EDITORIAL

Nicholas R. Cozzarelli

Unfettered access to published results
PNAS 2001 98: 8159; published online before print July 10, 2001, 10.1073/pnas.171309098 [Full Text] [PDF]  

COMMENTARIES

Robert E. Fleming and William S. Sly

Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
PNAS 2001 98: 8160-8162. [Full Text] [PDF]  

Virginia Walbot and Dmitri A. Petrov

Gene galaxies in the maize genome
PNAS 2001 98: 8163-8164. [Full Text] [PDF]  

Murray Stewart

Structural basis for bending tropomyosin around actin in muscle thin filaments
PNAS 2001 98: 8165-8166. [Full Text] [PDF]  

Samuel S. C. Yen

Dehydroepiandrosterone sulfate and longevity: New clues for an old friend
PNAS 2001 98: 8167-8169. [Full Text] [PDF]  

Paul R. Thompson and Philip A. Cole

Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick
PNAS 2001 98: 8170-8171. [Full Text] [PDF]  

COLLOQUIUM:
Papers from the National Academy of Sciences Colloquium on Links Between Recombination and Replication: Vital Roles of Recombination

Charles Radding

Introduction: Links between recombination and replication: Vital roles of recombination
PNAS 2001 98: 8172. [Full Text] [PDF]  

Michael M. Cox

Historical overview: Searching for replication help in all of the rec places
PNAS 2001 98: 8173-8180. [Abstract] [Full Text] [PDF]  

Bénédicte Michel, Maria-Jose Flores, Enrique Viguera, Gianfranco Grompone, Marie Seigneur, and Vladimir Bidnenko

Rescue of arrested replication forks by homologous recombination
PNAS 2001 98: 8181-8188. [Abstract] [Full Text] [PDF]  

François-Xavier Barre, Britta Søballe, Bénédicte Michel, Mira Aroyo, Malcolm Robertson, and David Sherratt

Circles: The replication-recombination-chromosome segregation connection
PNAS 2001 98: 8189-8195. [Abstract] [Full Text] [PDF]  

Justin Courcelle and Philip C. Hanawalt

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination
PNAS 2001 98: 8196-8202. [Abstract] [Full Text] [PDF]  

Jesse D. McCool and Steven J. Sandler

Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2::kan mutant
PNAS 2001 98: 8203-8210. [Abstract] [Full Text] [PDF]  

Mara E. Robu, Ross B. Inman, and Michael M. Cox

RecA protein promotes the regression of stalled replication forks in vitro
PNAS 2001 98: 8211-8218. [Abstract] [Full Text] [PDF]  

Lisa Postow, Nancy J. Crisona, Brian J. Peter, Christine D. Hardy, and Nicholas R. Cozzarelli

Topological challenges to DNA replication: Conformations at the fork
PNAS 2001 98: 8219-8226. [Abstract] [Full Text] [PDF]  

Peter McGlynn and Robert G. Lloyd

Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation
PNAS 2001 98: 8227-8234. [Abstract] [Full Text] [PDF]  

Peter McGlynn, Robert G. Lloyd, and Kenneth J. Marians

Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
PNAS 2001 98: 8235-8240. [Abstract] [Full Text] [PDF]  

Andrei Kuzminov

Single-strand interruptions in replicating chromosomes cause double-strand breaks
PNAS 2001 98: 8241-8246. [Abstract] [Full Text] [PDF]  

Hiroshi Nakai, Victoria Doseeva, and Jessica M. Jones

Handoff from recombinase to replisome: Insights from transposition
PNAS 2001 98: 8247-8254. [Abstract] [Full Text] [PDF]  

Eliyahu Kraus, Wai-Ying Leung, and James E. Haber

Break-induced replication: A review and an example in budding yeast
PNAS 2001 98: 8255-8262. [Abstract] [Full Text] [PDF]  

Hélène Debrauwère, Sophie Loeillet, Waka Lin, Judith Lopes, and Alain Nicolas

Links between replication and recombination in Saccharomyces cerevisiae: A hypersensitive requirement for homologous recombination in the absence of Rad27 activity
PNAS 2001 98: 8263-8269. [Abstract] [Full Text] [PDF]  

Dena R. Carson and Michael F. Christman

Evidence that replication fork components catalyze establishment of cohesion between sister chromatids
PNAS 2001 98: 8270-8275. [Abstract] [Full Text] [PDF]  

