Find articles in this issue containing these words:

COMMENTARIES

Stephen C. Stearns

Progress on canalization
PNAS 2002 99: 10229-10230; published online before print July 30 2002, 10.1073/pnas.172388999 [Extract] [Full Text] [PDF]  

Senitiroh Hakomori

Glycosylation defining cancer malignancy: New wine in an old bottle
PNAS 2002 99: 10231-10233; published online before print July 30 2002, 10.1073/pnas.172380699 [Extract] [Full Text] [PDF]  

Bess B. Ward

How many species of prokaryotes are there?
PNAS 2002 99: 10234-10236; published online before print July 30 2002, 10.1073/pnas.162359199 [Extract] [Full Text] [PDF]  

Marcus E. Raichle and Debra A. Gusnard

Appraising the brain's energy budget
PNAS 2002 99: 10237-10239; published online before print July 29 2002, 10.1073/pnas.172399499 [Extract] [Full Text] [PDF]  

Roger P. Wise and Daryl R. Pring

Nuclear-mediated mitochondrial gene regulation and male fertility in higher plants: Light at the end of the tunnel?
PNAS 2002 99: 10240-10242; published online before print July 29 2002, 10.1073/pnas.172388899 [Extract] [Full Text] [PDF]  

Carmen Sapienza

Imprinted gene expression, transplantation medicine, and the "other" human embryonic stem cell
PNAS 2002 99: 10243-10245; published online before print July 30 2002, 10.1073/pnas.172384299 [Extract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Gregory Beylkin and Martin J. Mohlenkamp

Numerical operator calculus in higher dimensions
PNAS 2002 99: 10246-10251; published online before print July 24 2002, 10.1073/pnas.112329799 [Abstract] [Full Text] [PDF]  

Hong Qian, Saveez Saffarian, and Elliot L. Elson

Concentration fluctuations in a mesoscopic oscillating chemical reaction system
PNAS 2002 99: 10376-10381; published online before print July 17 2002, 10.1073/pnas.152007599 [Abstract] [Full Text] [PDF]  

Jayanth R. Banavar, John Damuth, Amos Maritan, and Andrea Rinaldo

Supply-demand balance and metabolic scaling
PNAS 2002 99: 10506-10509; published online before print July 29 2002, 10.1073/pnas.162216899 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

Yueh-Lin Loo, Takao Someya, Kirk W. Baldwin, Zhenan Bao, Peter Ho, Ananth Dodabalapur, Howard E. Katz, and John A. Rogers

Soft, conformable electrical contacts for organic semiconductors: High-resolution plastic circuits by lamination
PNAS 2002 99: 10252-10256; published online before print July 26 2002, 10.1073/pnas.162128299 [Abstract] [Full Text] [PDF]  

P. R. Garabedian

Three-dimensional stellarator codes
PNAS 2002 99: 10257-10259; published online before print July 24 2002, 10.1073/pnas.162330399 [Abstract] [Full Text] [PDF]  

Chemistry

Chad M. Rienstra, Lisa Tucker-Kellogg, Christopher P. Jaroniec, Morten Hohwy, Bernd Reif, Michael T. McMahon, Bruce Tidor, Tomás Lozano-Pérez, and Robert G. Griffin

De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy
PNAS 2002 99: 10260-10265; published online before print July 29 2002, 10.1073/pnas.152346599 [Abstract] [Full Text] [PDF] [Supporting Tables]  

J. D. van Beek, S. Hess, F. Vollrath, and B. H. Meier From the Cover: The molecular structure of spider dragline silk: Folding and orientation of the protein backbone PNAS 2002 99: 10266-10271; published online before print July 29 2002, 10.1073/pnas.152162299 [Abstract] [Full Text] [PDF] [Supporting Figure]

Engineering

Frédéric Pain, Laurent Besret, Françoise Vaufrey, Marie-Claude Grégoire, Laurent Pinot, Philippe Gervais, Lydie Ploux, Gilles Bloch, Roland Mastrippolito, Philippe Lanièce, and Philippe Hantraye

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution ⁺-sensitive microprobe
PNAS 2002 99: 10807-10812; published online before print July 22 2002, 10.1073/pnas.162368899 [Abstract] [Full Text] [PDF]  

