COMMENTARIES

C. Roland Wolf

Chemoprevention: Increased potential to bear fruit
PNAS 2001 98: 2941-2943. [Full Text] [PDF]  

Murtaza F. Alibhai and William C. Stallings

Closing down on glyphosate inhibitionwith a new structure for drug discovery
PNAS 2001 98: 2944-2946. [Full Text] [PDF]  

Leslie A. Leinwand

Calcineurin inhibition and cardiac hypertrophy: A matter of balance
PNAS 2001 98: 2947-2949. [Full Text] [PDF]  

Mitchell Kronenberg, Olga Naidenko, and Frits Koning

Right on target: Novel approaches for the direct visualization of CD1-specific T cell responses
PNAS 2001 98: 2950-2952. [Full Text] [PDF]  

Steven E. Churchill

Hand morphology, manipulation, and tool use in Neandertals and early modern humans of the Near East
PNAS 2001 98: 2953-2955. [Full Text] [PDF]  

S. Marc Breedlove and Cynthia L. Jordan

The increasingly plastic, hormone-responsive adult brain
PNAS 2001 98: 2956-2957. [Full Text] [PDF]  

Neville Kallenbach

Breaking open a protein barrel
PNAS 2001 98: 2958-2960. [Full Text] [PDF]  

PHYSICAL SCIENCES
Applied Physical Sciences

Daniel T. Chiu, Elena Pezzoli, Hongkai Wu, Abraham D. Stroock, and George M. Whitesides From the Cover: Using three-dimensional microfluidic networks for solving computationally hard problems PNAS 2001 98: 2961-2966. [Abstract] [Full Text] [PDF] [Supplemental Figure]

Chemistry

Tamim Nazif and Matthew Bogyo

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
PNAS 2001 98: 2967-2972. [Abstract] [Full Text] [PDF] [Supplemental Data]  

F. Remacle, E. W. Schlag, H. Selzle, K. L. Kompa, U. Even, and R. D. Levine

Logic gates using high Rydberg states
PNAS 2001 98: 2973-2978. [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
Anthropology

Wesley A. Niewoehner

Behavioral inferences from the Skhul/Qafzeh early modern human hand remains
PNAS 2001 98: 2979-2984; published online before print February 6, 2001, 10.1073/pnas.041588898 [Abstract] [Full Text] [PDF]  

Biochemistry

Tamim Nazif and Matthew Bogyo

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
PNAS 2001 98: 2967-2972. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Darwin O. V. Alonso, Stephen J. DeArmond, Fred E. Cohen, and Valerie Daggett

Mapping the early steps in the pH-induced conformational conversion of the prion protein
PNAS 2001 98: 2985-2989; published online before print February 27, 2001, 10.1073/pnas.061555898 [Abstract] [Full Text] [PDF]  

Adrian H. Elcock and J. Andrew McCammon

Identification of protein oligomerization states by analysis of interface conservation
PNAS 2001 98: 2990-2994; published online before print March 6, 2001, 10.1073/pnas.061411798 [Abstract] [Full Text] [PDF]  

Sean Crosson and Keith Moffat

Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction
PNAS 2001 98: 2995-3000; published online before print February 27, 2001, 10.1073/pnas.051520298 [Abstract] [Full Text] [PDF]  

Pham My-Chan Dang, Andrew R. Cross, and Bernard M. Babior

Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67^PHOX and cytochrome b₅₅₈
PNAS 2001 98: 3001-3005. [Abstract] [Full Text] [PDF]  

Michael D. Altose, Yuangang Zheng, Jian Dong, Bruce A. Palfey, and Paul R. Carey

Comparing protein-ligand interactions in solution and single crystals by Raman spectroscopy
PNAS 2001 98: 3006-3011; published online before print March 6, 2001, 10.1073/pnas.061029598 [Abstract] [Full Text] [PDF]  

Andrew M. Petros, Ales Medek, David G. Nettesheim, Daniel H. Kim, Ho Sup Yoon, Kerry Swift, Edmund D. Matayoshi, Tilman Oltersdorf, and Stephen W. Fesik

Solution structure of the antiapoptotic protein bcl-2
PNAS 2001 98: 3012-3017; published online before print February 27, 2001, 10.1073/pnas.041619798 [Abstract] [Full Text] [PDF]  

Hong-Yo Kang, Hui-Kuan Lin, Yueh-Chiang Hu, Shuyuan Yeh, Ko-En Huang, and Chawnshang Chang

From transforming growth factor- signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells
PNAS 2001 98: 3018-3023; published online before print March 6, 2001, 10.1073/pnas.061305498 [Abstract] [Full Text] [PDF]  

