EDITORIAL

Steven M. Stanley

The past climate change heats up
PNAS 2000 97: 1319. [Full Text] [PDF]  

COMMENTARIES

Svante Pääbo

Of bears, conservation genetics, and the value of time travel
PNAS 2000 97: 1320-1321. [Full Text] [PDF]  

Victor F. Holmes and Nicholas R. Cozzarelli

Closing the ring: Links between SMC proteins and chromosome partitioning, condensation, and supercoiling
PNAS 2000 97: 1322-1324; published online before print February 11, 2000, 10.1073/pnas.040576797 [Full Text] [PDF]  

Uttam L. RajBhandary

More surprises in translation: Initiation without the initiator tRNA
PNAS 2000 97: 1325-1327; published online before print February 11, 2000, 10.1073/pnas.040579197 [Full Text] [PDF]  

Junghuei Chen and David Harlan Wood

Computation with biomolecules
PNAS 2000 97: 1328-1330. [Full Text] [PDF]  

PERSPECTIVES

Richard B. Alley

Ice-core evidence of abrupt climate changes
PNAS 2000 97: 1331-1334. [Abstract] [Full Text] [PDF]  

Jonathan Overpeck and Robert Webb

Nonglacial rapid climate events: Past and future
PNAS 2000 97: 1335-1338. [Abstract] [Full Text] [PDF]  

Wallace S. Broecker

Was a change in thermohaline circulation responsible for the Little Ice Age?
PNAS 2000 97: 1339-1342. [Full Text] [PDF]  

L. D. Keigwin and E. A. Boyle

Detecting Holocene changes in thermohaline circulation
PNAS 2000 97: 1343-1346. [Abstract] [Full Text] [PDF]  

Jochem Marotzke

Abrupt climate change and thermohaline circulation: Mechanisms and predictability
PNAS 2000 97: 1347-1350. [Abstract] [Full Text] [PDF]  

Thomas V. Lowell

As climate changes, so do glaciers
PNAS 2000 97: 1351-1354. [Abstract] [Full Text] [PDF]  

R. T. Pierrehumbert

Climate change and the tropical Pacific: The sleeping dragon wakes
PNAS 2000 97: 1355-1358. [Full Text] [PDF]  

Dorothy Peteet

Sensitivity and rapidity of vegetational response to abrupt climate change
PNAS 2000 97: 1359-1361. [Abstract] [Full Text] [PDF]  

Thomas F. Stocker and Olivier Marchal

Abrupt climate change in the computer: Is it real?
PNAS 2000 97: 1362-1365. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Mathematics

G. I. Barenblatt, E. A. Ingerman, H. Shvets, and J. L. Vázquez

Very intense pulse in the groundwater flow in fissurized-porous stratum
PNAS 2000 97: 1366-1369. [Abstract] [PDF]  

Applied Physical Sciences

M. Warner, B. L. Thiel, and A. M. Donald

The elasticity and failure of fluid-filled cellular solids: Theory and experiment
PNAS 2000 97: 1370-1375; published online before print January 31, 2000, 10.1073/pnas.020501797 [Abstract] [Full Text] [PDF]  

Chemistry

Eric W.-G. Diau, Joseph Casanova, John D. Roberts, and Ahmed H. Zewail

Femtosecond observation of benzyne intermediates in a molecular beam: Bergman rearrangement in the isolated molecule
PNAS 2000 97: 1376-1379; published online before print January 31, 2000, 10.1073/pnas.030524797 [Abstract] [Full Text] [PDF]  

Stefan Leininger, Jun Fan, Marion Schmitz, and Peter J. Stang

Archimedean solids: Transition metal mediated rational self-assembly of supramolecular-truncated tetrahedra
PNAS 2000 97: 1380-1384; published online before print February 4, 2000, 10.1073/pnas.030264697 [Abstract] [Full Text] [PDF] [Supplementary Material and Methods]  

Computer Sciences

Dirk Faulhammer, Anthony R. Cukras, Richard J. Lipton, and Laura F. Landweber

From the Cover: Molecular computation: RNA solutions to chess problems
PNAS 2000 97: 1385-1389. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Engineering

Hiroshi Mitsuoka, Erik B. Kistler, and Geert W. Schmid-Schönbein

Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes
PNAS 2000 97: 1772-1777. [Abstract] [Full Text] [PDF]  

Geology

Hilary H. Birks and Brigitta Ammann

Two terrestrial records of rapid climatic change during the glacial-Holocene transition (14,000- 9,000 calendar years B.P.) from Europe
PNAS 2000 97: 1390-1394. [Abstract] [Full Text] [PDF]  