Physics

Tae-Hee Lee, Jose I. Gonzalez, and Robert M. Dickson

Strongly enhanced field-dependent single-molecule electroluminescence
PNAS 2002 99: 10272-10275; published online before print July 29 2002, 10.1073/pnas.162356799 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Dolores R. Piperno, Irene Holst, Linda Wessel-Beaver, and Thomas C. Andres

Evidence for the control of phytolith formation in Cucurbita fruits by the hard rind (Hr) genetic locus: Archaeological and ecological implications
PNAS 2002 99: 10923-10928; published online before print July 29 2002, 10.1073/pnas.152275499 [Abstract] [Full Text] [PDF] [Supporting Table]  

Social Sciences

Dana P. Goldman and James P. Smith

Can patient self-management help explain the SES health gradient?
PNAS 2002 99: 10929-10934; published online before print July 24 2002, 10.1073/pnas.162086599 [Abstract] [Full Text] [PDF] [Supporting Appendixes]  

Edward H. Kaplan, David L. Craft, and Lawrence M. Wein

Emergency response to a smallpox attack: The case for mass vaccination
PNAS 2002 99: 10935-10940; published online before print July 12 2002, 10.1073/pnas.162282799 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Imre Szabo, Xiao-Hong Chen, Li Xin, Martin W. Adler, O. M. Z. Howard, Joost J. Oppenheim, and Thomas J. Rogers

Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain
PNAS 2002 99: 10276-10281; published online before print July 18 2002, 10.1073/pnas.102327699 [Abstract] [Full Text] [PDF]  

Lucia Bartoloni, Jean-Louis Blouin, Yanzhen Pan, Corinne Gehrig, Amit K. Maiti, Nathalie Scamuffa, Colette Rossier, Mark Jorissen, Miguel Armengot, Maggie Meeks, Hannah M. Mitchison, Eddie M. K. Chung, Celia D. Delozier-Blanchet, William J. Craigen, and Stylianos E. Antonarakis

Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia
PNAS 2002 99: 10282-10286; published online before print July 25 2002, 10.1073/pnas.152337699 [Abstract] [Full Text] [PDF] [Supporting Figure]  

William G. Brodbeck, Jasmine Patel, Gabriela Voskerician, Elizabeth Christenson, Matthew S. Shive, Yasuhide Nakayama, Takehisa Matsuda, Nicholas P. Ziats, and James M. Anderson

Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo
PNAS 2002 99: 10287-10292; published online before print July 16 2002, 10.1073/pnas.162124199 [Abstract] [Full Text] [PDF]  

Biochemistry

Xiaorong Zhu, An Zhou, Arunangsu Dey, Christina Norrbom, Raymond Carroll, Chunling Zhang, Virginie Laurent, Iris Lindberg, Randi Ugleholdt, Jens J. Holst, and Donald F. Steiner

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
PNAS 2002 99: 10293-10298; published online before print July 26 2002, 10.1073/pnas.162352599 [Abstract] [Full Text] [PDF] [Supporting Information]  

Xiaorong Zhu, Lelio Orci, Raymond Carroll, Christina Norrbom, Mariella Ravazzola, and Donald F. Steiner

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
PNAS 2002 99: 10299-10304; published online before print July 22 2002, 10.1073/pnas.162352799 [Abstract] [Full Text] [PDF]  

Lars O. Hansson, Assaf Friedler, Stefan Freund, Stefan Rüdiger, and Alan R. Fersht

Two sequence motifs from HIF-1 bind to the DNA-binding site of p53
PNAS 2002 99: 10305-10309; published online before print July 17 2002, 10.1073/pnas.122347199 [Abstract] [Full Text] [PDF]  

Ramón Campos-Olivas, John M. Louis, Danielle Clérot, Bruno Gronenborn, and Angela M. Gronenborn

The structure of a replication initiator unites diverse aspects of nucleic acid metabolism
PNAS 2002 99: 10310-10315; published online before print July 18 2002, 10.1073/pnas.152342699 [Abstract] [Full Text] [PDF]  

Evette S. Radisky and Daniel E. Koshland, Jr. From the Cover: A clogged gutter mechanism for protease inhibitors PNAS 2002 99: 10316-10321; published online before print July 25 2002, 10.1073/pnas.112332899 [Abstract] [Full Text] [PDF] [Supporting Table]

Blanca Barquera, Weidong Zhou, Joel E. Morgan, and Robert B. Gennis

Riboflavin is a component of the Na⁺-pumping NADH-quinone oxidoreductase from Vibrio cholerae
PNAS 2002 99: 10322-10324; published online before print July 16 2002, 10.1073/pnas.162361299 [Abstract] [Full Text] [PDF]  

