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COMMENTARIES

Tomas Ganz

Epithelia: Not just physical barriers
PNAS 2002 99: 3357-3358. [Extract] [Full Text] [PDF]  

Patricia J. Johnson

Spliceosomal introns in a deep-branching eukaryote: The splice of life
PNAS 2002 99: 3359-3361. [Extract] [Full Text] [PDF]  

Edward S. Mocarski, Jr.

Virus self-improvement through inflammation: No pain, no gain
PNAS 2002 99: 3362-3364. [Extract] [Full Text] [PDF]  

Bryan Grenfell

Rivers dam waves of rabies
PNAS 2002 99: 3365-3367. [Extract] [Full Text] [PDF]  

Johan G. de Boer

A new mutator phenotype in breast cancer?
PNAS 2002 99: 3368-3369. [Extract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Alexander Egner, Stefan Jakobs, and Stefan W. Hell

Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast
PNAS 2002 99: 3370-3375. [Abstract] [Full Text] [PDF] [Supporting Movie]  

Chemistry

Xin Xu, Richard P. Muller, and William A. Goddard, III

The gas phase reaction of singlet dioxygen with water: A water-catalyzed mechanism
PNAS 2002 99: 3376-3381; published online before print March 12 2002, 10.1073/pnas.052710099 [Abstract] [Full Text] [PDF]  

Matthias Hochgürtel, Heiko Kroth, Dorothea Piecha, Michael W. Hofmann, Claude Nicolau, Sonja Krause, Otmar Schaaf, Gabriele Sonnenmoser, and Alexey V. Eliseev

Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries
PNAS 2002 99: 3382-3387; published online before print March 12 2002, 10.1073/pnas.052703799 [Abstract] [Full Text] [PDF] [Supporting Schemes]  

Computer Sciences

P. Oscar Boykin, Tal Mor, Vwani Roychowdhury, Farrokh Vatan, and Rutger Vrijen

Algorithmic cooling and scalable NMR quantum computers
PNAS 2002 99: 3388-3393. [Abstract] [Full Text] [PDF] [Supporting Information]  

Engineering

Song Li, Peter Butler, Yingxiao Wang, Yingli Hu, Dong Cho Han, Shunichi Usami, Jun-Lin Guan, and Shu Chien

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells
PNAS 2002 99: 3546-3551; published online before print March 12 2002, 10.1073/pnas.052018099 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Physics

P. Oscar Boykin, Tal Mor, Vwani Roychowdhury, Farrokh Vatan, and Rutger Vrijen

Algorithmic cooling and scalable NMR quantum computers
PNAS 2002 99: 3388-3393. [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Psychology

Thomas J. Palmeri, Randolph Blake, René Marois, Marci A. Flanery, and William Whetsell, Jr.

The perceptual reality of synesthetic colors
PNAS 2002 99: 4127-4131. [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Mahmoud Desouky, Ravin Jugdaohsingh, Catherine R. McCrohan, Keith N. White, and Jonathan J. Powell

Aluminum-dependent regulation of intracellular silicon in the aquatic invertebrate Lymnaea stagnalis
PNAS 2002 99: 3394-3399; published online before print March 12 2002, 10.1073/pnas.062478699 [Abstract] [Full Text] [PDF]  

Philipp Mayer-Kuckuk, Debabrata Banerjee, Sundeep Malhotra, Mikhail Doubrovin, Marian Iwamoto, Tim Akhurst, Julius Balatoni, William Bornmann, Ronald Finn, Steven Larson, Yuman Fong, Juri Gelovani Tjuvajev, Ronald Blasberg, and Joseph R. Bertino

Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression
PNAS 2002 99: 3400-3405; published online before print March 12 2002, 10.1073/pnas.062036899 [Abstract] [Full Text] [PDF]  

Günter Kraus, Rebeca Geffin, Gina Spruill, Andrea K. Young, Rachel Seivright, Diana Cardona, Jennifer Burzawa, and H. James Hnatyszyn

Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences
PNAS 2002 99: 3406-3411. [Abstract] [Full Text] [PDF]  

Biochemistry

Shi-Xian Deng, Narine Bharat, Marian C. Fischman, and Donald W. Landry

Covalent modification of proteins by cocaine
PNAS 2002 99: 3412-3416; published online before print March 12 2002, 10.1073/pnas.042700599 [Abstract] [Full Text] [PDF]  

