COMMENTARIES

Ben M. Dunn

The 2-Å postdoc
PNAS 2001 98: 1319-1320. [Full Text] [PDF]

Gerrit van Meer

What sugar next? Dimerization of sphingolipid glycosyltransferases
PNAS 2001 98: 1321-1323. [Full Text] [PDF]

Bruce D. Smith

Documenting plant domestication: The consilience of biological and archaeological approaches
PNAS 2001 98: 1324-1326. [Full Text] [PDF]

Ross C. Hardison

New views of evolution and regulation of vertebrate -like globin gene clusters from an orphaned gene in marsupials
PNAS 2001 98: 1327-1329. [Full Text] [PDF]

Gerald J. Roth

A new "kid" on the platelet thrombin receptor "block": Glycoprotein Ib-IX-V
PNAS 2001 98: 1330-1331. [Full Text] [PDF]

Debabrata RayChaudhuri, G. Scott Gordon, and Andrew Wright

Protein acrobatics and bacterial cell polarity
PNAS 2001 98: 1332-1334. [Full Text] [PDF]

Pat Shipman

What can you do with a bone fragment?
PNAS 2001 98: 1335-1337. [Full Text] [PDF]

Nancy A. Moran

Bacterial menageries inside insects
PNAS 2001 98: 1338-1340. [Full Text] [PDF]

PHYSICAL SCIENCES
Applied Mathematics

Andrew J. Majda and Boualem Khouider

A numerical strategy for efficient modeling of the equatorial wave guide
PNAS 2001 98: 1341-1346; published online before print February 6 2001, 10.1073/pnas.041583698 [Abstract] [Full Text] [PDF]

Astronomy

Harvey M. Bricker, Anthony F. Aveni, and Victoria R. Bricker

Ancient Maya documents concerning the movements of Mars
PNAS 2001 98: 2107-2110. [Abstract] [Full Text] [PDF]

Chemistry

Vasiliy Goral, Marina I. Nelen, Alexey V. Eliseev, and Jean-Marie Lehn

Double-level "orthogonal" dynamic combinatorial libraries on transition metal template
PNAS 2001 98: 1347-1352. [Abstract] [Full Text] [PDF] [Supplemental Data]

Engineering

H. T. Jung, B. Coldren, J. A. Zasadzinski, D. J. Iampietro, and E. W. Kaler

The origins of stability of spontaneous vesicles
PNAS 2001 98: 1353-1357; published online before print January 30 2001, 10.1073/pnas.041420998 [Abstract] [Full Text] [PDF]

SOCIAL SCIENCES
Anthropology

Lucinda R. Backwell and Francesco d'Errico From the Cover: Evidence of termite foraging by Swartkrans early hominids PNAS 2001 98: 1358-1363; published online before print January 16 2001, 10.1073/pnas.021551598 [Abstract] [Full Text] [PDF] [Supplemental Figures]

D. R. Piperno and K. V. Flannery

The earliest archaeological maize (Zea mays L.) from highland Mexico: New accelerator mass spectrometry dates and their implications
PNAS 2001 98: 2101-2103. [Abstract] [Full Text] [PDF]

Bruce F. Benz

Archaeological evidence of teosinte domestication from Guilá Naquitz, Oaxaca
PNAS 2001 98: 2104-2106. [Abstract] [Full Text] [PDF]

Harvey M. Bricker, Anthony F. Aveni, and Victoria R. Bricker

Ancient Maya documents concerning the movements of Mars
PNAS 2001 98: 2107-2110. [Abstract] [Full Text] [PDF]

BIOLOGICAL SCIENCES
Anthropology

Lucinda R. Backwell and Francesco d'Errico From the Cover: Evidence of termite foraging by Swartkrans early hominids PNAS 2001 98: 1358-1363; published online before print January 16 2001, 10.1073/pnas.021551598 [Abstract] [Full Text] [PDF] [Supplemental Figures]

D. R. Piperno and K. V. Flannery

The earliest archaeological maize (Zea mays L.) from highland Mexico: New accelerator mass spectrometry dates and their implications
PNAS 2001 98: 2101-2103. [Abstract] [Full Text] [PDF]

Bruce F. Benz

Archaeological evidence of teosinte domestication from Guilá Naquitz, Oaxaca
PNAS 2001 98: 2104-2106. [Abstract] [Full Text] [PDF]

Biochemistry

Moisés Santillán and Michael C. Mackey

Dynamic regulation of the tryptophan operon: A modeling study and comparison with experimental data
PNAS 2001 98: 1364-1369. [Abstract] [Full Text] [PDF] [Supplemental Data]

John D. Kulman, Jeff E. Harris, Ling Xie, and Earl W. Davie

Identification of two novel transmembrane -carboxyglutamic acid proteins expressed broadly in fetal and adult tissues
PNAS 2001 98: 1370-1375. [Abstract] [Full Text] [PDF]

Ernst Schönbrunn, Susanne Eschenburg, Wendy A. Shuttleworth, John V. Schloss, Nikolaus Amrhein, Jeremy N. S. Evans, and Wolfgang Kabsch

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
PNAS 2001 98: 1376-1380. [Abstract] [Full Text] [PDF]

