COMMENTARIES

John Damuth

Scaling of growth: Plants and animals are not so different
PNAS 2001 98: 2113-2114. [Full Text] [PDF]  

Joshua Lederberg

H1N1-influenza as Lazarus: Genomic resurrection from the tomb of an unknown
PNAS 2001 98: 2115-2116. [Full Text] [PDF]  

Robert C. Robinson, Senyon Choe, and Leslie D. Burtnick

The disintegration of a molecule: The role of gelsolin in FAF, familial amyloidosis (Finnish type)
PNAS 2001 98: 2117-2118. [Full Text] [PDF]  

Beverley R. Green

Was "molecular opportunism" a factor in the evolution of different photosynthetic light-harvesting pigment systems?
PNAS 2001 98: 2119-2121. [Full Text] [PDF]  

Gerald J. Chader

PEDF: Raising both hopes and questions in controlling angiogenesis
PNAS 2001 98: 2122-2124. [Full Text] [PDF]  

Margaret E. Saks

Making sense out of nonsense
PNAS 2001 98: 2125-2127. [Full Text] [PDF]  

PERSPECTIVES

John D. Rummel

Special Feature: Planetary exploration in the time of astrobiology: Protecting against biological contamination
PNAS 2001 98: 2128-2131. [Abstract] [Full Text] [PDF]  

REVIEWS

Hugh G. M. Hill, Carol A. Grady, Joseph A. Nuth III, Susan L. Hallenbeck, and Michael L. Sitko

Special Feature: Constraints on nebular dynamics and chemistry based on observations of annealed magnesium silicate grains in comets and in disks surrounding Herbig Ae/Be stars
PNAS 2001 98: 2182-2187. [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES
Astronomy

Brad Lobitz, Byron L. Wood, Maurice M. Averner, and Christopher P. McKay

Special Feature: Use of spacecraft data to derive regions on Mars where liquid water would be stable
PNAS 2001 98: 2132-2137. [Abstract] [Full Text] [PDF]  

Chemistry

Pascale Ehrenfreund, Daniel P. Glavin, Oliver Botta, George Cooper, and Jeffrey L. Bada

Special Feature: Extraterrestrial amino acids in Orgueil and Ivuna: Tracing the parent body of CI type carbonaceous chondrites
PNAS 2001 98: 2138-2141. [Abstract] [Full Text] [PDF]  

Friedemann Freund, Aaron Staple, and John Scoville

Special Feature: Organic protomolecule assembly in igneous minerals
PNAS 2001 98: 2142-2147. [Abstract] [Full Text] [PDF]  

Yaakov Levy, Joshua Jortner, and Oren M. Becker

Solvent effects on the energy landscapes and folding kinetics of polyalanine
PNAS 2001 98: 2188-2193; published online before print February 20, 2001, 10.1073/pnas.041611998 [Abstract] [Full Text] [PDF]  

Michael D. Bartberger, Jon M. Fukuto, and K. N. Houk

On the acidity and reactivity of HNO in aqueous solution and biological systems
PNAS 2001 98: 2194-2198. [Abstract] [Full Text] [PDF]  

Geology

Ruth E. Blake, Jeffrey C. Alt, and Anna M. Martini

Special Feature: Oxygen isotope ratios of PO₄: An inorganic indicator of enzymatic activity and P metabolism and a new biomarker in the search for life
PNAS 2001 98: 2148-2153. [Abstract] [Full Text] [PDF]  

Geophysics

M. F. Gerstell, J. S. Francisco, Y. L. Yung, C. Boxe, and E. T. Aaltonee

Special Feature: Keeping Mars warm with new super greenhouse gases
PNAS 2001 98: 2154-2157. [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES
Social Sciences

Gabriele Doblhammer and James W. Vaupel

Lifespan depends on month of birth
PNAS 2001 98: 2934-2939; published online before print February 20, 2001, 10.1073/pnas.041431898 [Abstract] [Full Text] [PDF] [Supplemental Data]  

BIOLOGICAL SCIENCES
Applied Biological Sciences

Rika Miki, Koji Kadota, Hidemasa Bono, Yosuke Mizuno, Yasuhiro Tomaru, Piero Carninci, Masayoshi Itoh, Kazuhiro Shibata, Jun Kawai, Hideaki Konno, Sachihiko Watanabe, Kenjiro Sato, Yumiko Tokusumi, Noriko Kikuchi, Yoshiyuki Ishii, Yohei Hamaguchi, Itaru Nishizuka, Hitoshi Goto, Hiroyuki Nitanda, Susumu Satomi, Atsushi Yoshiki, Moriaki Kusakabe, Joseph L. DeRisi, Michael B. Eisen, Vishwnath R. Iyer, Patrick O. Brown, Masami Muramatsu, Hiroshi Shimada, Yasushi Okazaki, and Yoshihide Hayashizaki

Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays
PNAS 2001 98: 2199-2204. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

William S. Sly, Carole Vogler, Jeffrey H. Grubb, Mi Zhou, Jinxing Jiang, Xiao Yan Zhou, Shunji Tomatsu, Yanhua Bi, and Elizabeth M. Snella

Active site mutant transgene confers tolerance to human -glucuronidase without affecting the phenotype of MPS VII mice
PNAS 2001 98: 2205-2210; published online before print February 13, 2001, 10.1073/pnas.051623698 [Abstract] [Full Text] [PDF]  

Teresa Johnson-Pais, Catherine Degnin, and Mathew J. Thayer

pRB induces Sp1 activity by relieving inhibition mediated by MDM2
PNAS 2001 98: 2211-2216. [Abstract] [Full Text] [PDF]  

Jennifer E. Padilla, Christos Colovos, and Todd O. Yeates

Nanohedra: Using symmetry to design self assembling protein cages, layers, crystals, and filaments
PNAS 2001 98: 2217-2221; published online before print February 20, 2001, 10.1073/pnas.041614998 [Abstract] [Full Text] [PDF]  

Mijung Yim, Takashi Ono, and Tatsuro Irimura

Mutated plant lectin library useful to identify different cells
PNAS 2001 98: 2222-2225. [Abstract] [Full Text] [PDF]  