Stephen M. Prince, Mark Achtman, and Jeremy P. Derrick

Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis
PNAS 2002 99: 3417-3421; published online before print March 12 2002, 10.1073/pnas.062630899 [Abstract] [Full Text] [PDF]  

R. A. Merrill, L. A. Plum, M. E. Kaiser, and M. Clagett-Dame

A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos
PNAS 2002 99: 3422-3427. [Abstract] [Full Text] [PDF]  

Qiulong Huang, Andrew M. Petros, Herbert W. Virgin, Stephen W. Fesik, and Edward T. Olejniczak

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus
PNAS 2002 99: 3428-3433. [Abstract] [Full Text] [PDF]  

Jonathan M. Wojciak, Dibyendu Sarkar, Arthur Landy, and Robert T. Clubb

Arm-site binding by -integrase: Solution structure and functional characterization of its amino-terminal domain
PNAS 2002 99: 3434-3439. [Abstract] [Full Text] [PDF]  

Christopher S. Hayes, Baundauna Bose, and Robert T. Sauer

Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli
PNAS 2002 99: 3440-3445; published online before print March 12 2002, 10.1073/pnas.052707199 [Abstract] [Full Text] [PDF]  

Frank Staubli, Thomas J. D. Jørgensen, Giuseppe Cazzamali, Michael Williamson, Camilla Lenz, Leif Søndergaard, Peter Roepstorff, and Cornelis J. P. Grimmelikhuijzen

Molecular identification of the insect adipokinetic hormone receptors
PNAS 2002 99: 3446-3451. [Abstract] [Full Text] [PDF]  

J. Klein-Seetharaman, P. J. Reeves, M. C. Loewen, E. V. Getmanova, J. Chung, H. Schwalbe, P. E. Wright, and H. G. Khorana

Solution NMR spectroscopy of [-¹⁵N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence
PNAS 2002 99: 3452-3457. [Abstract] [Full Text] [PDF]  

José Antonio Márquez, Sonja Hasenbein, Brigitte Koch, Sonia Fieulaine, Sylvie Nessler, Robert B. Russell, Wolfgang Hengstenberg, and Klaus Scheffzek

Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 Å resolution: Mimicking the product/substrate of the phospho transfer reactions
PNAS 2002 99: 3458-3463. [Abstract] [Full Text] [PDF] [Supporting Information]  

Georg Groth

Structure of spinach chloroplast F₁-ATPase complexed with the phytopathogenic inhibitor tentoxin
PNAS 2002 99: 3464-3468. [Abstract] [Full Text] [PDF]  

Tom Wehrman, Benjamin Kleaveland, Jeng-Horng Her, Robert F. Balint, and Helen M. Blau

Protein-protein interactions monitored in mammalian cells via complementation of -lactamase enzyme fragments
PNAS 2002 99: 3469-3474. [Abstract] [Full Text] [PDF]  

Lan Guan, Franklin D. Murphy, and H. Ronald Kaback

Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking
PNAS 2002 99: 3475-3480. [Abstract] [Full Text] [PDF]  

Michael Graham Espey, Sandhya Xavier, Douglas D. Thomas, Katrina M. Miranda, and David A. Wink

Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms
PNAS 2002 99: 3481-3486. [Abstract] [Full Text] [PDF]  

José Luis Vázquez-Ibar, Adam B. Weinglass, and H. Ronald Kaback

Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer
PNAS 2002 99: 3487-3492. [Abstract] [Full Text] [PDF]  

Laura Tsujikawa, Oleg V. Tsodikov, and Pieter L. deHaseth

Interaction of RNA polymerase with forked DNA: Evidence for two kinetically significant intermediates on the pathway to the final complex
PNAS 2002 99: 3493-3498; published online before print March 12 2002, 10.1073/pnas.062487299 [Abstract] [Full Text] [PDF]  

Haruichi Asahara and Olke C. Uhlenbeck

The tRNA Specificity of Thermus thermophilus EF-Tu
PNAS 2002 99: 3499-3504; published online before print March 12 2002, 10.1073/pnas.052028599 [Abstract] [Full Text] [PDF]  

Maddalena Fratelli, Hans Demol, Magda Puype, Simona Casagrande, Ivano Eberini, Mario Salmona, Valentina Bonetto, Manuela Mengozzi, Francis Duffieux, Emeric Miclet, Angela Bachi, Joel Vandekerckhove, Elisabetta Gianazza, and Pietro Ghezzi