Xiaodun He and I. R. Lehman

An initial ATP-independent step in the unwinding of a herpes simplex virus type I origin of replication by a complex of the viral origin-binding protein and single-strand DNA-binding protein
PNAS 2001 98: 3024-3028; published online before print March 6, 2001, 10.1073/pnas.061028298 [Abstract] [Full Text] [PDF]  

Valérie Murer, Jean François Spetz, Ulrich Hengst, Ludger Maria Altrogge, Ariane de Agostini, and Denis Monard

Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1
PNAS 2001 98: 3029-3033; published online before print February 27, 2001, 10.1073/pnas.051630698 [Abstract] [Full Text] [PDF]  

Christopher J. DaFonseca, Fong Shu, and J. Jillian Zhang

Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-
PNAS 2001 98: 3034-3039; published online before print March 6, 2001, 10.1073/pnas.061487598 [Abstract] [Full Text] [PDF]  

A. Wali Karzai and Robert T. Sauer

Protein factors associated with the SsrA·SmpB tagging and ribosome rescue complex
PNAS 2001 98: 3040-3044; published online before print February 27, 2001, 10.1073/pnas.051628298 [Abstract] [Full Text] [PDF]  

Alexander V. Vologodskii, Wentao Zhang, Valentin V. Rybenkov, Alexei A. Podtelezhnikov, Deepa Subramanian, Jack D. Griffith, and Nicholas R. Cozzarelli

Mechanism of topology simplification by type II DNA topoisomerases
PNAS 2001 98: 3045-3049. [Abstract] [Full Text] [PDF]  

C. Kiong Ho and Stewart Shuman

A yeast-like mRNA capping apparatus in Plasmodium falciparum
PNAS 2001 98: 3050-3055; published online before print March 6, 2001, 10.1073/pnas.061636198 [Abstract] [Full Text] [PDF]  

Youming Xie and Alexander Varshavsky

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit
PNAS 2001 98: 3056-3061. [Abstract] [Full Text] [PDF]  

Jean-Louis Mergny, Laurent Lacroix, Marie-Paule Teulade-Fichou, Candide Hounsou, Lionel Guittat, Magali Hoarau, Paola B. Arimondo, Jean-Pierre Vigneron, Jean-Marie Lehn, Jean-François Riou, Thérèse Garestier, and Claude Hélène

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
PNAS 2001 98: 3062-3067. [Abstract] [Full Text] [PDF]  

Larissa M. Podust, Thomas L. Poulos, and Michael R. Waterman

Crystal structure of cytochrome P450 14-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors
PNAS 2001 98: 3068-3073. [Abstract] [Full Text] [PDF]  

Giampaolo Zuccheri, Anita Scipioni, Valeria Cavaliere, Giuseppe Gargiulo, Pasquale De Santis, and Bruno Samorì

Mapping the intrinsic curvature and flexibility along the DNA chain
PNAS 2001 98: 3074-3079; published online before print February 27, 2001, 10.1073/pnas.051631198 [Abstract] [Full Text] [PDF]  

Takuo Watanabe, Hsien-Bin Huang, Atsuko Horiuchi, Edgar F. da Cruze Silva, Linda Hsieh-Wilson, Patrick B. Allen, Shirish Shenolikar, Paul Greengard, and Angus C. Nairn

Protein phosphatase 1 regulation by inhibitors and targeting subunits
PNAS 2001 98: 3080-3085. [Abstract] [Full Text] [PDF]  

Karen Adelman, Brandy Salmon, and Joel D. Baines

Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery
PNAS 2001 98: 3086-3091. [Abstract] [Full Text] [PDF]  

J. A. Silverman, R. Balakrishnan, and P. B. Harbury From the Cover: Reverse engineering the (/)8 barrel fold PNAS 2001 98: 3092-3097. [Abstract] [Full Text] [PDF] [Supplemental Data]

Zsolt Török, Pierre Goloubinoff, Ibolya Horváth, Nelly M. Tsvetkova, Attila Glatz, Gábor Balogh, Viktória Varvasovszki, Dmitry A. Los, Elizabeth Vierling, John H. Crowe, and László Vígh

Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding
PNAS 2001 98: 3098-3103; published online before print February 27, 2001, 10.1073/pnas.051619498 [Abstract] [Full Text] [PDF]  

Subrahmanyam S. Chirala, Armugam Jayakumar, Zi-Wei Gu, and Salih J. Wakil

Human fatty acid synthase: Role of interdomain in the formation of catalytically active synthase dimer
PNAS 2001 98: 3104-3108. [Abstract] [Full Text] [PDF]  

