Table of Contents

From the Academy: Introduction to Frontiers of Science

• Henry L. Paulson,
• Nancy M. Bonini,
• and Kevin A. Roth

From the Academy: Polyglutamine disease and neuronal cell death

• Heinrich M. Jaeger,
• Troy Shinbrot,
• and Paul B. Umbanhowar

From the Academy: Does the granular matter?

• Robert A. Zierenberg,
• Michael W. W. Adams,
• and Alissa J. Arp

From the Academy: Life in extreme environments: Hydrothermal vents

• T. C. Hales,
• P. Sarnak,
• and M. C. Pugh

From the Academy: Advances in random matrix theory, zeta functions, and sphere packing

• Randall T. Peterson,
• Brian A. Link,
• John E. Dowling,
• and Stuart L. Schreiber

Small molecule developmental screens reveal the logic and timing of vertebrate development

• David S. Talaga,
• Wai Leung Lau,
• Heinrich Roder,
• Jianyong Tang,
• Yiwei Jia,
• William F. DeGrado,
• and Robin M. Hochstrasser

Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy

• Herbert Robbins
• and Cun-Hui Zhang

Efficiency of the u,v method of estimation

• Bruce E. Tabashnik,
• Amanda L. Patin,
• Timothy J. Dennehy,
• Yong-Biao Liu,
• Yves Carrière,
• Maria A. Sims,
• and Larry Antilla

Frequency of resistance to Bacillus thuringiensis in field populations of pink bollworm

• Amine O. Noueiry,
• Jianbo Chen,
• and Paul Ahlquist

A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA

• Shihai Huang,
• Sherry Murphy,
• and Andreas Matouschek

Effect of the protein import machinery at the mitochondrial surface on precursor stability

• Shipra Bunjun,
• Constantinos Stathopoulos,
• David Graham,
• Bokkee Min,
• Makoto Kitabatake,
• Alice L. Wang,
• Ching C. Wang,
• Christian P. Vivarès,
• Louis M. Weiss,
• and Dieter Söll

A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia

• Paul A. Wender,
• Dennis J. Mitchell,
• Kanaka Pattabiraman,
• Erin T. Pelkey,
• Lawrence Steinman,
• and Jonathan B. Rothbard

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters

• Steve A. Maxwell
• and George E. Davis

Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines

• Yutong Xue,
• Julie C. Canman,
• Cheol Soon Lee,
• Zuqin Nie,
• Dafeng Yang,
• G. Tony Moreno,
• Mary K. Young,
• E. D. Salmon,
• and Weidong Wang

The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes

• David S. Talaga,
• Wai Leung Lau,
• Heinrich Roder,
• Jianyong Tang,
• Yiwei Jia,
• William F. DeGrado,
• and Robin M. Hochstrasser

Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy

• David A. Dunbar,
• François Dragon,
• Sarah J. Lee,
• and Susan J. Baserga

A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis

• B. Nirmala Pudota,
• Masaru Miyagi,
• Kevin W. Hallgren,
• Karen A. West,
• John W. Crabb,
• Kunio S. Misono,
• and Kathleen L. Berkner

Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

• Kazuko Yorita,
• Takeshi Matsuoka,
• Hideo Misaki,
• and Vincent Massey

Interaction of two arginine residues in lactate oxidase with the enzyme flavin: Conversion of FMN to 8-formyl-FMN

• Oleg N. Antzutkin,
• John J. Balbach,
• Richard D. Leapman,
• Nancy W. Rizzo,
• Jennifer Reed,
• and Robert Tycko

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of β-sheets in Alzheimer's β-amyloid fibrils

• C. Roy D. Lancaster,
• Roland Groß,
• Alexander Haas,
• Michaela Ritter,
• Werner Mäntele,
• Jörg Simon,
• and Achim Kröger

Essential role of Glu-C66 for menaquinol oxidation indicates transmembrane electrochemical potential generation by Wolinella succinogenes fumarate reductase

• Ulrich Schubert,
• David E. Ott,
• Elena N. Chertova,
• Reinhold Welker,
• Uwe Tessmer,
• Michael F. Princiotta,
• Jack R. Bennink,
• Hans-Georg Kräusslich,
• and Jonathan W. Yewdell

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

• Bettina Strack,
• Arianna Calistri,
• Molly A. Accola,
• Giorgio Palù,
• and Heinrich G. Göttlinger

A role for ubiquitin ligase recruitment in retrovirus release

• Akash Patnaik,
• Vincent Chau,
• and John W. Wills

Ubiquitin is part of the retrovirus budding machinery

• Jorge A. Vila,
• Daniel R. Ripoll,
• and H. A. Scheraga

Physical reasons for the unusual α-helix stabilization afforded by charged or neutral polar residues in alanine-rich peptides

• Jonathan M. Caruthers,
• Eric R. Johnson,
• and David B. McKay

Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase

• Pia Ädelroth,
• Mark L. Paddock,
• Laura B. Sagle,
• George Feher,
• and Melvin Y. Okamura

Identification of the proton pathway in bacterial reaction centers: Both protons associated with reduction of Q B to Q B H 2 share a common entry point

• Michael N. Liang,
• Stephen P. Smith,
• Steven J. Metallo,
• Insung S. Choi,
• Mara Prentiss,
• and George M. Whitesides

Measuring the forces involved in polyvalent adhesion of uropathogenic Escherichia coli to mannose-presenting surfaces

• Xing Han
• and Lukas K. Tamm

A host–guest system to study structure–function relationships of membrane fusion peptides

• Daniel S. O'Connor,
• Douglas Grossman,
• Janet Plescia,
• Fengzhi Li,
• Hui Zhang,
• Antonello Villa,
• Simona Tognin,
• Pier Carlo Marchisio,
• and Dario C. Altieri

Regulation of apoptosis at cell division by p34 cdc2 phosphorylation of survivin

• Ann Kendall,
• Melissa W. Hull,
• Edouard Bertrand,
• Paul D. Good,
• Robert H. Singer,
• and David R. Engelke

A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing

• Marcela Bravo-Zehnder,
• Patricio Orio,
• Andrés Norambuena,
• Martin Wallner,
• Pratap Meera,
• Ligia Toro,
• Ramón Latorre,
• and Alfonso González

Apical sorting of a voltage- and Ca 2+ -activated K + channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation

• Manfred Alsheimer,
• Elisabeth von Glasenapp,
• Martina Schnölzer,
• Hans Heid,
• and Ricardo Benavente

Meiotic lamin C2: The unique amino-terminal hexapeptide GNAEGR is essential for nuclear envelope association

• Michael Raraty,
• Jeremy Ward,
• Gul Erdemli,
• Camille Vaillant,
• John P. Neoptolemos,
• Robert Sutton,
• and Ole H. Petersen

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

• Randall T. Peterson,
• Brian A. Link,
• John E. Dowling,
• and Stuart L. Schreiber

Small molecule developmental screens reveal the logic and timing of vertebrate development

• James E. Wilhelm,
• Ronald D. Vale,
• and Ramanujan S. Hegde

Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes

• Laurent M. Sachs
• and Yun-Bo Shi

Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development

• Marina Pasca di Magliano,
• Roberto Di Lauro,
• and Mariastella Zannini

Pax8 has a key role in thyroid cell differentiation