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
PNAS 2002 99: 3505-3510. [Abstract] [Full Text] [PDF]  

Tip W. Loo and David M. Clarke

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site
PNAS 2002 99: 3511-3516; published online before print March 12 2002, 10.1073/pnas.022049799 [Abstract] [Full Text] [PDF]  

G. Sebastiaan Winkler, Arnold Kristjuhan, Hediye Erdjument-Bromage, Paul Tempst, and Jesper Q. Svejstrup

Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo
PNAS 2002 99: 3517-3522. [Abstract] [Full Text] [PDF]  

Tapas K. Hazra, Tadahide Izumi, Istvan Boldogh, Barry Imhoff, Yoke W. Kow, Pawel Jaruga, Miral Dizdaroglu, and Sankar Mitra From the Cover: Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA PNAS 2002 99: 3523-3528. [Abstract] [Full Text] [PDF]

Éva Bálint, Andrew C. Phillips, Serguei Kozlov, Colin L. Stewart, and Karen H. Vousden

Induction of p57^KIP2 expression by p73
PNAS 2002 99: 3529-3534; published online before print March 12 2002, 10.1073/pnas.062491899 [Abstract] [Full Text] [PDF]  

Biophysics

Dmitrii E. Makarov, Craig A. Keller, Kevin W. Plaxco, and Horia Metiu

How the folding rate constant of simple, single-domain proteins depends on the number of native contacts
PNAS 2002 99: 3535-3539. [Abstract] [Full Text] [PDF]  

A. J. Rader, Brandon M. Hespenheide, Leslie A. Kuhn, and M. F. Thorpe

Protein unfolding: Rigidity lost
PNAS 2002 99: 3540-3545; published online before print March 12 2002, 10.1073/pnas.062492699 [Abstract] [Full Text] [PDF] [Supporting Information]  

Song Li, Peter Butler, Yingxiao Wang, Yingli Hu, Dong Cho Han, Shunichi Usami, Jun-Lin Guan, and Shu Chien

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells
PNAS 2002 99: 3546-3551; published online before print March 12 2002, 10.1073/pnas.052018099 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Igor Goychuk and Peter Hänggi

Ion channel gating: A first-passage time analysis of the Kramers type
PNAS 2002 99: 3552-3556; published online before print March 12 2002, 10.1073/pnas.052015699 [Abstract] [Full Text] [PDF]  

Jan Köhler, Gerhard Winkler, Imke Schulte, Tim Scholz, William McKenna, Bernhard Brenner, and Theresia Kraft

Mutation of the myosin converter domain alters cross-bridge elasticity
PNAS 2002 99: 3557-3562. [Abstract] [Full Text] [PDF]  

Holger Wille, Melissa D. Michelitsch, Vincent Guénebaut, Surachai Supattapone, Ana Serban, Fred E. Cohen, David A. Agard, and Stanley B. Prusiner

Structural studies of the scrapie prion protein by electron crystallography
PNAS 2002 99: 3563-3568. [Abstract] [Full Text] [PDF]  

Huan-Xiang Zhou

A Gaussian-chain model for treating residual charge-charge interactions in the unfolded state of proteins
PNAS 2002 99: 3569-3574; published online before print March 12 2002, 10.1073/pnas.052030599 [Abstract] [Full Text] [PDF]  

Ioan Kosztin, Robijn Bruinsma, Paul O'Lague, and Klaus Schulten

Mechanical force generation by G proteins
PNAS 2002 99: 3575-3580. [Abstract] [Full Text] [PDF]  

Chao Zhang, Jingtong Hou, and Sung-Hou Kim

Fold prediction of helical proteins using torsion angle dynamics and predicted restraints
PNAS 2002 99: 3581-3585. [Abstract] [Full Text] [PDF]  

Cell Biology

Rachel B. Cervantes, James R. Stringer, Changshun Shao, Jay A. Tischfield, and Peter J. Stambrook

Embryonic stem cells and somatic cells differ in mutation frequency and type
PNAS 2002 99: 3586-3590; published online before print March 12 2002, 10.1073/pnas.062527199 [Abstract] [Full Text] [PDF]  

Karen S. Hathcock, Michael T. Hemann, Kay Keyer Opperman, Margaret A. Strong, Carol W. Greider, and Richard J. Hodes

Haploinsufficiency of mTR results in defects in telomere elongation
PNAS 2002 99: 3591-3596. [Abstract] [Full Text] [PDF]  