Yongning He, Feng Lin, Paul R. Chipman, Carol M. Bator, Timothy S. Baker, Menachem Shoham, Richard J. Kuhn, M. Edward Medof, and Michael G. Rossmann

Structure of decay-accelerating factor bound to echovirus 7: A virus-receptor complex
PNAS 2002 99: 10325-10329; published online before print July 15 2002, 10.1073/pnas.152161599 [Abstract] [Full Text] [PDF]  

Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor

Absolute requirement of spermidine for growth and cell cycle progression of fission yeast (Schizosaccharomyces pombe)
PNAS 2002 99: 10330-10334; published online before print July 29 2002, 10.1073/pnas.162362899 [Abstract] [Full Text] [PDF]  

Nadim Jessani, Yongsheng Liu, Mark Humphrey, and Benjamin F. Cravatt

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
PNAS 2002 99: 10335-10340; published online before print July 29 2002, 10.1073/pnas.162187599 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Mahesh S. Joshi, T. Bruce Ferguson, Jr., Tae H. Han, Daniel R. Hyduke, James C. Liao, Tienush Rassaf, Nathan Bryan, Martin Feelisch, and Jack R. Lancaster, Jr.

Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions
PNAS 2002 99: 10341-10346; published online before print July 17 2002, 10.1073/pnas.152149699 [Abstract] [Full Text] [PDF]  

Alexia Garrigues, Alexandre E. Escargueil, and Stéphane Orlowski

The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
PNAS 2002 99: 10347-10352; published online before print July 26 2002, 10.1073/pnas.162366399 [Abstract] [Full Text] [PDF]  

Christopher S. Brower, Shigeo Sato, Chieri Tomomori-Sato, Takumi Kamura, Arnim Pause, Robert Stearman, Richard D. Klausner, Sohail Malik, William S. Lane, Irina Sorokina, Robert G. Roeder, Joan Weliky Conaway, and Ronald C. Conaway

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
PNAS 2002 99: 10353-10358; published online before print July 29 2002, 10.1073/pnas.162424199 [Abstract] [Full Text] [PDF]  

Erik J. Miller, Kael F. Fischer, and Susan Marqusee

Experimental evaluation of topological parameters determining protein-folding rates
PNAS 2002 99: 10359-10363; published online before print July 29 2002, 10.1073/pnas.162219099 [Abstract] [Full Text] [PDF]  

Chun-Qi Li, Laura J. Trudel, and Gerald N. Wogan

Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53
PNAS 2002 99: 10364-10369; published online before print July 22 2002, 10.1073/pnas.162356399 [Abstract] [Full Text] [PDF]  

Biophysics

I. I. Serysheva, S. J. Ludtke, M. R. Baker, W. Chiu, and S. L. Hamilton

Structure of the voltage-gated L-type Ca²⁺ channel by electron cryomicroscopy
PNAS 2002 99: 10370-10375; published online before print July 29 2002, 10.1073/pnas.162363499 [Abstract] [Full Text] [PDF]  

Hong Qian, Saveez Saffarian, and Elliot L. Elson

Concentration fluctuations in a mesoscopic oscillating chemical reaction system
PNAS 2002 99: 10376-10381; published online before print July 17 2002, 10.1073/pnas.152007599 [Abstract] [Full Text] [PDF]  

Yu Xia and Michael Levitt

Roles of mutation and recombination in the evolution of protein thermodynamics
PNAS 2002 99: 10382-10387; published online before print July 29 2002, 10.1073/pnas.162097799 [Abstract] [Full Text] [PDF]  

Gregory V. Nikiforovich and Carl Frieden

The search for local native-like nucleation centers in the unfolded state of -sheet proteins
PNAS 2002 99: 10388-10393; published online before print July 24 2002, 10.1073/pnas.162362199 [Abstract] [Full Text] [PDF]  

Avijit Ghosh, Ron Elber, and Harold A. Scheraga

An atomically detailed study of the folding pathways of protein A with the stochastic difference equation
PNAS 2002 99: 10394-10398; published online before print July 24 2002, 10.1073/pnas.142288099 [Abstract] [Full Text] [PDF]  

Hengbin Luo and Kim Sharp

On the calculation of absolute macromolecular binding free energies
PNAS 2002 99: 10399-10404; published online before print July 29 2002, 10.1073/pnas.162365999 [Abstract] [Full Text] [PDF]  

