Table 3.

Effect of transgene and serial transmission on incubation period

Inoculum (brain region)Mouse linePrimary transmissionIncubation time of mouse brain inoculated (d)Secondary transmission in M83+/−
Mean incubation time ± SEM (d)n/n0Mean incubation time ± SEM (d)n/n0
No inoculumTgM83+/−>4120/6259>3600/6
Tg(SNCA) Snca0/0>5800/9ND
TgM83+/−143 ± 17*7/8105113 ± 135/5
MSA1 (basal ganglia)WT>3600/7ND
Tg(SNCA) Snca0/0>3600/6ND
TgM83+/−109 ± 12*7/79192 ± 56/6
MSA2 (basal ganglia)WT>3600/2ND
Tg(SNCA) Snca0/0>3600/5ND
9 m.o. spont. TgM83+/+ (whole brain)TgM83+/−222 ± 15*6/6205193 ± 198/8
11 m.o. spont. TgM83+/+ (whole brain)TgM83+/−216 ± 18*8/8162175 ± 88/8
  • n, number of ill mice; n0, number of inoculated mice; ND, not determined.

  • * Data previously reported in ref. 13.

  • Data previously reported in ref. 14.