Joseph B. Pesavento, Jeffrey A. Lawton, Mary K. Estes, and B. V. Venkataram Prasad From the Cover: The reversible condensation and expansion of the rotavirus genome PNAS 2001 98: 1381-1386. [Abstract] [Full Text] [PDF]

Natalie de Paulsen, Alexander Brychzy, Marie-Christine Fournier, Richard D. Klausner, James R. Gnarra, Arnim Pause, and Stephen Lee

Role of transforming growth factor- in von Hippel- Lindau (VHL)^/ clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
PNAS 2001 98: 1387-1392; published online before print February 6 2001, 10.1073/pnas.031587498 [Abstract] [Full Text] [PDF]

Koji Tamura and Paul Schimmel

Oligonucleotide-directed peptide synthesis in a ribosome- and ribozyme-free system
PNAS 2001 98: 1393-1397. [Abstract] [Full Text] [PDF]

G. Ren, V. S. Reddy, A. Cheng, P. Melnyk, and A. K. Mitra

Visualization of a water-selective pore by electron crystallography in vitreous ice
PNAS 2001 98: 1398-1403; published online before print January 30 2001, 10.1073/pnas.041489198 [Abstract] [Full Text] [PDF]

Nancy L. Ogihara, Giovanna Ghirlanda, James W. Bryson, Mari Gingery, William F. DeGrado, and David Eisenberg

Design of three-dimensional domain-swapped dimers and fibrous oligomers
PNAS 2001 98: 1404-1409. [Abstract] [Full Text] [PDF]

Stephen M. Lu, Wuyuan Lu, M. A. Qasim, Stephen Anderson, Izydor Apostol, Wojciech Ardelt, Theresa Bigler, Yi Wen Chiang, James Cook, Michael N. G. James, Ikunoshin Kato, Clyde Kelly, William Kohr, Tomoko Komiyama, Tiao-Yin Lin, Michio Ogawa, Jacek Otlewski, Soon-Jae Park, Sabiha Qasim, Michael Ranjbar, Misao Tashiro, Nicholas Warne, Harry Whatley, Anna Wieczorek, Maciej Wieczorek, Tadeusz Wilusz, Richard Wynn, Wenlei Zhang, and Michael Laskowski, Jr.

Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases
PNAS 2001 98: 1410-1415; published online before print February 6 2001, 10.1073/pnas.031581398 [Abstract] [Full Text] [PDF]

Karim S. Echtay, Edith Winkler, Karina Frischmuth, and Martin Klingenberg

Uncoupling proteins 2 and 3 are highly active H⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
PNAS 2001 98: 1416-1421. [Abstract] [Full Text] [PDF]

Magnus Abrink, José A. Ortiz, Charlotta Mark, Cecilia Sanchez, Camilla Looman, Lars Hellman, Pierre Chambon, and Régine Losson

Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1
PNAS 2001 98: 1422-1426; published online before print February 6 2001, 10.1073/pnas.041616998 [Abstract] [Full Text] [PDF]

Wenlin Lee, Michael A. McDonough, Lakshmi P. Kotra, Zhi-Hong Li, Nicholas R. Silvaggi, Yoshifumi Takeda, Judith A. Kelly, and Shahriar Mobashery

A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis
PNAS 2001 98: 1427-1431. [Abstract] [Full Text] [PDF] [Supplemental Text]

Michael Moore, Yen Choo, and Aaron Klug From the Cover: Design of polyzinc finger peptides with structured linkers PNAS 2001 98: 1432-1436. [Abstract] [Full Text] [PDF]

Michael Moore, Aaron Klug, and Yen Choo From the Cover: Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units PNAS 2001 98: 1437-1441. [Abstract] [Full Text] [PDF]

Kazuhiro Yamada, Naoki Kunishima, Kouta Mayanagi, Takayuki Ohnishi, Tatsuya Nishino, Hiroshi Iwasaki, Hideo Shinagawa, and Kosuke Morikawa

Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8
PNAS 2001 98: 1442-1447; published online before print February 6 2001, 10.1073/pnas.031470598 [Abstract] [Full Text] [PDF]

Masahisa Horiuchi, Annette Nicke, Jesus Gomeza, Armaz Aschrafi, Günther Schmalzing, and Heinrich Betz

Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes
PNAS 2001 98: 1448-1453; published online before print February 6 2001, 10.1073/pnas.041329498 [Abstract] [Full Text] [PDF]

Angie You, Jeffrey K. Tong, Christina M. Grozinger, and Stuart L. Schreiber

CoREST is an integral component of the CoREST- human histone deacetylase complex
PNAS 2001 98: 1454-1458. [Abstract] [Full Text] [PDF]

Timothy C. Umland, Kimberly L. Taylor, Sangkee Rhee, Reed B. Wickner, and David R. Davies

The crystal structure of the nitrogen regulation fragment of the yeast prion protein Ure2p
PNAS 2001 98: 1459-1464; published online before print February 6 2001, 10.1073/pnas.041607898 [Abstract] [Full Text] [PDF]

Randall M. Story, Hong Li, and John N. Abelson

Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii
PNAS 2001 98: 1465-1470. [Abstract] [Full Text] [PDF]

Geoffrey C. Owens, Stephen A. Chappell, Vincent P. Mauro, and Gerald M. Edelman

Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides
PNAS 2001 98: 1471-1476. [Abstract] [Full Text] [PDF]

