COMMENTARIES

Benjamin Wolozin

A fluid connection: Cholesterol and A
PNAS 2001 98: 5371-5373. [Full Text] [PDF]  

Huntington F. Willard

Neocentromeres and human artificial chromosomes: An unnatural act
PNAS 2001 98: 5374-5376. [Full Text] [PDF]  

Thomas Gridley

Notch signaling during vascular development
PNAS 2001 98: 5377-5378. [Full Text] [PDF]  

Jarle Breivik

Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development
PNAS 2001 98: 5379-5381. [Full Text] [PDF]  

David E. MacHugh and Daniel G. Bradley

Livestock genetic origins: Goats buck the trend
PNAS 2001 98: 5382-5384. [Full Text] [PDF]  

G. Karsenty

When developmental biology meets human pathology
PNAS 2001 98: 5385-5386. [Full Text] [PDF]  

COLLOQUIUM:
Papers from the National Academy of Sciences Colloquium on The Future of Evolution

Norman Myers and Andrew H. Knoll

The biotic crisis and the future of evolution
PNAS 2001 98: 5389-5392. [Abstract] [Full Text] [PDF]  

David Jablonski

Lessons from the past: Evolutionary impacts of mass extinctions
PNAS 2001 98: 5393-5398. [Abstract] [Full Text] [PDF]  

Douglas H. Erwin

Lessons from the past: Biotic recoveries from mass extinctions
PNAS 2001 98: 5399-5403. [Abstract] [Full Text] [PDF]  

Michael L. Rosenzweig

Loss of speciation rate will impoverish future diversity
PNAS 2001 98: 5404-5410. [Abstract] [Full Text] [PDF]  

Jeremy B. C. Jackson

What was natural in the coastal oceans?
PNAS 2001 98: 5411-5418. [Abstract] [Full Text] [PDF]  

Nancy Knowlton

The future of coral reefs
PNAS 2001 98: 5419-5425. [Abstract] [Full Text] [PDF]  

Alan R. Templeton, Robert J. Robertson, Jennifer Brisson, and Jared Strasburg

Disrupting evolutionary processes: The effect of habitat fragmentation on collared lizards in the Missouri Ozarks
PNAS 2001 98: 5426-5432. [Abstract] [Full Text] [PDF]  

David Tilman and Clarence Lehman

Human-caused environmental change: Impacts on plant diversity and evolution
PNAS 2001 98: 5433-5440. [Abstract] [Full Text] [PDF]  

F. A. Bazzaz

Plant biology in the future
PNAS 2001 98: 5441-5445. [Abstract] [Full Text] [PDF]  

H. A. Mooney and E. E. Cleland

The evolutionary impact of invasive species
PNAS 2001 98: 5446-5451. [Abstract] [Full Text] [PDF]  

R. M. Cowling and R. L. Pressey

Rapid plant diversification: Planning for an evolutionary future
PNAS 2001 98: 5452-5457. [Abstract] [Full Text] [PDF]  

David Western

Human-modified ecosystems and future evolution
PNAS 2001 98: 5458-5465. [Abstract] [Full Text] [PDF]  

Michael J. Novacek and Elsa E. Cleland

The current biodiversity extinction event: Scenarios for mitigation and recovery
PNAS 2001 98: 5466-5470. [Abstract] [Full Text] [PDF]  

David S. Woodruff

Declines of biomes and biotas and the future of evolution
PNAS 2001 98: 5471-5476. [Abstract] [Full Text] [PDF]  

Paul R. Ehrlich

Intervening in evolution: Ethics and actions
PNAS 2001 98: 5477-5480. [Abstract] [Full Text] [PDF]  

FROM THE ACADEMY

New Members and Foreign Associates Elected to the National Academy of Sciences on May 1, 2001. 72 New Members Chosen by the Academy

PNAS 2001 98: 5387-5388; published online before print May 1, 2001, 10.1073/pnas.101188198 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Chemistry

Jaroslav Vacek and Josef Michl

Molecular dynamics of a grid-mounted molecular dipolar rotor in a rotating electric field
PNAS 2001 98: 5481-5486; published online before print May 1, 2001, 10.1073/pnas.091100598 [Abstract] [Full Text] [PDF]  

