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COMMENTARIES

Lisa McKerracher

Ganglioside rafts as MAG receptors that mediate blockade of axon growth
PNAS 2002 99: 7811-7813. [Extract] [Full Text] [PDF]  

Almira Vazdarjanova

Chasing "fear memories" to the cerebellum
PNAS 2002 99: 7814-7815. [Extract] [Full Text] [PDF]  

Louis J. Ignarro

After 130 years, the molecular mechanism of action of nitroglycerin is revealed
PNAS 2002 99: 7816-7817. [Extract] [Full Text] [PDF]  

Peter R. Grant

Founder effects and silvereyes
PNAS 2002 99: 7818-7820. [Extract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

M. Girvan and M. E. J. Newman

Community structure in social and biological networks
PNAS 2002 99: 7821-7826. [Abstract] [Full Text] [PDF]  

Chemistry

Colin G. Cameron and Michael S. Freund

Electrolytic actuators: Alternative, high-performance, material-based devices
PNAS 2002 99: 7827-7831. [Abstract] [Full Text] [PDF]  

Computer Sciences

Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig

Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
PNAS 2002 99: 8271-8276. [Abstract] [Full Text] [PDF]  

Geology

James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein

Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO₂ levels
PNAS 2002 99: 7832-7835; published online before print June 4 2002, 10.1073/pnas.122225499 [Abstract] [Full Text] [PDF]  

D. J. Beerling, B. H. Lomax, D. L. Royer, G. R. Upchurch, Jr., and L. R. Kump

An atmospheric pCO₂ reconstruction across the Cretaceous-Tertiary boundary from leaf megafossils
PNAS 2002 99: 7836-7840. [Abstract] [Full Text] [PDF]  

Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver

Latitudinal difference in biodiversity caused by higher tropical rate of increase
PNAS 2002 99: 7841-7843. [Abstract] [Full Text] [PDF] [Supporting Table]  

P. Buford Price, Oleg V. Nagornov, Ryan Bay, Dmitry Chirkin, Yudong He, Predrag Miocinovic, Austin Richards, Kurt Woschnagg, Bruce Koci, and Victor Zagorodnov

Temperature profile for glacial ice at the South Pole: Implications for life in a nearby subglacial lake
PNAS 2002 99: 7844-7847. [Abstract] [Full Text] [PDF]  

Geophysics

Ralph F. Keeling and Hernan E. Garcia

The change in oceanic O₂ inventory associated with recent global warming
PNAS 2002 99: 7848-7853; published online before print June 4 2002, 10.1073/pnas.122154899 [Abstract] [Full Text] [PDF]  

Physics

F. Brochard-Wyart and P. G. de Gennes

Adhesion induced by mobile binders: Dynamics
PNAS 2002 99: 7854-7859; published online before print June 4 2002, 10.1073/pnas.112221299 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

James B. Rossie, Elwyn L. Simons, Suellen C. Gauld, and D. Tab Rasmussen

Paranasal sinus anatomy of Aegyptopithecus: Implications for hominoid origins
PNAS 2002 99: 8454-8456. [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

P. E. Waggoner and J. H. Ausubel

A framework for sustainability science: A renovated IPAT identity
PNAS 2002 99: 7860-7865. [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

Liesbeth M. Veenendaal, Hangqing Jin, Sophia Ran, Lawrence Cheung, Nora Navone, John W. Marks, Johannes Waltenberger, Philip Thorpe, and Michael G. Rosenblum

In vitro and in vivo studies of a VEGF₁₂₁/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors
PNAS 2002 99: 7866-7871. [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biochemistry

Oliver Daltrop, James W. A. Allen, Anthony C. Willis, and Stuart J. Ferguson

In vitro formation of a c-type cytochrome
PNAS 2002 99: 7872-7876. [Abstract] [Full Text] [PDF]  

Robert E. Campbell, Oded Tour, Amy E. Palmer, Paul A. Steinbach, Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien

A monomeric red fluorescent protein
PNAS 2002 99: 7877-7882. [Abstract] [Full Text] [PDF] [Supporting Information]  

