Table 2.

Haplotype frequencies in PWC

GWAsReplicationPopulation
HaplotypeAffectedUnaffectedAffectedUnaffectedUnknown
(n = 15)(n = 35)(n = 32)(n = 13)(n = 273)
GCAAA0.570.970.780.850.79
ATGGT0.330.010.190.040.14
GCGGT0.070.010.020.040.04
ACAAA0.030.000.020.040.02
  • The four haplotypes present in PWC, and their frequencies across the GWA and replication datasets, as well as the population estimate based on unphenotyped PWC, are shown. Haplotypes were constructed by phasing genotype data for the variants at cfa25:45,435,040, cfa25:45,437,568, cfa25:45,443,320, cfa25:45,445,891, and cfa25:45,447,628 using PHASE (62, 63).