Mark I. Wallace, Liming Ying, Shankar Balasubramanian, and David Klenerman

Non-Arrhenius kinetics for the loop closure of a DNA hairpin
PNAS 2001 98: 5584-5589; published online before print April 24, 2001, 10.1073/pnas.101523498 [Abstract] [Full Text] [PDF]  

Geology

Robert M. Hazen, Timothy R. Filley, and Glenn A. Goodfriend

Selective adsorption of L- and D-amino acids on calcite: Implications for biochemical homochirality
PNAS 2001 98: 5487-5490; published online before print May 1, 2001, 10.1073/pnas.101085998 [Abstract] [Full Text] [PDF]  

Statistics

Lue Ping Zhao, Ross Prentice, and Linda Breeden

Statistical modeling of large microarray data sets to identify stimulus-response profiles
PNAS 2001 98: 5631-5636. [Abstract] [Full Text] [PDF] [Supplemental Appendix]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
Biochemistry

G. Tocchini-Valentini, N. Rochel, J. M. Wurtz, A. Mitschler, and D. Moras

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands
PNAS 2001 98: 5491-5496. [Abstract] [Full Text] [PDF]  

Hong-Tao Zhang, Janet E. Kacharmina, Kevin Miyashiro, Mark I. Greene, and James Eberwine

Protein quantification from complex protein mixtures using a proteomics methodology with single-cell resolution
PNAS 2001 98: 5497-5502; published online before print April 24, 2001, 10.1073/pnas.101124598 [Abstract] [Full Text] [PDF]  

Christian Hammann, David G. Norman, and David M. J. Lilley

Dissection of the ion-induced folding of the hammerhead ribozyme using ¹⁹F NMR
PNAS 2001 98: 5503-5508; published online before print May 1, 2001, 10.1073/pnas.091097498 [Abstract] [Full Text] [PDF]  

Charles S. Bond, Mamuka Kvaratskhelia, Derek Richard, Malcolm F. White, and William N. Hunter

Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus
PNAS 2001 98: 5509-5514; published online before print May 1, 2001, 10.1073/pnas.091613398 [Abstract] [Full Text] [PDF]  

Julie C. Lougheed, James M. Holton, Tom Alber, J. Fernando Bazan, and Tracy M. Handel

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins
PNAS 2001 98: 5515-5520; published online before print May 1, 2001, 10.1073/pnas.091601698 [Abstract] [Full Text] [PDF]  

Markus W. Ribbe and Barbara K. Burgess

The chaperone GroEL is required for the final assembly of the molybdenum-iron protein of nitrogenase
PNAS 2001 98: 5521-5525; published online before print May 1, 2001, 10.1073/pnas.101119498 [Abstract] [Full Text] [PDF]  

Toru Kumagai, James G. Davis, Takeo Horie, Donald M. O'Rourke, and Mark I. Greene

The role of distinct p185^neu extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling
PNAS 2001 98: 5526-5531; published online before print April 24, 2001, 10.1073/pnas.071060598 [Abstract] [Full Text] [PDF]  

Cameron Mura, Duilio Cascio, Michael R. Sawaya, and David S. Eisenberg

The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core
PNAS 2001 98: 5532-5537; published online before print May 1, 2001, 10.1073/pnas.091102298 [Abstract] [Full Text] [PDF]  

Hitoshi Kurumizaka, Shukuko Ikawa, Maki Nakada, Keiko Eda, Wataru Kagawa, Minoru Takata, Shunichi Takeda, Shigeyuki Yokoyama, and Takehiko Shibata

Homologous-pairing activity of the human DNA-repair proteins Xrcc3·Rad51C
PNAS 2001 98: 5538-5543; published online before print May 1, 2001, 10.1073/pnas.091603098 [Abstract] [Full Text] [PDF]  

Lori Spangler, Xiaoxue Wang, Joan W. Conaway, Ronald C. Conaway, and Arik Dvir

TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA
PNAS 2001 98: 5544-5549; published online before print May 1, 2001, 10.1073/pnas.101004498 [Abstract] [Full Text] [PDF]  

Rebecca S. Arnold, Jing Shi, Emma Murad, Anne M. Whalen, Carrie Q. Sun, Rathnagiri Polavarapu, Sampath Parthasarathy, John A. Petros, and J. David Lambeth

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
PNAS 2001 98: 5550-5555; published online before print May 1, 2001, 10.1073/pnas.101505898 [Abstract] [Full Text] [PDF]  