Michael Lisby, Rodney Rothstein, and Uffe H. Mortensen From the Cover: Rad52 forms DNA repair and recombination centers during S phase PNAS 2001 98: 8276-8282. [Abstract] [Full Text] [PDF]

Takashi Hishida, Hiroshi Iwasaki, Takayuki Ohno, Takashi Morishita, and Hideo Shinagawa

A yeast gene, MGS1, encoding a DNA-dependent AAA⁺ ATPase is required to maintain genome stability
PNAS 2001 98: 8283-8289. [Abstract] [Full Text] [PDF]  

James W. George, Bradley A. Stohr, Daniel J. Tomso, and Kenneth N. Kreuzer

The tight linkage between DNA replication and double-strand break repair in bacteriophage T4
PNAS 2001 98: 8290-8297. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Jill S. Bleuit, Hang Xu, Yujie Ma, Tongsheng Wang, Jie Liu, and Scott W. Morrical

Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair
PNAS 2001 98: 8298-8305. [Abstract] [Full Text] [PDF]  

Gisela Mosig, John Gewin, Andreas Luder, Nancy Colowick, and Daniel Vo

Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer
PNAS 2001 98: 8306-8311. [Abstract] [Full Text] [PDF]  

Charles E. Jones, Timothy C. Mueser, Kathleen C. Dudas, Kenneth N. Kreuzer, and Nancy G. Nossal

Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: A versatile couple with roles in replication and recombination
PNAS 2001 98: 8312-8318. [Abstract] [Full Text] [PDF]  

Malgorzata Bzymek and Susan T. Lovett

Instability of repetitive DNA sequences: The role of replication in multiple mechanisms
PNAS 2001 98: 8319-8325. [Abstract] [Full Text] [PDF]  

Zhi-Hong Zhou, Ercan Akgün, and Maria Jasin

Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
PNAS 2001 98: 8326-8333. [Abstract] [Full Text] [PDF]  

Harold J. Bull, Mary-Jane Lombardo, and Susan M. Rosenberg

Stationary-phase mutation in the bacterial chromosome: Recombination protein and DNA polymerase IV dependence
PNAS 2001 98: 8334-8341. [Abstract] [Full Text] [PDF]  

Mark D. Sutton and Graham C. Walker

Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination
PNAS 2001 98: 8342-8349. [Abstract] [Full Text] [PDF]  

Phuong Pham, Savithri Rangarajan, Roger Woodgate, and Myron F. Goodman

Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli
PNAS 2001 98: 8350-8354. [Abstract] [Full Text] [PDF]  

M. Todd Washington, Robert E. Johnson, Louise Prakash, and Satya Prakash

Accuracy of lesion bypass by yeast and human DNA polymerase
PNAS 2001 98: 8355-8360. [Abstract] [Full Text] [PDF]  

Richard D. Klemm and Stephen P. Bell

ATP bound to the origin recognition complex is important for preRC formation
PNAS 2001 98: 8361-8367. [Abstract] [Full Text] [PDF]  

Michael A. Trakselis, Stephen C. Alley, Ernesto Abel-Santos, and Stephen J. Benkovic

Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer
PNAS 2001 98: 8368-8375. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Francisco J. López de Saro and Mike O'Donnell

Interaction of the sliding clamp with MutS, ligase, and DNA polymerase I
PNAS 2001 98: 8376-8380. [Abstract] [Full Text] [PDF]  

Mark S. Dillingham, Panos Soultanas, Paul Wiley, Martin R. Webb, and Dale B. Wigley

Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase
PNAS 2001 98: 8381-8387. [Abstract] [Full Text] [PDF]  

Eiichiro Sonoda, Minoru Takata, Yukiko M. Yamashita, Ciaran Morrison, and Shunichi Takeda

Homologous DNA recombination in vertebrate cells
PNAS 2001 98: 8388-8394. [Abstract] [Full Text] [PDF]  

Luther Davis and Gerald R. Smith

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe
PNAS 2001 98: 8395-8402. [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Karen M. Vasquez, Kathleen Marburger, Zsofia Intody, and John H. Wilson

Manipulating the mammalian genome by homologous recombination
PNAS 2001 98: 8403-8410. [Abstract] [Full Text] [PDF]  

Stephen L. Gasior, Heidi Olivares, Uy Ear, Danielle M. Hari, Ralph Weichselbaum, and Douglas K. Bishop

Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis
PNAS 2001 98: 8411-8418. [Abstract] [Full Text] [PDF]  

Xiong Yu, Steven A. Jacobs, Stephen C. West, Tomoko Ogawa, and Edward H. Egelman

Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA
PNAS 2001 98: 8419-8424. [Abstract] [Full Text] [PDF]  

