, and Francis R. Boyd

Fossilized high pressure from the Earth's deep interior: The coesite-in-diamond barometer
PNAS 2000 97: 11875-11879; published online before print October 17, 2000, 10.1073/pnas.220408697 [Abstract] [Full Text] [PDF]  

Geophysics

Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida

Atmospheric aerosols as prebiotic chemical reactors
PNAS 2000 97: 11864-11868; published online before print October 17, 2000, 10.1073/pnas.200366897 [Abstract] [Full Text] [PDF]  

Leon Knopoff

The magnitude distribution of declustered earthquakes in Southern California
PNAS 2000 97: 11880-11884; published online before print October 17, 2000, 10.1073/pnas.190241297 [Abstract] [Full Text] [PDF]  

Statistics

Adrian Dobra and Stephen E. Fienberg INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Bounds for cell entries in contingency tables given marginal totals and decomposable graphs PNAS 2000 97: 11885-11892. [Abstract] [Full Text] [PDF]

SOCIAL SCIENCES
Social Sciences

Devon D. Brewer, John J. Potterat, Sharon B. Garrett, Stephen Q. Muth, John M. Roberts Jr., Danuta Kasprzyk, Daniel E. Montano, and William W. Darrow From the Cover: Prostitution and the sex discrepancy in reported number of sexual partners PNAS 2000 97: 12385-12388; published online before print October 10, 2000, 10.1073/pnas.210392097 [Abstract] [Full Text] [PDF] [Supplemental Appendix]

BIOLOGICAL SCIENCES
Applied Biological Sciences

Vassilis Doucas, Yanhong Shi, Shigeki Miyamoto, Andrew West, Inder Verma, and Ronald M. Evans

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-B and the glucocorticoid receptor
PNAS 2000 97: 11893-11898; published online before print October 10, 2000, 10.1073/pnas.220413297 [Abstract] [Full Text] [PDF]  

Biochemistry

J. Villà, M. trajbl, T. M. Glennon, Y. Y. Sham, Z. T. Chu, and A. Warshel

How important are entropic contributions to enzyme catalysis?
PNAS 2000 97: 11899-11904. [Abstract] [Full Text] [PDF]  

Joseph Bass, Christopher Turck, Mathias Rouard, and Donald F. Steiner

Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors
PNAS 2000 97: 11905-11909. [Abstract] [Full Text] [PDF]  

Melissa D. Michelitsch and Jonathan S. Weissman

A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions
PNAS 2000 97: 11910-11915. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Jay Parrish, Helen Metters, Lin Chen, and Ding Xue

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors
PNAS 2000 97: 11916-11921; published online before print October 10, 2000, 10.1073/pnas.210391597 [Abstract] [Full Text] [PDF]  

Angela Lombardi, Daniela Marasco, Ornella Maglio, Luigi Di Costanzo, Flavia Nastri, and Vincenzo Pavone

Miniaturized metalloproteins: Application to iron-sulfur proteins
PNAS 2000 97: 11922-11927. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cherie Purring-Koch and George McLendon

Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength
PNAS 2000 97: 11928-11931; published online before print October 17, 2000, 10.1073/pnas.220416197 [Abstract] [Full Text] [PDF]  

John H. Laity, H. Jane Dyson, and Peter E. Wright

Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein
PNAS 2000 97: 11932-11935. [Abstract] [Full Text] [PDF]  

Connie Chao, Shin'ichi Saito, Carl W. Anderson, Ettore Appella, and Yang Xu

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
PNAS 2000 97: 11936-11941; published online before print October 17, 2000, 10.1073/pnas.220252297 [Abstract] [Full Text] [PDF]  

Huawei Chen, Michael G. Thomas, Brian K. Hubbard, Heather C. Losey, Christopher T. Walsh, and Michael D. Burkart

Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis
PNAS 2000 97: 11942-11947; published online before print October 17, 2000, 10.1073/pnas.210395097 [Abstract] [Full Text] [PDF]  

