Table 2.

Transmission of α-synuclein prions to TgM83+/− mice

InoculumPrimary transmission
SampleBrain regionα-Synuclein inclusion density (per mm2)Total α-synuclein (μg/mL)Mean cell infection ± SEM (%)Mean incubation time ± SEM (d)n/n0Mean cell infection ± SEM (%)
GCIsLewy bodies
C1FC003.07 ± 1>3600/82 ± 0
PD1FC0*1.97 ± 3>3600/82 ± 1
PD2FC0*2.33 ± 1>3600/72 ± 0
PD3SN03.31.60> 2430/8ND
PD5SN03.02.46 ± 0> 2080/7ND
PD6SN07.30.615 ± 1> 2080/4ND
PD7SN06.81.510 ± 1> 2080/6ND
MSA1BG6904.211 ± 1143 ± 17§7/829 ± 4
MSA2BG8203.630 ± 1109 ± 12§7/731 ± 3
SN990NDND119 ± 107/721 ± 2
MSA3BG6902.542 ± 2114 ± 145/530 ± 2
SN2000.324 ± 2119 ± 107/724 ± 2
MSA4BG5400.425 ± 4135 ± 138/847 ± 3
SN250ND19 ± 5134 ± 78/833 ± 2
MSA5BG20000.647 ± 2119 ± 128/845 ± 3
MSA6BG5001.620 ± 3108 ± 108/843 ± 3
SNNDND0.140 ± 3106 ± 76/639 ± 3
MSA7BG2904.348 ± 1106 ± 108/824 ± 1
SN2100.258 ± 3122 ± 108/836 ± 4
MSA8P2200.331 ± 1108 ± 156/633 ± 1
MSA9P3.300.824 ± 1121 ± 87/714 ± 1
MSA10P1300.936 ± 1108 ± 86/642 ± 2
MSA11P1200.823 ± 2144 ± 166/637 ± 3
MSA12SN13300.829 ± 1117 ± 108/851 ± 3
MSA13SN12700.840 ± 2113 ± 98/841 ± 3
MSA14SN1700.923 ± 1130 ± 126/645 ± 2
  • BG, basal ganglia; FC, frontal cortex; n, number of ill mice; n0, number of inoculated mice; ND, not determined; P, pons; SN, substantia nigra.

  • * A single Lewy body was found in the entire section.

  • Average value from two alternate age-matched control samples.

  • Experiments ongoing.

  • § Data previously reported in ref. 13.

  • Data previously reported in ref. 14.