Benjamin P. Weiss, Yuk L. Yung, and Kenneth H. Nealson

Atmospheric energy for subsurface life on Mars?
PNAS 2000 97: 1395-1399; published online before print January 31, 2000, 10.1073/pnas.030538097 [Abstract] [Full Text] [PDF]  

Joseph L. Kirschvink, Eric J. Gaidos, L. Elizabeth Bertani, Nicholas J. Beukes, Jens Gutzmer, Linda N. Maepa, and Rachel E. Steinberger

Paleoproterozoic snowball Earth: Extreme climatic and geochemical global change and its biological consequences
PNAS 2000 97: 1400-1405. [Abstract] [Full Text] [PDF]  

Geophysics

Mark B. Dyurgerov and Mark F. Meier

Twentieth century climate change: Evidence from small glaciers
PNAS 2000 97: 1406-1411. [Abstract] [Full Text] [PDF]  

Dennis L. Hartmann, John M. Wallace, Varavut Limpasuvan, David W. J. Thompson, and James R. Holton

Can ozone depletion and global warming interact to produce rapid climate change?
PNAS 2000 97: 1412-1417. [Abstract] [Full Text] [PDF]  

Mathematics

Arthur Jaffe

Twist fields, the elliptic genus, and hidden symmetry
PNAS 2000 97: 1418-1422. [Abstract] [PDF]  

Statistics

Yehuda Vardi and Cun-Hui Zhang

The multivariate L₁-median and associated data depth
PNAS 2000 97: 1423-1426. [Abstract] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
Agricultural Sciences

Qihong Huang, Quinn L. Deveraux, Susumu Maeda, Guy S. Salvesen, Henning R. Stennicke, Bruce D. Hammock, and John C. Reed

Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9
PNAS 2000 97: 1427-1432. [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

Frank R. Stermitz, Peter Lorenz, Jeanne N. Tawara, Lauren A. Zenewicz, and Kim Lewis

Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor
PNAS 2000 97: 1433-1437; published online before print February 4, 2000, 10.1073/pnas.030540597 [Abstract] [Full Text] [PDF]  

Brad Lobitz, Louisa Beck, Anwar Huq, Byron Wood, George Fuchs, A. S. G. Faruque, and Rita Colwell

From the Cover: Climate and infectious disease: Use of remote sensing for detection of Vibrio cholerae by indirect measurement
PNAS 2000 97: 1438-1443. [Abstract] [Full Text] [PDF]  

Biochemistry

Dirk Faulhammer, Anthony R. Cukras, Richard J. Lipton, and Laura F. Landweber

From the Cover: Molecular computation: RNA solutions to chess problems
PNAS 2000 97: 1385-1389. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Lutfi Abu-Elheiga, William R. Brinkley, Ling Zhong, Subrahmanyam S. Chirala, Gebretateos Woldegiorgis, and Salih J. Wakil

The subcellular localization of acetyl-CoA carboxylase 2
PNAS 2000 97: 1444-1449. [Abstract] [Full Text] [PDF]  

Olga Vinogradova, Tom Haas, Edward F. Plow, and Jun Qin

A structural basis for integrin activation by the cytoplasmic tail of the _IIb-subunit
PNAS 2000 97: 1450-1455; published online before print February 4, 2000, 10.1073/pnas.040548197 [Abstract] [Full Text] [PDF]  

Xinli Lin, Gerald Koelsch, Shili Wu, Debbie Downs, Azar Dashti, and Jordan Tang

Human aspartic protease memapsin 2 cleaves the -secretase site of -amyloid precursor protein
PNAS 2000 97: 1456-1460. [Abstract] [Full Text] [PDF]  

Kunihiko Konno, Kathleen Ue, Mikhail Khoroshev, Hugo Martinez, Bruce Ray, and Manuel F. Morales

Consequences of placing an intramolecular crosslink in myosin S1
PNAS 2000 97: 1461-1466; published online before print February 4, 2000, 10.1073/pnas.030523997 [Abstract] [Full Text] [PDF]  

Keiko Yamamoto, Hiroyuki Masuno, Mihwa Choi, Kinichi Nakashima, Tetsuya Taga, Hiroshi Ooizumi, Kazuhiko Umesono, Wanda Sicinska, Janeen VanHooke, Hector F. DeLuca, and Sachiko Yamada

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain
PNAS 2000 97: 1467-1472; published online before print February 4, 2000, 10.1073/pnas.020522697 [Abstract] [Full Text] [PDF]  