Michel Schalk and Rodney Croteau

A single amino acid substitution (F363I) converts the regiochemistry of the spearmint ()-limonene hydroxylase from a C6- to a C3-hydroxylase
PNAS 2000 97: 11948-11953. [Abstract] [Full Text] [PDF]  

Guy Patchornik, Rivka Goldshleger, and Steven J. D. Karlish

The complex ATP-Fe²⁺ serves as a specific affinity cleavage reagent in ATP-Mg²⁺ sites of Na,K-ATPase: Altered ligation of Fe²⁺ (Mg²⁺) ions accompanies the E₁PE₂P conformational change
PNAS 2000 97: 11954-11959; published online before print October 17, 2000, 10.1073/pnas.220332897 [Abstract] [Full Text] [PDF]  

Xianjun Fang, Shuang Xing Yu, Yiling Lu, Robert C. Bast Jr., James R. Woodgett, and Gordon B. Mills

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
PNAS 2000 97: 11960-11965; published online before print October 17, 2000, 10.1073/pnas.220413597 [Abstract] [Full Text] [PDF]  

Bijoy K. Mohanty and Sidney R. Kushner

Polynucleotide phosphorylase functions both as a 3' 5' exonuclease and a poly(A) polymerase in Escherichia coli
PNAS 2000 97: 11966-11971; published online before print October 17, 2000, 10.1073/pnas.220295997 [Abstract] [Full Text] [PDF]  

Keiji Kimura and Tatsuya Hirano

Dual roles of the 11S regulatory subcomplex in condensin functions
PNAS 2000 97: 11972-11977; published online before print October 10, 2000, 10.1073/pnas.220326097 [Abstract] [Full Text] [PDF]  

Michele Wisniewski, Mini Balakrishnan, C. Palaniappan, Philip J. Fay, and Robert A. Bambara

Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
PNAS 2000 97: 11978-11983; published online before print October 17, 2000, 10.1073/pnas.210392297 [Abstract] [Full Text] [PDF]  

Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien

Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral
PNAS 2000 97: 11984-11989. [Abstract] [Full Text] [PDF]  

Larry A. Gross, Geoffrey S. Baird, Ross C. Hoffman, Kim K. Baldridge, and Roger Y. Tsien

The structure of the chromophore within DsRed, a red fluorescent protein from coral
PNAS 2000 97: 11990-11995. [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Biophysics

Ahmed A. Heikal, Samuel T. Hess, Geoffrey S. Baird, Roger Y. Tsien, and Watt W. Webb

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: Coral red (dsRed) and yellow (Citrine)
PNAS 2000 97: 11996-12001. [Abstract] [Full Text] [PDF]  

Berenike Maier, David Bensimon, and Vincent Croquette

Replication by a single DNA polymerase of a stretched single-stranded DNA
PNAS 2000 97: 12002-12007. [Abstract] [Full Text] [PDF]  

Mark T. Cancilla, Michael D. Leavell, Jason Chow, and Julie A. Leary

Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
PNAS 2000 97: 12008-12013; published online before print October 17, 2000, 10.1073/pnas.220403997 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Blake Gillespie and Kevin W. Plaxco

Nonglassy kinetics in the folding of a simple single-domain protein
PNAS 2000 97: 12014-12019. [Abstract] [Full Text] [PDF]  

Hong Pan, J. Ching Lee, and Vincent J. Hilser From the Cover: Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble PNAS 2000 97: 12020-12025; published online before print October 17, 2000, 10.1073/pnas.220240297 [Abstract] [Full Text] [PDF]

P. Martin, A. D. Mehta, and A. J. Hudspeth

Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell
PNAS 2000 97: 12026-12031; published online before print October 10, 2000, 10.1073/pnas.210389497 [Abstract] [Full Text] [PDF]  

Xiaogang Qu, John O. Trent, Izabela Fokt, Waldemar Priebe, and Jonathan B. Chaires From the Cover: Allosteric, chiral-selective drug binding to DNA PNAS 2000 97: 12032-12037; published online before print October 10, 2000, 10.1073/pnas.200221397 [Abstract] [Full Text] [PDF] [Supplemental Data]

