The 50 Most-Frequently Cited Articles in PNAS

The 50 Most-Frequently Cited Articles
in PNAS as of April 1, 2008 -- updated monthly

Most-cited rankings are recalculated at the beginning of the month.
Rankings are based on citations to articles on this journal site from articles in HighWire-hosted journals.

1. F. Sanger, S. Nicklen, A. R. Coulson
DNA Sequencing with Chain-Terminating Inhibitors
Proc. Natl. Acad. Sci. USA Dec 15, 1977; 74: 5463-5467.
(In "Journal_Article")   [Abstract]     [PDF]

2. Harry Towbin, Theophil Staehelin, Julian Gordon
Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications
Proc. Natl. Acad. Sci. USA Sep 15, 1979; 76: 4350-4354.
(In "Journal_Article")   [Abstract]     [PDF]

3. Michael B. Eisen, Paul T. Spellman, Patrick O. Brown, David Botstein
Cluster analysis and display of genome-wide expression patterns
Proc. Natl. Acad. Sci. USA Dec 08, 1998; 95: 14863-14868.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

4. William R. Pearson, David J. Lipman
Improved Tools for Biological Sequence Comparison
Proc. Natl. Acad. Sci. USA Apr 15, 1988; 85: 2444-2448.
(In "Journal_Article")   [Abstract]     [PDF]

5. George M. Church, Walter Gilbert
Genomic Sequencing
Proc. Natl. Acad. Sci. USA Apr 01, 1984; 81: 1991-1995.
(In "Journal_Article")   [Abstract]     [PDF]

6. Virginia Goss Tusher, Robert Tibshirani, Gilbert Chu
Significance analysis of microarrays applied to the ionizing radiation response
Proc. Natl. Acad. Sci. USA Apr 24, 2001; 98: 5116-5121.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

7. Thomas A. Kunkel
Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection
Proc. Natl. Acad. Sci. USA Jan 15, 1985; 82: 488-492.
(In "Journal_Article")   [Abstract]     [PDF]

8. Kirill A. Datsenko, Barry L. Wanner
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
Proc. Natl. Acad. Sci. USA Jun 06, 2000; 97: 6640-6645.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

9. Tong-Chuan He, Shibin Zhou, Luis T. da Costa, Jian Yu, Kenneth W. Kinzler, Bert Vogelstein
A simplified system for generating recombinant adenoviruses
Proc. Natl. Acad. Sci. USA Mar 03, 1998; 95: 2509-2514.
(In "Medical Sciences")   [Abstract]     [Full Text]     [PDF]

10. DT Dudley, L Pang, SJ Decker, AJ Bridges, AR Saltiel
A Synthetic Inhibitor of the Mitogen-Activated Protein Kinase Cascade
Proc. Natl. Acad. Sci. USA Aug 15, 1995; 92: 7686-7689.
(In "Article")   [Abstract]     [PDF]

11. M Gossen, H Bujard
Tight Control of Gene Expression in Mammalian Cells by Tetracycline-Responsive Promoters
Proc. Natl. Acad. Sci. USA Jun 15, 1992; 89: 5547-5551.
(In "Article")   [Abstract]     [PDF]

12. WS Pear, GP Nolan, ML Scott, D Baltimore
Production of High-Titer Helper-Free Retroviruses by Transient Transfection
Proc. Natl. Acad. Sci. USA Sep 15, 1993; 90: 8392-8396.
(In "Article")   [Abstract]     [PDF]

13. James G. Herman, Jeremy R. Graff, Sanna Myöhänen, Barry D. Nelkin, Stephen B. Baylin
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
Proc. Natl. Acad. Sci. USA Sep 03, 1996; 93: 9821-9826.
(In "Medical Sciences")   [Abstract]     [PDF]