Biochemistry

Michael D. Bartberger, Jon M. Fukuto, and K. N. Houk

On the acidity and reactivity of HNO in aqueous solution and biological systems
PNAS 2001 98: 2194-2198. [Abstract] [Full Text] [PDF]  

Takashi Kanazawa, Masahiko Watanabe, Yuko Matsushima-Hibiya, Takuo Kono, Noriaki Tanaka, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi

Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells
PNAS 2001 98: 2226-2231. [Abstract] [Full Text] [PDF]  

Francesca Cutruzzolà, Kieron Brown, Emma K. Wilson, Andrea Bellelli, Marzia Arese, Mariella Tegoni, Christian Cambillau, and Maurizio Brunori

The nitrite reductase from Pseudomonas aeruginosa: Essential role of two active-site histidines in the catalytic and structural properties
PNAS 2001 98: 2232-2237. [Abstract] [Full Text] [PDF]  

Edward B. Little, Kathryn L. Crossin, Leslie A. Krushel, Gerald M. Edelman, and Bruce A. Cunningham

A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-B activity in astrocytes
PNAS 2001 98: 2238-2243; published online before print February 20, 2001, 10.1073/pnas.041597098 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Norihito Shibata, Makoto Arita, Yuko Misaki, Naoshi Dohmae, Koji Takio, Teruo Ono, Keizo Inoue, and Hiroyuki Arai

Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis
PNAS 2001 98: 2244-2249. [Abstract] [Full Text] [PDF]  

Fang Xiao Zhou, Helen J. Merianos, Axel T. Brunger, and Donald M. Engelman

Polar residues drive association of polyleucine transmembrane helices
PNAS 2001 98: 2250-2255; published online before print February 13, 2001, 10.1073/pnas.041593698 [Abstract] [Full Text] [PDF]  

Akiko Maekawa, Yoshihide Kanaoka, Bing K. Lam, and K. Frank Austen

Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing
PNAS 2001 98: 2256-2261; published online before print February 13, 2001, 10.1073/pnas.041624398 [Abstract] [Full Text] [PDF]  

Wolfgang Lukowitz, Todd C. Nickle, David W. Meinke, Robert L. Last, Patricia L. Conklin, and Christopher R. Somerville

Arabidopsis cyt1 mutants are deficient in a mannose-1-phosphate guanylyltransferase and point to a requirement of N-linked glycosylation for cellulose biosynthesis
PNAS 2001 98: 2262-2267; published online before print February 20, 2001, 10.1073/pnas.051625798 [Abstract] [Full Text] [PDF]  

Anne K. Kowal, Caroline Köhrer, and Uttam L. RajBhandary From the Cover: Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria PNAS 2001 98: 2268-2273; published online before print January 23, 2001, 10.1073/pnas.031488298 [Abstract] [Full Text] [PDF]

Klas Broo, Jing Wei, Dawn Marshall, Fred Brown, Thomas J. Smith, John E. Johnson, Anette Schneemann, and Gary Siuzdak

Viral capsid mobility: A dynamic conduit for inactivation
PNAS 2001 98: 2274-2277; published online before print February 13, 2001, 10.1073/pnas.051598298 [Abstract] [Full Text] [PDF]  

Jason E. Kokoszka, Pinar Coskun, Luke A. Esposito, and Douglas C. Wallace

Increased mitochondrial oxidative stress in the Sod2 (+/) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis
PNAS 2001 98: 2278-2283; published online before print February 13, 2001, 10.1073/pnas.051627098 [Abstract] [Full Text] [PDF]  

Vincenza Dolce, Giuseppe Fiermonte, Michael J. Runswick, Ferdinando Palmieri, and John E. Walker

The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals
PNAS 2001 98: 2284-2288; published online before print February 20, 2001, 10.1073/pnas.031430998 [Abstract] [Full Text] [PDF]  

Mahipal Singh, Alexander Boutanaev, Paola Zucchi, and Lawrence Bogorad

Gene elements that affect the longevity of rbcL sequence-containing transcripts in Chlamydomonas reinhardtii chloroplasts
PNAS 2001 98: 2289-2294; published online before print February 13, 2001, 10.1073/pnas.041609798 [Abstract] [Full Text] [PDF]  

Tao Xu, Marc Purcell, Paola Zucchi, Tim Helentjaris, and Lawrence Bogorad

TRM1, a YY1-like suppressor of rbcS-m3 expression in maize mesophyll cells
PNAS 2001 98: 2295-2300. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Arie Berggrun and Robert T. Sauer

Contributions of distinct quaternary contacts to cooperative operator binding by Mnt repressor
PNAS 2001 98: 2301-2305; published online before print February 13, 2001, 10.1073/pnas.041612198 [Abstract] [Full Text] [PDF]  

Adolfo Saiardi, Eiichiro Nagata, Hongbo R. Luo, Akira Sawa, Xiaojiang Luo, Adele M. Snowman, and Solomon H. Snyder

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate
PNAS 2001 98: 2306-2311; published online before print February 13, 2001, 10.1073/pnas.041614598 [Abstract] [Full Text] [PDF]  

Ervin Welker, Mahesh Narayan, William J. Wedemeyer, and Harold A. Scheraga

Structural determinants of oxidative folding in proteins
PNAS 2001 98: 2312-2316. [Abstract] [Full Text] [PDF]  

Bin Ye, Wolfgang Maret, and Bert L. Vallee

Zinc metallothionein imported into liver mitochondria modulates respiration
PNAS 2001 98: 2317-2322; published online before print February 13, 2001, 10.1073/pnas.041619198 [Abstract] [Full Text] [PDF]  

Christian Wolfrum, Carola M. Borrmann, Torsten Börchers, and Friedrich Spener

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors - and -mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
PNAS 2001 98: 2323-2328; published online before print February 20, 2001, 10.1073/pnas.051619898 [Abstract] [Full Text] [PDF]  

Biophysics

Jaroslaw Pillardy, Cezary Czaplewski, Adam Liwo, Jooyoung Lee, Daniel R. Ripoll, Rajmund Kamierkiewicz, Stanislaw Oldziej, William J. Wedemeyer, Kenneth D. Gibson, Yelena A. Arnautova, Jeff Saunders, Yuan-Jie Ye, and Harold A. Scheraga