Chung-Jung Tsai, Jacob V. Maizel Jr., and Ruth Nussinov

Anatomy of protein structures: Visualizing how a one-dimensional protein chain folds into a three-dimensional shape
PNAS 2000 97: 12038-12043. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cell Biology

John P. Incardona, Ju Ho Lee, Christie P. Robertson, Kristi Enga, Raj P. Kapur, and Henk Roelink

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
PNAS 2000 97: 12044-12049; published online before print October 10, 2000, 10.1073/pnas.220251997 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Yibin Deng and Xiangwei Wu

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria
PNAS 2000 97: 12050-12055. [Abstract] [Full Text] [PDF]  

Barbi A. Judd, Peggy S. Myung, Lijun Leng, Achim Obergfell, Warren S. Pear, Sanford J. Shattil, and Gary A. Koretzky

Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through IIb3 and collagen receptors
PNAS 2000 97: 12056-12061. [Abstract] [Full Text] [PDF]  

Vinit B. Mahajan, Karnire S. Pai, Alice Lau, and Dennis D. Cunningham

Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton
PNAS 2000 97: 12062-12067. [Abstract] [Full Text] [PDF]  

Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss

A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
PNAS 2000 97: 12068-12073; published online before print October 17, 2000, 10.1073/pnas.210397997 [Abstract] [Full Text] [PDF]  

Stephen P. O'Brien, Katja Seipel, Quintus G. Medley, Roderick Bronson, Rosalind Segal, and Michel Streuli

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
PNAS 2000 97: 12074-12078. [Abstract] [Full Text] [PDF]  

Gad Getz, Erel Levine, and Eytan Domany

Coupled two-way clustering analysis of gene microarray data
PNAS 2000 97: 12079-12084; published online before print October 17, 2000, 10.1073/pnas.210134797 [Abstract] [Full Text] [PDF]  

Kristi L. Neufeld, David A. Nix, Hal Bogerd, Yibin Kang, Mary C. Beckerle, Bryan R. Cullen, and Raymond L. White

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
PNAS 2000 97: 12085-12090; published online before print October 17, 2000, 10.1073/pnas.220401797 [Abstract] [Full Text] [PDF]  

Cormac T. Taylor, Glenn T. Furuta, Kristin Synnestvedt, and Sean P. Colgan

Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia
PNAS 2000 97: 12091-12096; published online before print October 17, 2000, 10.1073/pnas.220211797 [Abstract] [Full Text] [PDF]  

Asha Venkateswaran, Bryan A. Laffitte, Sean B. Joseph, Puiying A. Mak, Damien C. Wilpitz, Peter A. Edwards, and Peter Tontonoz

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR
PNAS 2000 97: 12097-12102; published online before print October 17, 2000, 10.1073/pnas.200367697 [Abstract] [Full Text] [PDF]  

Martin P. Playford, David Bicknell, Walter F. Bodmer, and Valentine M. Macaulay

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of -catenin
PNAS 2000 97: 12103-12108; published online before print October 17, 2000, 10.1073/pnas.210394297 [Abstract] [Full Text] [PDF]  

Janusz H. S. Kabarowski, Jamison D. Feramisco, Lu Q. Le, Jennifer L. Gu, Shiuh-Wen Luoh, Melvin I. Simon, and Owen N. Witte

Direct genetic demonstration of G13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement
PNAS 2000 97: 12109-12114. [Abstract] [Full Text] [PDF]  

Edward M. Marcotte, Ioannis Xenarios, Alexander M. van der Bliek, and David Eisenberg

Localizing proteins in the cell from their phylogenetic profiles
PNAS 2000 97: 12115-12120; published online before print October 17, 2000, 10.1073/pnas.220399497 [Abstract] [Full Text] [PDF]  

Developmental Biology

Atsuo Kawahara, Thomas Wilm, Lilianna Solnica-Krezel, and Igor B. Dawid

Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation
PNAS 2000 97: 12121-12126. [Abstract] [Full Text] [PDF]  

