Table 1.

Secondary products of nicotine heterogeneous nitrosation by HONO.

Product no.Product nameProduct structurem/zYield %*
Gas-phase products1FormaldehydeFormulaN/A< 0.05
2N-nitroso-pyrrolidineFormula100, 70, 68< 0.05
3Methyl 3-pyridinecarboxylate (Methyl nicotinate)Formula137, 106, 78< 0.05
4N-methylnicotinamideFormula136, 106, 780.1
Cellulose-sorbed species54-(N-methyl-N-nitrosamino)-2-oxi-mino-1-(3-pyridyl)-1-butanoneFormula219, 106, 130, 165, 78< 0.05
61-methyl-5-pyridin-3-yl-pyrrolidin-2-one (Cotinine)Formula176, 118, 980.3
71-methyl-5-(3 pyridinyl) pyrazoleFormula159, 158, 130, 118, 104, 780.8
  • *Yields were determined on the basis of the ratio of peak areas of each product over nicotine.

  • Formaldehyde was determined by dinitrophenylhydrazine derivatization and HPLC analysis with UV detection.