14. George G. J. M. Kuiper, Eva Enmark, Markku Pelto-Huikko, Stefan Nilsson, Jan-Åke Gustafsson
Cloning of a novel estrogen receptor expressed in rat prostate and ovary
Proc. Natl. Acad. Sci. USA Jun 11, 1996; 93: 5925-5930.
(In "Biochemistry")   [Abstract]     [PDF]

15. JS Beckman, TW Beckman, J Chen, PA Marshall, BA Freeman
Apparent Hydroxyl Radical Production by Peroxynitrite: Implications for Endothelial Injury from Nitric Oxide and Superoxide
Proc. Natl. Acad. Sci. USA Feb 15, 1990; 87: 1620-1624.
(In "Article")   [Abstract]     [PDF]

16. Michael A. Frohman, Michael K. Dush, Gail R. Martin
Rapid Production of Full-Length cDNAs from Rare Transcripts: Amplification Using a Single Gene-Specific Oligonucleotide Primer
Proc. Natl. Acad. Sci. USA Dec 01, 1988; 85: 8998-9002.
(In "Journal_Article")   [Abstract]     [PDF]

17. GL Wang, B Jiang, EA Rue, GL Semenza
Hypoxia-Inducible Factor 1 is a Basic-Helix-Loop-Helix-PAS Heterodimer Regulated by Cellular O₂ Tension
Proc. Natl. Acad. Sci. USA Jun 06, 1995; 92: 5510-5514.
(In "Article")   [Abstract]     [PDF]

18. Thomas R. Fuerst, Edward G. Niles, F. William Studier, Bernard Moss
Eukaryotic Transient-Expression System Based on Recombinant Vaccinia Virus that Synthesizes Bacteriophage T7 RNA Polymerase
Proc. Natl. Acad. Sci. USA Nov 01, 1986; 83: 8122-8126.
(In "Journal_Article")   [Abstract]     [PDF]

19. Cheng Li, Wing Hung Wong
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection
Proc. Natl. Acad. Sci. USA Jan 02, 2001; 98: 31-36.
(In "Statistics")   [Abstract]     [Full Text]     [PDF]

20. O Thastrup, PJ Cullen, BK Drobak, MR Hanley, AP Dawson
Thapsigargin, a Tumor Promoter, Discharges Intracellular Ca²⁺ Stores by Specific Inhibition of the Endoplasmic Reticulum Ca²⁺-ATPase
Proc. Natl. Acad. Sci. USA Apr 01, 1990; 87: 2466-2470.
(In "Article")   [Abstract]     [PDF]

21. GP Dimri, X Lee, G Basile, M Acosta, G Scott, C Roskelley, EE Medrano, M Linskens, I Rubelj, O Pereira-Smith, M Peacocke, J Campisi
A Biomarker that Identifies Senescent Human Cells in Culture and in Aging Skin in vivo
Proc. Natl. Acad. Sci. USA Sep 26, 1995; 92: 9363-9367.
(In "Article")   [Abstract]     [PDF]

22. Lloyd A. Greene, Arthur S. Tischler
Establishment of a Noradrenergic Clonal Line of Rat Adrenal Pheochromocytoma Cells which Respond to Nerve Growth Factor
Proc. Natl. Acad. Sci. USA Jul 15, 1976; 73: 2424-2428.
(In "Journal_Article")   [Abstract]     [PDF]

23. Stanley B. Prusiner
Prions
Proc. Natl. Acad. Sci. USA Nov 10, 1998; 95: 13363-13383.
(In "Nobel")   [Abstract]     [Full Text]     [PDF]

24. A Nagy, J Rossant, R Nagy, W Abramow-Newerly, JC Roder
Derivation of Completely Cell Culture-Derived Mice from Early-Passage Embryonic Stem Cells
Proc. Natl. Acad. Sci. USA Sep 15, 1993; 90: 8424-8428.
(In "Article")   [Abstract]     [PDF]

