Table 1.

Body weight and plasma parameters in WT and FGF21-KO mice

ParameterFed
Fasted
WTFGF21-KOWTFGF21-KO
Body weight, g21.2 ± 2.1421.0 ± 2.5620.3 ± 2.2019.8 ± 1.28
Glucose, mg/dL140 ± 8.94136 ± 11.476.4 ± 2.6464.1 ± 1.90**
β-Hydroxybutyrate, μM35.9 ± 6.5824.5 ± 8.23*857 ± 93.1792 ± 125
NEFA, meq/L0.627 ± 0.0630.624 ± 0.0603.07 ± 0.1723.96 ± 0.294
Insulin, ng/mL0.467 ± 0.1070.440 ± 0.1610.163 ± 0.0890.115 ± 0.056
Glucagon, pg/ml40.0 ± 7.9639.1 ± 6.10102 ± 13.9105 ± 14.7
Triglyceride, mg/dL140 ± 4.11135 ± 15.642.7 ± 6.1752.3 ± 14.1
  • *, P < 0.05;

  • **, P < 0.01.