Takehiko Shibata, Taro Nishinaka, Tsutomu Mikawa, Hideki Aihara, Hitoshi Kurumizaka, Shigeyuki Yokoyama, and Yutaka Ito

Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: A possible advantage of DNA over RNA as genomic material
PNAS 2001 98: 8425-8432. [Abstract] [Full Text] [PDF]  

R. C. Gupta, E. Golub, B. Bi, and C. M. Radding

The synaptic activity of HsDmc1, a human recombination protein specific to meiosis
PNAS 2001 98: 8433-8439. [Abstract] [Full Text] [PDF]  

Jean-Yves Masson, Alicja Z. Stasiak, Andrzej Stasiak, Fiona E. Benson, and Stephen C. West

Complex formation by the human RAD51C and XRCC3 recombination repair proteins
PNAS 2001 98: 8440-8446. [Abstract] [Full Text] [PDF]  

Jachen Armon Solinger and Wolf-Dietrich Heyer

Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange
PNAS 2001 98: 8447-8453. [Abstract] [Full Text] [PDF]  

Dejan Ristic, Claire Wyman, Coen Paulusma, and Roland Kanaar

The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA
PNAS 2001 98: 8454-8460. [Abstract] [Full Text] [PDF]  

Andrei Kuzminov

DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination
PNAS 2001 98: 8461-8468. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Chemistry

Gadi Peleg, Pejman Ghanouni, Brian K. Kobilka, and Richard N. Zare

Single-molecule spectroscopy of the ₂ adrenergic receptor: Observation of conformational substates in a membrane protein
PNAS 2001 98: 8469-8474; published online before print July 3, 2001, 10.1073/pnas.151239698 [Abstract] [Full Text] [PDF]  

S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed

The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies
PNAS 2001 98: 8475-8479; published online before print July 10, 2001, 10.1073/pnas.141220198 [Abstract] [Full Text] [PDF]  

Albert J. Chmura, Molly S. Orton, and Claude F. Meares

Antibodies with infinite affinity
PNAS 2001 98: 8480-8484; published online before print July 10, 2001, 10.1073/pnas.151260298 [Abstract] [Full Text] [PDF]  

Physics

Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach

Tuning DNA "strings": Modulating the rate of DNA replication with mechanical tension
PNAS 2001 98: 8485-8489; published online before print July 10, 2001, 10.1073/pnas.151261198 [Abstract] [Full Text] [PDF]  

Simona Cocco, Rémi Monasson, and John F. Marko

Force and kinetic barriers to unzipping of the DNA double helix
PNAS 2001 98: 8608-8613; published online before print July 10, 2001, 10.1073/pnas.151257598 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
Biochemistry

Jenny Hizver, Haim Rozenberg, Felix Frolow, Dov Rabinovich, and Zippora Shakked

DNA bending by an adenine-thymine tract and its role in gene regulation
PNAS 2001 98: 8490-8495; published online before print July 3, 2001, 10.1073/pnas.151247298 [Abstract] [Full Text] [PDF]  

Jerry H. Brown, Kyoung-Hee Kim, Gyo Jun, Norma J. Greenfield, Roberto Dominguez, Niels Volkmann, Sarah E. Hitchcock-DeGregori, and Carolyn Cohen

Deciphering the design of the tropomyosin molecule
PNAS 2001 98: 8496-8501; published online before print July 3, 2001, 10.1073/pnas.131219198 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Vladimir N. Malashkevich, Mona Singh, and Peter S. Kim

The trimer-of-hairpins motif in membrane fusion: Visna virus
PNAS 2001 98: 8502-8506; published online before print July 10, 2001, 10.1073/pnas.151254798 [Abstract] [Full Text] [PDF]  

Karen Brown, Brian E. Hingerty, Elizabeth A. Guenther, V. V. Krishnan, Suse Broyde, Kenneth W. Turteltaub, and Monique Cosman

Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA
PNAS 2001 98: 8507-8512; published online before print July 3, 2001, 10.1073/pnas.151251898 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Jun Xi, Ying Ge, Cynthia Kinsland, Fred W. McLafferty, and Tadhg P. Begley

Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: Identification of an acyldisulfide-linked protein-protein conjugate that is functionally analogous to the ubiquitin/E1 complex
PNAS 2001 98: 8513-8518; published online before print July 3, 2001, 10.1073/pnas.141226698 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Marcus L. Hutcheon, Thomas M. Duncan, Helen Ngai, and Richard L. Cross