Yi Yang, Wolfgang Maret, and Bert L. Vallee

Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein
PNAS 2001 98: 5556-5559; published online before print May 1, 2001, 10.1073/pnas.101123298 [Abstract] [Full Text] [PDF]  

Shelly C. Lu, Luis Alvarez, Zong-Zhi Huang, Lixin Chen, Wei An, Fernando J. Corrales, Matías A. Avila, Gary Kanel, and José M. Mato

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
PNAS 2001 98: 5560-5565; published online before print April 24, 2001, 10.1073/pnas.091016398 [Abstract] [Full Text] [PDF]  

Hans E. Purkey, Michael I. Dorrell, and Jeffery W. Kelly

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
PNAS 2001 98: 5566-5571. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Biophysics

Masaki Warashina, Tomoko Kuwabara, Yoshio Kato, Masayuki Sano, and Kazunari Taira

RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA
PNAS 2001 98: 5572-5577. [Abstract] [Full Text] [PDF]  

Andrea G. Cochran, Nicholas J. Skelton, and Melissa A. Starovasnik

Tryptophan zippers: Stable, monomeric -hairpins
PNAS 2001 98: 5578-5583; published online before print May 1, 2001, 10.1073/pnas.091100898 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Mark I. Wallace, Liming Ying, Shankar Balasubramanian, and David Klenerman

Non-Arrhenius kinetics for the loop closure of a DNA hairpin
PNAS 2001 98: 5584-5589; published online before print April 24, 2001, 10.1073/pnas.101523498 [Abstract] [Full Text] [PDF]  

David Craig, André Krammer, Klaus Schulten, and Viola Vogel

Comparison of the early stages of forced unfolding for fibronectin type III modules
PNAS 2001 98: 5590-5595; published online before print May 1, 2001, 10.1073/pnas.101582198 [Abstract] [Full Text] [PDF]  

F. Rousseau, J. W. H. Schymkowitz, H. R. Wilkinson, and L. S. Itzhaki

Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues
PNAS 2001 98: 5596-5601. [Abstract] [Full Text] [PDF]  

Cell Biology

Aaron L. Kurtzman and Nisson Schechter

Ubc9 interacts with a nuclear localization signal and mediates nuclear localization of the paired-like homeobox protein Vsx-1 independent of SUMO-1 modification
PNAS 2001 98: 5602-5607; published online before print May 1, 2001, 10.1073/pnas.101129698 [Abstract] [Full Text] [PDF]  

I. Zucchi, L. Bini, R. Valaperta, A. Ginestra, D. Albani, L. Susani, J. C. Sanchez, S. Liberatori, B. Magi, R. Raggiaschi, D. F. Hochstrasser, V. Pallini, P. Vezzoni, and R. Dulbecco

Proteomic dissection of dome formation in a mammary cell line: Role of tropomyosin-5b and maspin
PNAS 2001 98: 5608-5613; published online before print May 1, 2001, 10.1073/pnas.091101898 [Abstract] [Full Text] [PDF]  

F.-C. Yang, S. J. Atkinson, Y. Gu, J. B. Borneo, A. W. Roberts, Y. Zheng, J. Pennington, and D. A. Williams

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
PNAS 2001 98: 5614-5618; published online before print April 24, 2001, 10.1073/pnas.101546898 [Abstract] [Full Text] [PDF]  

Luke H. Chamberlain, Robert D. Burgoyne, and Gwyn W. Gould

SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis
PNAS 2001 98: 5619-5624; published online before print May 1, 2001, 10.1073/pnas.091502398 [Abstract] [Full Text] [PDF]  

Markus Teige, Elisabeth Scheikl, Vladimir Reiser, Helmut Ruis, and Gustav Ammerer

Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast
PNAS 2001 98: 5625-5630. [Abstract] [Full Text] [PDF] [Supplemental Text]  

Lue Ping Zhao, Ross Prentice, and Linda Breeden

Statistical modeling of large microarray data sets to identify stimulus-response profiles
PNAS 2001 98: 5631-5636. [Abstract] [Full Text] [PDF] [Supplemental Appendix]  

Developmental Biology

Eric C. Lai and Gerald M. Rubin From the Cover: neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development PNAS 2001 98: 5637-5642. [Abstract] [Full Text] [PDF]

H. Uyttendaele, J. Ho, J. Rossant, and J. Kitajewski

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
PNAS 2001 98: 5643-5648. [Abstract] [Full Text] [PDF]  