Russell A. DeBose-Boyd, Jiafu Ou, Joseph L. Goldstein, and Michael S. Brown

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
PNAS 2001 98: 1477-1482. [Abstract] [Full Text] [PDF]

Cindy Voisine, Yu C. Cheng, Maikke Ohlson, Brenda Schilke, Kevin Hoff, Helmut Beinert, Jaroslaw Marszalek, and Elizabeth A. Craig

Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae
PNAS 2001 98: 1483-1488. [Abstract] [Full Text] [PDF]

I-hung Shih and Michael D. Been

Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage
PNAS 2001 98: 1489-1494. [Abstract] [Full Text] [PDF]

Mary E. Maxon and Ira Herskowitz

Ash1p is a site-specific DNA-binding protein that actively represses transcription
PNAS 2001 98: 1495-1500. [Abstract] [Full Text] [PDF]

Anne Schoendorf, Christopher D. Rithner, Robert M. Williams, and Rodney B. Croteau

Molecular cloning of a cytochrome P450 taxane 10-hydroxylase cDNA from Taxus and functional expression in yeast
PNAS 2001 98: 1501-1506. [Abstract] [Full Text] [PDF] [Supplemental Data]

Jun Zhu and Stephen C. Winans

The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization
PNAS 2001 98: 1507-1512. [Abstract] [Full Text] [PDF]

Alvaro Acosta-Serrano, Erik Vassella, Matthias Liniger, Christina Kunz Renggli, Reto Brun, Isabel Roditi, and Paul T. Englund

The surface coat of procyclic Trypanosoma brucei: Programmed expression and proteolytic cleavage of procyclin in the tsetse fly
PNAS 2001 98: 1513-1518; published online before print February 6 2001, 10.1073/pnas.041611698 [Abstract] [Full Text] [PDF]

Jeffrey M. Trimarchi, Brian Fairchild, Jessica Wen, and Jacqueline A. Lees

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
PNAS 2001 98: 1519-1524; published online before print January 30 2001, 10.1073/pnas.041597698 [Abstract] [Full Text] [PDF]

Jue Chen, Susan Sharma, Florante A. Quiocho, and Amy L. Davidson

Trapping the transition state of an ATP-binding cassette transporter: Evidence for a concerted mechanism of maltose transport
PNAS 2001 98: 1525-1530; published online before print February 6 2001, 10.1073/pnas.041542498 [Abstract] [Full Text] [PDF]

Wei Zhou, Gerald M. Edelman, and Vincent P. Mauro

Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells
PNAS 2001 98: 1531-1536. [Abstract] [Full Text] [PDF]

Guo-An Wang, Peide Gu, and Seymour Kaufman

Mutagenesis of the regulatory domain of phenylalanine hydroxylase
PNAS 2001 98: 1537-1542; published online before print February 6 2001, 10.1073/pnas.031561698 [Abstract] [Full Text] [PDF]

Yuhong Shen, Geeta Devgan, James E. Darnell, Jr., and Jacqueline F. Bromberg

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
PNAS 2001 98: 1543-1548; published online before print February 6 2001, 10.1073/pnas.041588198 [Abstract] [Full Text] [PDF]

Biophysics

Gina M. Clayton, Sew Y. Peak-Chew, Ronald M. Evans, and John W. R. Schwabe

The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation
PNAS 2001 98: 1549-1554; published online before print February 6 2001, 10.1073/pnas.041611298 [Abstract] [Full Text] [PDF]

G. Schmies, M. Engelhard, P. G. Wood, G. Nagel, and E. Bamberg

Electrophysiological characterization of specific interactions between bacterial sensory rhodopsins and their transducers
PNAS 2001 98: 1555-1559; published online before print January 30 2001, 10.1073/pnas.031562298 [Abstract] [Full Text] [PDF]

Guanghua Wu, Haifeng Ji, Karolyn Hansen, Thomas Thundat, Ram Datar, Richard Cote, Michael F. Hagan, Arup K. Chakraborty, and Arunava Majumdar

Origin of nanomechanical cantilever motion generated from biomolecular interactions
PNAS 2001 98: 1560-1564; published online before print February 6 2001, 10.1073/pnas.031362498 [Abstract] [Full Text] [PDF]

Philippe Carl, Carol H. Kwok, Gavin Manderson, David W. Speicher, and Dennis E. Discher

Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule
PNAS 2001 98: 1565-1570; published online before print January 30 2001, 10.1073/pnas.031409698 [Abstract] [Full Text] [PDF]

Hideki Kandori, Yoichi Yamazaki, Yoshinori Shichida, Jan Raap, Johan Lugtenburg, Marina Belenky, and Judith Herzfeld

Tight Asp-85-Thr-89 association during the pump switch of bacteriorhodopsin
PNAS 2001 98: 1571-1576. [Abstract] [Full Text] [PDF]

Eric O. Potma, Wim P. de Boeij, Peter J. M. van Haastert, and Douwe A. Wiersma

Real-time visualization of intracellular hydrodynamics in single living cells
PNAS 2001 98: 1577-1582; published online before print February 6 2001, 10.1073/pnas.031575698 [Abstract] [Full Text] [PDF]