25. Stanley Tabor, Charles C. Richardson
A Bacteriophage T7 RNA Polymerase/Promoter System for Controlled Exclusive Expression of Specific Genes
Proc. Natl. Acad. Sci. USA Feb 15, 1985; 82: 1074-1078.
(In "Journal_Article")   [Abstract]     [PDF]

26. David H. Figurski, Donald R. Helinski
Replication of an Origin-Containing Derivative of Plasmid RK2 Dependent on a Plasmid Function Provided in trans
Proc. Natl. Acad. Sci. USA Apr 15, 1979; 76: 1648-1652.
(In "Journal_Article")   [Abstract]     [PDF]

27. Takashi Ito, Tomoko Chiba, Ritsuko Ozawa, Mikio Yoshida, Masahira Hattori, Yoshiyuki Sakaki
A comprehensive two-hybrid analysis to explore the yeast protein interactome
Proc. Natl. Acad. Sci. USA Apr 10, 2001; 98: 4569-4574.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

28. S Henikoff, JG Henikoff
Amino Acid Substitution Matrices from Protein Blocks
Proc. Natl. Acad. Sci. USA Nov 15, 1992; 89: 10915-10919.
(In "Article")   [Abstract]     [PDF]

29. Jörg Schultz, Frank Milpetz, Peer Bork, Chris P. Ponting
SMART, a simple modular architecture research tool: Identification of signaling domains
Proc. Natl. Acad. Sci. USA May 26, 1998; 95: 5857-5864.
(In "Colloquium")   [Abstract]     [Full Text]     [PDF]

30. P Kubes, M Suzuki, DN Granger
Nitric Oxide: An Endogenous Modulator of Leukocyte Adhesion
Proc. Natl. Acad. Sci. USA Jun 01, 1991; 88: 4651-4655.
(In "Article")   [Abstract]     [PDF]

31. Hisataka Yasuda, Nobuyuki Shima, Nobuaki Nakagawa, Kyoji Yamaguchi, Masahiko Kinosaki, Shin-ichi Mochizuki, Akihiro Tomoyasu, Kazuki Yano, Masaaki Goto, Akihiko Murakami, Eisuke Tsuda, Tomonori Morinaga, Kanji Higashio, Nobuyuki Udagawa, Naoyuki Takahashi, Tatsuo Suda
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Proc. Natl. Acad. Sci. USA Mar 31, 1998; 95: 3597-3602.
(In "Cell Biology")   [Abstract]     [Full Text]     [PDF]

32. Brydon L. Bennett, Dennis T. Sasaki, Brion W. Murray, Eoin C. O''Leary, Steve T. Sakata, Weiming Xu, Jim C. Leisten, Aparna Motiwala, Steve Pierce, Yoshitaka Satoh, Shripad S. Bhagwat, Anthony M. Manning, David W. Anderson
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Proc. Natl. Acad. Sci. USA Nov 20, 2001; 98: 13681-13686.
(In "Cell Biology")   [Abstract]     [Full Text]     [PDF]

33. James J. Russo, Roy A. Bohenzky, Ming-Cheng Chien, Jing Chen, Ming Yan, Dawn Maddalena, J. Preston Parry, Daniela Peruzzi, Isidore S. Edelman, Yuan Chang, Patrick S. Moore
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
Proc. Natl. Acad. Sci. USA Dec 10, 1996; 93: 14862-14867.
(In "Microbiology")   [Abstract]     [Full Text]     [PDF]

34. Therese Sørlie, Charles M. Perou, Robert Tibshirani, Turid Aas, Stephanie Geisler, Hilde Johnsen, Trevor Hastie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffrey, Thor Thorsen, Hanne Quist, John C. Matese, Patrick O. Brown, David Botstein, Per Eystein Lønning, Anne-Lise Børresen-Dale
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Proc. Natl. Acad. Sci. USA Sep 11, 2001; 98: 10869-10874.
(In "Medical Sciences")   [Abstract]     [Full Text]     [PDF]