Robert O. Stuart, Kevin T. Bush, and Sanjay K. Nigam

Changes in global gene expression patterns during development and maturation of the rat kidney
PNAS 2001 98: 5649-5654; published online before print May 1, 2001, 10.1073/pnas.091110798 [Abstract] [Full Text] [PDF]  

Ecology

Hans W. Paerl, Jerad D. Bales, Larry W. Ausley, Christopher P. Buzzelli, Larry B. Crowder, Lisa A. Eby, John M. Fear, Malia Go, Benjamin L. Peierls, Tammi L. Richardson, and Joseph S. Ramus

Ecosystem impacts of three sequential hurricanes (Dennis, Floyd, and Irene) on the United States' largest lagoonal estuary, Pamlico Sound, NC
PNAS 2001 98: 5655-5660. [Abstract] [Full Text] [PDF]  

Walter Jetz and Carsten Rahbek

Geometric constraints explain much of the species richness pattern in African birds
PNAS 2001 98: 5661-5666. [Abstract] [Full Text] [PDF]  

D. Ross Robertson

Population maintenance among tropical reef fishes: Inferences from small-island endemics
PNAS 2001 98: 5667-5670; published online before print May 1, 2001, 10.1073/pnas.091367798 [Abstract] [Full Text] [PDF]  

Evolution

Joseph W. Thornton

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions
PNAS 2001 98: 5671-5676; published online before print May 1, 2001, 10.1073/pnas.091553298 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Adam K. Chippindale and William R. Rice

Y chromosome polymorphism is a strong determinant of male fitness in Drosophila melanogaster
PNAS 2001 98: 5677-5682; published online before print April 24, 2001, 10.1073/pnas.101456898 [Abstract] [Full Text] [PDF]  

Alastair D. Stutt and Michael T. Siva-Jothy

Traumatic insemination and sexual conflict in the bed bug Cimex lectularius
PNAS 2001 98: 5683-5687; published online before print May 1, 2001, 10.1073/pnas.101440698 [Abstract] [Full Text] [PDF]  

Gabriel Marais, Dominique Mouchiroud, and Laurent Duret

Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes
PNAS 2001 98: 5688-5692; published online before print April 24, 2001, 10.1073/pnas.091427698 [Abstract] [Full Text] [PDF]  

Nicholas A. Stover and Robert E. Steele

Trans-spliced leader addition to mRNAs in a cnidarian
PNAS 2001 98: 5693-5698; published online before print May 1, 2001, 10.1073/pnas.101049998 [Abstract] [Full Text] [PDF]  

Ricardo B. R. Azevedo and Armand M. Leroi

A power law for cells
PNAS 2001 98: 5699-5704; published online before print May 1, 2001, 10.1073/pnas.091485998 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Genetics

Richard Saffery, Lee H. Wong, Danielle V. Irvine, Melissa A. Bateman, Belinda Griffiths, Suzanne M. Cutts, Michael R. Cancilla, Angela C. Cendron, Angela J. Stafford, and K. H. Andy Choo From the Cover: Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation PNAS 2001 98: 5705-5710; published online before print May 1, 2001, 10.1073/pnas.091468498 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Outi Monni, Maarit Bärlund, Spyro Mousses, Juha Kononen, Guido Sauter, Mervi Heiskanen, Paulina Paavola, Kristiina Avela, Yidong Chen, Michael L. Bittner, and Anne Kallioniemi

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
PNAS 2001 98: 5711-5716; published online before print May 1, 2001, 10.1073/pnas.091582298 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Kelvin Y. Kwan and James C. Wang

Mice lacking DNA topoisomerase III develop to maturity but show a reduced mean lifespan
PNAS 2001 98: 5717-5721; published online before print May 1, 2001, 10.1073/pnas.101132498 [Abstract] [Full Text] [PDF]  

Takeshi Shiraishi, Teresa Druck, Koshi Mimori, Jacob Flomenberg, Lori Berk, Hansjuerg Alder, Webb Miller, Kay Huebner, and Carlo M. Croce

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
PNAS 2001 98: 5722-5727; published online before print April 24, 2001, 10.1073/pnas.091095898 [Abstract] [Full Text] [PDF]  

Ophelia Papoulas, Gary Daubresse, Jennifer A. Armstrong, Janet Jin, Matthew P. Scott, and John W. Tamkun