Ulrich Technau, Christoph Cramer von Laue, Fabian Rentzsch, Susanne Luft, Bert Hobmayer, Hans R. Bode, and Thomas W. Holstein

Parameters of self-organization in Hydra aggregates
PNAS 2000 97: 12127-12131. [Abstract] [Full Text] [PDF]  

Hiroshi Kubota and Lola M. Reid

Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen
PNAS 2000 97: 12132-12137. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Ronny Leemans, Boris Egger, Thomas Loop, Lars Kammermeier, Haiqiong He, Beate Hartmann, Ulrich Certa, Frank Hirth, and Heinrich Reichert

Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays
PNAS 2000 97: 12138-12143; published online before print October 17, 2000, 10.1073/pnas.210066997 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Ecology

Ian P. F. Owens and Peter M. Bennett From the Cover: Ecological basis of extinction risk in birds: Habitat loss versus human persecution and introduced predators PNAS 2000 97: 12144-12148; published online before print September 26, 2000, 10.1073/pnas.200223397 [Abstract] [Full Text] [PDF]

Evolution

Kenneth B. Armitage and Orlando A. Schwartz

Social enhancement of fitness in yellow-bellied marmots
PNAS 2000 97: 12149-12152; published online before print October 17, 2000, 10.1073/pnas.200196097 [Abstract] [Full Text] [PDF]  

Joseph W. Chihade, James R. Brown, Paul R. Schimmel, and Lluís Ribas de Pouplana

Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase
PNAS 2000 97: 12153-12157; published online before print October 17, 2000, 10.1073/pnas.220388797 [Abstract] [Full Text] [PDF]  

Genetics

Gad Getz, Erel Levine, and Eytan Domany

Coupled two-way clustering analysis of gene microarray data
PNAS 2000 97: 12079-12084; published online before print October 17, 2000, 10.1073/pnas.210134797 [Abstract] [Full Text] [PDF]  

Bing Guo, Cora A. Styles, Qinghua Feng, and Gerald R. Fink

A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating
PNAS 2000 97: 12158-12163; published online before print October 10, 2000, 10.1073/pnas.220420397 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Joel N. Hirschhorn, Pamela Sklar, Kerstin Lindblad-Toh, Yin-Mei Lim, Melisa Ruiz-Gutierrez, Stacey Bolk, Bradley Langhorst, Steven Schaffner, Ellen Winchester, and Eric S. Lander

SBE-TAGS: An array-based method for efficient single-nucleotide polymorphism genotyping
PNAS 2000 97: 12164-12169; published online before print October 17, 2000, 10.1073/pnas.210394597 [Abstract] [Full Text] [PDF]  

Arkady B. Khodursky, Brian J. Peter, Nicholas R. Cozzarelli, David Botstein, Patrick O. Brown, and Charles Yanofsky

DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli
PNAS 2000 97: 12170-12175; published online before print October 10, 2000, 10.1073/pnas.220414297 [Abstract] [Full Text] [PDF]  

Wailap Victor Ng, Sean P. Kennedy, Gregory G. Mahairas, Brian Berquist, Min Pan, Hem Dutt Shukla, Stephen R. Lasky, Nitin S. Baliga, Vesteinn Thorsson, Jennifer Sbrogna, Steven Swartzell, Douglas Weir, John Hall, Timothy A. Dahl, Russell Welti, Young Ah Goo, Brent Leithauser, Kim Keller, Randy Cruz, Michael J. Danson, David W. Hough, Deborah G. Maddocks, Peter E. Jablonski, Mark P. Krebs, Christine M. Angevine, Heather Dale, Thomas A. Isenbarger, Ronald F. Peck, Mechthild Pohlschroder, John L. Spudich, Kwang-Hwan Jung, Maqsudul Alam, Tracey Freitas, Shaobin Hou, Charles J. Daniels, Patrick P. Dennis, Arina D. Omer, Holger Ebhardt, Todd M. Lowe, Ping Liang, Monica Riley, Leroy Hood, and Shiladitya DasSarma From the Cover: Genome sequence of Halobacterium species NRC-1 PNAS 2000 97: 12176-12181; published online before print October 3, 2000, 10.1073/pnas.190337797 [Abstract] [Full Text] [PDF] [Supplemental Data]