Energy-driven subunit rotation at the interface between subunit a and the c oligomer in the F_O sector of Escherichia coli ATP synthase
PNAS 2001 98: 8519-8524; published online before print July 3, 2001, 10.1073/pnas.151236798 [Abstract] [Full Text] [PDF]  

Ho Cho, Weiru Wang, Rosalind Kim, Hisao Yokota, Steven Damo, Sung-Hou Kim, David Wemmer, Sydney Kustu, and Dalai Yan From the Cover: BeF3- acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeF3- complex with phosphoserine phosphatase PNAS 2001 98: 8525-8530; published online before print July 3, 2001, 10.1073/pnas.131213698 [Abstract] [Full Text] [PDF]

Graham S. Jackson, Ian Murray, Laszlo L. P. Hosszu, Nicholas Gibbs, Jonathan P. Waltho, Anthony R. Clarke, and John Collinge

Location and properties of metal-binding sites on the human prion protein
PNAS 2001 98: 8531-8535; published online before print July 3, 2001, 10.1073/pnas.151038498 [Abstract] [Full Text] [PDF]  

A. T. Aman, S. Fraser, E. A. Merritt, C. Rodigherio, M. Kenny, M. Ahn, W. G. J. Hol, N. A. Williams, W. I. Lencer, and T. R. Hirst

A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity
PNAS 2001 98: 8536-8541; published online before print July 10, 2001, 10.1073/pnas.161273098 [Abstract] [Full Text] [PDF]  

Anand Sethuraman, Narayana N. Rao, and Arthur Kornberg

The endopolyphosphatase gene: Essential in Saccharomyces cerevisiae
PNAS 2001 98: 8542-8547; published online before print July 10, 2001, 10.1073/pnas.151269398 [Abstract] [Full Text] [PDF]  

Hsien-Tai Chiu, Brian K. Hubbard, Aseema N. Shah, Jonathan Eide, Ross A. Fredenburg, Christopher T. Walsh, and Chaitan Khosla

Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
PNAS 2001 98: 8548-8553; published online before print July 10, 2001, 10.1073/pnas.151246498 [Abstract] [Full Text] [PDF]  

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai, Frank Mercurio, Craig M. Crews, and Raymond J. Deshaies

Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
PNAS 2001 98: 8554-8559; published online before print July 3, 2001, 10.1073/pnas.141230798 [Abstract] [Full Text] [PDF]  

Younus Meah, Bette Jo Brown, Sumita Chakraborty, and Vincent Massey

Old yellow enzyme: Reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate
PNAS 2001 98: 8560-8565; published online before print July 3, 2001, 10.1073/pnas.151249098 [Abstract] [Full Text] [PDF]  

Olivier J. Becherel and Robert P. P. Fuchs

Mechanism of DNA polymerase II-mediated frameshift mutagenesis
PNAS 2001 98: 8566-8571; published online before print July 10, 2001, 10.1073/pnas.141113398 [Abstract] [Full Text] [PDF]  

Christiane Schaffitzel, Imre Berger, Jan Postberg, Jozef Hanes, Hans J. Lipps, and Andreas Plückthun

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
PNAS 2001 98: 8572-8577; published online before print July 3, 2001, 10.1073/pnas.141229498 [Abstract] [Full Text] [PDF]  

Y. R. Hadari, N. Gotoh, H. Kouhara, I. Lax, and J. Schlessinger

Critical role for the docking-protein FRS2 in FGF receptor-mediated signal transduction pathways
PNAS 2001 98: 8578-8583; published online before print July 10, 2001, 10.1073/pnas.161259898 [Abstract] [Full Text] [PDF]  

Philippe T. Georgel, Madeleine A. Palacios DeBeer, Gregory Pietz, Catherine A. Fox, and Jeffrey C. Hansen

Sir3-dependent assembly of supramolecular chromatin structures in vitro
PNAS 2001 98: 8584-8589; published online before print July 10, 2001, 10.1073/pnas.151258798 [Abstract] [Full Text] [PDF]  

Jeannine M. Petersen, Lu-Shiun Her, and James E. Dahlberg

Multiple vesiculoviral matrix proteins inhibit both nuclear export and import
PNAS 2001 98: 8590-8595; published online before print July 10, 2001, 10.1073/pnas.151240998 [Abstract] [Full Text] [PDF]  