Qing Xie, Weishu Bu, Smita Bhatia, Joan Hare, Thayumanasamy Somasundaram, Arezki Azzi, and Michael S. Chapman

The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
PNAS 2002 99: 10405-10410; published online before print July 22 2002, 10.1073/pnas.162250899 [Abstract] [Full Text] [PDF]  

Bernard Sapoval, M. Filoche, and E. R. Weibel

Smaller is betterbut not too small: A physical scale for the design of the mammalian pulmonary acinus
PNAS 2002 99: 10411-10416; published online before print July 22 2002, 10.1073/pnas.122352499 [Abstract] [Full Text] [PDF]  

Cell Biology

James F. Morley, Heather R. Brignull, Jill J. Weyers, and Richard I. Morimoto

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
PNAS 2002 99: 10417-10422; published online before print July 16 2002, 10.1073/pnas.152161099 [Abstract] [Full Text] [PDF]  

Carsten Willam, Norma Masson, Ya-Min Tian, S. Aleema Mahmood, Michael I. Wilson, Roy Bicknell, Kai-Uwe Eckardt, Patrick H. Maxwell, Peter J. Ratcliffe, and Christopher W. Pugh

Peptide blockade of HIF degradation modulates cellular metabolism and angiogenesis
PNAS 2002 99: 10423-10428; published online before print July 29 2002, 10.1073/pnas.162119399 [Abstract] [Full Text] [PDF]  

Leonard James and Robert N. Eisenman

Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo
PNAS 2002 99: 10429-10434; published online before print July 29 2002, 10.1073/pnas.162369299 [Abstract] [Full Text] [PDF]  

Tzvi Tzfira, Manjusha Vaidya, and Vitaly Citovsky

Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1
PNAS 2002 99: 10435-10440; published online before print July 17 2002, 10.1073/pnas.162304099 [Abstract] [Full Text] [PDF]  

Guénahel H. Danet, Jennifer L. Luongo, Gary Butler, Min Min Lu, Andrea J. Tenner, M. Celeste Simon, and Dominique A. Bonnet

C1qR_p defines a new human stem cell population with hematopoietic and hepatic potential
PNAS 2002 99: 10441-10445; published online before print July 24 2002, 10.1073/pnas.162104799 [Abstract] [Full Text] [PDF]  

Undine Lauf, Ben N. G. Giepmans, Patricia Lopez, Sébastien Braconnot, Shu-Chih Chen, and Matthias M. Falk

Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells
PNAS 2002 99: 10446-10451; published online before print July 29 2002, 10.1073/pnas.162055899 [Abstract] [Full Text] [PDF] [Supporting Infromation]  

T. Omelchenko, J. M. Vasiliev, I. M. Gelfand, H. H. Feder, and E. M. Bonder

Mechanisms of polarization of the shape of fibroblasts and epitheliocytes: Separation of the roles of microtubules and Rho-dependent actin-myosin contractility
PNAS 2002 99: 10452-10457; published online before print July 29 2002, 10.1073/pnas.152339899 [Abstract] [Full Text] [PDF]  

Developmental Biology

Maria P. De Miguel, Linzhao Cheng, Eric C. Holland, Mark J. Federspiel, and Peter J. Donovan

Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer
PNAS 2002 99: 10458-10463; published online before print July 24 2002, 10.1073/pnas.122249399 [Abstract] [Full Text] [PDF]  

Stacey Rentschler, Jennifer Zander, Kathleen Meyers, David France, Rebecca Levine, George Porter, Scott A. Rivkees, Gregory E. Morley, and Glenn I. Fishman

Neuregulin-1 promotes formation of the murine cardiac conduction system
PNAS 2002 99: 10464-10469; published online before print July 29 2002, 10.1073/pnas.162301699 [Abstract] [Full Text] [PDF]  

Percy Lee, Katsutoshi Goishi, Alan J. Davidson, Robert Mannix, Leonard Zon, and Michael Klagsbrun

Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish
PNAS 2002 99: 10470-10475; published online before print July 25 2002, 10.1073/pnas.162366299 [Abstract] [Full Text] [PDF]  

Sara C. Ahlgren, Vijaya Thakur, and Marianne Bronner-Fraser

Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure
PNAS 2002 99: 10476-10481; published online before print July 24 2002, 10.1073/pnas.162356199 [Abstract] [Full Text] [PDF]  