Cell Biology

Volker H. Haase, Jonathan N. Glickman, Merav Socolovsky, and Rudolf Jaenisch

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
PNAS 2001 98: 1583-1588. [Abstract] [Full Text] [PDF]

Michael J. Anderson, G. Diane Shelton, Webster K. Cavenee, and Karen C. Arden

Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3
PNAS 2001 98: 1589-1594. [Abstract] [Full Text] [PDF]

Fumio Takada, Douglas L. Vander Woude, Hui-Qi Tong, Terri G. Thompson, Simon C. Watkins, Louis M. Kunkel, and Alan H. Beggs

Myozenin: An -actinin- and -filamin-binding protein of skeletal muscle Z lines
PNAS 2001 98: 1595-1600; published online before print February 6 2001, 10.1073/pnas.041609698 [Abstract] [Full Text] [PDF]

Trudy A. Kohout, Fang-Tsyr Lin, Stephen J. Perry, David A. Conner, and Robert J. Lefkowitz

-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
PNAS 2001 98: 1601-1606; published online before print February 6 2001, 10.1073/pnas.041608198 [Abstract] [Full Text] [PDF]

Wei-Zhong Zhu, Ming Zheng, Walter J. Koch, Robert J. Lefkowitz, Brian K. Kobilka, and Rui-Ping Xiao

Dual modulation of cell survival and cell death by ₂-adrenergic signaling in adult mouse cardiac myocytes
PNAS 2001 98: 1607-1612. [Abstract] [Full Text] [PDF]

Eve Reaven, Susan Leers-Sucheta, Ann Nomoto, and Salman Azhar

Expression of scavenger receptor class B type 1 (SR-BI) promotes microvillar channel formation and selective cholesteryl ester transport in a heterologous reconstituted system
PNAS 2001 98: 1613-1618. [Abstract] [Full Text] [PDF]

Limin Li, Jian Liao, Jürgen Ruland, Tak W. Mak, and Stanley N. Cohen

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
PNAS 2001 98: 1619-1624. [Abstract] [Full Text] [PDF]

Claudio G. Giraudo, Jose L. Daniotti, and Hugo J. F. Maccioni From the Cover: Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus PNAS 2001 98: 1625-1630; published online before print January 23 2001, 10.1073/pnas.031458398 [Abstract] [Full Text] [PDF]

Jeffrey P. Henderson, Jaeman Byun, Michelle V. Williams, Michael L. McCormick, William C. Parks, Lisa A. Ridnour, and Jay W. Heinecke

Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors
PNAS 2001 98: 1631-1636; published online before print February 6 2001, 10.1073/pnas.041146998 [Abstract] [Full Text] [PDF]

Mireille Cormont, Muriel Mari, Antoine Galmiche, Paul Hofman, and Yannick Le Marchand-Brustel

A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic
PNAS 2001 98: 1637-1642; published online before print January 30 2001, 10.1073/pnas.031586998 [Abstract] [Full Text] [PDF]

Su X. Liu, Mohammad Athar, Istvan Lippai, Charles Waldren, and Tom K. Hei

Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity
PNAS 2001 98: 1643-1648; published online before print February 6 2001, 10.1073/pnas.031482998 [Abstract] [Full Text] [PDF]

Developmental Biology

Wei Liu, Zeqian Mo, and Mengqing Xiang

The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development
PNAS 2001 98: 1649-1654. [Abstract] [Full Text] [PDF]

K. Hardy, S. Spanos, D. Becker, P. Iannelli, R. M. L. Winston, and J. Stark

From cell death to embryo arrest: Mathematical models of human preimplantation embryo development
PNAS 2001 98: 1655-1660. [Abstract] [Full Text] [PDF] [Supplemental Data]

Evolution

Michael S. Engel

Monophyly and extensive extinction of advanced eusocial bees: Insights from an unexpected Eocene diversity
PNAS 2001 98: 1661-1664; published online before print February 6 2001, 10.1073/pnas.041600198 [Abstract] [Full Text] [PDF]

Adam H. Neidert, Vikrant Virupannavar, Gillian W. Hooker, and James A. Langeland

Lamprey Dlx genes and early vertebrate evolution
PNAS 2001 98: 1665-1670. [Abstract] [Full Text] [PDF] [Supplemental Figure]

Adam K. Chippindale, Jonathan R. Gibson, and William R. Rice

Negative genetic correlation for adult fitness between sexes reveals ontogenetic conflict in Drosophila
PNAS 2001 98: 1671-1675; published online before print January 30 2001, 10.1073/pnas.041378098 [Abstract] [Full Text] [PDF]

Genetics

Shani Peretz, Ryan Jensen, Renato Baserga, and Peter M. Glazer

ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
PNAS 2001 98: 1676-1681; published online before print February 6 2001, 10.1073/pnas.041416598 [Abstract] [Full Text] [PDF]

Xin Ye, Cihui Zhu, and J. Wade Harper

A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene
PNAS 2001 98: 1682-1686; published online before print February 6 2001, 10.1073/pnas.041596198 [Abstract] [Full Text] [PDF]

Nabil Arrach, Rafael Fernández-Martín, Enrique Cerdá-Olmedo, and Javier Avalos

A single gene for lycopene cyclase, phytoene synthase, and regulation of carotene biosynthesis in Phycomyces
PNAS 2001 98: 1687-1692; published online before print February 6 2001, 10.1073/pnas.021555298 [Abstract] [Full Text] [PDF]