Ute Felbor, Benedikt Kessler, Walther Mothes, Hans H. Goebel, Hidde L. Ploegh, Roderick T. Bronson, and Bjorn R. Olsen

Neuronal loss and brain atrophy in mice lacking cathepsins B and L
PNAS 2002 99: 7883-7888; published online before print June 4 2002, 10.1073/pnas.112632299 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Ryan Hagglund and Bernard Roizman

Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0
PNAS 2002 99: 7889-7894. [Abstract] [Full Text] [PDF]  

Dengming Ming, Yifei Kong, Salih J. Wakil, Jacob Brink, and Jianpeng Ma

Domain movements in human fatty acid synthase by quantized elastic deformational model
PNAS 2002 99: 7895-7899. [Abstract] [Full Text] [PDF]  

Michael J. MacCoss, W. Hayes McDonald, Anita Saraf, Rovshan Sadygov, Judy M. Clark, Joseph J. Tasto, Kathleen L. Gould, Dirk Wolters, Michael Washburn, Avery Weiss, John I. Clark, and John R. Yates, III

Shotgun identification of protein modifications from protein complexes and lens tissue
PNAS 2002 99: 7900-7905. [Abstract] [Full Text] [PDF]  

Daniel P. Morse, P. Joseph Aruscavage, and Brenda L. Bass

RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA
PNAS 2002 99: 7906-7911; published online before print June 4 2002, 10.1073/pnas.112704299 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, and Sunghoon Kim

p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance
PNAS 2002 99: 7912-7916. [Abstract] [Full Text] [PDF] [Supporting Information]  

Jong-Il Kim and Michael M. Cox

The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways
PNAS 2002 99: 7917-7921; published online before print June 4 2002, 10.1073/pnas.122218499 [Abstract] [Full Text] [PDF]  

Zachary E. R. Newby, Edmond Y. Lau, and Thomas C. Bruice

A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N⁶)-methyltransferase from Thermus aquaticus
PNAS 2002 99: 7922-7927. [Abstract] [Full Text] [PDF]  

Sara Richter, Yueh-Hsin Ping, and Tariq M. Rana

TAR RNA loop: A scaffold for the assembly of a regulatory switch in HIV replication
PNAS 2002 99: 7928-7933; published online before print June 4 2002, 10.1073/pnas.122119999 [Abstract] [Full Text] [PDF]  

Dipali Sharma and Joseph D. Fondell

Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo
PNAS 2002 99: 7934-7939; published online before print May 28 2002, 10.1073/pnas.122004799 [Abstract] [Full Text] [PDF]  

Zheng Liu, Didier Auboeuf, Jiemin Wong, J. Don Chen, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley

Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
PNAS 2002 99: 7940-7944; published online before print June 4 2002, 10.1073/pnas.122225699 [Abstract] [Full Text] [PDF]  

Sanjit K. Roy, Junbo Hu, Qingjun Meng, Ying Xia, Paul S. Shapiro, Sekhar P. M. Reddy, Leonidas C. Platanias, Daniel J. Lindner, Peter F. Johnson, Catrin Pritchard, Gilles Pagés, Jacques Pouyssegur, and Dhananjaya V. Kalvakolanu

MEKK1 plays a critical role in activating the transcription factor C/EBP--dependent gene expression in response to IFN-
PNAS 2002 99: 7945-7950; published online before print June 4 2002, 10.1073/pnas.122075799 [Abstract] [Full Text] [PDF]  

Piyajit Watcharasit, Gautam N. Bijur, Jaroslaw W. Zmijewski, Ling Song, Anna Zmijewska, Xinbin Chen, Gail V. W. Johnson, and Richard S. Jope

Direct, activating interaction between glycogen synthase kinase-3 and p53 after DNA damage
PNAS 2002 99: 7951-7955; published online before print June 4 2002, 10.1073/pnas.122062299 [Abstract] [Full Text] [PDF]  