Ilian Simidjiev, Svetla Stoylova, Heinz Amenitsch, Tamás Jávorfi, László Mustárdy, Peter Laggner, and Andreas Holzenburg

Self-assembly of large, ordered lamellae from non-bilayer lipids and integral membrane proteins in vitro
PNAS 2000 97: 1473-1476. [Abstract] [Full Text] [PDF]  

Rudolf Beutler, Francesco Ruggiero, and Bernhard Erni

Folding and activity of circularly permuted forms of a polytopic membrane protein
PNAS 2000 97: 1477-1482; published online before print February 4, 2000, 10.1073/pnas.0305463397 [Abstract] [Full Text] [PDF]  

Mathew E. Sowa, Wei He, Theodore G. Wensel, and Olivier Lichtarge

A regulator of G protein signaling interaction surface linked to effector specificity
PNAS 2000 97: 1483-1488; published online before print February 4, 2000, 10.1073/pnas.030409597 [Abstract] [Full Text] [PDF]  

Kristen L. Pierce, Stuart Maudsley, Yehia Daaka, Louis M. Luttrell, and Robert J. Lefkowitz

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
PNAS 2000 97: 1489-1494. [Abstract] [Full Text] [PDF]  

Roger R. Beerli, Birgit Dreier, and Carlos F. Barbas III

Positive and negative regulation of endogenous genes by designed transcription factors
PNAS 2000 97: 1495-1500; published online before print January 31, 2000, 10.1073/pnas.040552697 [Abstract] [Full Text] [PDF]  

Eliane Hajnsdorf and Philippe Régnier

Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I
PNAS 2000 97: 1501-1505; published online before print February 4, 2000, 10.1073/pnas.040549897 [Abstract] [Full Text] [PDF]  

Kirk McMillan, Marc Adler, Douglas S. Auld, John J. Baldwin, Eric Blasko, Leslie J. Browne, Daniel Chelsky, David Davey, Ronald E. Dolle, Keith A. Eagen, Shawn Erickson, Richard I. Feldman, Charles B. Glaser, Cornell Mallari, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, John F. Parkinson, Gary B. Phillips, Mark A. Polokoff, Nolan H. Sigal, Ronald Vergona, Marc Whitlow, Tish A. Young, and James J. Devlin

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
PNAS 2000 97: 1506-1511. [Abstract] [Full Text] [PDF]  

Jun Sasaki and Nobuhiko Nakashima

From the Cover: Methionine-independent initiation of translation in the capsid protein of an insect RNA virus
PNAS 2000 97: 1512-1515; published online before print January 31, 2000, 10.1073/pnas.010426997 [Abstract] [Full Text] [PDF]  

Hyun Kim, Hangil Park, Lucy Montalvo, and William J. Lennarz

Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase
PNAS 2000 97: 1516-1520; published online before print February 4, 2000, 10.1073/pnas.040556797 [Abstract] [Full Text] [PDF]  

Ofer Yifrach and Amnon Horovitz

Coupling between protein folding and allostery in the GroE chaperonin system
PNAS 2000 97: 1521-1524; published online before print February 4, 2000, 10.1073/pnas.040449997 [Abstract] [Full Text] [PDF]  

Alan R. Fersht

Transition-state structure as a unifying basis in protein-folding mechanisms: Contact order, chain topology, stability, and the extended nucleus mechanism
PNAS 2000 97: 1525-1529. [Abstract] [Full Text] [PDF]  

James P. J. Chong, Mariko K. Hayashi, Martha N. Simon, Rui-Ming Xu, and Bruce Stillman

A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
PNAS 2000 97: 1530-1535; published online before print February 4, 2000, 10.1073/pnas.030539597 [Abstract] [Full Text] [PDF]  

Stephen A. Chappell, Gerald M. Edelman, and Vincent P. Mauro

A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity
PNAS 2000 97: 1536-1541. [Abstract] [Full Text] [PDF] [Supplemental Table]  

Biophysics

M. Warner, B. L. Thiel, and A. M. Donald

The elasticity and failure of fluid-filled cellular solids: Theory and experiment
PNAS 2000 97: 1370-1375; published online before print January 31, 2000, 10.1073/pnas.020501797 [Abstract] [Full Text] [PDF]  

H. L. Axelrod, E. C. Abresch, M. L. Paddock, M. Y. Okamura, and G. Feher

Determination of the binding sites of the proton transfer inhibitors Cd²⁺ and Zn²⁺ in bacterial reaction centers
PNAS 2000 97: 1542-1547. [Abstract] [Full Text] [PDF]  