The HMG-domain protein BAP111 is important for the function of the BRM chromatin-remodeling complex in vivo
PNAS 2001 98: 5728-5733; published online before print May 1, 2001, 10.1073/pnas.091533398 [Abstract] [Full Text] [PDF]  

A. J. Tipping, T. Pearson, N. V. Morgan, R. A. Gibson, L. P. Kuyt, C. Havenga, E. Gluckman, H. Joenje, T. de Ravel, S. Jansen, and C. G. Mathew

Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa
PNAS 2001 98: 5734-5739. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Isabella A. Graef, Julie M. Gastier, Uta Francke, and Gerald R. Crabtree

Evolutionary relationships among Rel domains indicate functional diversification by recombination
PNAS 2001 98: 5740-5745. [Abstract] [Full Text] [PDF]  

Immunology

Dong Zhang, Paul J. Beresford, Arnold H. Greenberg, and Judy Lieberman

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
PNAS 2001 98: 5746-5751; published online before print May 1, 2001, 10.1073/pnas.101329598 [Abstract] [Full Text] [PDF]  

Claudia Manca, Liana Tsenova, Amy Bergtold, Sherry Freeman, Michael Tovey, James M. Musser, Clifton E. Barry III, Victoria H. Freedman, and Gilla Kaplan

Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-/
PNAS 2001 98: 5752-5757; published online before print April 24, 2001, 10.1073/pnas.091096998 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Cliburn Chan, Andrew J. T. George, and Jaroslav Stark

Cooperative enhancement of specificity in a lattice of T cell receptors
PNAS 2001 98: 5758-5763. [Abstract] [Full Text] [PDF]  

Chiara Vitale, Chiara Romagnani, Antonio Puccetti, Daniel Olive, Regis Costello, Laura Chiossone, Anna Pitto, Andrea Bacigalupo, Lorenzo Moretta, and Maria Cristina Mingari

Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells
PNAS 2001 98: 5764-5769; published online before print April 24, 2001, 10.1073/pnas.091097198 [Abstract] [Full Text] [PDF]  

Medical Sciences

Alberto Bardelli, Daniel P. Cahill, Gabi Lederer, Michael R. Speicher, Kenneth W. Kinzler, Bert Vogelstein, and Christoph Lengauer From the Cover: Carcinogen-specific induction of genetic instability PNAS 2001 98: 5770-5775; published online before print April 10, 2001, 10.1073/pnas.081082898 [Abstract] [Full Text] [PDF]

Thomas Mercher, Maryvonne Busson-Le Coniat, Richard Monni, Martine Mauchauffé, Florence Nguyen Khac, Lætitia Gressin, Francine Mugneret, Thierry Leblanc, Nicole Dastugue, Roland Berger, and Olivier A. Bernard

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia
PNAS 2001 98: 5776-5779. [Abstract] [Full Text] [PDF]  

Frank J. Giordano, Hans-Peter Gerber, Simon-Peter Williams, Nicholas VanBruggen, Stuart Bunting, Pilar Ruiz-Lozano, Yusu Gu, Anjali K. Nath, Yan Huang, Reed Hickey, Nancy Dalton, Kirk L. Peterson, John Ross Jr., Kenneth R. Chien, and Napoleone Ferrara

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
PNAS 2001 98: 5780-5785; published online before print May 1, 2001, 10.1073/pnas.091415198 [Abstract] [Full Text] [PDF]  

Guangming Liu, Nanyue Chen, Akira Kaji, Ann M. Bode, Clarence A. Ryan, and Zigang Dong

Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells
PNAS 2001 98: 5786-5791; published online before print May 1, 2001, 10.1073/pnas.101116298 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Martin P. Moya, Andrew J. Gow, Timothy J. McMahon, Eric J. Toone, Ira M. Cheifetz, Ronald N. Goldberg, and Jonathan S. Stamler

S-nitrosothiol repletion by an inhaled gas regulates pulmonary function
PNAS 2001 98: 5792-5797; published online before print April 24, 2001, 10.1073/pnas.091109498 [Abstract] [Full Text] [PDF]  

G. Motyckova, K. N. Weilbaecher, M. Horstmann, D. J. Rieman, D. Z. Fisher, and D. E. Fisher

Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family
PNAS 2001 98: 5798-5803; published online before print May 1, 2001, 10.1073/pnas.091479298 [Abstract] [Full Text] [PDF] [Supplemental Methods]  