Neal S. Holter, Amos Maritan, Marek Cieplak, Nina V. Fedoroff, and Jayanth R. Banavar

Dynamic modeling of gene expression data
PNAS 2001 98: 1693-1698. [Abstract] [Full Text] [PDF]

Zhijian Tu

Eight novel families of miniature inverted repeat transposable elements in the African malaria mosquito, Anopheles gambiae
PNAS 2001 98: 1699-1704; published online before print February 6 2001, 10.1073/pnas.041593198 [Abstract] [Full Text] [PDF]

Ohtsura Niwa and Ryo Kominami

Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F₁ mice born to irradiated spermatozoa
PNAS 2001 98: 1705-1710; published online before print February 6 2001, 10.1073/pnas.031439298 [Abstract] [Full Text] [PDF]

Maria E. Gallego and Charles I. White

RAD50 function is essential for telomere maintenance in Arabidopsis
PNAS 2001 98: 1711-1716. [Abstract] [Full Text] [PDF]

Immunology

Kristina K. Peachman, Douglas S. Lyles, and David A. Bass

Mitochondria in eosinophils: Functional role in apoptosis but not respiration
PNAS 2001 98: 1717-1722. [Abstract] [Full Text] [PDF]

Bryan K. Cho, Kuo-Chiang Lian, Peter Lee, Anders Brunmark, Carol McKinley, Jianzhu Chen, David M. Kranz, and Herman N. Eisen

Differences in antigen recognition and cytolytic activity of CD8⁺ and CD8 T cells that express the same antigen-specific receptor
PNAS 2001 98: 1723-1727. [Abstract] [Full Text] [PDF]

Qing Ge, Varada P. Rao, Bryan K. Cho, Herman N. Eisen, and Jianzhu Chen

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors
PNAS 2001 98: 1728-1733. [Abstract] [Full Text] [PDF]

Mar Valés-Gómez, Robert A. Erskine, Matthew P. Deacon, Jack L. Strominger, and Hugh T. Reyburn

The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins
PNAS 2001 98: 1734-1739; published online before print February 6 2001, 10.1073/pnas.041618298 [Abstract] [Full Text] [PDF]

Daniel Fishman, Brodyanski Irena, Sigal Kellman-Pressman, Michael Karas, and Shraga Segal

The role of MHC class I glycoproteins in the regulation of induction of cell death in immunocytes by malignant melanoma cells
PNAS 2001 98: 1740-1744; published online before print February 6 2001, 10.1073/pnas.041591298 [Abstract] [Full Text] [PDF]

Jochen Hess, Annick Werner, Thomas Wirth, Fritz Melchers, Hans-Martin Jäck, and Thomas H. Winkler

Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor
PNAS 2001 98: 1745-1750; published online before print February 6 2001, 10.1073/pnas.041492098 [Abstract] [Full Text] [PDF]

Masahide Tone, Yukiko Tone, Paul J. Fairchild, Michelle Wykes, and Herman Waldmann

Regulation of CD40 function by its isoforms generated through alternative splicing
PNAS 2001 98: 1751-1756. [Abstract] [Full Text] [PDF]

Julie Audet, Cindy L. Miller, Stefan Rose-John, James M. Piret, and Connie J. Eaves

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells
PNAS 2001 98: 1757-1762. [Abstract] [Full Text] [PDF]

Gerald T. Nepom, John D. Lippolis, Forest M. White, Susan Masewicz, Jarrod A. Marto, Andrew Herman, C. John Luckey, Ben Falk, Jeffrey Shabanowitz, Donald F. Hunt, Victor H. Engelhard, and Barbara S. Nepom

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)
PNAS 2001 98: 1763-1768. [Abstract] [Full Text] [PDF]

Axel Behrens, Kanaga Sabapathy, Isabella Graef, Mike Cleary, Gerald R. Crabtree, and Erwin F. Wagner

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)
PNAS 2001 98: 1769-1774. [Abstract] [Full Text] [PDF]

Lynn L. Rumfelt, David Avila, Marilyn Diaz, Simona Bartl, E. Churchill McKinney, and Martin F. Flajnik

A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG
PNAS 2001 98: 1775-1780. [Abstract] [Full Text] [PDF] [Supplemental Data]

Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, Bruce D. Walker, and the HIV Controller Study Collaboration

The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals
PNAS 2001 98: 1781-1786. [Abstract] [Full Text] [PDF] [Supplemental Data]

Laurence Morel, Kim R. Blenman, Byron P. Croker, and Edward K. Wakeland

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
PNAS 2001 98: 1787-1792; published online before print January 23 2001, 10.1073/pnas.031336098 [Abstract] [Full Text] [PDF]

Medical Sciences

R. Anthony Williamson, Mark P. Burgoon, Gregory P. Owens, Omar Ghausi, Estelle Leclerc, Louise Firme, Sharon Carlson, John Corboy, Paul W. H. I. Parren, Pietro P. Sanna, Donald H. Gilden, and Dennis R. Burton

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis
PNAS 2001 98: 1793-1798; published online before print February 6 2001, 10.1073/pnas.031567598 [Abstract] [Full Text] [PDF]