Recent improvements in prediction of protein structure by global optimization of a potential energy function
PNAS 2001 98: 2329-2333; published online before print February 20, 2001, 10.1073/pnas.041609598 [Abstract] [Full Text] [PDF]  

Gayathri Ratnaswamy, Mary E. Huff, Andrew I. Su, Severine Rion, and Jeffery W. Kelly

Destabilization of Ca²⁺-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type
PNAS 2001 98: 2334-2339; published online before print February 20, 2001, 10.1073/pnas.041452598 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Fumimasa Nomura, Miki Nagata, Takehiko Inaba, Haruka Hiramatsu, Hirokazu Hotani, and Kingo Takiguchi

Capabilities of liposomes for topological transformation
PNAS 2001 98: 2340-2345; published online before print February 20, 2001, 10.1073/pnas.041419098 [Abstract] [Full Text] [PDF] [Supplemental Movies]  

P. T. F. Williamson, J. A. Watts, G. H. Addona, K. W. Miller, and A. Watts

Dynamics and orientation of N⁺(CD₃)₃-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor
PNAS 2001 98: 2346-2351; published online before print February 20, 2001, 10.1073/pnas.031361698 [Abstract] [Full Text] [PDF]  

Huaping Mo, Richard C. Moore, Fred E. Cohen, David Westaway, Stanley B. Prusiner, Peter E. Wright, and H. Jane Dyson

Two different neurodegenerative diseases caused by proteins with similar structures
PNAS 2001 98: 2352-2357. [Abstract] [Full Text] [PDF]  

César Fernández, Koba Adeishvili, and Kurt Wüthrich

Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles
PNAS 2001 98: 2358-2363; published online before print February 20, 2001, 10.1073/pnas.051629298 [Abstract] [Full Text] [PDF]  

Claudiu C. Gradinaru, John T. M. Kennis, Emmanouil Papagiannakis, Ivo H. M. van Stokkum, Richard J. Cogdell, Graham R. Fleming, Robert A. Niederman, and Rienk van Grondelle

An unusual pathway of excitation energy deactivation in carotenoids: Singlet-to-triplet conversion on an ultrafast timescale in a photosynthetic antenna
PNAS 2001 98: 2364-2369; published online before print February 20, 2001, 10.1073/pnas.051501298 [Abstract] [Full Text] [PDF]  

Hans Frauenfelder, Benjamin H. McMahon, Robert H. Austin, Kelvin Chu, and John T. Groves

The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin
PNAS 2001 98: 2370-2374; published online before print February 20, 2001, 10.1073/pnas.041614298 [Abstract] [Full Text] [PDF]  

Melinda Balbirnie, Robert Grothe, and David S. Eisenberg

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated -sheet structure for amyloid
PNAS 2001 98: 2375-2380; published online before print February 20, 2001, 10.1073/pnas.041617698 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cell Biology

Lia Baki, Philippe Marambaud, Spiros Efthimiopoulos, Anastasios Georgakopoulos, Paul Wen, Wen Cui, Junichi Shioi, Eduard Koo, Masayuki Ozawa, Victor L. Friedrich Jr., and Nikolaos K. Robakis

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
PNAS 2001 98: 2381-2386. [Abstract] [Full Text] [PDF]  

Chafen Lu, Motomu Shimaoka, Mazen Ferzly, Claus Oxvig, Junichi Takagi, and Timothy A. Springer

An isolated, surface-expressed I domain of the integrin L2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond
PNAS 2001 98: 2387-2392. [Abstract] [Full Text] [PDF]  

Chafen Lu, Motomu Shimaoka, Qun Zang, Junichi Takagi, and Timothy A. Springer

Locking in alternate conformations of the integrin L2 I domain with disulfide bonds reveals functional relationships among integrin domains
PNAS 2001 98: 2393-2398. [Abstract] [Full Text] [PDF]  

Brad J. Marsh, David N. Mastronarde, Karolyn F. Buttle, Kathryn E. Howell, and J. Richard McIntosh INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography PNAS 2001 98: 2399-2406. [Abstract] [Full Text] [PDF] [Supplemental Movies]

Thomas Radtke, Dirk Schmalz, Elias Coutavas, Tarik M. Soliman, and Reiner Peters

Kinetics of protein import into isolated Xenopus oocyte nuclei
PNAS 2001 98: 2407-2412; published online before print February 20, 2001, 10.1073/pnas.051616598 [Abstract] [Full Text] [PDF]  

Akimasa Someya, Makoto Sata, Kazuyo Takeda, Gustavo Pacheco-Rodriguez, Victor J. Ferrans, Joel Moss, and Martha Vaughan

ARF-GEP₁₀₀, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
PNAS 2001 98: 2413-2418. [Abstract] [Full Text] [PDF]  

Justin A. MacDonald, Meredith A. Borman, Andrea Murányi, Avril V. Somlyo, David J. Hartshorne, and Timothy A. J. Haystead

Identification of the endogenous smooth muscle myosin phosphatase-associated kinase
PNAS 2001 98: 2419-2424. [Abstract] [Full Text] [PDF]  

Bahman Aghdasi, Keqiang Ye, Adam Resnick, Alex Huang, Hyo Chol Ha, Xin Guo, Ted M. Dawson, Valina L. Dawson, and Solomon H. Snyder

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle
PNAS 2001 98: 2425-2430; published online before print February 20, 2001, 10.1073/pnas.041614198 [Abstract] [Full Text] [PDF]  

Noa Zerangue, Michael J. Malan, Sharon R. Fried, Paul F. Dazin, Yuh Nung Jan, Lily Yeh Jan, and Blanche Schwappach

Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells
PNAS 2001 98: 2431-2436. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Akira Honda, Stephen R. Adams, Carolyn L. Sawyer, Varda Lev-Ram, Roger Y. Tsien, and Wolfgang R. G. Dostmann

Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
PNAS 2001 98: 2437-2442. [Abstract] [Full Text] [PDF] [Supplemental Movie]  