Ann Hellstrom, Carole Perruzzi, Meihua Ju, Eva Engström, Anna-Lena Hård, Jun-Li Liu, Kerstin Albertsson-Wikland, Björn Carlsson, Aimon Niklasson, Lena Sjödell, Derek LeRoith, Donald R. Senger, and Lois E. H. Smith

Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity
PNAS 2001 98: 5804-5808; published online before print May 1, 2001, 10.1073/pnas.101113998 [Abstract] [Full Text] [PDF]  

Victoria B. Harding, Larry R. Jones, Robert J. Lefkowitz, Walter J. Koch, and Howard A. Rockman

Cardiac ARK1 inhibition prolongs survival and augments blocker therapy in a mouse model of severe heart failure
PNAS 2001 98: 5809-5814; published online before print May 1, 2001, 10.1073/pnas.091102398 [Abstract] [Full Text] [PDF]  

Elzbieta Kojro, Gerald Gimpl, Sven Lammich, Winfried März, and Falk Fahrenholz From the Cover: Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the -secretase ADAM 10 PNAS 2001 98: 5815-5820; published online before print April 17, 2001, 10.1073/pnas.081612998 [Abstract] [Full Text] [PDF]

Valsala Haridas, Masahiro Higuchi, Gamini S. Jayatilake, David Bailey, Kalpana Mujoo, Mary E. Blake, Charles J. Arntzen, and Jordan U. Gutterman

Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation
PNAS 2001 98: 5821-5826. [Abstract] [Full Text] [PDF]  

David J. Christini, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, David J. Slotwiner, Marc A. Scheiner, Sei Iwai, and Bruce B. Lerman

Nonlinear-dynamical arrhythmia control in humans
PNAS 2001 98: 5827-5832; published online before print April 24, 2001, 10.1073/pnas.091553398 [Abstract] [Full Text] [PDF]  

Microbiology

L. G. Miller, R. M. Kalin, S. E. McCauley, J. T. G. Hamilton, D. B. Harper, D. B. Millet, R. S. Oremland, and A. H. Goldstein

Large carbon isotope fractionation associated with oxidation of methyl halides by methylotrophic bacteria
PNAS 2001 98: 5833-5837. [Abstract] [Full Text] [PDF]  

María Cecilia Rojas, Peter Hedden, Paul Gaskin, and Bettina Tudzynski

The P450-1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis
PNAS 2001 98: 5838-5843; published online before print April 24, 2001, 10.1073/pnas.091096298 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Nagraj Mani and Bruno Dupuy

Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor
PNAS 2001 98: 5844-5849; published online before print April 24, 2001, 10.1073/pnas.101126598 [Abstract] [Full Text] [PDF]  

Corrella S. Detweiler, Dolores B. Cunanan, and Stanley Falkow

Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death
PNAS 2001 98: 5850-5855; published online before print April 24, 2001, 10.1073/pnas.091110098 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Neurobiology

K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, S. Kühl, T. Bertsch, K. von Bergmann, M. Hennerici, K. Beyreuther, and T. Hartmann

Simvastatin strongly reduces levels of Alzheimer's disease -amyloid peptides A42 and A40 in vitro and in vivo
PNAS 2001 98: 5856-5861; published online before print April 10, 2001, 10.1073/pnas.081620098 [Abstract] [Full Text] [PDF]  

Kevin D. Long, Grace Kennedy, and Evan Balaban

Transferring an inborn auditory perceptual predisposition with interspecies brain transplants
PNAS 2001 98: 5862-5867; published online before print April 24, 2001, 10.1073/pnas.091080098 [Abstract] [Full Text] [PDF]  

Kinichi Nakashima, Takumi Takizawa, Wataru Ochiai, Makoto Yanagisawa, Tatsuhiro Hisatsune, Masato Nakafuku, Kohei Miyazono, Tadamitsu Kishimoto, Ryoichiro Kageyama, and Tetsuya Taga

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
PNAS 2001 98: 5868-5873; published online before print May 1, 2001, 10.1073/pnas.101109698 [Abstract] [Full Text] [PDF]  

Shinichi Yoshimura, Yasushi Takagi, Jun Harada, Tetsuyuki Teramoto, Sunu S. Thomas, Christian Waeber, Joanna C. Bakowska, Xandra O. Breakefield, and Michael A. Moskowitz