Yie Liu, Hue Kha, Mark Ungrin, Murray O. Robinson, and Lea Harrington

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
PNAS 2002 99: 3597-3602. [Abstract] [Full Text] [PDF]  

Michael Hannigan, Lijun Zhan, Zhong Li, Youxi Ai, Dianqing Wu, and Chi-Kuang Huang

Neutrophils lacking phosphoinositide 3-kinase show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
PNAS 2002 99: 3603-3608. [Abstract] [Full Text] [PDF] [Supporting Movies]  

Naoki Itano, Fukiko Atsumi, Takahiro Sawai, Yoichi Yamada, Osamu Miyaishi, Takeshi Senga, Michinari Hamaguchi, and Koji Kimata

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration
PNAS 2002 99: 3609-3614; published online before print March 12 2002, 10.1073/pnas.052026799 [Abstract] [Full Text] [PDF]  

Luca Roz, Marcella Gramegna, Hideshi Ishii, Carlo M. Croce, and Gabriella Sozzi

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines
PNAS 2002 99: 3615-3620; published online before print March 12 2002, 10.1073/pnas.062030799 [Abstract] [Full Text] [PDF]  

S. Rashkova, S. E. Karam, and M.-L. Pardue

Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm
PNAS 2002 99: 3621-3626; published online before print March 12 2002, 10.1073/pnas.032071999 [Abstract] [Full Text] [PDF]  

Jean McArthur Lewis, Tony Nguyen Truong, and Martin Alexander Schwartz

Integrins regulate the apoptotic response to DNA damage through modulation of p53
PNAS 2002 99: 3627-3632. [Abstract] [Full Text] [PDF]  

C. B. Shuster and D. R. Burgess

Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis
PNAS 2002 99: 3633-3638; published online before print March 12 2002, 10.1073/pnas.052342699 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Jean-Etienne Allain, Ibrahim Dagher, Dominique Mahieu-Caputo, Nathalie Loux, Marion Andreoletti, Karen Westerman, Pascale Briand, Dominique Franco, Philippe Leboulch, and Anne Weber

Immortalization of a primate bipotent epithelial liver stem cell
PNAS 2002 99: 3639-3644. [Abstract] [Full Text] [PDF]  

Mohammed Bendahmane, Judit Szécsi, Iju Chen, R. Howard Berg, and Roger N. Beachy

Characterization of mutant tobacco mosaic virus coat protein that interferes with virus cell-to-cell movement
PNAS 2002 99: 3645-3650; published online before print March 12 2002, 10.1073/pnas.062041499 [Abstract] [Full Text] [PDF]  

Developmental Biology

Zhennan Lai, Ina Han, Misun Park, and Roscoe O. Brady

Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cells
PNAS 2002 99: 3651-3656; published online before print March 12 2002, 10.1073/pnas.062032499 [Abstract] [Full Text] [PDF]  

Seiji Takashima, Masafumi Kitakaze, Masanori Asakura, Hiroshi Asanuma, Shoji Sanada, Fumi Tashiro, Hitoshi Niwa, Jun-ichi Miyazaki, Seiichi Hirota, Yukihiko Kitamura, Takashi Kitsukawa, Hajime Fujisawa, Michael Klagsbrun, and Masatsugu Hori

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
PNAS 2002 99: 3657-3662; published online before print March 12 2002, 10.1073/pnas.022017899 [Abstract] [Full Text] [PDF]  

Ying Guo, Robert Costa, Heather Ramsey, Trevor Starnes, Gail Vance, Kent Robertson, Mark Kelley, Rolland Reinbold, Hans Scholer, and Robert Hromas

The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression
PNAS 2002 99: 3663-3667; published online before print March 12 2002, 10.1073/pnas.062041099 [Abstract] [Full Text] [PDF]  

Ecology

David W. Steadman, Gregory K. Pregill, and David V. Burley

Rapid prehistoric extinction of iguanas and birds in Polynesia
PNAS 2002 99: 3673-3677. [Abstract] [Full Text] [PDF]  

Enric Sala and Michael H. Graham From the Cover: Community-wide distribution of predator-prey interaction strength in kelp forests PNAS 2002 99: 3678-3683; published online before print March 12 2002, 10.1073/pnas.052028499 [Abstract] [Full Text] [PDF]