Amy C. Bendixen, Nirupama K. Shevde, Krista M. Dienger, Timothy M. Willson, Colin D. Funk, and J. Wesley Pike

IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor 1
PNAS 2001 98: 2443-2448; published online before print February 20, 2001, 10.1073/pnas.041493198 [Abstract] [Full Text] [PDF]  

Louis M. Luttrell, Francine L. Roudabush, Eric W. Choy, William E. Miller, Michael E. Field, Kristen L. Pierce, and Robert J. Lefkowitz

Activation and targeting of extracellular signal-regulated kinases by -arrestin scaffolds
PNAS 2001 98: 2449-2454; published online before print February 20, 2001, 10.1073/pnas.041604898 [Abstract] [Full Text] [PDF]  

Satrajit Sinha and Elaine Fuchs

Identification and dissection of an enhancer controlling epithelial gene expression in skin
PNAS 2001 98: 2455-2460. [Abstract] [Full Text] [PDF]  

Developmental Biology

Chunguang Ma, Lianchun Fan, Rosemarie Ganassin, Niels Bols, and Paul Collodi

Production of zebrafish germ-line chimeras from embryo cell cultures
PNAS 2001 98: 2461-2466; published online before print February 13, 2001, 10.1073/pnas.041449398 [Abstract] [Full Text] [PDF]  

Ludovic Vallier, Jimmy Mancip, Suzy Markossian, Agnès Lukaszewicz, Colette Dehay, Daniel Metzger, Pierre Chambon, Jacques Samarut, and Pierre Savatier

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives
PNAS 2001 98: 2467-2472; published online before print February 20, 2001, 10.1073/pnas.041617198 [Abstract] [Full Text] [PDF]  

Ecology

Melanie Summit and John A. Baross

Special Feature: A novel microbial habitat in the mid-ocean ridge subseafloor
PNAS 2001 98: 2158-2163. [Abstract] [Full Text] [PDF]  

Kevin L. Griffin, O. Roger Anderson, Mary D. Gastrich, James D. Lewis, Guanghui Lin, William Schuster, Jeffrey R. Seemann, David T. Tissue, Matthew H. Turnbull, and David Whitehead

Plant growth in elevated CO₂ alters mitochondrial number and chloroplast fine structure
PNAS 2001 98: 2473-2478. [Abstract] [Full Text] [PDF]  

Xianzhong Wang, James D. Lewis, David T. Tissue, Jeffrey R. Seemann, and Kevin L. Griffin

Effects of elevated atmospheric CO₂ concentration on leaf dark respiration of Xanthium strumarium in light and in darkness
PNAS 2001 98: 2479-2484. [Abstract] [Full Text] [PDF]  

Marjorie Brooks Lovvorn, George C. Frison, and Larry L. Tieszen

Paleoclimate and Amerindians: Evidence from stable isotopes and atmospheric circulation
PNAS 2001 98: 2485-2490; published online before print February 20, 2001, 10.1073/pnas.041616098 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Rick A. Relyea and Nathan Mills

Predator-induced stress makes the pesticide carbaryl more deadly to gray treefrog tadpoles (Hyla versicolor)
PNAS 2001 98: 2491-2496; published online before print February 13, 2001, 10.1073/pnas.031076198 [Abstract] [Full Text] [PDF]  

Evolution

Kathie L. Thomas-Keprta, Simon J. Clemett, Dennis A. Bazylinski, Joseph L. Kirschvink, David S. McKay, Susan J. Wentworth, Hojatollah Vali, Everett K. Gibson Jr., Mary Fae McKay, and Christopher S. Romanek

Special Feature: Truncated hexa-octahedral magnetite crystals in ALH84001: Presumptive biosignatures
PNAS 2001 98: 2164-2169. [Abstract] [Full Text] [PDF] [Supplemental Figures]  

G. C. Dismukes, V. V. Klimov, S. V. Baranov, Yu. N. Kozlov, J. DasGupta, and A. Tyryshkin

Special Feature: The origin of atmospheric oxygen on Earth: The innovation of oxygenic photosynthesis
PNAS 2001 98: 2170-2175. [Abstract] [Full Text] [PDF]  

Masatoshi Nei, Ping Xu, and Galina Glazko

Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms
PNAS 2001 98: 2497-2502; published online before print February 20, 2001, 10.1073/pnas.051611498 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Paul J. Planet, Scott C. Kachlany, Rob DeSalle, and David H. Figurski

Phylogeny of genes for secretion NTPases: Identification of the widespread tadA subfamily and development of a diagnostic key for gene classification
PNAS 2001 98: 2503-2508. [Abstract] [Full Text] [PDF]  

Willie J. Swanson, Ziheng Yang, Mariana F. Wolfner, and Charles F. Aquadro

Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals
PNAS 2001 98: 2509-2514; published online before print February 20, 2001, 10.1073/pnas.051605998 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Genetics

Esther Latres, Roberto Chiarle, Brenda A. Schulman, Nikola P. Pavletich, Angel Pellicer, Giorgio Inghirami, and Michele Pagano

Role of the F-box protein Skp2 in lymphomagenesis
PNAS 2001 98: 2515-2520; published online before print February 20, 2001, 10.1073/pnas.041475098 [Abstract] [Full Text] [PDF]  

Nitin S. Baliga, Sean P. Kennedy, Wailap Victor Ng, Leroy Hood, and Shiladitya DasSarma

Genomic and genetic dissection of an archaeal regulon
PNAS 2001 98: 2521-2525; published online before print February 20, 2001, 10.1073/pnas.051632498 [Abstract] [Full Text] [PDF]  

Mathew C. Casimiro, Björn C. Knollmann, Steven N. Ebert, Jay C. Vary Jr., Anne E. Greene, Michael R. Franz, Alexander Grinberg, Sing Ping Huang, and Karl Pfeifer

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange- Nielsen Syndrome
PNAS 2001 98: 2526-2531. [Abstract] [Full Text] [PDF] [Supplemental Figure]  

John J. Gregory Jr., John E. Wagner, Peter C. Verlander, Orna Levran, Sat Dev Batish, Cindy R. Eide, Amy Steffenhagen, Betsy Hirsch, and Arleen D. Auerbach

Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells
PNAS 2001 98: 2532-2537; published online before print February 13, 2001, 10.1073/pnas.051609898 [Abstract] [Full Text] [PDF]  

Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David Bicknell, Walter F. Bodmer, Mark J. Arends, Andrew H. Wyllie, and Paul A. W. Edwards

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement
PNAS 2001 98: 2538-2543; published online before print February 20, 2001, 10.1073/pnas.041603298 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Minoru Tanaka, Masato Kinoshita, Daisuke Kobayashi, and Yoshitaka Nagahama

Establishment of medaka (Oryzias latipes) transgenic lines with the expression of green fluorescent protein fluorescence exclusively in germ cells: A useful model to monitor germ cells in a live vertebrate
PNAS 2001 98: 2544-2549; published online before print February 20, 2001, 10.1073/pnas.041315498 [Abstract] [Full Text] [PDF]  

Zafar Zaman, Aseem Z. Ansari, Sang Seok Koh, Richard Young, and Mark Ptashne

Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression
PNAS 2001 98: 2550-2554. [Abstract] [Full Text] [PDF]  

Tina K. Van Dyk, Yan Wei, Michael K. Hanafey, Maureen Dolan, Mary Jane G. Reeve, J. Antoni Rafalski, Lucia B. Rothman-Denes, and Robert A. LaRossa

A genomic approach to gene fusion technology
PNAS 2001 98: 2555-2560; published online before print February 13, 2001, 10.1073/pnas.041620498 [Abstract] [Full Text] [PDF]  

Immunology

Andrés Vázquez-Torres, Giamila Fantuzzi, Carl K. Edwards III, Charles A. Dinarello, and Ferric C. Fang

Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages
PNAS 2001 98: 2561-2565; published online before print February 13, 2001, 10.1073/pnas.041618998 [Abstract] [Full Text] [PDF]  

Julie Strong, Qi Wang, and Nigel Killeen

Impaired survival of T helper cells in the absence of CD4
PNAS 2001 98: 2566-2571; published online before print February 20, 2001, 10.1073/pnas.051329698 [Abstract] [Full Text] [PDF]  

Yann Szpak, Jean-Claude Vieville, Thierry Tabary, Marie-Christine Naud, Martine Chopin, Catherine Edelson, Jacques H. M. Cohen, Jean Dausset, Yvonne de Kozak, and Marika Pla

Spontaneous retinopathy in HLA-A29 transgenic mice
PNAS 2001 98: 2572-2576; published online before print February 13, 2001, 10.1073/pnas.051595998 [Abstract] [Full Text] [PDF]  

Ken-ichiro Seino, Katashi Fukao, Kenzo Muramoto, Kazuhiko Yanagisawa, Yasutsugu Takada, Shigeru Kakuta, Yoichiro Iwakura, Luc Van Kaer, Kazuyoshi Takeda, Toshinori Nakayama, Masaru Taniguchi, Hisashi Bashuda, Hideo Yagita, and Ko Okumura

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance
PNAS 2001 98: 2577-2581; published online before print February 20, 2001, 10.1073/pnas.041608298 [Abstract] [Full Text] [PDF]  

Yoshihiro Baba, Shoji Hashimoto, Masato Matsushita, Dai Watanabe, Tadamitsu Kishimoto, Tomohiro Kurosaki, and Satoshi Tsukada

BLNK mediates Syk-dependent Btk activation
PNAS 2001 98: 2582-2586; published online before print February 13, 2001, 10.1073/pnas.051626198 [Abstract] [Full Text] [PDF]  

Timothy J. Sullivan, John J. Letterio, Andreas van Elsas, Mizuko Mamura, Jocea van Amelsfort, Shellyann Sharpe, Barbara Metzler, Cynthia A. Chambers, and James P. Allison

Lack of a role for transforming growth factor- in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
PNAS 2001 98: 2587-2592; published online before print February 20, 2001, 10.1073/pnas.051632398 [Abstract] [Full Text] [PDF]  

Medical Sciences

Veronica Stellmach, Susan E. Crawford, Wei Zhou, and Noël Bouck

Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
PNAS 2001 98: 2593-2597; published online before print January 23, 2001, 10.1073/pnas.031252398 [Abstract] [Full Text] [PDF]  

Ben Ho Park, Bert Vogelstein, and Kenneth W. Kinzler

Genetic disruption of PPAR decreases the tumorigenicity of human colon cancer cells
PNAS 2001 98: 2598-2603. [Abstract] [Full Text] [PDF]  

Dai Fukumura, Takeshi Gohongi, Ananth Kadambi, Yotaro Izumi, Jennifer Ang, Chae-Ok Yun, Donald G. Buerk, Paul L. Huang, and Rakesh K. Jain

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
PNAS 2001 98: 2604-2609. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Thierry Claudel, Mark D. Leibowitz, Catherine Fiévet, Anne Tailleux, Brandee Wagner, Joyce J. Repa, Gérard Torpier, Jean-Marc Lobaccaro, James R. Paterniti, David J. Mangelsdorf, Richard A. Heyman, and Johan Auwerx

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor
PNAS 2001 98: 2610-2615; published online before print February 20, 2001, 10.1073/pnas.041609298 [Abstract] [Full Text] [PDF]  

Meng Yang, Eugene Baranov, Xiao-Ming Li, Jin Wei Wang, Ping Jiang, Lingna Li, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman

Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors
PNAS 2001 98: 2616-2621. [Abstract] [Full Text] [PDF]  

Raed A. Dweik, Suzy A. A. Comhair, Benjamin Gaston, Frederik B. J. M. Thunnissen, Carol Farver, Mary Jane Thomassen, Mani Kavuru, Jeffrey Hammel, Husam M. Abu-Soud, and Serpil C. Erzurum

NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response
PNAS 2001 98: 2622-2627; published online before print February 20, 2001, 10.1073/pnas.051629498 [Abstract] [Full Text] [PDF]  

Nilamadhab Mishra, Doris R. Brown, Irene M. Olorenshaw, and Gary M. Kammer

Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon- gene and protein expression in lupus T cells
PNAS 2001 98: 2628-2633; published online before print February 20, 2001, 10.1073/pnas.051507098 [Abstract] [Full Text] [PDF]  