Sayuri Sakuragi, Toshiyuki Goto, Kouichi Sano, and Yuko Morikawa

HIV type 1 Gag virus-like particle budding from spheroplasts of Saccharomyces cerevisiae
PNAS 2002 99: 7956-7961. [Abstract] [Full Text] [PDF]  

Joseph N. McLaughlin, Craig D. Thulin, Sarah J. Hart, Katheryn A. Resing, Natalie G. Ahn, and Barry M. Willardson

Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex
PNAS 2002 99: 7962-7967. [Abstract] [Full Text] [PDF]  

Tin-Wein Yu, Linquan Bai, Dorothee Clade, Dietmar Hoffmann, Sabine Toelzer, Khue Q. Trinh, Jun Xu, Steven J. Moss, Eckhard Leistner, and Heinz G. Floss

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum
PNAS 2002 99: 7968-7973. [Abstract] [Full Text] [PDF] [Supporting Information]  

Tina Wilson-Sali and Tao-shih Hsieh

Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase III
PNAS 2002 99: 7974-7979; published online before print June 4 2002, 10.1073/pnas.122007999 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biophysics

Dong Hae Shin, Hisao Yokota, Rosalind Kim, and Sung-Hou Kim

Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus
PNAS 2002 99: 7980-7985. [Abstract] [Full Text] [PDF]  

N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders

Obligatory heterotetramerization of three previously uncharacterized Kv channel -subunits identified in the human genome
PNAS 2002 99: 7986-7991. [Abstract] [Full Text] [PDF]  

Jan M. Kriegl, Aninda J. Bhattacharyya, Karin Nienhaus, Pengchi Deng, Oleksandr Minkow, and G. Ulrich Nienhaus

Ligand binding and protein dynamics in neuroglobin
PNAS 2002 99: 7992-7997; published online before print June 4 2002, 10.1073/pnas.082244399 [Abstract] [Full Text] [PDF]  

Sebastian Spörlein, Heiko Carstens, Helmut Satzger, Christian Renner, Raymond Behrendt, Luis Moroder, Paul Tavan, Wolfgang Zinth, and Josef Wachtveitl

Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation
PNAS 2002 99: 7998-8002. [Abstract] [Full Text] [PDF]  

Ludovic R. Otterbein, Christophe Cosio, Philip Graceffa, and Roberto Dominguez

Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system
PNAS 2002 99: 8003-8008; published online before print June 4 2002, 10.1073/pnas.122126299 [Abstract] [Full Text] [PDF]  

Thomas Szyperski, Deok C. Yeh, Dinesh K. Sukumaran, Hunter N. B. Moseley, and Gaetano T. Montelione

Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment
PNAS 2002 99: 8009-8014. [Abstract] [Full Text] [PDF] [Supporting Information]  

Marcel Wellner, Omer Berenfeld, José Jalife, and Arkady M. Pertsov

Minimal principle for rotor filaments
PNAS 2002 99: 8015-8018; published online before print June 4 2002, 10.1073/pnas.112026199 [Abstract] [Full Text] [PDF]  

D. K. Klimov, D. Newfield, and D. Thirumalai

Simulations of -hairpin folding confined to spherical pores using distributed computing
PNAS 2002 99: 8019-8024. [Abstract] [Full Text] [PDF]  

Cell Biology

Tobias Moehlmann, Edith Winkler, Xuefeng Xia, Dieter Edbauer, Jill Murrell, Anja Capell, Christoph Kaether, Hui Zheng, Bernardino Ghetti, Christian Haass, and Harald Steiner

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on A₄₂ production
PNAS 2002 99: 8025-8030; published online before print June 4 2002, 10.1073/pnas.112686799 [Abstract] [Full Text] [PDF]  

Luis R. Miranda, Brian C. Schaefer, Abraham Kupfer, Zixin Hu, and Alex Franzusoff

Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules
PNAS 2002 99: 8031-8036. [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cynthia R. Wagner, Anthony P. Mahowald, and Kathryn G. Miller