Evolution

R. Brosch, S. V. Gordon, M. Marmiesse, P. Brodin, C. Buchrieser, K. Eiglmeier, T. Garnier, C. Gutierrez, G. Hewinson, K. Kremer, L. M. Parsons, A. S. Pym, S. Samper, D. van Soolingen, and S. T. Cole

A new evolutionary scenario for the Mycobacterium tuberculosis complex
PNAS 2002 99: 3684-3689; published online before print March 12 2002, 10.1073/pnas.052548299 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Douglas R. Taylor, Clifford Zeyl, and Erin Cooke

Conflicting levels of selection in the accumulation of mitochondrial defects in Saccharomyces cerevisiae
PNAS 2002 99: 3690-3694; published online before print March 12 2002, 10.1073/pnas.072660299 [Abstract] [Full Text] [PDF]  

Hiroshi Akashi and Takashi Gojobori

Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis
PNAS 2002 99: 3695-3700. [Abstract] [Full Text] [PDF] [Supporting Information]  

Julie E. J. Nixon, Amy Wang, Hilary G. Morrison, Andrew G. McArthur, Mitchell L. Sogin, Brendan J. Loftus, and John Samuelson From the Cover: A spliceosomal intron in Giardia lamblia PNAS 2002 99: 3701-3705; published online before print February 19 2002, 10.1073/pnas.042700299 [Abstract] [Full Text] [PDF]

John Alroy

How many named species are valid?
PNAS 2002 99: 3706-3711; published online before print March 12 2002, 10.1073/pnas.062691099 [Abstract] [Full Text] [PDF]  

Genetics

Robert H. Waterston, Eric S. Lander, and John E. Sulston

On the sequencing of the human genome
PNAS 2002 99: 3712-3716; published online before print March 5 2002, 10.1073/pnas.042692499 [Abstract] [Full Text] [PDF]  

Hui Liu, Simon C. Heath, Christina Sobin, J. Louw Roos, Brandi L. Galke, Maude L. Blundell, Marge Lenane, Brian Robertson, Ellen M. Wijsman, Judith L. Rapoport, Joseph A. Gogos, and Maria Karayiorgou

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia
PNAS 2002 99: 3717-3722; published online before print March 12 2002, 10.1073/pnas.042700699 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Appendix]  

Ji-Long Chen, Kathryn L. Huisinga, Michaela M. Viering, Sharon A. Ou, C.-ting Wu, and Pamela K. Geyer

Enhancer action in trans is permitted throughout the Drosophila genome
PNAS 2002 99: 3723-3728. [Abstract] [Full Text] [PDF]  

Bernice Porjesz, Laura Almasy, Howard J. Edenberg, Kongming Wang, David B. Chorlian, Tatiana Foroud, Alison Goate, John P. Rice, Sean J. O'Connor, John Rohrbaugh, Samuel Kuperman, Lance O. Bauer, Raymond R. Crowe, Marc A. Schuckit, Victor Hesselbrock, P. Michael Conneally, Jay A. Tischfield, Ting-Kai Li, Theodore Reich, and Henri Begleiter

Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus
PNAS 2002 99: 3729-3733; published online before print March 12 2002, 10.1073/pnas.052716399 [Abstract] [Full Text] [PDF]  

Yuhua Shang, Xiaoyuan Song, Josephine Bowen, Robert Corstanje, Yan Gao, Jacek Gaertig, and Martin A. Gorovsky

A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila
PNAS 2002 99: 3734-3739; published online before print March 12 2002, 10.1073/pnas.052016199 [Abstract] [Full Text] [PDF]  

Daiya Takai and Peter A. Jones

Comprehensive analysis of CpG islands in human chromosomes 21 and 22
PNAS 2002 99: 3740-3745; published online before print March 12 2002, 10.1073/pnas.052410099 [Abstract] [Full Text] [PDF]  

Xiaolan Zhao and Rodney Rothstein

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1
PNAS 2002 99: 3746-3751. [Abstract] [Full Text] [PDF]  

Annabel Guichard, Shaila Srinivasan, Georgianna Zimm, and Ethan Bier

A screen for dominant mutations applied to components in the Drosophila EGF-R pathway
PNAS 2002 99: 3752-3757. [Abstract] [Full Text] [PDF]  

Chris Allen, Akihiro Kurimasa, Mark A. Brenneman, David J. Chen, and Jac A. Nickoloff

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
PNAS 2002 99: 3758-3763. [Abstract] [Full Text] [PDF]  