Pierre Meneton, May Bloch-Faure, Albert A. Hagege, Hartmut Ruetten, Wei Huang, Sonia Bergaya, Debbie Ceiler, Doris Gehring, Isabelle Martins, Georges Salmon, Chantal M. Boulanger, Jürg Nussberger, Bertrand Crozatier, Jean-Marie Gasc, Didier Heudes, Patrick Bruneval, Tom Doetschman, Joël Ménard, and François Alhenc-Gelas

Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice
PNAS 2001 98: 2634-2639; published online before print February 20, 2001, 10.1073/pnas.051619598 [Abstract] [Full Text] [PDF]  

Ie-Ming Shih, Tian-Li Wang, Giovanni Traverso, Kathy Romans, Stanley R. Hamilton, Shmuel Ben-Sasson, Kenneth W. Kinzler, and Bert Vogelstein

Top-down morphogenesis of colorectal tumors
PNAS 2001 98: 2640-2645; published online before print February 20, 2001, 10.1073/pnas.051629398 [Abstract] [Full Text] [PDF]  

Katherine J. Martin, Edgard Graner, Yi Li, Laura M. Price, Brian M. Kritzman, Marcia V. Fournier, Esther Rhei, and Arthur B. Pardee

High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood
PNAS 2001 98: 2646-2651; published online before print February 20, 2001, 10.1073/pnas.041622398 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Stefano Fiorucci, Andrea Mencarelli, Barbara Palazzetti, Piero Del Soldato, Antonio Morelli, and Louis J. Ignarro

An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity
PNAS 2001 98: 2652-2657; published online before print February 13, 2001, 10.1073/pnas.041603898 [Abstract] [Full Text] [PDF]  

Douglas C. Saffran, Arthur B. Raitano, Rene S. Hubert, Owen N. Witte, Robert E. Reiter, and Aya Jakobovits

Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts
PNAS 2001 98: 2658-2663; published online before print February 13, 2001, 10.1073/pnas.051624698 [Abstract] [Full Text] [PDF]  

Benoit Gamain, Louis H. Miller, and Dror I. Baruch

The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes
PNAS 2001 98: 2664-2669; published online before print February 13, 2001, 10.1073/pnas.041602598 [Abstract] [Full Text] [PDF]  

Stefan Pöhlmann, Elizabeth J. Soilleux, Frédéric Baribaud, George J. Leslie, Lesley S. Morris, John Trowsdale, Benhur Lee, Nicholas Coleman, and Robert W. Doms

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
PNAS 2001 98: 2670-2675. [Abstract] [Full Text] [PDF]  

Sung-Chul Jung, Ina P. Han, Advait Limaye, Ruian Xu, Monique P. Gelderman, Patricia Zerfas, Kamala Tirumalai, Gary J. Murray, Matthew J. During, Roscoe O. Brady, and Pankaj Qasba

Adeno-associated viral vector-mediated gene transfer results in long-term enzymatic and functional correction in multiple organs of Fabry mice
PNAS 2001 98: 2676-2681. [Abstract] [Full Text] [PDF]  

Michael A. Huie, Mei-Chi Cheung, Marcus O. Muench, Baltazar Becerril, Yuet W. Kan, and James D. Marks

Antibodies to human fetal erythroid cells from a nonimmune phage antibody library
PNAS 2001 98: 2682-2687. [Abstract] [Full Text] [PDF]  

Hajime Nakamura, Stephen C. De Rosa, Junji Yodoi, Arne Holmgren, Pietro Ghezzi, Leonard A. Herzenberg, and Leonore A. Herzenberg

Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS
PNAS 2001 98: 2688-2693. [Abstract] [Full Text] [PDF]  

Sylvia Bartlett, Josef Straub, Susan Tonks, Rush Spencer Wells, Julia G. Bodmer, and Walter F. Bodmer

Alkaline-mediated differential interaction (AMDI): A simple automatable single-nucleotide polymorphism assay
PNAS 2001 98: 2694-2697; published online before print February 20, 2001, 10.1073/pnas.041619998 [Abstract] [Full Text] [PDF]  

Sam Thiagalingam, Steve Laken, James K. V. Willson, Sanford D. Markowitz, Kenneth W. Kinzler, Bert Vogelstein, and Christoph Lengauer

Mechanisms underlying losses of heterozygosity in human colorectal cancers
PNAS 2001 98: 2698-2702; published online before print February 13, 2001, 10.1073/pnas.051625398 [Abstract] [Full Text] [PDF]  

Ichiro Kishimoto, Kristen Rossi, and David L. Garbers

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy
PNAS 2001 98: 2703-2706; published online before print February 13, 2001, 10.1073/pnas.051625598 [Abstract] [Full Text] [PDF]  

Robert E. Fleming, Christopher C. Holden, Shunji Tomatsu, Abdul Waheed, Elizabeth M. Brunt, Robert S. Britton, Bruce R. Bacon, Derry C. Roopenian, and William S. Sly

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
PNAS 2001 98: 2707-2711. [Abstract] [Full Text] [PDF]  

Maya Robert-Nicoud, Marjorie Flahaut, Jean-Marc Elalouf, Marie Nicod, Miguel Salinas, Marcelle Bens, Alain Doucet, Patrick Wincker, François Artiguenave, Jean-Daniel Horisberger, Alain Vandewalle, Bernard C. Rossier, and Dmitri Firsov

Transcriptome of a mouse kidney cortical collecting duct cell line: Effects of aldosterone and vasopressin
PNAS 2001 98: 2712-2716; published online before print February 20, 2001, 10.1073/pnas.051603198 [Abstract] [Full Text] [PDF]  

Microbiology

E. Imre Friedmann, Jacek Wierzchos, Carmen Ascaso, and Michael Winklhofer

Special Feature: Chains of magnetite crystals in the meteorite ALH84001: Evidence of biological origin
PNAS 2001 98: 2176-2181. [Abstract] [Full Text] [PDF] [Supplemental Appendixes]  