Anne-Karina T. Perl, Susan E. Wert, Andras Nagy, Corrinne G. Lobe, and Jeffrey A. Whitsett

Early restriction of peripheral and proximal cell lineages during formation of the lung
PNAS 2002 99: 10482-10487; published online before print July 26 2002, 10.1073/pnas.152238499 [Abstract] [Full Text] [PDF]  

Zhan Yin, Jennifer Haynie, Xiaoming Yang, Baoguang Han, Songsak Kiatchoosakun, Joseph Restivo, Saying Yuan, Nanduri R. Prabhakar, Karl Herrup, Ronald A. Conlon, Brian D. Hoit, Michiko Watanabe, and Yu-Chung Yang

The essential role of Cited2, a negative regulator for HIF-1, in heart development and neurulation
PNAS 2002 99: 10488-10493; published online before print July 29 2002, 10.1073/pnas.162371799 [Abstract] [Full Text] [PDF]  

Ecology

Brian Reed Silliman and Mark D. Bertness

A trophic cascade regulates salt marsh primary production
PNAS 2002 99: 10500-10505; published online before print July 29 2002, 10.1073/pnas.162366599 [Abstract] [Full Text] [PDF]  

Jayanth R. Banavar, John Damuth, Amos Maritan, and Andrea Rinaldo

Supply-demand balance and metabolic scaling
PNAS 2002 99: 10506-10509; published online before print July 29 2002, 10.1073/pnas.162216899 [Abstract] [Full Text] [PDF]  

Dolores R. Piperno, Irene Holst, Linda Wessel-Beaver, and Thomas C. Andres

Evidence for the control of phytolith formation in Cucurbita fruits by the hard rind (Hr) genetic locus: Archaeological and ecological implications
PNAS 2002 99: 10923-10928; published online before print July 29 2002, 10.1073/pnas.152275499 [Abstract] [Full Text] [PDF] [Supporting Table]  

Evolution

Daniel O. Daley, Rachel Clifton, and James Whelan

Intracellular gene transfer: Reduced hydrophobicity facilitates gene transfer for subunit 2 of cytochrome c oxidase
PNAS 2002 99: 10510-10515; published online before print July 25 2002, 10.1073/pnas.122354399 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Alan R. Lemmon and Michel C. Milinkovitch

The metapopulation genetic algorithm: An efficient solution for the problem of large phylogeny estimation
PNAS 2002 99: 10516-10521; published online before print July 25 2002, 10.1073/pnas.162224399 [Abstract] [Full Text] [PDF] [Supporting Text]  

Igor Ovchinnikov, Adrienne Rubin, and Gary D. Swergold

Tracing the LINEs of human evolution
PNAS 2002 99: 10522-10527; published online before print July 23 2002, 10.1073/pnas.152346799 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Mark L. Siegal and Aviv Bergman

Waddington's canalization revisited: Developmental stability and evolution
PNAS 2002 99: 10528-10532; published online before print June 24 2002, 10.1073/pnas.102303999 [Abstract] [Full Text] [PDF]  

Sergey Gavrilets and David Waxman

Sympatric speciation by sexual conflict
PNAS 2002 99: 10533-10538; published online before print July 29 2002, 10.1073/pnas.152011499 [Abstract] [Full Text] [PDF]  

Michael J. Bamshad, Srinivas Mummidi, Enrique Gonzalez, Seema S. Ahuja, Diane M. Dunn, W. Scott Watkins, Stephen Wooding, Anne C. Stone, Lynn B. Jorde, Robert B. Weiss, and Sunil K. Ahuja

A strong signature of balancing selection in the 5' cis-regulatory region of CCR5
PNAS 2002 99: 10539-10544; published online before print July 29 2002, 10.1073/pnas.162046399 [Abstract] [Full Text] [PDF] [Supporting Appendix]  

Kristina Kusche, Hilke Ruhberg, and Thorsten Burmester

A hemocyanin from the Onychophora and the emergence of respiratory proteins
PNAS 2002 99: 10545-10548; published online before print July 29 2002, 10.1073/pnas.152241199 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Genetics

Haruko Takeda, Marika Takami, Tomoko Oguni, Takehito Tsuji, Kazuhiro Yoneda, Hiroaki Sato, Naoya Ihara, Tomohito Itoh, Srinivas R. Kata, Yuji Mishina, James E. Womack, Yasuo Moritomo, Yoshikazu Sugimoto, and Tetsuo Kunieda

Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism
PNAS 2002 99: 10549-10554; published online before print July 22 2002, 10.1073/pnas.152337899 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michal Ronen, Revital Rosenberg, Boris I. Shraiman, and Uri Alon

Assigning numbers to the arrows: Parameterizing a gene regulation network by using accurate expression kinetics
PNAS 2002 99: 10555-10560; published online before print July 26 2002, 10.1073/pnas.152046799 [Abstract] [Full Text] [PDF]  

N. Avrion Mitchison and Jürgen Roes

Patterned variation in murine MHC promoters
PNAS 2002 99: 10561-10566; published online before print July 19 2002, 10.1073/pnas.152329999 [Abstract] [Full Text] [PDF]  

John Cairns

Somatic stem cells and the kinetics of mutagenesis and carcinogenesis
PNAS 2002 99: 10567-10570; published online before print July 29 2002, 10.1073/pnas.162369899 [Abstract] [Full Text] [PDF]  

Jordi Surrallés, María J. Ramírez, Ricard Marcos, Adayapalam T. Natarajan, and Leon H. F. Mullenders

Clusters of transcription-coupled repair in the human genome
PNAS 2002 99: 10571-10574; published online before print July 25 2002, 10.1073/pnas.162278199 [Abstract] [Full Text] [PDF]  

Knud Nairz, Hugo Stocker, Benno Schindelholz, and Ernst Hafen

High-resolution SNP mapping by denaturing HPLC
PNAS 2002 99: 10575-10580; published online before print July 29 2002, 10.1073/pnas.162136299 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cornelia Kiefer, Emerich Sumser, Mathias F. Wernet, and Johannes von Lintig

A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila
PNAS 2002 99: 10581-10586; published online before print July 22 2002, 10.1073/pnas.162182899 [Abstract] [Full Text] [PDF]  

Vijay K. Yechoor, Mary-Elizabeth Patti, Robert Saccone, and C. Ronald Kahn

Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice
PNAS 2002 99: 10587-10592; published online before print July 29 2002, 10.1073/pnas.142301999 [Abstract] [Full Text] [PDF] [Supporting Information]  

Béatrice Benoit, François Juge, Florence Iral, Agnès Audibert, and Martine Simonelig

Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila
PNAS 2002 99: 10593-10598; published online before print July 29 2002, 10.1073/pnas.162191899 [Abstract] [Full Text] [PDF]  

Patrick Onyango, Shan Jiang, Hiroshi Uejima, Michael J. Shamblott, John D. Gearhart, Hengmi Cui, and Andrew P. Feinberg

Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages
PNAS 2002 99: 10599-10604; published online before print July 11 2002, 10.1073/pnas.152327599 [Abstract] [Full Text] [PDF]  

Denise Hanway, Jodie K. Chin, Gang Xia, Guy Oshiro, Elizabeth A. Winzeler, and Floyd E. Romesberg

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
PNAS 2002 99: 10605-10610; published online before print July 29 2002, 10.1073/pnas.152264899 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jinshui Fan, Xiaoling Yang, Wengong Wang, William H. Wood, III, Kevin G. Becker, and Myriam Gorospe

Global analysis of stress-regulated mRNA turnover by using cDNA arrays
PNAS 2002 99: 10611-10616; published online before print July 29 2002, 10.1073/pnas.162212399 [Abstract] [Full Text] [PDF] [Supporting Table]  

Immunology

Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Ju Chang, Wook-Jin Chae, Jin-Hwan Han, Duck-Jong Han, Tomohiro Morio, Jung-Jin Yang, Alfred Bothwell, and Sang-Kyou Lee

Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction
PNAS 2002 99: 10617-10622; published online before print July 29 2002, 10.1073/pnas.162522099 [Abstract] [Full Text] [PDF] [Supporting Information]  

Liying Guo, Jane Hu-Li, Jinfang Zhu, Cynthia J. Watson, Michael J. Difilippantonio, Christophe Pannetier, and William E. Paul

In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production
PNAS 2002 99: 10623-10628; published online before print July 29 2002, 10.1073/pnas.162360199 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yasuhiro Nagata, Satoru Ono, Mitsutoshi Matsuo, Sacha Gnjatic, Danila Valmori, Gerd Ritter, Wendy Garrett, Lloyd J. Old, and Ira Mellman