M. J. Nohaile, Z. S. Hendsch, B. Tidor, and R. T. Sauer

Altering dimerization specificity by changes in surface electrostatics
PNAS 2001 98: 3109-3114; published online before print February 27, 2001, 10.1073/pnas.051624498 [Abstract] [Full Text] [PDF]  

Katsuhiko Kamada, Jacqueline De Angelis, Robert G. Roeder, and Stephen K. Burley

Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF
PNAS 2001 98: 3115-3120. [Abstract] [Full Text] [PDF]  

P. Heikinheimo, V. Tuominen, A.-K. Ahonen, A. Teplyakov, B. S. Cooperman, A. A. Baykov, R. Lahti, and A. Goldman

Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase
PNAS 2001 98: 3121-3126; published online before print March 6, 2001, 10.1073/pnas.061612498 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

C. Kent Brown, Kevin Madauss, Wei Lian, Moriah R. Beck, W. David Tolbert, and David W. Rodgers

Structure of neurolysin reveals a deep channel that limits substrate access
PNAS 2001 98: 3127-3132; published online before print March 6, 2001, 10.1073/pnas.051633198 [Abstract] [Full Text] [PDF]  

Biophysics

Lars Ellgaard, Roland Riek, Torsten Herrmann, Peter Güntert, Daniel Braun, Ari Helenius, and Kurt Wüthrich

NMR structure of the calreticulin P-domain
PNAS 2001 98: 3133-3138; published online before print March 6, 2001, 10.1073/pnas.051630098 [Abstract] [Full Text] [PDF]  

Neeti Sinha and Ruth Nussinov

Point mutations and sequence variability in proteins: Redistributions of preexisting populations
PNAS 2001 98: 3139-3144. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Howard R. Petty and Andrei L. Kindzelskii

Dissipative metabolic patterns respond during neutrophil transmembrane signaling
PNAS 2001 98: 3145-3149; published online before print March 6, 2001, 10.1073/pnas.061014298 [Abstract] [Full Text] [PDF]  

Germán Rivas, Javier A. Fernández, and Allen P. Minton

Direct observation of the enhancement of noncooperative protein self-assembly by macromolecular crowding: Indefinite linear self-association of bacterial cell division protein FtsZ
PNAS 2001 98: 3150-3155. [Abstract] [Full Text] [PDF]  

Cell Biology

Graziella Pellegrini, Elena Dellambra, Osvaldo Golisano, Enrica Martinelli, Ivana Fantozzi, Sergio Bondanza, Diego Ponzin, Frank McKeon, and Michele De Luca

p63 identifies keratinocyte stem cells
PNAS 2001 98: 3156-3161. [Abstract] [Full Text] [PDF]  

Istvan R. Boldogh, Hyeong-Cheol Yang, W. Dan Nowakowski, Sharon L. Karmon, Lara G. Hays, John R. Yates III, and Liza A. Pon

Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast
PNAS 2001 98: 3162-3167. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Zongming Zhang, Jisen Tang, Svetlana Tikunova, J. David Johnson, Zhangguo Chen, Ning Qin, Alexander Dietrich, Enrico Stefani, Lutz Birnbaumer, and Michael Xi Zhu

Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain
PNAS 2001 98: 3168-3173; published online before print February 27, 2001, 10.1073/pnas.051632698 [Abstract] [Full Text] [PDF]  

Haim Cohen and David A. Sinclair

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
PNAS 2001 98: 3174-3179; published online before print March 6, 2001, 10.1073/pnas.061579598 [Abstract] [Full Text] [PDF]  

Frank Lafont and Kai Simons

Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling
PNAS 2001 98: 3180-3184. [Abstract] [Full Text] [PDF]  

Iwan Walev, Sebastian Chakrit Bhakdi, Fred Hofmann, Nabil Djonder, Angela Valeva, Klaus Aktories, and Sucharit Bhakdi

Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
PNAS 2001 98: 3185-3190; published online before print March 6, 2001, 10.1073/pnas.051429498 [Abstract] [Full Text] [PDF]  

Xiaosheng Wu, Lawryn H. Kasper, Ralitsa T. Mantcheva, George T. Mantchev, Margaret J. Springett, and Jan M. A. van Deursen

Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function
PNAS 2001 98: 3191-3196. [Abstract] [Full Text] [PDF]  

Takeharu Nagai, Asako Sawano, Eun Sun Park, and Atsushi Miyawaki

Circularly permuted green fluorescent proteins engineered to sense Ca²⁺
PNAS 2001 98: 3197-3202; published online before print March 6, 2001, 10.1073/pnas.051636098 [Abstract] [Full Text] [PDF]  

Bin Liu, Mitchell Gross, Johanna ten Hoeve, and Ke Shuai

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
PNAS 2001 98: 3203-3207. [Abstract] [Full Text] [PDF]  