One of the two cytoplasmic actin isoforms in Drosophila is essential
PNAS 2002 99: 8037-8042; published online before print May 28 2002, 10.1073/pnas.082235499 [Abstract] [Full Text] [PDF]  

Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, and Valeria Poli

Mutational switch of an IL-6 response to an interferon--like response
PNAS 2002 99: 8043-8047. [Abstract] [Full Text] [PDF]  

Sayyed K. Zaidi, Andrew J. Sullivan, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
PNAS 2002 99: 8048-8053. [Abstract] [Full Text] [PDF]  

Timothy E. Hawkins, Debipriya Das, Barry Young, and Stephen E. Moss

DT40 cells lacking the Ca²⁺-binding protein annexin 5 are resistant to Ca²⁺-dependent apoptosis
PNAS 2002 99: 8054-8059. [Abstract] [Full Text] [PDF] [Supporting Information]  

Fumio Otsuka and Shunichi Shimasaki

A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis
PNAS 2002 99: 8060-8065; published online before print June 4 2002, 10.1073/pnas.122066899 [Abstract] [Full Text] [PDF]  

Yoshinori Akiyama

Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP- dependent protease in Escherichia coli
PNAS 2002 99: 8066-8071; published online before print May 28 2002, 10.1073/pnas.122616899 [Abstract] [Full Text] [PDF]  

Balraj Doray, Kerry Bruns, Pradipta Ghosh, and Stuart A. Kornfeld

Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif
PNAS 2002 99: 8072-8077. [Abstract] [Full Text] [PDF]  

Developmental Biology

Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Bryon E. Petersen, and Ammon B. Peck

In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
PNAS 2002 99: 8078-8083; published online before print June 4 2002, 10.1073/pnas.122210699 [Abstract] [Full Text] [PDF]  

Mariela Zirlinger, Liching Lo, Jill McMahon, Andrew P. McMahon, and David J. Anderson

Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate
PNAS 2002 99: 8084-8089. [Abstract] [Full Text] [PDF]  

M. Todd Valerius, Larry T. Patterson, Yuxin Feng, and S. Steven Potter

Hoxa 11 is upstream of Integrin 8 expression in the developing kidney
PNAS 2002 99: 8090-8095. [Abstract] [Full Text] [PDF]  

Ecology

Gary R. Graves, Christopher S. Romanek, and Alejandro Rodriguez Navarro

Stable isotope signature of philopatry and dispersal in a migratory songbird
PNAS 2002 99: 8096-8100; published online before print May 28 2002, 10.1073/pnas.082240899 [Abstract] [Full Text] [PDF]  

William V. Sobczak, James E. Cloern, Alan D. Jassby, and Anke B. Müller-Solger

Bioavailability of organic matter in a highly disturbed estuary: The role of detrital and algal resources
PNAS 2002 99: 8101-8105. [Abstract] [Full Text] [PDF]  

Evolution

James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein

Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO₂ levels
PNAS 2002 99: 7832-7835; published online before print June 4 2002, 10.1073/pnas.122225499 [Abstract] [Full Text] [PDF]  

Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver

Latitudinal difference in biodiversity caused by higher tropical rate of increase
PNAS 2002 99: 7841-7843. [Abstract] [Full Text] [PDF] [Supporting Table]  

David C. Hayward, Gabrielle Samuel, Patricia C. Pontynen, Julian Catmull, Robert Saint, David J. Miller, and Eldon E. Ball

Localized expression of a dpp/BMP2/4 ortholog in a coral embryo
PNAS 2002 99: 8106-8111; published online before print June 4 2002, 10.1073/pnas.112021499 [Abstract] [Full Text] [PDF]  

Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala

A methodological bias toward overestimation of molecular evolutionary time scales
PNAS 2002 99: 8112-8115. [Abstract] [Full Text] [PDF]  

Isaac Salazar-Ciudad and Jukka Jernvall

A gene network model accounting for development and evolution of mammalian teeth
PNAS 2002 99: 8116-8120; published online before print June 4 2002, 10.1073/pnas.132069499 [Abstract] [Full Text] [PDF]  

