Table 1.

Biophysical properties of L554P channels in mouse DRG neurons

ActivationSteady-state fast inactivationSlow inactivation
NaV1.8Reversal potential, mVV1/2,actknV1/2,fastkA%nV1/2,slowkA%n
WT59.1 ± 0.7−9.8 ± 1.4−7.47 ± 0.3227−35.3 ± 1.27.07 ± 0.286.69 ± 0.5627−49.6 ± 1.19.64 ± 0.474.25 ± 0.8410
L554P60.2 ± 0.6−11.6 ± 1.6−6.95 ± 0.3725−33.6 ± 1.06.61 ± 0.306.80 ± 0.9624−49.7 ± 1.49.62 ± 0.403.06 ± 0.6712