Beatriz M. A. Fontoura, Samuel Dales, Günter Blobel, and Hualin Zhong

The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR
PNAS 2001 98: 3208-3213. [Abstract] [Full Text] [PDF]  

Antonia E. Stephen, Peter T. Masiakos, Dorry L. Segev, Joseph P. Vacanti, Patricia K. Donahoe, and David T. MacLaughlin

Tissue-engineered cells producing complex recombinant proteins inhibit ovarian cancer in vivo
PNAS 2001 98: 3214-3219; published online before print February 27, 2001, 10.1073/pnas.051625998 [Abstract] [Full Text] [PDF]  

Lin Wang, Roger K. Sunahara, Andrejs Krumins, Guy Perkins, Marsha L. Crochiere, Mason Mackey, Sean Bell, Mark H. Ellisman, and Susan S. Taylor

Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein
PNAS 2001 98: 3220-3225. [Abstract] [Full Text] [PDF]  

Evolution

Gregory L. Moore, Costas D. Maranas, Stefan Lutz, and Stephen J. Benkovic

Predicting crossover generation in DNA shuffling
PNAS 2001 98: 3226-3231. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Genetics

E. Levy-Lahad, A. Lahad, S. Eisenberg, E. Dagan, T. Paperna, L. Kasinetz, R. Catane, B. Kaufman, U. Beller, P. Renbaum, and R. Gershoni-Baruch

A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers
PNAS 2001 98: 3232-3236. [Abstract] [Full Text] [PDF]  

Sofia A. Oliveira and Thomas E. Shenk

Murine cytomegalovirus M78 protein, a G protein-coupled receptor homologue, is a constituent of the virion and facilitates accumulation of immediate-early viral mRNA
PNAS 2001 98: 3237-3242. [Abstract] [Full Text] [PDF]  

JoAnn Sekiguchi, David O. Ferguson, Hua Tang Chen, Eva Mary Yang, John Earle, Karen Frank, Scott Whitlow, Yansong Gu, Yang Xu, André Nussenzweig, and Frederick W. Alt

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
PNAS 2001 98: 3243-3248; published online before print March 6, 2001, 10.1073/pnas.051632098 [Abstract] [Full Text] [PDF]  

Keh-Weei Tzung, Roy M. Williams, Stewart Scherer, Nancy Federspiel, Ted Jones, Nancy Hansen, Vesna Bivolarevic, Lucas Huizar, Caridad Komp, Ray Surzycki, Raquel Tamse, Ronald W. Davis, and Nina Agabian

Genomic evidence for a complete sexual cycle in Candida albicans
PNAS 2001 98: 3249-3253. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Gloria H. Su, Ravi Bansal, Kathleen M. Murphy, Elizabeth Montgomery, Charles J. Yeo, Ralph H. Hruban, and Scott E. Kern

ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
PNAS 2001 98: 3254-3257. [Abstract] [Full Text] [PDF]  

Y. C. Chang, L. A. Penoyer, and K. J. Kwon-Chung

The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence
PNAS 2001 98: 3258-3263; published online before print February 27, 2001, 10.1073/pnas.061031998 [Abstract] [Full Text] [PDF]  

Immunology

Valery Kudryashov, Peter W. Glunz, Lawrence J. Williams, Samuel Hintermann, Samuel J. Danishefsky, and Kenneth O. Lloyd

Toward optimized carbohydrate-based anticancer vaccines: Epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewis^y conjugates in mice
PNAS 2001 98: 3264-3269. [Abstract] [Full Text] [PDF]  

Teresa Gilewski, Govindaswami Ragupathi, Sonal Bhuta, Lawrence J. Williams, Cristina Musselli, Xu-Fang Zhang, Kalman P. Bencsath, Katherine S. Panageas, Jeanette Chin, Clifford A. Hudis, Larry Norton, Alan N. Houghton, Philip O. Livingston, and Samuel J. Danishefsky

Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial
PNAS 2001 98: 3270-3275. [Abstract] [Full Text] [PDF]  

Richard S. Lee, Kazuhiko Yamada, Stuart L. Houser, Karl L. Womer, Michaella E. Maloney, Harris S. Rose, Mohamed H. Sayegh, and Joren C. Madsen

Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy
PNAS 2001 98: 3276-3281. [Abstract] [Full Text] [PDF] [Supplemental Table]  

Toshiro Ono, Takushi Kurashige, Naoki Harada, Yuji Noguchi, Takashi Saika, Norio Niikawa, Motoi Aoe, Shinichiro Nakamura, Toshihiro Higashi, Akio Hiraki, Hisashi Wada, Hiromi Kumon, Lloyd J. Old, and Eiichi Nakayama

Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen
PNAS 2001 98: 3282-3287. [Abstract] [Full Text] [PDF]  

Myriam M. Altamirano, Adrian Woolfson, Alena Donda, Abdijapar Shamshiev, Luis Briseño-Roa, Nicholas W. Foster, Dmitry B. Veprintsev, Gennaro De Libero, Alan R. Fersht, and César Milstein From the Cover: Ligand-independent assembly of recombinant human CD1 by using oxidative refolding chromatography PNAS 2001 98: 3288-3293. [Abstract] [Full Text] [PDF]

Anastasios Karadimitris, Stephan Gadola, Myriam Altamirano, Dave Brown, Adrian Woolfson, Paul Klenerman, Ji-Li Chen, Yasuhiko Koezuka, Irene A. G. Roberts, David A. Price, Geoff Dusheiko, César Milstein, Alan Fersht, Lucio Luzzatto, and Vincenzo Cerundolo From the Cover: Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography PNAS 2001 98: 3294-3298. [Abstract] [Full Text] [PDF]

Kevin J. Maloy, Iris Erdmann, Veronique Basch, Sophie Sierro, Thomas A. Kramps, Rolf M. Zinkernagel, Stefan Oehen, and Thomas M. Kündig

Intralymphatic immunization enhances DNA vaccination
PNAS 2001 98: 3299-3303; published online before print February 27, 2001, 10.1073/pnas.051630798 [Abstract] [Full Text] [PDF]  

Soo-Hyun M. Kim, Tania Azam, Do-Young Yoon, Leonid L. Reznikov, Daniela Novick, Menachem Rubinstein, and Charles A. Dinarello

Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
PNAS 2001 98: 3304-3309. [Abstract] [Full Text] [PDF]  

Kohtaro Fujihashi, Taeko Dohi, Paul D. Rennert, Masafumi Yamamoto, Toshiya Koga, Hiroshi Kiyono, and Jerry R. McGhee

Peyer's patches are required for oral tolerance to proteins
PNAS 2001 98: 3310-3315. [Abstract] [Full Text] [PDF]  

Alessio D'Alessio, Anna Riccioli, Paola Lauretti, Fabrizio Padula, Barbara Muciaccia, Paola De Cesaris, Antonio Filippini, Shigekazu Nagata, and Elio Ziparo

Testicular FasL is expressed by sperm cells
PNAS 2001 98: 3316-3321; published online before print February 27, 2001, 10.1073/pnas.051566098 [Abstract] [Full Text] [PDF]  

Medical Sciences

Leon J. De Windt, Hae W. Lim, Orlando F. Bueno, Qiangrong Liang, Ulrike Delling, Julian C. Braz, Betty J. Glascock, Thomas F. Kimball, Federica del Monte, Roger J. Hajjar, and Jeffery D. Molkentin

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
PNAS 2001 98: 3322-3327. [Abstract] [Full Text] [PDF]  

Beverly A. Rothermel, Timothy A. McKinsey, Rick B. Vega, Rebekka L. Nicol, Pradeep Mammen, John Yang, Christopher L. Antos, John M. Shelton, Rhonda Bassel-Duby, Eric N. Olson, and R. Sanders Williams

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
PNAS 2001 98: 3328-3333. [Abstract] [Full Text] [PDF]  

Eric M. Reiman, Richard J. Caselli, Kewei Chen, Gene E. Alexander, Daniel Bandy, and Jennifer Frost

Declining brain activity in cognitively normal apolipoprotein E 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
PNAS 2001 98: 3334-3339. [Abstract] [Full Text] [PDF]  

Sanggyu Lee, Guolin Zhou, Terry Clark, Jianjun Chen, Janet D. Rowley, and San Ming Wang

The pattern of gene expression in human CD15⁺ myeloid progenitor cells
PNAS 2001 98: 3340-3345. [Abstract] [Full Text] [PDF]  

Kristoffel R. Dumon, Hideshi Ishii, Louise Y. Y. Fong, Nicola Zanesi, Vincenzo Fidanza, Rita Mancini, Andrea Vecchione, Raffaele Baffa, Francesco Trapasso, Matthew J. During, Kay Huebner, and Carlo M. Croce

FHIT gene therapy prevents tumor development in Fhit-deficient mice
PNAS 2001 98: 3346-3351; published online before print February 27, 2001, 10.1073/pnas.061020098 [Abstract] [Full Text] [PDF]  

Lubor Borsig, Richard Wong, James Feramisco, David R. Nadeau, Nissi M. Varki, and Ajit Varki

Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
PNAS 2001 98: 3352-3357. [Abstract] [Full Text] [PDF] [Supplemental Movies]  