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations
PNAS 2002 99: 10629-10634; published online before print July 23 2002, 10.1073/pnas.112331099 [Abstract] [Full Text] [PDF]  

Medical Sciences

Zhenning He and J. Eric Russell

A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease
PNAS 2002 99: 10635-10640; published online before print July 17 2002, 10.1073/pnas.162269099 [Abstract] [Full Text] [PDF]  

Andrea E. Prota, David R. Sage, Thilo Stehle, and Joyce D. Fingeroth

The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding
PNAS 2002 99: 10641-10646; published online before print July 16 2002, 10.1073/pnas.162360499 [Abstract] [Full Text] [PDF]  

Sanaz Memarzadeh, Katherine R. Kozak, Lisbeth Chang, Sathima Natarajan, Peter Shintaku, Srinivasa T. Reddy, and Robin Farias-Eisner

Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer
PNAS 2002 99: 10647-10652; published online before print July 18 2002, 10.1073/pnas.152127499 [Abstract] [Full Text] [PDF]  

Robert E. Fleming, John R. Ahmann, Mary C. Migas, Abdul Waheed, H. Phillip Koeffler, Hiroshi Kawabata, Robert S. Britton, Bruce R. Bacon, and William S. Sly

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
PNAS 2002 99: 10653-10658; published online before print July 19 2002, 10.1073/pnas.162360699 [Abstract] [Full Text] [PDF]  

Anna K. Junk, Antonios Mammis, Sean I. Savitz, Manjeet Singh, Steven Roth, Samit Malhotra, Pearl S. Rosenbaum, Anthony Cerami, Michael Brines, and Daniel M. Rosenbaum

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
PNAS 2002 99: 10659-10664; published online before print July 18 2002, 10.1073/pnas.152321399 [Abstract] [Full Text] [PDF]  

Mårten Falkenberg, Clifford Tom, Mary Beth DeYoung, Shan Wen, Ruth Linnemann, and David A. Dichek

Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth
PNAS 2002 99: 10665-10670; published online before print July 29 2002, 10.1073/pnas.162236599 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

C. Dirk Keene, Cecilia M. P. Rodrigues, Tacjana Eich, Manik S. Chhabra, Clifford J. Steer, and Walter C. Low

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
PNAS 2002 99: 10671-10676; published online before print July 29 2002, 10.1073/pnas.162362299 [Abstract] [Full Text] [PDF]  

Murat Gunel, Maxwell S. H. Laurans, Dana Shin, Michael L. DiLuna, Jennifer Voorhees, Keith Choate, Carol Nelson-Williams, and Richard P. Lifton

KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein
PNAS 2002 99: 10677-10682; published online before print July 24 2002, 10.1073/pnas.122354499 [Abstract] [Full Text] [PDF]  

Frederick Y. Wu, Qi-Qun Tang, Honglin Chen, Colette ApRhys, Christopher Farrell, Jianmeng Chen, Masahiro Fujimuro, M. Daniel Lane, and Gary S. Hayward

Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21^CIP-1-mediated G₁ cell cycle arrest through CCAAT/enhancer-binding protein-
PNAS 2002 99: 10683-10688; published online before print July 26 2002, 10.1073/pnas.162352299 [Abstract] [Full Text] [PDF]  

Jennifer Peters, Elizabeth Fowler, Michelle Gatton, Nanhua Chen, Allan Saul, and Qin Cheng

High diversity and rapid changeover of expressed var genes during the acute phase of Plasmodium falciparum infections in human volunteers
PNAS 2002 99: 10689-10694; published online before print July 25 2002, 10.1073/pnas.162349899 [Abstract] [Full Text] [PDF]  

Donald A. McClain, William A. Lubas, Robert C. Cooksey, Mark Hazel, Glendon J. Parker, Dona C. Love, and John A. Hanover

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia
PNAS 2002 99: 10695-10699; published online before print July 22 2002, 10.1073/pnas.152346899 [Abstract] [Full Text] [PDF]  

Sergei Roumiantsev, Neil P. Shah, Mercedes E. Gorre, John Nicoll, Bradley B. Brasher, Charles L. Sawyers, and Richard A. Van Etten

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
PNAS 2002 99: 10700-10705; published online before print July 29 2002, 10.1073/pnas.162140299 [Abstract] [Full Text] [PDF]  

Patrick P. Ng, Jay S. Dela Cruz, David N. Sorour, James M. Stinebaugh, Seung-Uon Shin, Daniel S. Shin, Sherie L. Morrison, and Manuel L. Penichet