Baohe Shen, H. Liu, Edward Y. Skolnik, and James L. Manley

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
PNAS 2001 98: 8596-8601; published online before print July 10, 2001, 10.1073/pnas.141235698 [Abstract] [Full Text] [PDF]  

Biophysics

S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed

The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies
PNAS 2001 98: 8475-8479; published online before print July 10, 2001, 10.1073/pnas.141220198 [Abstract] [Full Text] [PDF]  

Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach

Tuning DNA "strings": Modulating the rate of DNA replication with mechanical tension
PNAS 2001 98: 8485-8489; published online before print July 10, 2001, 10.1073/pnas.151261198 [Abstract] [Full Text] [PDF]  

Sergej Vasil'ev, Peter Orth, Athina Zouni, Thomas G. Owens, and Doug Bruce

Excited-state dynamics in photosystem II: Insights from the x-ray crystal structure
PNAS 2001 98: 8602-8607. [Abstract] [Full Text] [PDF]  

Simona Cocco, Rémi Monasson, and John F. Marko

Force and kinetic barriers to unzipping of the DNA double helix
PNAS 2001 98: 8608-8613; published online before print July 10, 2001, 10.1073/pnas.151257598 [Abstract] [Full Text] [PDF]  

Mukund Thattai and Alexander van Oudenaarden

Intrinsic noise in gene regulatory networks
PNAS 2001 98: 8614-8619; published online before print July 3, 2001, 10.1073/pnas.151588598 [Abstract] [Full Text] [PDF]  

Christoph Kuhn

Computer-modeling origin of a simple genetic apparatus
PNAS 2001 98: 8620-8625. [Abstract] [Full Text] [PDF]  

Cell Biology

Annarosa Leri, Laura Barlucchi, Federica Limana, Andrzej Deptala, Zbigniew Darzynkiewicz, Thomas H. Hintze, Jan Kajstura, Bernardo Nadal-Ginard, and Piero Anversa

Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart
PNAS 2001 98: 8626-8631; published online before print July 10, 2001, 10.1073/pnas.151013298 [Abstract] [Full Text] [PDF]  

T. Omelchenko, E. Fetisova, O. Ivanova, E. M. Bonder, H. Feder, J. M. Vasiliev, and I. M. Gelfand

Contact interactions between epitheliocytes and fibroblasts: Formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization
PNAS 2001 98: 8632-8637; published online before print July 10, 2001, 10.1073/pnas.151247698 [Abstract] [Full Text] [PDF]  

Raymond W. Ganster, Bradley S. Taylor, Lifang Shao, and David A. Geller

Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-B
PNAS 2001 98: 8638-8643; published online before print July 3, 2001, 10.1073/pnas.151239498 [Abstract] [Full Text] [PDF]  

Fen Xia, Danielle G. Taghian, Jeffrey S. DeFrank, Zhao-Chong Zeng, Henning Willers, George Iliakis, and Simon N. Powell

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
PNAS 2001 98: 8644-8649; published online before print July 10, 2001, 10.1073/pnas.151253498 [Abstract] [Full Text] [PDF]  

Je-Yong Choi, Jitesh Pratap, Amjad Javed, S. Kaleem Zaidi, Lianping Xing, Eva Balint, Sara Dalamangas, Brendan Boyce, André J. van Wijnen, Jane B. Lian, Janet L. Stein, Stephen N. Jones, and Gary S. Stein

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
PNAS 2001 98: 8650-8655; published online before print July 3, 2001, 10.1073/pnas.151236498 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Anne-Marie C. Yvon, David J. Gross, and Patricia Wadsworth

Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells
PNAS 2001 98: 8656-8661; published online before print July 3, 2001, 10.1073/pnas.141224198 [Abstract] [Full Text] [PDF]  

Yasuyuki Suzuki, Yui Nakabayashi, and Ryosuke Takahashi

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
PNAS 2001 98: 8662-8667; published online before print July 10, 2001, 10.1073/pnas.161506698 [Abstract] [Full Text] [PDF]  

Developmental Biology

Juan Galceran, Shu-Chi Hsu, and Rudolf Grosschedl

Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression
PNAS 2001 98: 8668-8673; published online before print July 10, 2001, 10.1073/pnas.151258098 [Abstract] [Full Text] [PDF]  

Jianxiang Liu, Chijen Lin, Anatoli Gleiberman, Kenneth A. Ohgi, Thomas Herman, Hsiang-Po Huang, Ming-Jer Tsai, and Michael G. Rosenfeld

