Table 1.

IgA and IgG isotypes of anti-PR3 antibodies are present in patients with GPA

ControlsWGGERVCRC
IgA positive only1 (1%)12 (3.6%)45 (17.1%)
IgG positive only1 (1%)151 (45.1%)80 (30.4%)
IgA and IgG positive0 (0%)49 (14.6%)56 (21.3%)
Negative97 (98%)123 (36.7%)82 (31.2%)
Total99335263
  • Data were obtained by ELISA. Of the 463 Caucasian patients with GPA in WGGER, 335 had single samples available. Patients from the VCRC cohort typically contributed multiple samples (263 participants, 1,470 samples), and a patient was counted as positive if any sample tested positive. Healthy controls were assayed to determine a threshold for positivity, as described in Methods.