35. Luda Diatchenko, Yun-Fai Chris Lau, Aaron P. Campbell, Alex Chenchik, Fauzia Moqadam, Betty Huang, Sergey Lukyanov, Konstantin Lukyanov, Nadya Gurskaya, Eugene D. Sverdlov, Paul D. Siebert
Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
Proc. Natl. Acad. Sci. USA Jun 11, 1996; 93: 6025-6030.
(In "Biochemistry")   [Abstract]     [PDF]

36. Robert E. Campbell, Oded Tour, Amy E. Palmer, Paul A. Steinbach, Geoffrey S. Baird, David A. Zacharias, Roger Y. Tsien
A monomeric red fluorescent protein
Proc. Natl. Acad. Sci. USA Jun 11, 2002; 99: 7877-7882.
(In "Biochemistry")   [Abstract]     [Full Text]     [PDF]

37. Martin C. J. Maiden, Jane A. Bygraves, Edward Feil, Giovanna Morelli, Joanne E. Russell, Rachel Urwin, Qing Zhang, Jiaji Zhou, Kerstin Zurth, Dominique A. Caugant, Ian M. Feavers, Mark Achtman, Brian G. Spratt
Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
Proc. Natl. Acad. Sci. USA Mar 17, 1998; 95: 3140-3145.
(In "Microbiology")   [Abstract]     [Full Text]     [PDF]

38. Barry Marc Forman, Jasmine Chen, Ronald M. Evans
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors $alpha$ and $delta$
Proc. Natl. Acad. Sci. USA Apr 29, 1997; 94: 4312-4317.
(In "Biochemistry")   [Abstract]     [Full Text]     [PDF]

39. Louis J. Ignarro, Georgette M. Buga, Keith S. Wood, Russell E. Byrns, Gautam Chaudhuri
Endothelium-Derived Relaxing Factor Produced and Released from Artery and Vein is Nitric Oxide
Proc. Natl. Acad. Sci. USA Dec 15, 1987; 84: 9265-9269.
(In "Journal_Article")   [Abstract]     [PDF]

40. Pablo Tamayo, Donna Slonim, Jill Mesirov, Qing Zhu, Sutisak Kitareewan, Ethan Dmitrovsky, Eric S. Lander, Todd R. Golub
Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
Proc. Natl. Acad. Sci. USA Mar 16, 1999; 96: 2907-2912.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

41. BN Ames, MK Shigenaga, TM Hagen
Oxidants, Antioxidants, and the Degenerative Diseases of Aging
Proc. Natl. Acad. Sci. USA Sep 01, 1993; 90: 7915-7922.
(In "Article")   [Abstract]     [PDF]

42. Michael Shtutman, Jacob Zhurinsky, Inbal Simcha, Chris Albanese, Mark D''Amico, Richard Pestell, Avri Ben-Ze''ev
The cyclin D1 gene is a target of the $beta$ -catenin/LEF-1 pathway
Proc. Natl. Acad. Sci. USA May 11, 1999; 96: 5522-5527.
(In "Cell Biology")   [Abstract]     [Full Text]     [PDF]

43. Fernando L. Rock, Gary Hardiman, Jackie C. Timans, Robert A. Kastelein, J. Fernando Bazan
A family of human receptors structurally related to Drosophila Toll
Proc. Natl. Acad. Sci. USA Jan 20, 1998; 95: 588-593.
(In "Developmental Biology")   [Abstract]     [Full Text]     [PDF]

44. DS Bredt, SH Snyder
Isolation of Nitric Oxide Synthetase, a Calmodulin-Requiring Enzyme
Proc. Natl. Acad. Sci. USA Jan 15, 1990; 87: 682-685.
(In "Article")   [Abstract]     [PDF]

45. J Blenis
Signal Transduction via the MAP Kinases: Proceed at Your Own RSK
Proc. Natl. Acad. Sci. USA Jul 01, 1993; 90: 5889-5892.
(In "Article")   [Abstract]     [PDF]