An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells
PNAS 2002 99: 10706-10711; published online before print July 29 2002, 10.1073/pnas.162362999 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Ven Natarajan, Richard A. Lempicki, Irini Sereti, Yunden Badralmaa, Joseph W. Adelsberger, Julia A. Metcalf, Darue A. Prieto, Randy Stevens, Michael W. Baseler, Joseph A. Kovacs, and H. Clifford Lane

Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection
PNAS 2002 99: 10712-10717; published online before print July 29 2002, 10.1073/pnas.162352399 [Abstract] [Full Text] [PDF]  

Yoichiro Kakugawa, Tadashi Wada, Kazunori Yamaguchi, Hideaki Yamanami, Kiyoaki Ouchi, Ikuro Sato, and Taeko Miyagi

Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression
PNAS 2002 99: 10718-10723; published online before print July 29 2002, 10.1073/pnas.152597199 [Abstract] [Full Text] [PDF]  

Jingfeng Li, Alexei Protopopov, Fuli Wang, Vera Senchenko, Valentin Petushkov, Olga Vorontsova, Lev Petrenko, Veronika Zabarovska, Olga Muravenko, Eleonora Braga, Lev Kisselev, Michael I. Lerman, Vladimir Kashuba, George Klein, Ingemar Ernberg, Claes Wahlestedt, and Eugene R. Zabarovsky

NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes
PNAS 2002 99: 10724-10729; published online before print July 29 2002, 10.1073/pnas.132271699 [Abstract] [Full Text] [PDF]  

Maria A. Rupnick, Dipak Panigrahy, Chen-Yu Zhang, Susan M. Dallabrida, Bradford B. Lowell, Robert Langer, and M. Judah Folkman From the Cover: Adipose tissue mass can be regulated through the vasculature PNAS 2002 99: 10730-10735; published online before print July 29 2002, 10.1073/pnas.162349799 [Abstract] [Full Text] [PDF]

Microbiology

Gary K. Geiss, Mirella Salvatore, Terrence M. Tumpey, Victoria S. Carter, Xiuyan Wang, Christopher F. Basler, Jeffery K. Taubenberger, Roger E. Bumgarner, Peter Palese, Michael G. Katze, and Adolfo García-Sastre

Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
PNAS 2002 99: 10736-10741; published online before print July 29 2002, 10.1073/pnas.112338099 [Abstract] [Full Text] [PDF] [Supporting Information]  

P. J. Daborn, N. Waterfield, C. P. Silva, C. P. Y. Au, S. Sharma, and R. H. ffrench-Constant

A single Photorhabdus gene, makes caterpillars floppy (mcf), allows Escherichia coli to persist within and kill insects
PNAS 2002 99: 10742-10747; published online before print July 22 2002, 10.1073/pnas.102068099 [Abstract] [Full Text] [PDF]  

Edwin D. Kilbourne, Catherine Smith, Ian Brett, Barbara A. Pokorny, Bert Johansson, and Nancy Cox

The total influenza vaccine failure of 1947 revisited: Major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic
PNAS 2002 99: 10748-10752; published online before print July 22 2002, 10.1073/pnas.162366899 [Abstract] [Full Text] [PDF]  

Chunlei Su, Daniel K. Howe, J. P. Dubey, James W. Ajioka, and L. David Sibley

Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii
PNAS 2002 99: 10753-10758; published online before print July 29 2002, 10.1073/pnas.172117099 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kevin Pethe, Pablo Bifani, Hervé Drobecq, Christian Sergheraert, Anne-Sophie Debrie, Camille Locht, and Franco D. Menozzi

Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis
PNAS 2002 99: 10759-10764; published online before print July 29 2002, 10.1073/pnas.162246899 [Abstract] [Full Text] [PDF]  

Neurobiology

Fahmeed Hyder, Douglas L. Rothman, and Robert G. Shulman From the Cover: Total neuroenergetics support localized brain activity: Implications for the interpretation of fMRI PNAS 2002 99: 10771-10776; published online before print July 19 2002, 10.1073/pnas.132272299 [Abstract] [Full Text] [PDF]

Yong Yue, Zhi-Yong Chen, Nick W. Gale, Jan Blair-Flynn, Tian-Jing Hu, Xin Yue, Margaret Cooper, David P. Crockett, George D. Yancopoulos, Lino Tessarollo, and Renping Zhou