Ana Llopart, Josep M. Comeron, Frédéric G. Brunet, Daniel Lachaise, and Manyuan Long

Intron presence-absence polymorphism in Drosophila driven by positive Darwinian selection
PNAS 2002 99: 8121-8126. [Abstract] [Full Text] [PDF]  

Sonya M. Clegg, Sandie M. Degnan, Jiro Kikkawa, Craig Moritz, Arnaud Estoup, and Ian P. F. Owens From the Cover: Genetic consequences of sequential founder events by an island-colonizing bird PNAS 2002 99: 8127-8132; published online before print May 28 2002, 10.1073/pnas.102583399 [Abstract] [Full Text] [PDF]

Shaoxing Huang, Anchalee Sirikhachornkit, Xiujuan Su, Justin Faris, Bikram Gill, Robert Haselkorn, and Piotr Gornicki

Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat
PNAS 2002 99: 8133-8138. [Abstract] [Full Text] [PDF] [Supporting Table]  

David Jablonski

Survival without recovery after mass extinctions
PNAS 2002 99: 8139-8144. [Abstract] [Full Text] [PDF] [Supporting Table]  

R. B. Hough, A. Avivi, J. Davis, A. Joel, E. Nevo, and J. Piatigorsky

Adaptive evolution of small heat shock protein/ B-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi
PNAS 2002 99: 8145-8150. [Abstract] [Full Text] [PDF]  

Ulfur Arnason, Joseph A. Adegoke, Kristina Bodin, Erik W. Born, Yuzine B. Esa, Anette Gullberg, Maria Nilsson, Roger V. Short, Xiufeng Xu, and Axel Janke

Mammalian mitogenomic relationships and the root of the eutherian tree
PNAS 2002 99: 8151-8156; published online before print May 28 2002, 10.1073/pnas.102164299 [Abstract] [Full Text] [PDF]  

Glennis E. Julian, Jennifer H. Fewell, Jürgen Gadau, Robert A. Johnson, and Debbie Larrabee

Genetic determination of the queen caste in an ant hybrid zone
PNAS 2002 99: 8157-8160; published online before print May 28 2002, 10.1073/pnas.112222099 [Abstract] [Full Text] [PDF]  

Genetics

Kathleen Heppner Goss, Chris Trzepacz, Thérèse M. F. Tuohy, and Joanna Groden

Attenuated APC alleles produce functional protein from internal translation initiation
PNAS 2002 99: 8161-8166; published online before print May 28 2002, 10.1073/pnas.112072199 [Abstract] [Full Text] [PDF]  

Irina A. Udalova, Richard Mott, Dawn Field, and Dominic Kwiatkowski

Quantitative prediction of NF-B DNA- protein interactions
PNAS 2002 99: 8167-8172; published online before print June 4 2002, 10.1073/pnas.102674699 [Abstract] [Full Text] [PDF] [Supporting Information]  

Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, Heikyung Suh, Scott R. Whitlow, James C. Fleming, Brianna C. Monroe, David N. Ciccone, Catherine Yan, Katerina Vlasakova, David M. Livingston, David O. Ferguson, Ralph Scully, and Frederick W. Alt

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
PNAS 2002 99: 8173-8178; published online before print May 28 2002, 10.1073/pnas.122228699 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Dana Thomasová, Lucas Q. Ton, Richard R. Copley, Evgeny M. Zdobnov, Xuelan Wang, Young S. Hong, Cheolho Sim, Peer Bork, Fotis C. Kafatos, and Frank H. Collins

Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae
PNAS 2002 99: 8179-8184. [Abstract] [Full Text] [PDF] [Supporting Information]  

Sebastián Kadener, Juan Pablo Fededa, Michael Rosbash, and Alberto R. Kornblihtt

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
PNAS 2002 99: 8185-8190. [Abstract] [Full Text] [PDF]  

Steven E. Artandi, Scott Alson, Maja K. Tietze, Norman E. Sharpless, Siqin Ye, Roger A. Greenberg, Diego H. Castrillon, James W. Horner, Sarah R. Weiler, Ruben D. Carrasco, and Ronald A. DePinho

