Table 2.

Biochemical pathway abnormalities in CFS, males

No.Pathway nameMeasured metabolites in the pathway, NExpected pathway proportion, P = N/431Expected hits in sample of 61, P * 61Observed hits in the top 61 metabolitesFold enrichment, obs/expImpact, sum VIP scoreFraction of impact explained, % of 114.7IncreasedDecreased
1Sphingolipids720.16710.2302.955.749%030
2Phospholipids760.17610.890.818.016%27
3P5C, Arg, Ornithine, Pro60.0140.844.77.57%31
4Glycosphingolipids130.0301.831.67.26%03
5Cholesterol, nongonadal steroids150.0352.131.45.04%03
6Branch chain amino acids100.0231.432.14.94%03
7Purines190.0442.720.73.33%02
8Microbiome metabolism200.0462.810.42.12%01
9Vitamin B2 (riboflavin)20.0050.313.52.12%01
10Serine, 1-carbon metabolism50.0120.711.41.92%10
11SAM, SAH, methionine, glutathione130.0301.810.51.92%10
12Very long chain fatty acid oxidation20.0050.313.51.82%01
13Propiogenic amino acids20.0050.313.51.61%01
14Threonine metabolism40.0090.611.81.61%10
Subtotal853
Total61