M. L. Paddock, G. Feher, and M. Y. Okamura

Identification of the proton pathway in bacterial reaction centers: Replacement of Asp-M17 and Asp-L210 with Asn reduces the proton transfer rate in the presence of Cd²⁺
PNAS 2000 97: 1548-1553. [Abstract] [Full Text] [PDF]  

Marten H. Vos, Vitaliy B. Borisov, Ursula Liebl, Jean-Louis Martin, and Alexander A. Konstantinov

Femtosecond resolution of ligand-heme interactions in the high-affinity quinol oxidase bd: A di-heme active site?
PNAS 2000 97: 1554-1559; published online before print January 31, 2000, 10.1073/pnas.030528197 [Abstract] [Full Text] [PDF]  

Cell Biology

Ferran Valderrama, Ana Luna, Teresa Babià, José A. Martínez-Menárguez, José Ballesta, Holger Barth, Christine Chaponnier, Jaime Renau-Piqueras, and Gustavo Egea

The Golgi-associated COPI-coated buds and vesicles contain /-actin
PNAS 2000 97: 1560-1565. [Abstract] [Full Text] [PDF]  

Ji Li, Ildiko Sarosi, Xiao-Qiang Yan, Sean Morony, Casey Capparelli, Hong-Lin Tan, Susan McCabe, Robin Elliott, Sheila Scully, Gwyneth Van, Stephen Kaufman, Shao-Chieh Juan, Yu Sun, John Tarpley, Laura Martin, Kathleen Christensen, James McCabe, Paul Kostenuik, Hailing Hsu, Frederick Fletcher, Colin R. Dunstan, David L. Lacey, and William J. Boyle

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
PNAS 2000 97: 1566-1571. [Abstract] [Full Text] [PDF]  

Tal Raveh, Hanna Berissi, Miriam Eisenstein, Taly Spivak, and Adi Kimchi

A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity
PNAS 2000 97: 1572-1577; published online before print February 4, 2000, 10.1073/pnas.020519497 [Abstract] [Full Text] [PDF]  

Xingming Deng, Peter Ruvolo, Boyd Carr, and W. Stratford May Jr.

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases
PNAS 2000 97: 1578-1583. [Abstract] [Full Text] [PDF]  

Sa Wang, Min Guo, Honghai Ouyang, Xiaoling Li, Carlos Cordon-Cardo, Akihiro Kurimasa, David J. Chen, Zvi Fuks, C. Clifton Ling, and Gloria C. Li

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
PNAS 2000 97: 1584-1588. [Abstract] [Full Text] [PDF]  

Sylvia Krobitsch and Susan Lindquist

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
PNAS 2000 97: 1589-1594. [Abstract] [Full Text] [PDF]  

Corinne Pellieux, Thérèse Sauthier, Andrea Domenighetti, Donald J. Marsh, Richard D. Palmiter, Hans-R. Brunner, and Thierry Pedrazzini

Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors
PNAS 2000 97: 1595-1600; published online before print January 31, 2000, 10.1073/pnas.030533197 [Abstract] [Full Text] [PDF]  

Pierre G. Lutz, Christel Moog-Lutz, Edith Coumau-Gatbois, Ladan Kobari, Yolande Di Gioia, and Yvon E. Cayre

Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells
PNAS 2000 97: 1601-1606. [Abstract] [Full Text] [PDF]  

Developmental Biology

Gérard Gradwohl, Andrée Dierich, Marianne LeMeur, and François Guillemot

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
PNAS 2000 97: 1607-1611. [Abstract] [Full Text] [PDF]  

Ralph J. DiLeone, Gregory A. Marcus, Michelle D. Johnson, and David M. Kingsley

Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes
PNAS 2000 97: 1612-1617. [Abstract] [Full Text] [PDF]  

Takeharu Nagai, Jun Aruga, Osamu Minowa, Takashi Sugimoto, Yoshiki Ohno, Tetsuo Noda, and Katsuhiko Mikoshiba

Zic2 regulates the kinetics of neurulation
PNAS 2000 97: 1618-1623. [Abstract] [Full Text] [PDF]  

Koji Watanabe, Trent R. Clarke, Andrew H. Lane, Xinzhong Wang, and Patricia K. Donahoe

Endogenous expression of Müllerian inhibiting substance in early postnatal rat Sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites
PNAS 2000 97: 1624-1629. [Abstract] [Full Text] [PDF] [Supplemental Table]  

Ecology

David W. Inouye, Billy Barr, Kenneth B. Armitage, and Brian D. Inouye

Climate change is affecting altitudinal migrants and hibernating species
PNAS 2000 97: 1630-1633. [Abstract] [Full Text] [PDF]  