Constitutive telomerase expression promotes mammary carcinomas in aging mice
PNAS 2002 99: 8191-8196; published online before print May 28 2002, 10.1073/pnas.112515399 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Immunology

Venkataraman Sriram, Sungyoo Cho, Ping Li, Patrick W. O'Donnell, Claire Dunn, Kyoko Hayakawa, Janice S. Blum, and Randy R. Brutkiewicz

Inhibition of glycolipid shedding rescues recognition of a CD1⁺ T cell lymphoma by natural killer T (NKT) cells
PNAS 2002 99: 8197-8202. [Abstract] [Full Text] [PDF]  

Marcus Pericin, Alana Althage, Stefan Freigang, Hans Hengartner, Eric Rolland, Philippe Dupraz, Bernard Thorens, Patrick Aebischer, and Rolf M. Zinkernagel

Allogeneic -islet cells correct diabetes and resist immune rejection
PNAS 2002 99: 8203-8206. [Abstract] [Full Text] [PDF]  

Hans-Christian von Büdingen, Stephen L. Hauser, Antje Fuhrmann, Cameron B. Nabavi, Joy I. Lee, and Claude P. Genain

Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination
PNAS 2002 99: 8207-8212. [Abstract] [Full Text] [PDF] [Supporting Primer List]  

Shohei Hori, Matthias Haury, António Coutinho, and Jocelyne Demengeot

Specificity requirements for selection and effector functions of CD25⁺4⁺ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
PNAS 2002 99: 8213-8218; published online before print May 28 2002, 10.1073/pnas.122224799 [Abstract] [Full Text] [PDF]  

Medical Sciences

Richard P. Visconti, Charlene D. Richardson, and Thomas N. Sato

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)
PNAS 2002 99: 8219-8224; published online before print June 4 2002, 10.1073/pnas.122109599 [Abstract] [Full Text] [PDF]  

Sylvia G. Lehmann, Enzo Lalli, and Paolo Sassone-Corsi From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein PNAS 2002 99: 8225-8230; published online before print May 28 2002, 10.1073/pnas.122044099 [Abstract] [Full Text] [PDF]

Gregorino Paone, Akihiro Wada, Linda A. Stevens, Abul Matin, Toshiya Hirayama, Rodney L. Levine, and Joel Moss

ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
PNAS 2002 99: 8231-8235. [Abstract] [Full Text] [PDF]  

Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas, Philippe A. Halban, and Marc Y. Donath

FLIP switches Fas-mediated glucose signaling in human pancreatic cells from apoptosis to cell replication
PNAS 2002 99: 8236-8241. [Abstract] [Full Text] [PDF]  

Hiroshi Mori, Susan M. Colman, Zhijian Xiao, Anthony M. Ford, Lyn E. Healy, Craig Donaldson, Jill M. Hows, Cristina Navarrete, and Mel Greaves

Chromosome translocations and covert leukemic clones are generated during normal fetal development
PNAS 2002 99: 8242-8247; published online before print June 4 2002, 10.1073/pnas.112218799 [Abstract] [Full Text] [PDF]  

Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Scott G. Morham, Maria Luisa S. Sequeira Lopez, R. Ariel Gomez, Timothy L. Reudelhuber, and Oliver Smithies

A genetically clamped renin transgene for the induction of hypertension
PNAS 2002 99: 8248-8252; published online before print May 28 2002, 10.1073/pnas.112222199 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tatsuaki Tsuruyama, Takuro Nakamura, Guang Jin, Munetaka Ozeki, Yoshihiro Yamada, and Hiroshi Hiai

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
PNAS 2002 99: 8253-8258; published online before print June 4 2002, 10.1073/pnas.112202899 [Abstract] [Full Text] [PDF]  

Tonia Vincent, Monika Hermansson, Mark Bolton, Robin Wait, and Jeremy Saklatvala

Basic FGF mediates an immediate response of articular cartilage to mechanical injury
PNAS 2002 99: 8259-8264; published online before print May 28 2002, 10.1073/pnas.122033199 [Abstract] [Full Text] [PDF]  

Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler

Targeted inactivation of CTNNB1 reveals unexpected effects of -catenin mutation
PNAS 2002 99: 8265-8270. [Abstract] [Full Text] [PDF]  

Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig

Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
PNAS 2002 99: 8271-8276. [Abstract] [Full Text] [PDF]  

Karine Croizet-Berger, Chantal Daumerie, Marianne Couvreur, Pierre J. Courtoy, and Marie-France van den Hove

The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production
PNAS 2002 99: 8277-8282; published online before print May 28 2002, 10.1073/pnas.122187699 [Abstract] [Full Text] [PDF]  

Louise M. Kelly, Jeffrey L. Kutok, Ifor R. Williams, Christina L. Boulton, Sonia M. Amaral, David P. Curley, Timothy J. Ley, and D. Gary Gilliland

PML/RAR and FLT3-ITD induce an APL-like disease in a mouse model
PNAS 2002 99: 8283-8288. [Abstract] [Full Text] [PDF]  

Yongmei Li, Arthur Karlin, John D. Loike, and Samuel C. Silverstein

A critical concentration of neutrophils is required for effective bacterial killing in suspension
PNAS 2002 99: 8289-8294. [Abstract] [Full Text] [PDF]  

Neil C. Josephson, George Vassilopoulos, Grant D. Trobridge, Greg V. Priestley, Brent L. Wood, Thalia Papayannopoulou, and David W. Russell

Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors
PNAS 2002 99: 8295-8300. [Abstract] [Full Text] [PDF] [Supporting Figure]  

Farhad R. Danesh, Mehran M. Sadeghi, Nail Amro, Carrie Philips, Lixia Zeng, Sun Lin, Atul Sahai, and Yashpal S. Kanwar

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy
PNAS 2002 99: 8301-8305; published online before print June 4 2002, 10.1073/pnas.122228799 [Abstract] [Full Text] [PDF]  

Zhiqiang Chen, Jian Zhang, and Jonathan S. Stamler From the Cover: Identification of the enzymatic mechanism of nitroglycerin bioactivation PNAS 2002 99: 8306-8311; published online before print June 4 2002, 10.1073/pnas.122225199 [Abstract] [Full Text] [PDF]

Microbiology

Urs A. Ochsner, Aleksandra Snyder, Adriana I. Vasil, and Michael L. Vasil

Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis
PNAS 2002 99: 8312-8317; published online before print May 28 2002, 10.1073/pnas.082238299 [Abstract] [Full Text] [PDF]  

Maria Teresa Sciortino, Brunella Taddeo, Alice P. W. Poon, Antonio Mastino, and Bernard Roizman

Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection
PNAS 2002 99: 8318-8323. [Abstract] [Full Text] [PDF]  

Scott C. Dawson and Norman R. Pace

Novel kingdom-level eukaryotic diversity in anoxic environments
PNAS 2002 99: 8324-8329. [Abstract] [Full Text] [PDF] [Supporting Figures]  

Deepak Kaushal, Benjamin G. Schroeder, Sandeep Tyagi, Tetsuyuki Yoshimatsu, Cherise Scott, Chiew Ko, Liane Carpenter, Jyoti Mehrotra, Yukari C. Manabe, Robert D. Fleischmann, and William R. Bishai

Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative factor, SigH
PNAS 2002 99: 8330-8335. [Abstract] [Full Text] [PDF] [Supporting Table]  

Catharina Casper-Lindley, Douglas Dahlbeck, Eszter T. Clark, and Brian J. Staskawicz

Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells
PNAS 2002 99: 8336-8341. [Abstract] [Full Text] [PDF]  

Marie-Françoise Noirot-Gros, Etienne Dervyn, Ling Juan Wu, Peggy Mervelet, Jeffery Errington, S. Dusko Ehrlich, and Philippe Noirot

An expanded view of bacterial DNA replication
PNAS 2002 99: 8342-8347. [Abstract] [Full Text] [PDF]  