Tbx19, a tissue-selective regulator of POMC gene expression
PNAS 2001 98: 8674-8679; published online before print July 10, 2001, 10.1073/pnas.141234898 [Abstract] [Full Text] [PDF]  

Jr-Gang Cheng, Jim Ray Chen, Lidia Hernandez, W. Greg Alvord, and Colin L. Stewart

Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
PNAS 2001 98: 8680-8685; published online before print July 3, 2001, 10.1073/pnas.151180898 [Abstract] [Full Text] [PDF]  

Momoyo Hanazawa, Makoto Mochii, Naoto Ueno, Yuji Kohara, and Yuichi Iino

Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans
PNAS 2001 98: 8686-8691; published online before print July 10, 2001, 10.1073/pnas.141004698 [Abstract] [Full Text] [PDF]  

Evolution

L. Lacey Knowles and Therese A. Markow

Sexually antagonistic coevolution of a postmating-prezygotic reproductive character in desert Drosophila
PNAS 2001 98: 8692-8696; published online before print July 10, 2001, 10.1073/pnas.151123998 [Abstract] [Full Text] [PDF]  

Genetics

Taizo Wada, Shepherd H. Schurman, Makoto Otsu, Elizabeth K. Garabedian, Hans D. Ochs, David L. Nelson, and Fabio Candotti

Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism
PNAS 2001 98: 8697-8702; published online before print July 10, 2001, 10.1073/pnas.151260498 [Abstract] [Full Text] [PDF]  

Bo Hong, Peter Reeves, Barbara Panning, Maurice S. Swanson, and Thomas P. Yang

Identification of an autoimmune serum containing antibodies against the Barr body
PNAS 2001 98: 8703-8708; published online before print July 3, 2001, 10.1073/pnas.151259598 [Abstract] [Full Text] [PDF]  

N. Doane Chilcoat, Nels C. Elde, and Aaron P. Turkewitz

An antisense approach to phenotype-based gene cloning in Tetrahymena
PNAS 2001 98: 8709-8713; published online before print July 3, 2001, 10.1073/pnas.151243498 [Abstract] [Full Text] [PDF]  

Vladimir V. Kapitonov and Jerzy Jurka

Rolling-circle transposons in eukaryotes
PNAS 2001 98: 8714-8719; published online before print July 10, 2001, 10.1073/pnas.151269298 [Abstract] [Full Text] [PDF]  

Brian K. Kennedy, Oliver W. Liu, Fred A. Dick, Nick Dyson, Ed Harlow, and Marc Vidal

Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft
PNAS 2001 98: 8720-8725; published online before print July 10, 2001, 10.1073/pnas.151240898 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Martin Hirst, Cynthia Ho, Luc Sabourin, Michael Rudnicki, Linda Penn, and Ivan Sadowski

A two-hybrid system for transactivator bait proteins
PNAS 2001 98: 8726-8731; published online before print July 10, 2001, 10.1073/pnas.141413598 [Abstract] [Full Text] [PDF]  

Immunology

Joyce T. Tan, Eric Dudl, Eric LeRoy, Richard Murray, Jonathan Sprent, Kenneth I. Weinberg, and Charles D. Surh

IL-7 is critical for homeostatic proliferation and survival of naïve T cells
PNAS 2001 98: 8732-8737; published online before print July 10, 2001, 10.1073/pnas.161126098 [Abstract] [Full Text] [PDF]  

Karin Jooss, Bernard Gjata, Olivier Danos, Harald von Boehmer, and Adelaida Sarukhan

Regulatory function of in vivo anergized CD4⁺ T cells
PNAS 2001 98: 8738-8743; published online before print July 3, 2001, 10.1073/pnas.151088898 [Abstract] [Full Text] [PDF]  

Bojan Polic, Desiree Kunkel, Alexander Scheffold, and Klaus Rajewsky

How T cells deal with induced TCR ablation
PNAS 2001 98: 8744-8749; published online before print July 10, 2001, 10.1073/pnas.141218898 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Britta C. Urban, Nick Willcox, and David J. Roberts

A role for CD36 in the regulation of dendritic cell function
PNAS 2001 98: 8750-8755; published online before print July 10, 2001, 10.1073/pnas.151028698 [Abstract] [Full Text] [PDF]  

Medical Sciences

Uta Fuchs, Gönna Rehkamp, Oskar A. Haas, Robert Slany, Margit König, Stig Bojesen, Rainer M. Bohle, Christine Damm-Welk, Wolf-Dieter Ludwig, Jochen Harbott, and Arndt Borkhardt