46. Alfred G. Knudson
Mutation and Cancer: Statistical Study of Retinoblastoma
Proc. Natl. Acad. Sci. USA Apr 15, 1971; 68: 820-823.
(In "Journal_Article")   [Abstract]     [PDF]

47. Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones, Peter J. Brown, G. Bruce Wisely, Cecilia S. Koble, Pallavi Devchand, Walter Wahli, Timothy M. Willson, James M. Lenhard, Jürgen M. Lehmann
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors $alpha$ and $gamma$
Proc. Natl. Acad. Sci. USA Apr 29, 1997; 94: 4318-4323.
(In "Biochemistry")   [Abstract]     [Full Text]     [PDF]

48. JF Bazan
Structural Design and Molecular Evolution of a Cytokine Receptor Superfamily
Proc. Natl. Acad. Sci. USA Sep 15, 1990; 87: 6934-6938.
(In "Article")   [Abstract]     [PDF]

49. Stefano Censini, Christina Lange, Zhaoying Xiang, Jean E. Crabtree, Paolo Ghiara, Mark Borodovsky, Rino Rappuoli, Antonello Covacci
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
Proc. Natl. Acad. Sci. USA Dec 10, 1996; 93: 14648-14653.
(In "Genetics")   [Abstract]     [Full Text]     [PDF]

50. Lewis C. Cantley, Benjamin G. Neel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
Proc. Natl. Acad. Sci. USA Apr 13, 1999; 96: 4240-4245.
(In "Review")   [Abstract]     [Full Text]     [PDF]

= from the current issue

1.	F. Sanger, S. Nicklen, A. R. Coulson
		DNA Sequencing with Chain-Terminating Inhibitors
		Proc. Natl. Acad. Sci. USA Dec 15, 1977; 74: 5463-5467. (In "Journal_Article") [Abstract] [PDF]


2.	Harry Towbin, Theophil Staehelin, Julian Gordon
		Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications
		Proc. Natl. Acad. Sci. USA Sep 15, 1979; 76: 4350-4354. (In "Journal_Article") [Abstract] [PDF]


3.	Michael B. Eisen, Paul T. Spellman, Patrick O. Brown, David Botstein
		Cluster analysis and display of genome-wide expression patterns
		Proc. Natl. Acad. Sci. USA Dec 08, 1998; 95: 14863-14868. (In "Genetics") [Abstract] [Full Text] [PDF]


4.	William R. Pearson, David J. Lipman
		Improved Tools for Biological Sequence Comparison
		Proc. Natl. Acad. Sci. USA Apr 15, 1988; 85: 2444-2448. (In "Journal_Article") [Abstract] [PDF]


5.	George M. Church, Walter Gilbert
		Genomic Sequencing
		Proc. Natl. Acad. Sci. USA Apr 01, 1984; 81: 1991-1995. (In "Journal_Article") [Abstract] [PDF]


6.	Virginia Goss Tusher, Robert Tibshirani, Gilbert Chu
		Significance analysis of microarrays applied to the ionizing radiation response
		Proc. Natl. Acad. Sci. USA Apr 24, 2001; 98: 5116-5121. (In "Genetics") [Abstract] [Full Text] [PDF]


7.	Thomas A. Kunkel
		Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection
		Proc. Natl. Acad. Sci. USA Jan 15, 1985; 82: 488-492. (In "Journal_Article") [Abstract] [PDF]


8.	Kirill A. Datsenko, Barry L. Wanner
		One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
		Proc. Natl. Acad. Sci. USA Jun 06, 2000; 97: 6640-6645. (In "Genetics") [Abstract] [Full Text] [PDF]


9.	Tong-Chuan He, Shibin Zhou, Luis T. da Costa, Jian Yu, Kenneth W. Kinzler, Bert Vogelstein
		A simplified system for generating recombinant adenoviruses
		Proc. Natl. Acad. Sci. USA Mar 03, 1998; 95: 2509-2514. (In "Medical Sciences") [Abstract] [Full Text] [PDF]