Atul J. Butte, Pablo Tamayo, Donna Slonim, Todd R. Golub, and Isaac S. Kohane

Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
PNAS 2000 97: 12182-12186; published online before print October 10, 2000, 10.1073/pnas.220392197 [Abstract] [Full Text] [PDF]  

Kuei-Shu Tung, Eun-Jin Erica Hong, and G. Shirleen Roeder

The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80
PNAS 2000 97: 12187-12192; published online before print October 17, 2000, 10.1073/pnas.220464597 [Abstract] [Full Text] [PDF]  

Immunology

Bradford C. Braden, Fernando A. Goldbaum, Bi-Xing Chen, Austin N. Kirschner, Stephen R. Wilson, and Bernard F. Erlanger

X-ray crystal structure of an anti-Buckminsterfullerene antibody Fab fragment: Biomolecular recognition of C₆₀
PNAS 2000 97: 12193-12197; published online before print October 17, 2000, 10.1073/pnas.210396197 [Abstract] [Full Text] [PDF]  

Elke Jäger, Sacha Gnjatic, Yasuhiro Nagata, Elisabeth Stockert, Dirk Jäger, Julia Karbach, Antje Neumann, Julia Rieckenberg, Yao-Tseng Chen, Gerd Ritter, Eric Hoffman, Michael Arand, Lloyd J. Old, and Alexander Knuth

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers
PNAS 2000 97: 12198-12203; published online before print October 10, 2000, 10.1073/pnas.220413497 [Abstract] [Full Text] [PDF]  

Fred Lühder, Cynthia Chambers, James P. Allison, Christophe Benoist, and Diane Mathis

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
PNAS 2000 97: 12204-12209; published online before print October 17, 2000, 10.1073/pnas.200348397 [Abstract] [Full Text] [PDF]  

Sungae Cho, Vijay Mehra, Sybille Thoma-Uszynski, Steffen Stenger, Natalya Serbina, Richard J. Mazzaccaro, JoAnne L. Flynn, Peter F. Barnes, Scott Southwood, Esteban Celis, Barry R. Bloom, Robert L. Modlin, and Alessandro Sette

Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis
PNAS 2000 97: 12210-12215; published online before print October 17, 2000, 10.1073/pnas.210391497 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Medical Sciences

Vasantha Srikantan, Zhiqiang Zou, Gyorgy Petrovics, Linda Xu, Meena Augustus, Leland Davis, Jeffrey R. Livezey, Theresa Connell, Isabell A. Sesterhenn, Kiyoshi Yoshino, Gregory S. Buzard, F. K. Mostofi, David G. McLeod, Judd W. Moul, and Shiv Srivastava

PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer
PNAS 2000 97: 12216-12221. [Abstract] [Full Text] [PDF]  

Xue-Liang Du, Diane Edelstein, Luciano Rossetti, Ivan George Fantus, Howard Goldberg, Fuad Ziyadeh, Jie Wu, and Michael Brownlee

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
PNAS 2000 97: 12222-12226. [Abstract] [Full Text] [PDF]  

Alexander Pfeifer, Torsten Kessler, Steve Silletti, David A. Cheresh, and Inder M. Verma

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2
PNAS 2000 97: 12227-12232; published online before print October 17, 2000, 10.1073/pnas.220399597 [Abstract] [Full Text] [PDF]  

Young-Mi Lim, Stephane Wong, Gary Lau, Owen N. Witte, and John Colicelli

BCR/ABL inhibition by an escort/phosphatase fusion protein
PNAS 2000 97: 12233-12238; published online before print October 10, 2000, 10.1073/pnas.210253497 [Abstract] [Full Text] [PDF]  