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia
PNAS 2001 98: 8756-8761; published online before print July 3, 2001, 10.1073/pnas.121433898 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Toshiyuki Kobayashi, Osamu Minowa, Yoshinobu Sugitani, Setsuo Takai, Hiroaki Mitani, Etsuko Kobayashi, Tetsuo Noda, and Okio Hino

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
PNAS 2001 98: 8762-8767; published online before print July 3, 2001, 10.1073/pnas.151033798 [Abstract] [Full Text] [PDF]  

John Sheehan, Michael Templer, Michael Gregory, Ravikumar Hanumanthaiah, Dean Troyer, Thao Phan, Bharath Thankavel, and Pudur Jagadeeswaran

Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII
PNAS 2001 98: 8768-8773. [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Tsuyoshi Shuto, Haidong Xu, Beinan Wang, Jiahuai Han, Hirofumi Kai, Xin-Xing Gu, Timothy F. Murphy, David J. Lim, and Jian-Dong Li

Activation of NF-B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK/-IB and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
PNAS 2001 98: 8774-8779; published online before print July 3, 2001, 10.1073/pnas.151236098 [Abstract] [Full Text] [PDF]  

Gaël Nicolas, Myriam Bennoun, Isabelle Devaux, Carole Beaumont, Bernard Grandchamp, Axel Kahn, and Sophie Vaulont From the Cover: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice PNAS 2001 98: 8780-8785; published online before print July 10, 2001, 10.1073/pnas.151179498 [Abstract] [Full Text] [PDF]

Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, and Tatyana S. Levchenko

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
PNAS 2001 98: 8786-8791; published online before print July 3, 2001, 10.1073/pnas.151247498 [Abstract] [Full Text] [PDF]  

Isabelle Arrighi, May Bloch-Faure, Florian Grahammer, Markus Bleich, Richard Warth, Raymond Mengual, Milou-Daniel Drici, Jacques Barhanin, and Pierre Meneton

Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
PNAS 2001 98: 8792-8797; published online before print July 3, 2001, 10.1073/pnas.141233398 [Abstract] [Full Text] [PDF]  

Tohru Minamino, Helen Christou, Chung-Ming Hsieh, Yuxiang Liu, Vijender Dhawan, Nader G. Abraham, Mark A. Perrella, S. Alex Mitsialis, and Stella Kourembanas

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
PNAS 2001 98: 8798-8803; published online before print July 10, 2001, 10.1073/pnas.161272598 [Abstract] [Full Text] [PDF]  

Samir Taneja, Jennifer MacGregor, Steven Markus, Susan Ha, and Ian Mohr

Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
PNAS 2001 98: 8804-8808; published online before print July 3, 2001, 10.1073/pnas.161011798 [Abstract] [Full Text] [PDF]  

Lawrence Fong, Yafei Hou, Alberto Rivas, Claudia Benike, Alan Yuen, George A. Fisher, Mark M. Davis, and Edgar G. Engleman

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
PNAS 2001 98: 8809-8814; published online before print June 26, 2001, 10.1073/pnas.141226398 [Abstract] [Full Text] [PDF]  

Microbiology

Charles Van Sant, Ryan Hagglund, Pascal Lopez, and Bernard Roizman

The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity
PNAS 2001 98: 8815-8820; published online before print July 10, 2001, 10.1073/pnas.161283098 [Abstract] [Full Text] [PDF]  

J. Ross Fitzgerald, Daniel E. Sturdevant, Stacy M. Mackie, Steven R. Gill, and James M. Musser

Evolutionary genomics of Staphylococcus aureus: Insights into the origin of methicillin-resistant strains and the toxic shock syndrome epidemic
PNAS 2001 98: 8821-8826; published online before print July 10, 2001, 10.1073/pnas.161098098 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Neurobiology

Sean P. MacEvoy and Michael A. Paradiso

Lightness constancy in primary visual cortex
PNAS 2001 98: 8827-8831; published online before print July 10, 2001, 10.1073/pnas.161280398 [Abstract] [Full Text] [PDF]  

Xiaoning Bi, Alex P. Yong, Jun Zhou, Charles E. Ribak, and Gary Lynch

Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice
PNAS 2001 98: 8832-8837; published online before print July 3, 2001, 10.1073/pnas.151253098 [Abstract] [Full Text] [PDF]  

Yadong Huang, Xiao Qin Liu, Tony Wyss-Coray, Walter J. Brecht, David A. Sanan, and Robert W. Mahley