Domenico Praticò, Cyrus Tillmann, Zhi-Bing Zhang, Hongwei Li, and Garret A. FitzGerald

Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice
PNAS 2001 98: 3358-3363; published online before print March 6, 2001, 10.1073/pnas.061607398 [Abstract] [Full Text] [PDF]  

Hyo Chol Ha, Krishna Juluri, Yan Zhou, Steve Leung, Monika Hermankova, and Solomon H. Snyder

Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration
PNAS 2001 98: 3364-3368; published online before print March 6, 2001, 10.1073/pnas.051633498 [Abstract] [Full Text] [PDF]  

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones, Diane Hawkins-Brown, Kathleen I. MacKenzie, Anne LaTour, Yaping Liu, Curtis D. Klaassen, Kathleen K. Brown, John Reinhard, Timothy M. Willson, Beverly H. Koller, and Steven A. Kliewer

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
PNAS 2001 98: 3369-3374. [Abstract] [Full Text] [PDF]  

Wen Xie, Anna Radominska-Pandya, Yanhong Shi, Cynthia M. Simon, Michael C. Nelson, Erwin S. Ong, David J. Waxman, and Ronald M. Evans

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
PNAS 2001 98: 3375-3380. [Abstract] [Full Text] [PDF]  

Kee-Ho Lee, K. Lenhard Rudolph, Yeun-Jin Ju, Roger A. Greenberg, Linda Cannizzaro, Lynda Chin, Sarah R. Weiler, and Ronald A. DePinho

Telomere dysfunction alters the chemotherapeutic profile of transformed cells
PNAS 2001 98: 3381-3386. [Abstract] [Full Text] [PDF]  

Virpi Launonen, Outi Vierimaa, Maija Kiuru, Jorma Isola, Stina Roth, Eero Pukkala, Pertti Sistonen, Riitta Herva, and Lauri A. Aaltonen

Inherited susceptibility to uterine leiomyomas and renal cell cancer
PNAS 2001 98: 3387-3392; published online before print February 27, 2001, 10.1073/pnas.051633798 [Abstract] [Full Text] [PDF]  

Alexander M. Trbovich, Patrick M. Sluss, V. Matt Laurich, Francis H. O'Neill, David T. MacLaughlin, Patricia K. Donahoe, and Jose Teixeira

Müllerian Inhibiting Substance lowers testosterone in luteinizing hormone-stimulated rodents
PNAS 2001 98: 3393-3397; published online before print March 6, 2001, 10.1073/pnas.051632298 [Abstract] [Full Text] [PDF]  

Hadas Schori, Jonathan Kipnis, Eti Yoles, Elizabeth WoldeMussie, Guadalupe Ruiz, Larry A. Wheeler, and Michal Schwartz

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma
PNAS 2001 98: 3398-3403; published online before print March 6, 2001, 10.1073/pnas.041609498 [Abstract] [Full Text] [PDF]  

Albena T. Dinkova-Kostova, Michael A. Massiah, Richard E. Bozak, Ronald J. Hicks, and Paul Talalay From the Cover: Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups PNAS 2001 98: 3404-3409. [Abstract] [Full Text] [PDF]

Minerva Ramos-Gomez, Mi-Kyoung Kwak, Patrick M. Dolan, Ken Itoh, Masayuki Yamamoto, Paul Talalay, and Thomas W. Kensler From the Cover: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice PNAS 2001 98: 3410-3415. [Abstract] [Full Text] [PDF]

Christelle Forcet, Xin Ye, Laure Granger, Véronique Corset, Hwain Shin, Dale E. Bredesen, and Patrick Mehlen

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
PNAS 2001 98: 3416-3421; published online before print February 27, 2001, 10.1073/pnas.051378298 [Abstract] [Full Text] [PDF]  

Christine Reynet and C. Ronald Kahn

Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle
PNAS 2001 98: 3422-3427. [Abstract] [Full Text] [PDF]  

Gangjian Qin, Toshihiro Takenaka, Kimberly Telsch, Leslie Kelley, Tazuko Howard, Thierry Levade, Robert Deans, Bruce H. Howard, Harry L. Malech, Roscoe O. Brady, and Jeffrey A. Medin

Preselective gene therapy for Fabry disease
PNAS 2001 98: 3428-3433; published online before print March 6, 2001, 10.1073/pnas.061020598 [Abstract] [Full Text] [PDF]  

Radu Marches, Ellen S. Vitetta, and Jonathan W. Uhr

A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas
PNAS 2001 98: 3434-3439; published online before print February 27, 2001, 10.1073/pnas.061028998 [Abstract] [Full Text] [PDF]  