Abraham Karpas, Alla Dremucheva, and Barbara H. Czepulkowski

A human myeloma cell line suitable for the generation of human monoclonal antibodies
PNAS 2001 98: 1799-1804. [Abstract] [Full Text] [PDF]

Arnab Pain, David J. P. Ferguson, Oscar Kai, Britta C. Urban, Brett Lowe, Kevin Marsh, and David J. Roberts

Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria
PNAS 2001 98: 1805-1810. [Abstract] [Full Text] [PDF]

Sébastien Holbert, Isabelle Denghien, Tamara Kiechle, Adam Rosenblatt, Cheryll Wellington, Michael R. Hayden, Russell L. Margolis, Christopher A. Ross, Jean Dausset, Robert J. Ferrante, and Christian Néri

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis
PNAS 2001 98: 1811-1816; published online before print January 30 2001, 10.1073/pnas.041566798 [Abstract] [Full Text] [PDF]

Edward A. Ratovitski, Meera Patturajan, Kenji Hibi, Barry Trink, Kengo Yamaguchi, and David Sidransky

p53 associates with and targets Np63 into a protein degradation pathway
PNAS 2001 98: 1817-1822. [Abstract] [Full Text] [PDF] [Supplemental Tables]

Vanitha Ramakrishnan, Francis DeGuzman, Ming Bao, Scott W. Hall, Lawrence L. Leung, and David R. Phillips

A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V
PNAS 2001 98: 1823-1828. [Abstract] [Full Text] [PDF]

Magdolna Kovacs, Andrew V. Schally, Balazs Csernus, and Zoltan Rekasi

Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH
PNAS 2001 98: 1829-1834; published online before print January 30 2001, 10.1073/pnas.031582398 [Abstract] [Full Text] [PDF]

Paul A. Sieving, Prem Chaudhry, Mineo Kondo, Matthew Provenzano, David Wu, Thomas J. Carlson, Ronald A. Bush, and Debra A. Thompson

Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy
PNAS 2001 98: 1835-1840; published online before print February 6 2001, 10.1073/pnas.041606498 [Abstract] [Full Text] [PDF]

Hong Tang and Alan McLachlan

Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism
PNAS 2001 98: 1841-1846; published online before print February 6 2001, 10.1073/pnas.041479698 [Abstract] [Full Text] [PDF]

Tohru Ikuta, Sabrina Ausenda, and Maria D. Cappellini

Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway
PNAS 2001 98: 1847-1852; published online before print February 6 2001, 10.1073/pnas.041599798 [Abstract] [Full Text] [PDF]

Brunhilde Felding-Habermann, Timothy E. O'Toole, Jeffrey W. Smith, Emilia Fransvea, Zaverio M. Ruggeri, Mark H. Ginsberg, Paul E. Hughes, Nisar Pampori, Sanford J. Shattil, Alan Saven, and Barbara M. Mueller

Integrin activation controls metastasis in human breast cancer
PNAS 2001 98: 1853-1858. [Abstract] [Full Text] [PDF]

Jürgen Ruland, Christian Sirard, Andrew Elia, David MacPherson, Andrew Wakeham, Limin Li, José Luis de la Pompa, Stanley N. Cohen, and Tak W. Mak

p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101
PNAS 2001 98: 1859-1864. [Abstract] [Full Text] [PDF]

Microbiology

Siu Chun Hung, Myung-Soo Kang, and Elliott Kieff

Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1
PNAS 2001 98: 1865-1870; published online before print February 6 2001, 10.1073/pnas.031584698 [Abstract] [Full Text] [PDF]

Talya Kunik, Tzvi Tzfira, Yoram Kapulnik, Yedidya Gafni, Colin Dingwall, and Vitaly Citovsky

Genetic transformation of HeLa cells by Agrobacterium
PNAS 2001 98: 1871-1876; published online before print January 30 2001, 10.1073/pnas.041327598 [Abstract] [Full Text] [PDF]

Yasushi Kawaguchi, Michiko Tanaka, Akihiko Yokoymama, Go Matsuda, Kentaro Kato, Hiroyuki Kagawa, Kanji Hirai, and Bernard Roizman

Herpes simplex virus 1 regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1
PNAS 2001 98: 1877-1882; published online before print February 6 2001, 10.1073/pnas.041592598 [Abstract] [Full Text] [PDF]

Colin Dale, Simon A. Young, Daniel T. Haydon, and Susan C. Welburn From the Cover: The insect endosymbiont Sodalis glossinidius utilizes a type III secretion system for cell invasion PNAS 2001 98: 1883-1888; published online before print January 30 2001, 10.1073/pnas.021450998 [Abstract] [Full Text] [PDF]

Marieke A. Tijms, Leonie C. van Dinten, Alexander E. Gorbalenya, and Eric J. Snijder

A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus
PNAS 2001 98: 1889-1894; published online before print February 6 2001, 10.1073/pnas.041390398 [Abstract] [Full Text] [PDF]

Dana G. Wolf, Charmain Tan Courcelle, Mark N. Prichard, and Edward S. Mocarski

Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation
PNAS 2001 98: 1895-1900. [Abstract] [Full Text] [PDF]

Edith Mazars, Sarah Lesjean, Anne-Laure Banuls, Michèle Gilbert, Véronique Vincent, Brigitte Gicquel, Michel Tibayrenc, Camille Locht, and Philip Supply

