Table 1.

Elimination half-life (t1/2) and plasma exposure (AUC0−t) for (−)-H-2, (+)-H-2, (−)-D-2, and (+)-D-2 (h−, h+, d−, and d+) in female CB.17 SCID mice orally administered protonated racemate, rac-H-2 (30 mg/kg), or deuterated enantiomers (−)-D-2 and (+)-D-2 (15 mg/kg each)

Compound dosedEnantiomer observed
(−)-H-2(+)-H-2(−)-D-2(+)-D-2
t1/2 (h)AUC (ng⋅h/mL)t1/2 (h)AUC (ng⋅h/mL)t1/2 (h)AUC (ng⋅h/mL)t1/2 (h)AUC (ng⋅h/mL)
rac-H-2 (30 mg/kg)2.122,5002.035,900
(−)-D-2 (15 mg/kg)1.26,160N/A1,1801.244,100N/A898
(+)-D-2 (15 mg/kg)N/A9931.06,120N/A6611.163,600
  • N/A, not applicable.