Thomas Eisner, Maria Eisner, Carmen Rossini, Vikram K. Iyengar, Braden L. Roach, Eva Benedikt, and Jerrold Meinwald

Chemical defense against predation in an insect egg
PNAS 2000 97: 1634-1639; published online before print February 4, 2000, 10.1073/pnas.030532797 [Abstract] [Full Text] [PDF]  

Evolution

Mario García-París, David A. Good, Gabriela Parra-Olea, and David B. Wake INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Biodiversity of Costa Rican salamanders: Implications of high levels of genetic differentiation and phylogeographic structure for species formation PNAS 2000 97: 1640-1647. [Abstract] [Full Text] [PDF]

T. W. Chapman, B. J. Crespi, B. D. Kranz, and M. P. Schwarz

High relatedness and inbreeding at the origin of eusociality in gall-inducing thrips
PNAS 2000 97: 1648-1650; published online before print January 31, 2000, 10.1073/pnas.020510097 [Abstract] [Full Text] [PDF]  

Jennifer A. Leonard, Robert K. Wayne, and Alan Cooper

From the Cover: Population genetics of Ice Age brown bears
PNAS 2000 97: 1651-1654; published online before print February 4, 2000, 10.1073/pnas.040453097 [Abstract] [Full Text] [PDF]  

Chang-Bae Kim, Chris Amemiya, Wendy Bailey, Kazuhiko Kawasaki, Jason Mezey, Webb Miller, Shinsei Minoshima, Nobuyoshi Shimizu, Günter Wagner, and Frank Ruddle

Hox cluster genomics in the horn shark, Heterodontus francisci
PNAS 2000 97: 1655-1660; published online before print February 4, 2000, 10.1073/pnas.030539697 [Abstract] [Full Text] [PDF]  

Xiaolei Hu, Harold S. Margolis, Robert H. Purcell, James Ebert, and Betty H. Robertson

Identification of hepatitis B virus indigenous to chimpanzees
PNAS 2000 97: 1661-1664. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Genetics

Sydney Brenner, Steven R. Williams, Eric H. Vermaas, Thorsten Storck, Keith Moon, Christie McCollum, Jen-I Mao, Shujun Luo, James J. Kirchner, Sam Eletr, Robert B. DuBridge, Timothy Burcham, and Glenn Albrecht

In vitro cloning of complex mixtures of DNA on microbeads: Physical separation of differentially expressed cDNAs
PNAS 2000 97: 1665-1670. [Abstract] [Full Text] [PDF]  

James A. Sawitzke and Stuart Austin

Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I
PNAS 2000 97: 1671-1676; published online before print January 31, 2000, 10.1073/pnas.030528397 [Abstract] [Full Text] [PDF]  

Gul N. Shah, David Hewett-Emmett, Jeffrey H. Grubb, Mary C. Migas, Robert E. Fleming, Abdul Waheed, and William S. Sly

Mitochondrial carbonic anhydrase CA VB: Differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles
PNAS 2000 97: 1677-1682. [Abstract] [Full Text] [PDF]  

Bente Larsen, Norma M. Wills, Chad Nelson, John F. Atkins, and Raymond F. Gesteland

Nonlinearity in genetic decoding: Homologous DNA replicase genes use alternatives of transcriptional slippage or translational frameshifting
PNAS 2000 97: 1683-1688. [Abstract] [Full Text] [PDF]  

Immunology

Robert Weissert, Anna Lobell, Katrien L. de Graaf, Sana Yousif Eltayeb, Roland Andersson, Tomas Olsson, and Hans Wigzell

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen
PNAS 2000 97: 1689-1694; published online before print February 4, 2000, 10.1073/pnas.030390097 [Abstract] [Full Text] [PDF]  

Sergei V. Kotenko, Simona Saccani, Lara S. Izotova, Olga V. Mirochnitchenko, and Sidney Pestka

Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
PNAS 2000 97: 1695-1700. [Abstract] [Full Text] [PDF]  

Liping Yu, David T. Robles, Norio Abiru, Paramjit Kaur, Marian Rewers, Katalin Kelemen, and George S. Eisenbarth

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
PNAS 2000 97: 1701-1706; published online before print February 4, 2000, 10.1073/pnas.040556697 [Abstract] [Full Text] [PDF]  

Ivy Suzuki and Pamela J. Fink

The dual functions of Fas ligand in the regulation of peripheral CD8⁺ and CD4⁺ T cells
PNAS 2000 97: 1707-1712. [Abstract] [Full Text] [PDF]  