Xiaolan Shen and Paul S. Masters

Evaluation of the role of heterogeneous nuclear ribonucleoprotein A1 as a host factor in murine coronavirus discontinuous transcription and genome replication
PNAS 2001 98: 2717-2722; published online before print February 20, 2001, 10.1073/pnas.031424298 [Abstract] [Full Text] [PDF]  

J. Jelenska, M. J. Crawford, O. S. Harb, E. Zuther, R. Haselkorn, D. S. Roos, and P. Gornicki

Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii
PNAS 2001 98: 2723-2728; published online before print February 13, 2001, 10.1073/pnas.051629998 [Abstract] [Full Text] [PDF]  

William J. Buikema and Robert Haselkorn

Expression of the Anabaena hetR gene from a copper-regulated promoter leads to heterocyst differentiation under repressing conditions
PNAS 2001 98: 2729-2734; published online before print February 20, 2001, 10.1073/pnas.051624898 [Abstract] [Full Text] [PDF]  

Alejandro Aballay and Frederick M. Ausubel

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing
PNAS 2001 98: 2735-2739; published online before print February 13, 2001, 10.1073/pnas.041613098 [Abstract] [Full Text] [PDF]  

Lee-Fong Lin, Janos Posfai, Richard J. Roberts, and Huimin Kong

Comparative genomics of the restriction-modification systems in Helicobacter pylori
PNAS 2001 98: 2740-2745; published online before print February 13, 2001, 10.1073/pnas.051612298 [Abstract] [Full Text] [PDF]  

Christopher F. Basler, Ann H. Reid, Jody K. Dybing, Thomas A. Janczewski, Thomas G. Fanning, Hongyong Zheng, Mirella Salvatore, Michael L. Perdue, David E. Swayne, Adolfo García-Sastre, Peter Palese, and Jeffery K. Taubenberger From the Cover: Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes PNAS 2001 98: 2746-2751. [Abstract] [Full Text] [PDF] [Supplemental Data]

Sudha A. Chugani, Marvin Whiteley, Kimberly M. Lee, David D'Argenio, Colin Manoil, and E. P. Greenberg

QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa
PNAS 2001 98: 2752-2757. [Abstract] [Full Text] [PDF]  

Mikhail Prosniak, D. Craig Hooper, Bernhard Dietzschold, and Hilary Koprowski

Effect of rabies virus infection on gene expression in mouse brain
PNAS 2001 98: 2758-2763. [Abstract] [Full Text] [PDF]  

Neurobiology

Toshio Ohshima, Masaharu Ogawa, Veeranna, Motoyuki Hirasawa, Glenn Longenecker, Koichi Ishiguro, Harish C. Pant, Roscoe O. Brady, Ashok B. Kulkarni, and Katsuhiko Mikoshiba

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain
PNAS 2001 98: 2764-2769; published online before print February 13, 2001, 10.1073/pnas.051628498 [Abstract] [Full Text] [PDF]  

Jason K. Pinkstaff, Stephen A. Chappell, Vincent P. Mauro, Gerald M. Edelman, and Les A. Krushel

Internal initiation of translation of five dendritically localized neuronal mRNAs
PNAS 2001 98: 2770-2775; published online before print February 20, 2001, 10.1073/pnas.051623398 [Abstract] [Full Text] [PDF]  

Simo Vanni, Topi Tanskanen, Mika Seppä, Kimmo Uutela, and Riitta Hari

Coinciding early activation of the human primary visual cortex and anteromedial cuneus
PNAS 2001 98: 2776-2780. [Abstract] [Full Text] [PDF] [Supplemental Movie]  

Guadalupe García-Alcocer, Jesús García-Colunga, Ataúlfo Martínez-Torres, and Ricardo Miledi

Characteristics of glycine receptors expressed by embryonic rat brain mRNAs
PNAS 2001 98: 2781-2785; published online before print February 13, 2001, 10.1073/pnas.031580798 [Abstract] [Full Text] [PDF]  

Cesar Labarca, Johannes Schwarz, Purnima Deshpande, Sigrid Schwarz, Mark W. Nowak, Carlos Fonck, Raad Nashmi, Paulo Kofuji, Hong Dang, Wenmei Shi, Melihat Fidan, Baljit S. Khakh, Zhoufeng Chen, Barbara J. Bowers, Jim Boulter, Jeanne M. Wehner, and Henry A. Lester

Point mutant mice with hypersensitive 4 nicotinic receptors show dopaminergic deficits and increased anxiety
PNAS 2001 98: 2786-2791; published online before print February 20, 2001, 10.1073/pnas.041582598 [Abstract] [Full Text] [PDF]  

Ling Wang, Sandra Andersson, Margaret Warner, and Jan-Åke Gustafsson

Morphological abnormalities in the brains of estrogen receptor knockout mice
PNAS 2001 98: 2792-2796; published online before print February 20, 2001, 10.1073/pnas.041617498 [Abstract] [Full Text] [PDF]  

Lubica Beuková, Velayudhan Rema, Michael Armstrong-James, and Ford F. Ebner

Theory for normal and impaired experience-dependent plasticity in neocortex of adult rats
PNAS 2001 98: 2797-2802; published online before print February 20, 2001, 10.1073/pnas.051346398 [Abstract] [Full Text] [PDF]  

Matilde Cordero-Erausquin and Jean-Pierre Changeux

Tonic nicotinic modulation of serotoninergic transmission in the spinal cord
PNAS 2001 98: 2803-2807; published online before print February 20, 2001, 10.1073/pnas.041600698 [Abstract] [Full Text] [PDF]  

Gang-Yi Wu, Karl Deisseroth, and Richard W. Tsien

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
PNAS 2001 98: 2808-2813; published online before print February 20, 2001, 10.1073/pnas.051634198 [Abstract] [Full Text] [PDF]  

Lillian W. Chiang, Jill M. Grenier, Laurence Ettwiller, Lorayne P. Jenkins, Dave Ficenec, John Martin, Fenyu Jin, Peter S. DiStefano, and Andrew Wood

An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis
PNAS 2001 98: 2814-2819. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Lawrence P. Reagan, Naira Gorovits, Elena K. Hoskin, Stephen E. Alves, Ellen B. Katz, Claudia A. Grillo, Gerardo G. Piroli, Bruce S. McEwen, and Maureen J. Charron

Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
PNAS 2001 98: 2820-2825; published online before print February 13, 2001, 10.1073/pnas.051629798 [Abstract] [Full Text] [PDF]  

Geoffrey A. Manley, Des L. Kirk, Christine Köppl, and Graeme K. Yates

In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards
PNAS 2001 98: 2826-2831; published online before print February 13, 2001, 10.1073/pnas.041604998 [Abstract] [Full Text] [PDF]  

Jill S. Cameron, Laurence Dryer, and Stuart E. Dryer

-Neuregulin-1 is required for the in vivo development of functional Ca²⁺-activated K⁺ channels in parasympathetic neurons
PNAS 2001 98: 2832-2836; published online before print February 6, 2001, 10.1073/pnas.041394098 [Abstract] [Full Text] [PDF]  

Miquel Vila, Vernice Jackson-Lewis, Slobodanka Vukosavic, Ruth Djaldetti, Gabriel Liberatore, Daniel Offen, Stanley J. Korsmeyer, and Serge Przedborski

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
PNAS 2001 98: 2837-2842; published online before print February 13, 2001, 10.1073/pnas.051633998 [Abstract] [Full Text] [PDF]  

T. M. Reyes, K. Lewis, M. H. Perrin, K. S. Kunitake, J. Vaughan, C. A. Arias, J. B. Hogenesch, J. Gulyas, J. Rivier, W. W. Vale, and P. E. Sawchenko

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
PNAS 2001 98: 2843-2848. [Abstract] [Full Text] [PDF]  

Erbo Dong, Kinzo Matsumoto, Veska Uzunova, Ikuko Sugaya, Hiroki Takahata, Hiroaki Nomura, Hiroshi Watanabe, Erminio Costa, and Alessandro Guidotti

Brain 5-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation
PNAS 2001 98: 2849-2854. [Abstract] [Full Text] [PDF]  

Pharmacology

Randi B. Silver, Christina J. Mackins, Neil C. E. Smith, Irina L. Koritchneva, Kara Lefkowitz, Timothy W. Lovenberg, and Roberto Levi

Coupling of histamine H₃ receptors to neuronal Na⁺/H⁺ exchange: A novel protective mechanism in myocardial ischemia
PNAS 2001 98: 2855-2859; published online before print February 20, 2001, 10.1073/pnas.051599198 [Abstract] [Full Text] [PDF]  

Claudio Napoli, Giuseppe Cirino, Piero Del Soldato, Raffaella Sorrentino, Vincenzo Sica, Mario Condorelli, Aldo Pinto, and Louis J. Ignarro

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
PNAS 2001 98: 2860-2864. [Abstract] [Full Text] [PDF]  

James D. Fessenden, Lili Chen, Yaming Wang, Cecilia Paolini, Clara Franzini-Armstrong, Paul D. Allen, and Isaac N. Pessah

Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine
PNAS 2001 98: 2865-2870; published online before print February 13, 2001, 10.1073/pnas.041608898 [Abstract] [Full Text] [PDF]  

Physiology

Benjamin J. Pomerantz, Leonid L. Reznikov, Alden H. Harken, and Charles A. Dinarello

Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1
PNAS 2001 98: 2871-2876. [Abstract] [Full Text] [PDF]  

Yuejin Wu, Roger J. Colbran, and Mark E. Anderson

Calmodulin kinase is a molecular switch for cardiac excitation -contraction coupling
PNAS 2001 98: 2877-2881. [Abstract] [Full Text] [PDF]  

Etienne A. Cartier, Lisa R. Conti, Carol A. Vandenberg, and Show-Ling Shyng

Defective trafficking and function of K_ATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy
PNAS 2001 98: 2882-2887. [Abstract] [Full Text] [PDF]  

Mario J. Borgnia and Peter Agre

Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli
PNAS 2001 98: 2888-2893; published online before print February 20, 2001, 10.1073/pnas.051628098 [Abstract] [Full Text] [PDF]  

Virginia Leitch, Peter Agre, and Landon S. King

Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
PNAS 2001 98: 2894-2898. [Abstract] [Full Text] [PDF]  

Plant Biology

Hans Bakker, Muriel Bardor, Jos W. Molthoff, Véronique Gomord, Ingrid Elbers, Lucas H. Stevens, Wilco Jordi, Arjen Lommen, Loïc Faye, Patrice Lerouge, and Dirk Bosch

Galactose-extended glycans of antibodies produced by transgenic plants
PNAS 2001 98: 2899-2904. [Abstract] [Full Text] [PDF]  

Francis X. Cunningham Jr. and Elisabeth Gantt

One ring or two? Determination of ring number in carotenoids by lycopene -cyclases
PNAS 2001 98: 2905-2910; published online before print February 20, 2001, 10.1073/pnas.051618398 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Beatrice Grabowski, Francis X. Cunningham Jr., and Elisabeth Gantt

Chlorophyll and carotenoid binding in a simple red algal light-harvesting complex crosses phylogenetic lines
PNAS 2001 98: 2911-2916; published online before print February 13, 2001, 10.1073/pnas.031587198 [Abstract] [Full Text] [PDF]  

Alexander Szyroki, Natalya Ivashikina, Petra Dietrich, M. Rob G. Roelfsema, Peter Ache, Birgit Reintanz, Rosalia Deeken, Matthias Godde, Hubert Felle, Ralf Steinmeyer, Klaus Palme, and Rainer Hedrich

KAT1 is not essential for stomatal opening
PNAS 2001 98: 2917-2921; published online before print February 20, 2001, 10.1073/pnas.051616698 [Abstract] [Full Text] [PDF]  

Karl J. Niklas and Brian J. Enquist From the Cover: Invariant scaling relationships for interspecific plant biomass production rates and body size PNAS 2001 98: 2922-2927; published online before print February 6, 2001, 10.1073/pnas.041590298 [Abstract] [Full Text] [PDF]

Population Biology

Kevin Higgins and Michael Lynch

Metapopulation extinction caused by mutation accumulation
PNAS 2001 98: 2928-2933; published online before print February 20, 2001, 10.1073/pnas.031358898 [Abstract] [Full Text] [PDF]