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
PNAS 2001 98: 8838-8843; published online before print July 10, 2001, 10.1073/pnas.151254698 [Abstract] [Full Text] [PDF]  

Annette Schenck, Barbara Bardoni, Annamaria Moro, Claudia Bagni, and Jean-Louis Mandel

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
PNAS 2001 98: 8844-8849; published online before print July 3, 2001, 10.1073/pnas.151231598 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Ronald B. DeMattos, Kelly R. Bales, David J. Cummins, Jean-Cosme Dodart, Steven M. Paul, and David M. Holtzman

Peripheral anti-A antibody alters CNS and plasma A clearance and decreases brain A burden in a mouse model of Alzheimer's disease
PNAS 2001 98: 8850-8855; published online before print July 3, 2001, 10.1073/pnas.151261398 [Abstract] [Full Text] [PDF]  

Kristen L. Brunson, Mariam Eghbal-Ahmadi, Roland Bender, Yuncai Chen, and Tallie Z. Baram

Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress
PNAS 2001 98: 8856-8861; published online before print July 10, 2001, 10.1073/pnas.151224898 [Abstract] [Full Text] [PDF]  

Monica Mody, Yanxiang Cao, Zhenzhong Cui, Khoon-Yen Tay, Andy Shyong, Eiji Shimizu, Kelvin Pham, Peter Schultz, Douglas Welsh, and Joe Z. Tsien

Genome-wide gene expression profiles of the developing mouse hippocampus
PNAS 2001 98: 8862-8867; published online before print July 3, 2001, 10.1073/pnas.141244998 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Luis Ruiz-Avila, Gwendolyn T. Wong, Sami Damak, and Robert F. Margolskee

Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in -gustducin
PNAS 2001 98: 8868-8873; published online before print July 10, 2001, 10.1073/pnas.151235798 [Abstract] [Full Text] [PDF]  

Stephen T. Ross and Ivan Soltesz

Long-term plasticity in interneurons of the dentate gyrus
PNAS 2001 98: 8874-8879; published online before print July 3, 2001, 10.1073/pnas.141042398 [Abstract] [Full Text] [PDF]  

Pharmacology

Peter Coward, Doris Lee, Mitchell V. Hull, and Jürgen M. Lehmann

4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor
PNAS 2001 98: 8880-8884; published online before print July 10, 2001, 10.1073/pnas.151244398 [Abstract] [Full Text] [PDF]  

Physiology

David A. Rudnick, David H. Perlmutter, and Louis J. Muglia

Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
PNAS 2001 98: 8885-8890; published online before print July 10, 2001, 10.1073/pnas.151217998 [Abstract] [Full Text] [PDF]  

Teddy Fauquier, Nathalie C. Guérineau, R. Anne McKinney, Karl Bauer, and Patrice Mollard

Folliculostellate cell network: A route for long-distance communication in the anterior pituitary
PNAS 2001 98: 8891-8896; published online before print July 3, 2001, 10.1073/pnas.151339598 [Abstract] [Full Text] [PDF]  

Stefano Fiorucci, Elisabetta Antonelli, Olivia Morelli, Andrea Mencarelli, Alessandro Casini, Tommaso Mello, Barbara Palazzetti, Dominique Tallet, Piero del Soldato, and Antonio Morelli

NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
PNAS 2001 98: 8897-8902; published online before print July 10, 2001, 10.1073/pnas.151136298 [Abstract] [Full Text] [PDF]  

Plant Biology

Huihua Fu, Wonkeun Park, Xianghe Yan, Zhenwei Zheng, Binzhang Shen, and Hugo K. Dooner From the Cover: The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome PNAS 2001 98: 8903-8908; published online before print July 3, 2001, 10.1073/pnas.141221898 [Abstract] [Full Text] [PDF]

Hironori Itoh, Miyako Ueguchi-Tanaka, Naoki Sentoku, Hidemi Kitano, Makoto Matsuoka, and Masatomo Kobayashi

Cloning and functional analysis of two gibberellin 3-hydroxylase genes that are differently expressed during the growth of rice
PNAS 2001 98: 8909-8914; published online before print July 3, 2001, 10.1073/pnas.141239398 [Abstract] [Full Text] [PDF]  

Soheil S. Mahmoud and Rodney B. Croteau From the Cover: Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase PNAS 2001 98: 8915-8920; published online before print June 26, 2001, 10.1073/pnas.141237298 [Abstract] [Full Text] [PDF]

CORRECTIONS

Correction for vol. 98, p. 6372 [Full Text] [PDF]