Richard J. Cornall, Alex M. Cheng, Tony Pawson, and Christopher C. Goodnow

Role of Syk in B-cell development and antigen-receptor signaling
PNAS 2000 97: 1713-1718. [Abstract] [Full Text] [PDF]  

P. Caturegli, M. Hejazi, K. Suzuki, O. Dohan, N. Carrasco, L. D. Kohn, and N. R. Rose

Hypothyroidism in transgenic mice expressing IFN- in the thyroid
PNAS 2000 97: 1719-1724; published online before print February 4, 2000, 10.1073/pnas.020522597 [Abstract] [Full Text] [PDF]  

Francisco A. Bonilla, Ross M. Fujita, Vadim I. Pivniouk, Andrew C. Chan, and Raif S. Geha

Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fc receptors I and II/III
PNAS 2000 97: 1725-1730; published online before print February 4, 2000, 10.1073/pnas.040543597 [Abstract] [Full Text] [PDF]  

Medical Sciences

Keetae Kim, Iain Drummond, Oxana Ibraghimov-Beskrovnaya, Katherine Klinger, and M. Amin Arnaout

Polycystin 1 is required for the structural integrity of blood vessels
PNAS 2000 97: 1731-1736; published online before print February 4, 2000, 10.1073/pnas.040550097 [Abstract] [Full Text] [PDF]  

Takumi Era and Owen N. Witte

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
PNAS 2000 97: 1737-1742. [Abstract] [Full Text] [PDF]  

Hiroshi Deguchi, José A. Fernández, Tilman M. Hackeng, Carole L. Banka, and John H. Griffin

Cardiolipin is a normal component of human plasma lipoproteins
PNAS 2000 97: 1743-1748. [Abstract] [Full Text] [PDF]  

Bing-Hua Jiang, Jenny Z. Zheng, Masahiro Aoki, and Peter K. Vogt

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
PNAS 2000 97: 1749-1753; published online before print February 4, 2000, 10.1073/pnas.040560897 [Abstract] [Full Text] [PDF]  

Arul M. Chinnaiyan, Uttara Prasad, Sunita Shankar, Daniel A. Hamstra, Murthy Shanaiah, Thomas L. Chenevert, Brian D. Ross, and Alnawaz Rehemtulla

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy
PNAS 2000 97: 1754-1759; published online before print February 4, 2000, 10.1073/pnas.030545097 [Abstract] [Full Text] [PDF]  

Grace M. Cuenco, Giuseppina Nucifora, and Ruibao Ren

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for human AML
PNAS 2000 97: 1760-1765; published online before print February 4, 2000, 10.1073/pnas.030421197 [Abstract] [Full Text] [PDF]  

Joseph D. Smith, Alister G. Craig, Neline Kriek, Diana Hudson-Taylor, Sue Kyes, Toby Fagan, Robert Pinches, Dror I. Baruch, Chris I. Newbold, and Louis H. Miller

Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria
PNAS 2000 97: 1766-1771; published online before print February 4, 2000, 10.1073/pnas.040545897 [Abstract] [Full Text] [PDF]  

Hiroshi Mitsuoka, Erik B. Kistler, and Geert W. Schmid-Schönbein

Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes
PNAS 2000 97: 1772-1777. [Abstract] [Full Text] [PDF]  

Naftali Kaminski, John D. Allard, Jean F. Pittet, Fengrong Zuo, Mark J. D. Griffiths, David Morris, Xiaozhu Huang, Dean Sheppard, and Renu A. Heller

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis
PNAS 2000 97: 1778-1783. [Abstract] [Full Text] [PDF]  

Yan-Ting Zhou, Paul Grayburn, Asad Karim, Michio Shimabukuro, Moritake Higa, Dany Baetens, Lelio Orci, and Roger H. Unger

Lipotoxic heart disease in obese rats: Implications for human obesity
PNAS 2000 97: 1784-1789. [Abstract] [Full Text] [PDF]  

Helger Stege, Len Roza, Arie A. Vink, Markus Grewe, Thomas Ruzicka, Susanne Grether-Beck, and Jean Krutmann

Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
PNAS 2000 97: 1790-1795; published online before print January 31, 2000, 10.1073/pnas.030528897 [Abstract] [Full Text] [PDF]  

Jon A. J. Burrows, Lauren K. Willis, and David H. Perlmutter

Chemical chaperones mediate increased secretion of mutant 1-antitrypsin (1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in 1-AT deficiency
PNAS 2000 97: 1796-1801. [Abstract] [Full Text] [PDF]  