FGF-2 regulation of neurogenesis in adult hippocampus after brain injury
PNAS 2001 98: 5874-5879; published online before print April 24, 2001, 10.1073/pnas.101034998 [Abstract] [Full Text] [PDF]  

Alexei Savchenko, Timothy W. Kraft, Elena Molokanova, and Richard H. Kramer

Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue
PNAS 2001 98: 5880-5885; published online before print April 24, 2001, 10.1073/pnas.101524998 [Abstract] [Full Text] [PDF]  

Pharmacology

Richard D. Kopke, Ronald L. Jackson, Geming Li, Mark D. Rasmussen, Michael E. Hoffer, Dorothy A. Frenz, Michael Costello, Peter Schultheiss, and Thomas R. Van de Water

Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function
PNAS 2001 98: 5886-5891; published online before print May 1, 2001, 10.1073/pnas.101120898 [Abstract] [Full Text] [PDF]  

Physiology

Christina M. Wilkens, Nicole Kasielke, Bernhard E. Flucher, Kurt G. Beam, and Manfred Grabner

Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the _1S II-III loop
PNAS 2001 98: 5892-5897; published online before print April 24, 2001, 10.1073/pnas.101618098 [Abstract] [Full Text] [PDF]  

Bihong Zhao, Steven S. Chua, Mark M. Burcin, Susan D. Reynolds, Barry R. Stripp, Robert A. Edwards, Milton J. Finegold, Sophia Y. Tsai, and Francesco J. DeMayo

Phenotypic consequences of lung-specific inducible expression of FGF-3
PNAS 2001 98: 5898-5903; published online before print May 1, 2001, 10.1073/pnas.101116598 [Abstract] [Full Text] [PDF]  

Simon Papadopoulos, Volker Endeward, Brigitta Revesz-Walker, Klaus D. Jürgens, and Gerolf Gros

Radial and longitudinal diffusion of myoglobin in single living heart and skeletal muscle cells
PNAS 2001 98: 5904-5909; published online before print April 24, 2001, 10.1073/pnas.101109798 [Abstract] [Full Text] [PDF]  

Plant Biology

Rouven M. Klug and Christoph Benning

Two enzymes of diacylglyceryl-O-4'-(N,N,N,-trimethyl)homoserine biosynthesis are encoded by btaA and btaB in the purple bacterium Rhodobacter sphaeroides
PNAS 2001 98: 5910-5915; published online before print May 1, 2001, 10.1073/pnas.101037998 [Abstract] [Full Text] [PDF]  

Jia Li, Kevin A. Lease, Frans E. Tax, and John C. Walker

BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana
PNAS 2001 98: 5916-5921; published online before print April 24, 2001, 10.1073/pnas.091065998 [Abstract] [Full Text] [PDF]  

Ruth C. Martin, Machteld C. Mok, Jeffrey E. Habben, and David W. S. Mok

A maize cytokinin gene encoding an O-glucosyltransferase specific to cis-zeatin
PNAS 2001 98: 5922-5926; published online before print May 1, 2001, 10.1073/pnas.101128798 [Abstract] [Full Text] [PDF]  

Population Biology

Gordon Luikart, Ludovic Gielly, Laurent Excoffier, Jean-Denis Vigne, Jean Bouvet, and Pierre Taberlet From the Cover: Multiple maternal origins and weak phylogeographic structure in domestic goats PNAS 2001 98: 5927-5932. [Abstract] [Full Text] [PDF] [Supplemental Data]

Psychology

Peter Indefrey, Colin M. Brown, Frauke Hellwig, Katrin Amunts, Hans Herzog, Rüdiger J. Seitz, and Peter Hagoort

A neural correlate of syntactic encoding during speech production
PNAS 2001 98: 5933-5936; published online before print May 1, 2001, 10.1073/pnas.101118098 [Abstract] [Full Text] [PDF]  

Diana Reiss and Lori Marino

Mirror self-recognition in the bottlenose dolphin: A case of cognitive convergence
PNAS 2001 98: 5937-5942; published online before print May 1, 2001, 10.1073/pnas.101086398 [Abstract] [Full Text] [PDF] [Supplemental Movies]  

CORRECTIONS

Retraction for vol. 97, p. 297 [Full Text] [PDF]