Robert P. Friedland, Thomas Fritsch, Kathleen A. Smyth, Elisabeth Koss, Alan J. Lerner, Chien Hsiun Chen, Grace J. Petot, and Sara M. Debanne

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members
PNAS 2001 98: 3440-3445; published online before print March 6, 2001, 10.1073/pnas.061002998 [Abstract] [Full Text] [PDF]  

Microbiology

Johan H. J. Leveau and Steven E. Lindow INAUGURAL ARTICLE by a Recently Elected Academy Member: Inaugural Article: Appetite of an epiphyte: Quantitative monitoring of bacterial sugar consumption in the phyllosphere PNAS 2001 98: 3446-3453. [Abstract] [Full Text] [PDF]

M. T. Brandl, B. Quiñones, and S. E. Lindow

Heterogeneous transcription of an indoleacetic acid biosynthetic gene in Erwinia herbicola on plant surfaces
PNAS 2001 98: 3454-3459. [Abstract] [Full Text] [PDF]  

Barbara J. May, Qing Zhang, Ling Ling Li, Michael L. Paustian, Thomas S. Whittam, and Vivek Kapur

Complete genomic sequence of Pasteurella multocida, Pm70
PNAS 2001 98: 3460-3465; published online before print March 6, 2001, 10.1073/pnas.051634598 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Gregory A. Smith, Steven P. Gross, and Lynn W. Enquist

Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons
PNAS 2001 98: 3466-3470. [Abstract] [Full Text] [PDF] [Supplemental Movies]  

Hin C. Lee and Harris D. Bernstein

The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal
PNAS 2001 98: 3471-3476; published online before print February 27, 2001, 10.1073/pnas.051484198 [Abstract] [Full Text] [PDF]  

Neurobiology

Wen Sheng Liu, Christine Pesold, Miguel A. Rodriguez, Giovanni Carboni, James Auta, Pascal Lacor, John Larson, Brian G. Condie, Alessandro Guidotti, and Erminio Costa

Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
PNAS 2001 98: 3477-3482. [Abstract] [Full Text] [PDF]  

Emanuela Izzo, James Auta, Francesco Impagnatiello, Christine Pesold, Alessandro Guidotti, and Erminio Costa

Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines
PNAS 2001 98: 3483-3488. [Abstract] [Full Text] [PDF]  

Alessandra L. Scotti and Harald Reuter

Synaptic and extrasynaptic -aminobutyric acid type A receptor clusters in rat hippocampal cultures during development
PNAS 2001 98: 3489-3494; published online before print March 6, 2001, 10.1073/pnas.061028798 [Abstract] [Full Text] [PDF]  

Patrik Vuilleumier, Noam Sagiv, Eliot Hazeltine, Russel A. Poldrack, Diane Swick, Robert D. Rafal, and John D. E. Gabrieli

Neural fate of seen and unseen faces in visuospatial neglect: A combined event-related functional MRI and event-related potential study
PNAS 2001 98: 3495-3500; published online before print March 6, 2001, 10.1073/pnas.051436898 [Abstract] [Full Text] [PDF]  

A. Belén Elgoyhen, Douglas E. Vetter, Eleonora Katz, Carla V. Rothlin, Stephen F. Heinemann, and Jim Boulter

10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
PNAS 2001 98: 3501-3506; published online before print March 6, 2001, 10.1073/pnas.051622798 [Abstract] [Full Text] [PDF]  

Masashi Sakai and Nobuo Suga

Plasticity of the cochleotopic (frequency) map in specialized and nonspecialized auditory cortices
PNAS 2001 98: 3507-3512; published online before print March 6, 2001, 10.1073/pnas.061021698 [Abstract] [Full Text] [PDF]  

Norbert Weidner, Arvin Ner, Nima Salimi, and Mark H. Tuszynski

Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
PNAS 2001 98: 3513-3518. [Abstract] [Full Text] [PDF]  

Kwok-Keung Tai, Sylvie E. Blondelle, John M. Ostresh, Richard A. Houghten, and Mauricio Montal

An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity
PNAS 2001 98: 3519-3524. [Abstract] [Full Text] [PDF]  

Maya Yankova, Sharron A. Hart, and Catherine S. Woolley From the Cover: Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: A serial electron-microscopic study PNAS 2001 98: 3525-3530; published online before print February 20, 2001, 10.1073/pnas.051624598 [Abstract] [Full Text] [PDF]

J. M. Cimadevilla, M. Wesierska, A. A. Fenton, and J. Bures

Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena
PNAS 2001 98: 3531-3536. [Abstract] [Full Text] [PDF]  