Michael Ristow, Markus F. Pfister, Andrew J. Yee, Markus Schubert, Laura Michael, Chen-Yu Zhang, Kojhiro Ueki, M. Dodson Michael II, Bradford B. Lowell, and C. Ronald Kahn

Frataxin activates mitochondrial energy conversion and oxidative phosphorylation
PNAS 2000 97: 12239-12243; published online before print October 17, 2000, 10.1073/pnas.220403797 [Abstract] [Full Text] [PDF]  

Sergei N. Rodin and Andrew S. Rodin

Human lung cancer and p53: The interplay between mutagenesis and selection
PNAS 2000 97: 12244-12249; published online before print October 17, 2000, 10.1073/pnas.180320897 [Abstract] [Full Text] [PDF]  

Gregory J. Babcock and David A. Thorley-Lawson

Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors
PNAS 2000 97: 12250-12255; published online before print October 17, 2000, 10.1073/pnas.200366597 [Abstract] [Full Text] [PDF]  

Geoffrey Shaw, Marilyn B. Renfree, Michael W. Leihy, Cedric H. L. Shackleton, Esther Roitman, and Jean D. Wilson

Prostate formation in a marsupial is mediated by the testicular androgen 5-androstane-3,17-diol
PNAS 2000 97: 12256-12259; published online before print October 17, 2000, 10.1073/pnas.220412297 [Abstract] [Full Text] [PDF]  

Shane P. Dormady, Xin-Min Zhang, and Ross S. Basch

Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)
PNAS 2000 97: 12260-12265. [Abstract] [Full Text] [PDF]  

Eric Tse and Terence H. Rabbitts

Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy
PNAS 2000 97: 12266-12271. [Abstract] [Full Text] [PDF]  

Antonio J. Oliveira-dos-Santos, Goichi Matsumoto, Bryan E. Snow, Donglin Bai, Frank P. Houston, Ian Q. Whishaw, Sanjeev Mariathasan, Takehiko Sasaki, Andrew Wakeham, Pamela S. Ohashi, John C. Roder, Carol A. Barnes, David P. Siderovski, and Josef M. Penninger

Regulation of T cell activation, anxiety, and male aggression by RGS2
PNAS 2000 97: 12272-12277; published online before print October 10, 2000, 10.1073/pnas.220414397 [Abstract] [Full Text] [PDF]  

Meng Yang, Eugene Baranov, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman

Visualizing gene expression by whole-body fluorescence imaging
PNAS 2000 97: 12278-12282. [Abstract] [Full Text] [PDF]  

Microbiology

Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss

A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
PNAS 2000 97: 12068-12073; published online before print October 17, 2000, 10.1073/pnas.210397997 [Abstract] [Full Text] [PDF]  

Catherine A. Lee, Milton Silva, Andrew M. Siber, Aaron J. Kelly, Edouard Galyov, and Beth A. McCormick

A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration
PNAS 2000 97: 12283-12288. [Abstract] [Full Text] [PDF]  

Christopher F. Basler, Xiuyan Wang, Elke Mühlberger, Victor Volchkov, Jason Paragas, Hans-Dieter Klenk, Adolfo García-Sastre, and Peter Palese

The Ebola virus VP35 protein functions as a type I IFN antagonist
PNAS 2000 97: 12289-12294; published online before print October 10, 2000, 10.1073/pnas.220398297 [Abstract] [Full Text] [PDF]  

Greg Towers, Michael Bock, Samia Martin, Yasuhiro Takeuchi, Jonathan P. Stoye, and Olivier Danos

A conserved mechanism of retrovirus restriction in mammals
PNAS 2000 97: 12295-12299; published online before print October 10, 2000, 10.1073/pnas.200286297 [Abstract] [Full Text] [PDF]  

Neurobiology

David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
PNAS 2000 97: 11869-11874. [Abstract] [Full Text] [PDF]  

Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon

Functional switching of GABAergic synapses by ryanodine receptor activation
PNAS 2000 97: 12300-12305; published online before print October 10, 2000, 10.1073/pnas.210396697 [Abstract] [Full Text] [PDF]  

