Table 1. Summary of DNA sequences with methylation changes identified by AIMS in MZ twin pairs
CpG methylation,* %
Locus Accession Function Chr. loc. No. CpGs Twin A Twin B Change
Alu-Sx AC006271 19p13.2 30 72.1 55.3 16.8
Alu-Sp U14572 19p13+3 17 68.1 29.9 38.2
Alu-E2F3 AF547386 6p22 2 81.8 100 18.2
PKD1P2 NG_002795 Polycystic kidney disease 1 16p13 7 90.9 83.5 7.4
Alu-Sc U14571 8p11+1 4 66.6 63.3 3.3
GUK1 BC006249 Guanylate kinase 1 1q42 18 2.8 9.7 6.9
  • Chr. loc., chromosome location; –, unknown.

  • * Twelve clones per locus