A. Stuchlik, A. A. Fenton, and J. Bures

Substratal idiothetic navigation of rats is impaired by removal or devaluation of extramaze and intramaze cues
PNAS 2001 98: 3537-3542. [Abstract] [Full Text] [PDF]  

Laure Rondi-Reig, Megan Libbey, Howard Eichenbaum, and Susumu Tonegawa

CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task
PNAS 2001 98: 3543-3548; published online before print March 6, 2001, 10.1073/pnas.041620798 [Abstract] [Full Text] [PDF]  

Catalina Hernández-Sánchez, Anthony S. Basile, Irina Fedorova, Hiroshi Arima, Bethel Stannard, Ana M. Fernandez, Yutaka Ito, and Derek LeRoith

Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death
PNAS 2001 98: 3549-3554; published online before print February 27, 2001, 10.1073/pnas.051012898 [Abstract] [Full Text] [PDF]  

Francis S. Lee and Moses V. Chao

Activation of Trk neurotrophin receptors in the absence of neurotrophins
PNAS 2001 98: 3555-3560; published online before print March 6, 2001, 10.1073/pnas.061020198 [Abstract] [Full Text] [PDF]  

Vytenis A. Skeberdis, Jian-yu Lan, Xin Zheng, R. Suzanne Zukin, and Michael V. L. Bennett

Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis
PNAS 2001 98: 3561-3566. [Abstract] [Full Text] [PDF]  

Markus Fischer, Pierre-Jean Corringer, Karin Schott, Adelbert Bacher, and Jean-Pierre Changeux

A method for soluble overexpression of the 7 nicotinic acetylcholine receptor extracellular domain
PNAS 2001 98: 3567-3570. [Abstract] [Full Text] [PDF]  

Elke C. Fuchs, Helen Doheny, Howard Faulkner, Antonio Caputi, Roger D. Traub, Andrea Bibbig, Nancy Kopell, Miles A. Whittington, and Hannah Monyer

Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation
PNAS 2001 98: 3571-3576. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Meisheng Jiang, Karsten Spicher, Guylain Boulay, Ying Wang, and Lutz Birnbaumer

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go
PNAS 2001 98: 3577-3582; published online before print March 6, 2001, 10.1073/pnas.051632598 [Abstract] [Full Text] [PDF]  

Pharmacology

Shehla Pervin, Rajan Singh, and Gautam Chaudhuri

Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1
PNAS 2001 98: 3583-3588. [Abstract] [Full Text] [PDF]  

Lauren Nathan, Weibin Shi, Hillary Dinh, Tapan K. Mukherjee, Xuping Wang, Aldons J. Lusis, and Gautam Chaudhuri

Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
PNAS 2001 98: 3589-3593; published online before print March 6, 2001, 10.1073/pnas.051003698 [Abstract] [Full Text] [PDF]  

Physiology

Daniel J. Hennager, Mutsuhiro Ikuma, Toshinori Hoshi, and Michael J. Welsh

A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle
PNAS 2001 98: 3594-3599; published online before print March 6, 2001, 10.1073/pnas.051633298 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Barbara A. Niemeyer, Christiane Bergs, Ulrich Wissenbach, Veit Flockerzi, and Claudia Trost

Competitive regulation of CaT-like-mediated Ca²⁺ entry by protein kinase C and calmodulin
PNAS 2001 98: 3600-3605. [Abstract] [Full Text] [PDF]  

Yong-Fu Xiao, Qingen Ke, Sho-Ya Wang, Klaus Auktor, Yinke Yang, Ging Kuo Wang, James P. Morgan, and Alexander Leaf

Single point mutations affect fatty acid block of human myocardial sodium channel subunit Na⁺ channels
PNAS 2001 98: 3606-3611; published online before print March 6, 2001, 10.1073/pnas.061003798 [Abstract] [Full Text] [PDF]  

Plant Biology

Hiroko Hanzawa, Katsuhiko Inomata, Hideki Kinoshita, Takashi Kakiuchi, Krishanthi Padmarani Jayasundera, Daisuke Sawamoto, Atsuko Ohta, Kenko Uchida, Keishiro Wada, and Masaki Furuya

In vitro assembly of phytochrome B apoprotein with synthetic analogs of the phytochrome chromophore
PNAS 2001 98: 3612-3617. [Abstract] [Full Text] [PDF]  

Population Biology

S. M. Blower, K. Koelle, D. E. Kirschner, and J. Mills

Live attenuated HIV vaccines: Predicting the tradeoff between efficacy and safety
PNAS 2001 98: 3618-3623. [Abstract] [Full Text] [PDF] [Supplemental Data]  

CORRECTIONS

Correction for vol. 98, p. 1465 [Full Text] [PDF]  

Correction for vol. 97, p. 6880 [Full Text] [PDF]