Sharon Avkin, Sheera Adar, Gil Blander, and Zvi Livneh

Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase
PNAS 2002 99: 3764-3769; published online before print March 12 2002, 10.1073/pnas.062038699 [Abstract] [Full Text] [PDF]  

Shiquan Liu, Wenjing Liu, John L. Jakubczak, Gregory L. Erexson, Kenneth R. Tindall, Richard Chan, William J. Muller, Sankar Adhya, Susan Garges, and Glenn Merlino

Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis
PNAS 2002 99: 3770-3775; published online before print February 26 2002, 10.1073/pnas.052710299 [Abstract] [Full Text] [PDF]  

Immunology

Fabio Facchetti, Marina Cella, Silvana Festa, Daved H. Fremont, and Marco Colonna

An unusual Fc receptor-related protein expressed in human centroblasts
PNAS 2002 99: 3776-3781; published online before print March 12 2002, 10.1073/pnas.022042699 [Abstract] [Full Text] [PDF]  

David H. Wagner, Jr., Gisela Vaitaitis, Richard Sanderson, Michelle Poulin, Cathleen Dobbs, and Kathryn Haskins

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes
PNAS 2002 99: 3782-3787; published online before print March 12 2002, 10.1073/pnas.052247099 [Abstract] [Full Text] [PDF]  

Diana Bellavia, Antonio F. Campese, Saula Checquolo, Anna Balestri, Andrea Biondi, Giovanni Cazzaniga, Urban Lendahl, Hans J. Fehling, Adrian C. Hayday, Luigi Frati, Harald von Boehmer, Alberto Gulino, and Isabella Screpanti

Combined expression of pT and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
PNAS 2002 99: 3788-3793; published online before print March 12 2002, 10.1073/pnas.062050599 [Abstract] [Full Text] [PDF]  

Navin Rao, Sachiko Miyake, Alagarsamy Lakku Reddi, Patrice Douillard, Amiya K. Ghosh, Ingrid L. Dodge, Pengcheng Zhou, Norvin D. Fernandes, and Hamid Band

Negative regulation of Lck by Cbl ubiquitin ligase
PNAS 2002 99: 3794-3799. [Abstract] [Full Text] [PDF]  

Takao Kodera, Tracy L. McGaha, Robert Phelps, William E. Paul, and Constantin A. Bona

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF- production by fibroblasts
PNAS 2002 99: 3800-3805; published online before print March 12 2002, 10.1073/pnas.052709999 [Abstract] [Full Text] [PDF]  

Medical Sciences

Sutisak Kitareewan, Ian Pitha-Rowe, David Sekula, Christopher H. Lowrey, Michael J. Nemeth, Todd R. Golub, Sarah J. Freemantle, and Ethan Dmitrovsky

UBE1L is a retinoid target that triggers PML/RAR degradation and apoptosis in acute promyelocytic leukemia
PNAS 2002 99: 3806-3811; published online before print March 12 2002, 10.1073/pnas.052011299 [Abstract] [Full Text] [PDF]  

Patrick J. Bosque, Chongsuk Ryou, Glenn Telling, David Peretz, Giuseppe Legname, Stephen J. DeArmond, and Stanley B. Prusiner

Prions in skeletal muscle
PNAS 2002 99: 3812-3817. [Abstract] [Full Text] [PDF]  

David Q. Shih, Markus Heimesaat, Satoru Kuwajima, Roland Stein, Christopher V. E. Wright, and Markus Stoffel

Profound defects in pancreatic -cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1, and Hnf-3
PNAS 2002 99: 3818-3823. [Abstract] [Full Text] [PDF] [Supporting Tables]  

Meng Yang, Eugene Baranov, Jin-Wei Wang, Ping Jiang, Xiaoen Wang, Fang-Xian Sun, Michael Bouvet, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman

Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model
PNAS 2002 99: 3824-3829; published online before print March 12 2002, 10.1073/pnas.052029099 [Abstract] [Full Text] [PDF]  

Thorsten Berg, Steven B. Cohen, Joel Desharnais, Corinna Sonderegger, Daniel J. Maslyar, Joel Goldberg, Dale L. Boger, and Peter K. Vogt

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
PNAS 2002 99: 3830-3835; published online before print March 12 2002, 10.1073/pnas.062036999 [Abstract] [Full Text] [PDF]  

Ana M. Bajo, Andrew V. Schally, Magdalena Krupa, Francine Hebert, Kate Groot, and Karoly Szepeshazi

Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes
PNAS 2002 99: 3836-3841; published online before print March 12 2002, 10.1073/pnas.052715299 [Abstract] [Full Text] [PDF]  

Silvia C. Finnemann, Lawrence W. Leung, and Enrique Rodriguez-Boulan

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium
PNAS 2002 99: 3842-3847. [Abstract] [Full Text] [PDF] [Supporting Figure]  

Robyn N. McKeller, Jennifer L. Fowler, Justine J. Cunningham, Nikita Warner, Richard J. Smeyne, Frederique Zindy, and Stephen X. Skapek

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development
PNAS 2002 99: 3848-3853; published online before print March 12 2002, 10.1073/pnas.052484199 [Abstract] [Full Text] [PDF]  

Peter Chu, Dieter Deforce, Irene M. Pedersen, Youngsoo Kim, Shinichi Kitada, John C. Reed, and Thomas J. Kipps

Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia
PNAS 2002 99: 3854-3859; published online before print March 12 2002, 10.1073/pnas.022604399 [Abstract] [Full Text] [PDF]  

Dror I. Baruch, Benoit Gamain, John W. Barnwell, JoAnn S. Sullivan, Anthony Stowers, G. Gale Galland, Louis H. Miller, and William E. Collins

Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line
PNAS 2002 99: 3860-3865. [Abstract] [Full Text] [PDF]  

Tetsuo Minamino, Toshiaki Yujiri, Naohiro Terada, George E. Taffet, Lloyd H. Michael, Gary L. Johnson, and Michael D. Schneider

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq
PNAS 2002 99: 3866-3871; published online before print March 12 2002, 10.1073/pnas.062453699 [Abstract] [Full Text] [PDF]  

Robin A. Felder, Hironobu Sanada, Jing Xu, Pei-Ying Yu, Zheng Wang, Hidetsuna Watanabe, Laureano D. Asico, Wei Wang, Shaopeng Zheng, Ikuyo Yamaguchi, Scott M. Williams, James Gainer, Nancy J. Brown, Debra Hazen-Martin, Lee-Jun C. Wong, Jean E. Robillard, Robert M. Carey, Gilbert M. Eisner, and Pedro A. Jose

G protein-coupled receptor kinase 4 gene variants in human essential hypertension
PNAS 2002 99: 3872-3877. [Abstract] [Full Text] [PDF]  

Mohammed Kashani-Sabet, Yong Liu, Sylvia Fong, Pierre-Yves Desprez, Shuqing Liu, Guanghuan Tu, Mehdi Nosrati, Chakkrapong Handumrongkul, Denny Liggitt, Ann D. Thor, and Robert J. Debs

Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice
PNAS 2002 99: 3878-3883; published online before print March 12 2002, 10.1073/pnas.002025599 [Abstract] [Full Text] [PDF]  

Lynda Elghazi, Corentin Cras-Méneur, Paul Czernichow, and Raphael Scharfmann

Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation
PNAS 2002 99: 3884-3889; published online before print March 12 2002, 10.1073/pnas.062321799 [Abstract] [Full Text] [PDF]  

Julie Wells, Carrie R. Graveel, Stephanie M. Bartley, Steven J. Madore, and Peggy J. Farnham

The identification of E2F1-specific target genes
PNAS 2002 99: 3890-3895. [Abstract] [Full Text] [PDF]  

Juan Mucci, Alejandra Hidalgo, Esteban Mocetti, Pablo F. Argibay, M. Susana Leguizamón, and Oscar Campetella

Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex
PNAS 2002 99: 3896-3901; published online before print March 12 2002, 10.1073/pnas.052496399 [Abstract] [Full Text] [PDF]  

Geraldine Canny, Ofer Levy, Glenn T. Furuta, Sailaja Narravula-Alipati, Richard B. Sisson, Charles N. Serhan, and Sean P. Colgan

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia
PNAS 2002 99: 3902-3907; published online before print March 12 2002, 10.1073/pnas.052533799 [Abstract] [Full Text] [PDF]  

Chunming Dong, Shoukang Zhu, Tao Wang, Woohyun Yoon, Zhiru Li, Rene J. Alvarez, Peter ten Dijke, Barbara White, Fredrick M. Wigley, and Pascal J. Goldschmidt-Clermont