Minh Dang Nguyen, Roxanne C. Larivière, and Jean-Pierre Julien

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1
PNAS 2000 97: 12306-12311. [Abstract] [Full Text] [PDF]  

Avtandil Nanobashvili, Matti S. Airaksinen, Merab Kokaia, Jari Rossi, Fredrik Asztély, Klara Olofsdotter, Paul Mohapel, Mart Saarma, Olle Lindvall, and Zaal Kokaia

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor 2
PNAS 2000 97: 12312-12317. [Abstract] [Full Text] [PDF]  

Alice J. Paquette, Sharon E. Perez, and David J. Anderson

Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo
PNAS 2000 97: 12318-12323. [Abstract] [Full Text] [PDF]  

Roland Brandstätter, Vinod Kumar, Ute Abraham, and Eberhard Gwinner

Photoperiodic information acquired and stored in vivo is retained in vitro by a circadian oscillator, the avian pineal gland
PNAS 2000 97: 12324-12328; published online before print September 26, 2000, 10.1073/pnas.200354997 [Abstract] [Full Text] [PDF]  

Pharmacology

John S. Mitcheson, Jun Chen, Monica Lin, Chris Culberson, and Michael C. Sanguinetti

A structural basis for drug-induced long QT syndrome
PNAS 2000 97: 12329-12333; published online before print September 26, 2000, 10.1073/pnas.210244497 [Abstract] [Full Text] [PDF]  

Physiology

Damian McHugh, Elizabeth M. Sharp, Todd Scheuer, and William A. Catterall

Inhibition of cardiac L-type calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain
PNAS 2000 97: 12334-12338; published online before print October 17, 2000, 10.1073/pnas.210384297 [Abstract] [Full Text] [PDF]  

Linda Ste. Marie, Grant I. Miura, Donald J. Marsh, Keith Yagaloff, and Richard D. Palmiter

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
PNAS 2000 97: 12339-12344; published online before print October 10, 2000, 10.1073/pnas.220409497 [Abstract] [Full Text] [PDF]  

Plant Biology

Paloma Más and Roger N. Beachy

Role of microtubules in the intracellular distribution of tobacco mosaic virus movement protein
PNAS 2000 97: 12345-12349. [Abstract] [Full Text] [PDF]  

Edgar B. Cahoon and John Shanklin

Substrate-dependent mutant complementation to select fatty acid desaturase variants for metabolic engineering of plant seed oils
PNAS 2000 97: 12350-12355; published online before print October 10, 2000, 10.1073/pnas.210276297 [Abstract] [Full Text] [PDF]  

Elizabeth E. Rogers, David J. Eide, and Mary Lou Guerinot

Altered selectivity in an Arabidopsis metal transporter
PNAS 2000 97: 12356-12360; published online before print October 17, 2000, 10.1073/pnas.210214197 [Abstract] [Full Text] [PDF]  

Enid A. C. MacRobbie INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: ABA activates multiple Ca2+ fluxes in stomatal guard cells, triggering vacuolar K+(Rb+) release PNAS 2000 97: 12361-12368; published online before print October 10, 2000, 10.1073/pnas.220417197 [Abstract] [Full Text] [PDF]

Population Biology

Duccio Cavalieri, Jeffrey P. Townsend, and Daniel L. Hartl

Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis
PNAS 2000 97: 12369-12374; published online before print October 17, 2000, 10.1073/pnas.210395297 [Abstract] [Full Text] [PDF]  

Psychology

Joseph R. Manns, Craig E. L. Stark, and Larry R. Squire

The visual paired-comparison task as a measure of declarative memory
PNAS 2000 97: 12375-12379; published online before print October 10, 2000, 10.1073/pnas.220398097 [Abstract] [Full Text] [PDF]  

Andrei Gorea and Dov Sagi

Failure to handle more than one internal representation in visual detection tasks
PNAS 2000 97: 12380-12384. [Abstract] [Full Text] [PDF]