D. B. Axworthy, J. M. Reno, M. D. Hylarides, R. W. Mallett, L. J. Theodore, L. M. Gustavson, F.-M. Su, L. J. Hobson, P. L. Beaumier, and A. R. Fritzberg

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity
PNAS 2000 97: 1802-1807. [Abstract] [Full Text] [PDF]  

Marc Lipsitch, Carl T. Bergstrom, and Bruce R. Levin

From the Cover: The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions
PNAS 2000 97: 1938-1943. [Abstract] [Full Text] [PDF]  

Microbiology

Benjamin P. Weiss, Yuk L. Yung, and Kenneth H. Nealson

Atmospheric energy for subsurface life on Mars?
PNAS 2000 97: 1395-1399; published online before print January 31, 2000, 10.1073/pnas.030538097 [Abstract] [Full Text] [PDF]  

Hans L. Kornberg, Linda T. M. Lambourne, and Andrew A. Sproul

Facilitated diffusion of fructose via the phosphoenolpyruvate/glucose phosphotransferase system of Escherichia coli
PNAS 2000 97: 1808-1812. [Abstract] [Full Text] [PDF]  

Giulio Petroni, Stefan Spring, Karl-Heinz Schleifer, Franco Verni, and Giovanna Rosati

Defensive extrusive ectosymbionts of Euplotidium (Ciliophora) that contain microtubule-like structures are bacteria related to Verrucomicrobia
PNAS 2000 97: 1813-1817; published online before print January 31, 2000, 10.1073/pnas.030438197 [Abstract] [Full Text] [PDF]  

Lorren C. Tran, Jennifer M. Kissner, Larry E. Westerman, and Amy E. Sears

A herpes simplex virus 1 recombinant lacking the glycoprotein G coding sequences is defective in entry through apical surfaces of polarized epithelial cells in culture and in vivo
PNAS 2000 97: 1818-1822; published online before print February 4, 2000, 10.1073/pnas.020510297 [Abstract] [Full Text] [PDF]  

Neurobiology

Gilles Gheusi, Harold Cremer, Heather McLean, Geneviève Chazal, Jean-Didier Vincent, and Pierre-Marie Lledo

Importance of newly generated neurons in the adult olfactory bulb for odor discrimination
PNAS 2000 97: 1823-1828. [Abstract] [Full Text] [PDF]  

Deok-Jin Chang, Xiao-Ching Li, Yong-Seok Lee, Hyong-Kyu Kim, Ueon Suk Kim, Nam Jeong Cho, Xinmian Lo, Klaudiusz R. Weiss, Eric R. Kandel, and Bong-Kiun Kaang

Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in Aplysia sensory neurons
PNAS 2000 97: 1829-1834. [Abstract] [Full Text] [PDF]  

Seana O'Regan, Elisabeth Traiffort, Martial Ruat, Nathalie Cha, Désiré Compaoré, and François-Marie Meunier

An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins
PNAS 2000 97: 1835-1840; published online before print February 4, 2000, 10.1073/pnas.030339697 [Abstract] [Full Text] [PDF]  

Ljubomir Kojic, Richard H. Dyck, Qiang Gu, Robert M. Douglas, Joanne Matsubara, and Max S. Cynader

Columnar distribution of serotonin-dependent plasticity within kitten striate cortex
PNAS 2000 97: 1841-1844. [Abstract] [Full Text] [PDF]  

Andrew A. Pieper, Seth Blackshaw, Emily E. Clements, Daniel J. Brat, David K. Krug, Alison J. White, Patricia Pinto-Garcia, Antonella Favit, Jill R. Conover, Solomon H. Snyder, and Ajay Verma

Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
PNAS 2000 97: 1845-1850. [Abstract] [Full Text] [PDF]  

L. Xue, G. Farrugia, S. M. Miller, C. D. Ferris, S. H. Snyder, and J. H. Szurszewski

Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
PNAS 2000 97: 1851-1855. [Abstract] [Full Text] [PDF]  

P. Svenningsson, M. Lindskog, C. Ledent, M. Parmentier, P. Greengard, B. B. Fredholm, and G. Fisone

Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D₁, dopamine D₂, and adenosine A_2A receptors
PNAS 2000 97: 1856-1860. [Abstract] [Full Text] [PDF]  

Elizabeth A. Vitalis, James L. Costantin, Pei-San Tsai, Hideya Sakakibara, Sreenivasan Paruthiyil, Taroh Iiri, Jean-Francois Martini, Michiyoshi Taga, Amy L. H. Choi, Andrew C. Charles, and Richard I. Weiner

Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells
PNAS 2000 97: 1861-1866; published online before print February 4, 2000, 10.1073/pnas.040545197 [Abstract] [Full Text] [PDF]  

N. Kopell, G. B. Ermentrout, M. A. Whittington, and R. D. Traub

Gamma rhythms and beta rhythms have different synchronization properties
PNAS 2000 97: 1867-1872. [Abstract] [Full Text] [PDF]  

Rozi Andretic and Jay Hirsh

Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster
PNAS 2000 97: 1873-1878. [Abstract] [Full Text] [PDF]  

Brigitte Dumartin, Mohamed Jaber, Francois Gonon, Marc G. Caron, Bruno Giros, and Bertrand Bloch

Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice
PNAS 2000 97: 1879-1884. [Abstract] [Full Text] [PDF]  

Pharmacology

Philippe Pourquier, Yuji Takebayashi, Yoshimasa Urasaki, Christopher Gioffre, Glenda Kohlhagen, and Yves Pommier

Induction of topoisomerase I cleavage complexes by 1--D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells
PNAS 2000 97: 1885-1890. [Abstract] [Full Text] [PDF]  

Physiology

Sharada Karanth, Wen H. Yu, Anna Walczewska, Claudio Mastronardi, and Samuel M. McCann

Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide
PNAS 2000 97: 1891-1896. [Abstract] [Full Text] [PDF]  

Plant Biology

John Vogel and Shauna Somerville

Isolation and characterization of powdery mildew-resistant Arabidopsis mutants
PNAS 2000 97: 1897-1902; published online before print February 4, 2000, 10.1073/pnas.030531997 [Abstract] [Full Text] [PDF]  

Elke Logemann, Annette Tavernaro, Wolfgang Schulz, Imre E. Somssich, and Klaus Hahlbrock

UV light selectively coinduces supply pathways from primary metabolism and flavonoid secondary product formation in parsley
PNAS 2000 97: 1903-1907. [Abstract] [Full Text] [PDF]  

S. P. Dinesh-Kumar and Barbara J. Baker

Alternatively spliced N resistance gene transcripts: Their possible role in tobacco mosaic virus resistance
PNAS 2000 97: 1908-1913; published online before print January 31, 2000, 10.1073/pnas.020367497 [Abstract] [Full Text] [PDF]  

Henriette Horvath, Jintai Huang, Oi Wong, Elizabeth Kohl, Thomas Okita, C. Gamini Kannangara, and Diter von Wettstein

The production of recombinant proteins in transgenic barley grains
PNAS 2000 97: 1914-1919; published online before print February 4, 2000, 10.1073/pnas.030527497 [Abstract] [Full Text] [PDF]  

Seiji Takayama, Hiroshi Shiba, Megumi Iwano, Hiroko Shimosato, Fang-Sik Che, Naoko Kai, Masao Watanabe, Go Suzuki, Kokichi Hinata, and Akira Isogai

The pollen determinant of self-incompatibility in Brassica campestris
PNAS 2000 97: 1920-1925; published online before print February 4, 2000, 10.1073/pnas.040556397 [Abstract] [Full Text] [PDF]  

Justin DeLille, Eric C. Peterson, Tracey Johnson, Misty Moore, Alicia Kight, and Ralph Henry

A novel precursor recognition element facilitates posttranslational binding to the signal recognition particle in chloroplasts
PNAS 2000 97: 1926-1931; published online before print January 31, 2000, 10.1073/pnas.030395197 [Abstract] [Full Text] [PDF]  

Helen Goddard, N. F. H. Manison, D. Tomos, and C. Brownlee

Elemental propagation of calcium signals in response-specific patterns determined by environmental stimulus strength
PNAS 2000 97: 1932-1937; published online before print February 4, 2000, 10.1073/pnas.020516397 [Abstract] [Full Text] [PDF]  

Population Biology

Marc Lipsitch, Carl T. Bergstrom, and Bruce R. Levin

From the Cover: The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions
PNAS 2000 97: 1938-1943. [Abstract] [Full Text] [PDF]  

Psychology

Cameron S. Carter, Angus M. Macdonald, Matthew Botvinick, Laura L. Ross, V. Andrew Stenger, Douglas Noll, and Jonathan D. Cohen

Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex
PNAS 2000 97: 1944-1948. [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for vol. 96, p. 14094 [Full Text]  

RETRACTIONS

Retraction for vol. 87, p. 9290 [Full Text]  

Retraction for vol. 87, p. 9290 [Full Text]