Deficient Smad7 expression: A putative molecular defect in scleroderma
PNAS 2002 99: 3908-3913. [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jin Huang, Fred J. DeGraves, Stephen D. Lenz, Dongya Gao, Pu Feng, Dan Li, Tobias Schlapp, and Bernhard Kaltenboeck

The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease
PNAS 2002 99: 3914-3919. [Abstract] [Full Text] [PDF] [Supporting Figures]  

Microbiology

Kaman Chan, Timothy Knaak, Laura Satkamp, Olivier Humbert, Stanley Falkow, and Lalita Ramakrishnan

Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection
PNAS 2002 99: 3920-3925; published online before print March 12 2002, 10.1073/pnas.002024599 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eric Soupene, Haidy Lee, and Sydney Kustu

Ammonium/methylammonium transport (Amt) proteins facilitate diffusion of NH₃ bidirectionally
PNAS 2002 99: 3926-3931; published online before print March 12 2002, 10.1073/pnas.062043799 [Abstract] [Full Text] [PDF]  

Hua Zhu, Jian-Ping Cong, Deborah Yu, Wade A. Bresnahan, and Thomas E. Shenk From the Cover: Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication PNAS 2002 99: 3932-3937; published online before print February 26 2002, 10.1073/pnas.052713799 [Abstract] [Full Text] [PDF]

Gordon R. O. Campbell, Bradley L. Reuhs, and Graham C. Walker

Chronic intracellular infection of alfalfa nodules by Sinorhizobium meliloti requires correct lipopolysaccharide core
PNAS 2002 99: 3938-3943. [Abstract] [Full Text] [PDF]  

Lisa Z. Scheifele, Rachel A. Garbitt, Jonathan D. Rhoads, and Leslie J. Parent

Nuclear entry and CRM1-dependent nuclear export of the Rous sarcoma virus Gag polyprotein
PNAS 2002 99: 3944-3949; published online before print March 12 2002, 10.1073/pnas.062652199 [Abstract] [Full Text] [PDF]  

Neurobiology

Eleonora Palma, Anna M. Mileo, Ataúlfo Martínez-Torres, Fabrizio Eusebi, and Ricardo Miledi

Some properties of human neuronal 7 nicotinic acetylcholine receptors fused to the green fluorescent protein
PNAS 2002 99: 3950-3955; published online before print March 12 2002, 10.1073/pnas.052699299 [Abstract] [Full Text] [PDF]  

Sergio Fucile, Eleonora Palma, Ataúlfo Martínez-Torres, Ricardo Miledi, and Fabrizio Eusebi

The single-channel properties of human acetylcholine 7 receptors are altered by fusing 7 to the green fluorescent protein
PNAS 2002 99: 3956-3961; published online before print March 12 2002, 10.1073/pnas.052699599 [Abstract] [Full Text] [PDF]  

Serena M. Dudek and R. Douglas Fields

Somatic action potentials are sufficient for late-phase LTP-related cell signaling
PNAS 2002 99: 3962-3967; published online before print March 12 2002, 10.1073/pnas.062510599 [Abstract] [Full Text] [PDF]  

Ofer Wiser, Roy Cohen, and Daphne Atlas

Ionic dependence of Ca²⁺ channel modulation by syntaxin 1A
PNAS 2002 99: 3968-3973; published online before print March 12 2002, 10.1073/pnas.052017299 [Abstract] [Full Text] [PDF]  

Shu-ichi Okamoto, Zhen Li, Chung Ju, Marion N. Schölzke, Emily Mathews, Jiankun Cui, Guy S. Salvesen, Ella Bossy-Wetzel, and Stuart A. Lipton

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis
PNAS 2002 99: 3974-3979. [Abstract] [Full Text] [PDF]  

C. K. Abrams, M. V. L. Bennett, V. K. Verselis, and T. A. Bargiello

Voltage opens unopposed gap junction hemichannels formed by a connexin 32 mutant associated with X-linked Charcot-Marie-Tooth disease
PNAS 2002 99: 3980-3984; published online before print March 12 2002, 10.1073/pnas.261713499 [Abstract] [Full Text] [PDF]  

Beatriz Morte, Jimena Manzano, Thomas Scanlan, Björn Vennström, and Juan Bernal

Deletion of the thyroid hormone receptor 1 prevents the structural alterations of the cerebellum induced by hypothyroidism
PNAS 2002 99: 3985-3989; published online before print March 12 2002, 10.1073/pnas.062413299 [Abstract] [Full Text] [PDF]