Joanne Fanelli Panus, Craig A. Smith, Caroline A. Ray, Terri Davis Smith, Dhavalkumar D. Patel, and David J. Pickup

Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue
PNAS 2002 99: 8348-8353; published online before print May 28 2002, 10.1073/pnas.122238599 [Abstract] [Full Text] [PDF]  

Betty P. Guo and John J. Mekalanos

Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice
PNAS 2002 99: 8354-8359. [Abstract] [Full Text] [PDF]  

Neurobiology

Hua-Sheng Xiao, Qiu-Hua Huang, Fang-Xiong Zhang, Lan Bao, Ying-Jin Lu, Chao Guo, Liang Yang, Wein-Jing Huang, Gang Fu, Shu-Hua Xu, Xi-Ping Cheng, Qing Yan, Zhi-Dong Zhu, Xin Zhang, Zhu Chen, Ze-Guang Han, and Xu Zhang

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
PNAS 2002 99: 8360-8365. [Abstract] [Full Text] [PDF] [Supporting Tables]  

Shigeo Watanabe, Dax A. Hoffman, Michele Migliore, and Daniel Johnston

Dendritic K⁺ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons
PNAS 2002 99: 8366-8371; published online before print June 4 2002, 10.1073/pnas.122210599 [Abstract] [Full Text] [PDF]  

Dylan M. Dean, Wang Nguitragool, Andrew Miri, Sarah L. McCabe, and Anita L. Zimmerman

All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: A novel role for photoreceptor retinoids in the response to bright light?
PNAS 2002 99: 8372-8377; published online before print May 28 2002, 10.1073/pnas.122681899 [Abstract] [Full Text] [PDF]  

Gabriel Kreiman, Itzhak Fried, and Christof Koch

Single-neuron correlates of subjective vision in the human medial temporal lobe
PNAS 2002 99: 8378-8383; published online before print May 28 2002, 10.1073/pnas.072194099 [Abstract] [Full Text] [PDF]  

David Robbe, Manfred Kopf, Anne Remaury, Joel Bockaert, and Olivier J. Manzoni

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
PNAS 2002 99: 8384-8388. [Abstract] [Full Text] [PDF] [Supporting Figure]  

Varda Lev-Ram, Scott T. Wong, Daniel R. Storm, and Roger Y. Tsien

A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
PNAS 2002 99: 8389-8393; published online before print June 4 2002, 10.1073/pnas.122206399 [Abstract] [Full Text] [PDF]  

Jack C. Sipe, Kyle Chiang, Alexandra L. Gerber, Ernest Beutler, and Benjamin F. Cravatt

A missense mutation in human fatty acid amide hydrolase associated with problem drug use
PNAS 2002 99: 8394-8399. [Abstract] [Full Text] [PDF]  

Susan M. Huang, Tiziana Bisogno, Marcello Trevisani, Abdulmonem Al-Hayani, Luciano De Petrocellis, Filomena Fezza, Michele Tognetto, Timothy J. Petros, Jocelyn F. Krey, Constance J. Chu, Jeffrey D. Miller, Stephen N. Davies, Pierangelo Geppetti, J. Michael Walker, and Vincenzo Di Marzo

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
PNAS 2002 99: 8400-8405. [Abstract] [Full Text] [PDF]  

Benedetto Sacchetti, Elisabetta Baldi, Carlo Ambrogi Lorenzini, and Corrado Bucherelli From the Cover: Cerebellar role in fear-conditioning consolidation PNAS 2002 99: 8406-8411; published online before print May 28 2002, 10.1073/pnas.112660399 [Abstract] [Full Text] [PDF]

Alka A. Vyas, Himatkumar V. Patel, Susan E. Fromholt, Marija Heffer-Lauc, Kavita A. Vyas, Jiyoung Dang, Melitta Schachner, and Ronald L. Schnaar From the Cover: Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration PNAS 2002 99: 8412-8417. [Abstract] [Full Text] [PDF] [Supporting Figure]