Table 2.

Biophysical properties of A1304T channels in mouse DRG

ActivationSteady-state fast inactivationSlow inactivation
NaV1.8Reversal potential, mVV1/2,actknV1/2,fastkA%nV1/2,slowkA%n
WT62.6 ± 2.0−17.2 ± 2.2−5.7 ± 0.611−37.2 ± 2.25.7 ± 0.35.1 ± 0.713−52.1 ± 1.58.1 ± 0.67.2 ± 1.913
A1304T58.0 ± 2.1−23.0 ± 1.7*−4.1 ± 0.4*13−37.1 ± 1.05.3 ± 0.24.5 ± 0.814−52.8 ± 1.47.4 ± 0.43.3 ± 0.912