High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology
PNAS 2001 98: 1901-1906. [Abstract] [Full Text] [PDF] [Supplemental Table]

Neurobiology

Tai Sing Lee and My Nguyen

Dynamics of subjective contour formation in the early visual cortex
PNAS 2001 98: 1907-1911; published online before print January 30 2001, 10.1073/pnas.031579998 [Abstract] [Full Text] [PDF]

Luca Santarelli, Gabriella Gobbi, Pierre C. Debs, Etienne L. Sibille, Pierre Blier, René Hen, and Mark J. S. Heath

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
PNAS 2001 98: 1912-1917; published online before print January 30 2001, 10.1073/pnas.041596398 [Abstract] [Full Text] [PDF]

Seppo Parkkila, Anna-Kaisa Parkkila, Hannu Rajaniemi, Gul N. Shah, Jeffrey H. Grubb, Abdul Waheed, and William S. Sly

Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain
PNAS 2001 98: 1918-1923. [Abstract] [Full Text] [PDF]

Igor Timofeev, François Grenier, and Mircea Steriade

Disfacilitation and active inhibition in the neocortex during the natural sleep-wake cycle: An intracellular study
PNAS 2001 98: 1924-1929; published online before print February 6 2001, 10.1073/pnas.041430398 [Abstract] [Full Text] [PDF]

Cecilia H. Jiang, Joe Z. Tsien, Peter G. Schultz, and Yinghe Hu

The effects of aging on gene expression in the hypothalamus and cortex of mice
PNAS 2001 98: 1930-1934. [Abstract] [Full Text] [PDF] [Supplemental Tables]

Mariano Sigman, Guillermo A. Cecchi, Charles D. Gilbert, and Marcelo O. Magnasco

On a common circle: Natural scenes and Gestalt rules
PNAS 2001 98: 1935-1940; published online before print February 6 2001, 10.1073/pnas.031571498 [Abstract] [Full Text] [PDF]

J. M. Conner, M. A. Darracq, Jeff Roberts, and M. H. Tuszynski

Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
PNAS 2001 98: 1941-1946. [Abstract] [Full Text] [PDF]

Ataúlfo Martínez-Torres and Ricardo Miledi

Expression of -aminobutyric acid 1 and 1450 as gene fusions with the green fluorescent protein
PNAS 2001 98: 1947-1951; published online before print February 6 2001, 10.1073/pnas.031584898 [Abstract] [Full Text] [PDF]

Dena B. Dubal, Hong Zhu, Jin Yu, Shane W. Rau, Paul J. Shughrue, Istvan Merchenthaler, Mark S. Kindy, and Phyllis M. Wise

Estrogen receptor , not , is a critical link in estradiol-mediated protection against brain injury
PNAS 2001 98: 1952-1957; published online before print February 6 2001, 10.1073/pnas.041483198 [Abstract] [Full Text] [PDF]

A. Ragnauth, A. Schuller, M. Morgan, J. Chan, S. Ogawa, J. Pintar, R. J. Bodnar, and D. W. Pfaff

Female preproenkephalin-knockout mice display altered emotional responses
PNAS 2001 98: 1958-1963; published online before print February 6 2001, 10.1073/pnas.041598498 [Abstract] [Full Text] [PDF]

Zafar U. Khan, Peter Koulen, Marcelo Rubinstein, David K. Grandy, and Patricia S. Goldman-Rakic

An astroglia-linked dopamine D2-receptor action in prefrontal cortex
PNAS 2001 98: 1964-1969. [Abstract] [Full Text] [PDF]

Jiang-Fan Chen, Rosario Moratalla, Francesco Impagnatiello, David K. Grandy, Beatriz Cuellar, Marcelo Rubinstein, Mark A. Beilstein, Elizabeth Hackett, J. Stephen Fink, Malcolm J. Low, Ennio Ongini, and Michael A. Schwarzschild

The role of the D₂ dopamine receptor (D₂R) in A_2A adenosine receptor (A_2AR)-mediated behavioral and cellular responses as revealed by A_2A and D₂ receptor knockout mice
PNAS 2001 98: 1970-1975. [Abstract] [Full Text] [PDF]

Roberto Ciccocioppo, Pietro Paolo Sanna, and Friedbert Weiss

Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by D₁ antagonists
PNAS 2001 98: 1976-1981. [Abstract] [Full Text] [PDF]

Xiaoxi Zhuang, Ronald S. Oosting, Sara R. Jones, Raul R. Gainetdinov, Gary W. Miller, Marc G. Caron, and René Hen

Hyperactivity and impaired response habituation in hyperdopaminergic mice
PNAS 2001 98: 1982-1987. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Pharmacology

M. Rocío A. Carrera, Jon A. Ashley, Peter Wirsching, George F. Koob, and Kim D. Janda

A second-generation vaccine protects against the psychoactive effects of cocaine
PNAS 2001 98: 1988-1992; published online before print February 6 2001, 10.1073/pnas.041610998 [Abstract] [Full Text] [PDF]

Physiology

Andrew Y. Gracey, Joshua V. Troll, and George N. Somero

Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis
PNAS 2001 98: 1993-1998. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Dietmar Kültz and Devulapalli Chakravarty

Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells
PNAS 2001 98: 1999-2004. [Abstract] [Full Text] [PDF]

Joachim Fruebis, Tsu-Shuen Tsao, Sandrine Javorschi, Dana Ebbets-Reed, Mary Ruth S. Erickson, Frances T. Yen, Bernard E. Bihain, and Harvey F. Lodish

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
PNAS 2001 98: 2005-2010; published online before print February 6 2001, 10.1073/pnas.041591798 [Abstract] [Full Text] [PDF]

Renxue Wang, Myriam Salem, Ibrahim M. Yousef, Beatriz Tuchweber, Ping Lam, Sarah J. Childs, Cheryl D. Helgason, Cameron Ackerley, M. James Phillips, and Victor Ling

Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
PNAS 2001 98: 2011-2016; published online before print February 6 2001, 10.1073/pnas.031465498 [Abstract] [Full Text] [PDF]

Kinji Ohno, Akira Tsujino, Joan M. Brengman, C. Michel Harper, Zeljko Bajzer, Bjarne Udd, Roger Beyring, Stephanie Robb, Fenella J. Kirkham, and Andrew G. Engel

Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans
PNAS 2001 98: 2017-2022. [Abstract] [Full Text] [PDF]

Sun-Hee Woo and Martin Morad

Bimodal regulation of Na⁺-Ca²⁺ exchanger by -adrenergic signaling pathway in shark ventricular myocytes
PNAS 2001 98: 2023-2028; published online before print February 6 2001, 10.1073/pnas.041327398 [Abstract] [Full Text] [PDF]

Stephen Brannan, Mario Liotti, Gary Egan, Robert Shade, Lisa Madden, Rachel Robillard, Bart Abplanalp, Katie Stofer, Derek Denton, and Peter T. Fox

Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air
PNAS 2001 98: 2029-2034. [Abstract] [Full Text] [PDF]

Mario Liotti, Stephen Brannan, Gary Egan, Robert Shade, Lisa Madden, Bart Abplanalp, Rachel Robillard, Jack Lancaster, Frank E. Zamarripa, Peter T. Fox, and Derek Denton

Brain responses associated with consciousness of breathlessness (air hunger)
PNAS 2001 98: 2035-2040. [Abstract] [Full Text] [PDF]

Lawrence M. Parsons, Gary Egan, Mario Liotti, Stephen Brannan, Derek Denton, Robert Shade, Rachael Robillard, Lisa Madden, Bart Abplanalp, and Peter T. Fox

Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air
PNAS 2001 98: 2041-2046. [Abstract] [Full Text] [PDF]

Plant Biology

Oliver Oswald, Thomas Martin, Peter J. Dominy, and Ian A. Graham

Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression
PNAS 2001 98: 2047-2052; published online before print January 30 2001, 10.1073/pnas.021449998 [Abstract] [Full Text] [PDF]

Nobuyoshi Mochizuki, Judy A. Brusslan, Robert Larkin, Akira Nagatani, and Joanne Chory

Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals the involvement of Mg-chelatase H subunit in plastid-to-nucleus signal transduction
PNAS 2001 98: 2053-2058. [Abstract] [Full Text] [PDF]

Brendan K. Riely and Gregory B. Martin

Ancient origin of pathogen recognition specificity conferred by the tomato disease resistance gene Pto
PNAS 2001 98: 2059-2064. [Abstract] [Full Text] [PDF] [Supplemental Figures]

Chris A. Helliwell, Peter M. Chandler, Andrew Poole, Elizabeth S. Dennis, and W. James Peacock

The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway
PNAS 2001 98: 2065-2070; published online before print February 6 2001, 10.1073/pnas.041588998 [Abstract] [Full Text] [PDF]

Population Biology

Thomas E. Martin, A. P. Møller, S. Merino, and J. Clobert

Does clutch size evolve in response to parasites and immunocompetence?
PNAS 2001 98: 2071-2076. [Abstract] [Full Text] [PDF]

Psychology

Yuka Sasaki, Nouchine Hadjikhani, Bruce Fischl, Arthur K. Liu, Sean Marrett, Anders M. Dale, and Roger B. H. Tootell

Local and global attention are mapped retinotopically in human occipital cortex
PNAS 2001 98: 2077-2082. [Abstract] [Full Text] [PDF]

Robert Galambos, Orsolya Szabó-Salfay, Erzsébet Szatmári, Nóra Szilágyi, and Gábor Juhász

Sleep modifies retinal ganglion cell responses in the normal rat
PNAS 2001 98: 2083-2088. [Abstract] [Full Text] [PDF]

Diana S. Woodruff-Pak, Richard W. Vogel, III, and Gary L. Wenk

Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
PNAS 2001 98: 2089-2094; published online before print February 6 2001, 10.1073/pnas.031584398 [Abstract] [Full Text] [PDF]

Edward E. Smith, Anat Geva, John Jonides, Andrea Miller, Patricia Reuter-Lorenz, and Robert A. Koeppe

The neural basis of task-switching in working memory: Effects of performance and aging
PNAS 2001 98: 2095-2100. [Abstract] [Full Text] [PDF]

CORRECTIONS

Correction for vol. 97, p. 8051 [Full Text] [PDF]  

Correction for vol. 97, p. 12244 [Full Text] [PDF]