10.	DT Dudley, L Pang, SJ Decker, AJ Bridges, AR Saltiel
		A Synthetic Inhibitor of the Mitogen-Activated Protein Kinase Cascade
		Proc. Natl. Acad. Sci. USA Aug 15, 1995; 92: 7686-7689. (In "Article") [Abstract] [PDF]


11.	M Gossen, H Bujard
		Tight Control of Gene Expression in Mammalian Cells by Tetracycline-Responsive Promoters
		Proc. Natl. Acad. Sci. USA Jun 15, 1992; 89: 5547-5551. (In "Article") [Abstract] [PDF]


12.	WS Pear, GP Nolan, ML Scott, D Baltimore
		Production of High-Titer Helper-Free Retroviruses by Transient Transfection
		Proc. Natl. Acad. Sci. USA Sep 15, 1993; 90: 8392-8396. (In "Article") [Abstract] [PDF]


13.	James G. Herman, Jeremy R. Graff, Sanna Myöhänen, Barry D. Nelkin, Stephen B. Baylin
		Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
		Proc. Natl. Acad. Sci. USA Sep 03, 1996; 93: 9821-9826. (In "Medical Sciences") [Abstract] [PDF]


14.	George G. J. M. Kuiper, Eva Enmark, Markku Pelto-Huikko, Stefan Nilsson, Jan-Åke Gustafsson
		Cloning of a novel estrogen receptor expressed in rat prostate and ovary
		Proc. Natl. Acad. Sci. USA Jun 11, 1996; 93: 5925-5930. (In "Biochemistry") [Abstract] [PDF]


15.	JS Beckman, TW Beckman, J Chen, PA Marshall, BA Freeman
		Apparent Hydroxyl Radical Production by Peroxynitrite: Implications for Endothelial Injury from Nitric Oxide and Superoxide
		Proc. Natl. Acad. Sci. USA Feb 15, 1990; 87: 1620-1624. (In "Article") [Abstract] [PDF]


16.	Michael A. Frohman, Michael K. Dush, Gail R. Martin
		Rapid Production of Full-Length cDNAs from Rare Transcripts: Amplification Using a Single Gene-Specific Oligonucleotide Primer
		Proc. Natl. Acad. Sci. USA Dec 01, 1988; 85: 8998-9002. (In "Journal_Article") [Abstract] [PDF]


17.	GL Wang, B Jiang, EA Rue, GL Semenza
		Hypoxia-Inducible Factor 1 is a Basic-Helix-Loop-Helix-PAS Heterodimer Regulated by Cellular O₂ Tension
		Proc. Natl. Acad. Sci. USA Jun 06, 1995; 92: 5510-5514. (In "Article") [Abstract] [PDF]


18.	Thomas R. Fuerst, Edward G. Niles, F. William Studier, Bernard Moss
		Eukaryotic Transient-Expression System Based on Recombinant Vaccinia Virus that Synthesizes Bacteriophage T7 RNA Polymerase
		Proc. Natl. Acad. Sci. USA Nov 01, 1986; 83: 8122-8126. (In "Journal_Article") [Abstract] [PDF]


19.	Cheng Li, Wing Hung Wong
		Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection
		Proc. Natl. Acad. Sci. USA Jan 02, 2001; 98: 31-36. (In "Statistics") [Abstract] [Full Text] [PDF]


20.	O Thastrup, PJ Cullen, BK Drobak, MR Hanley, AP Dawson
		Thapsigargin, a Tumor Promoter, Discharges Intracellular Ca²⁺ Stores by Specific Inhibition of the Endoplasmic Reticulum Ca²⁺-ATPase
		Proc. Natl. Acad. Sci. USA Apr 01, 1990; 87: 2466-2470. (In "Article") [Abstract] [PDF]


21.	GP Dimri, X Lee, G Basile, M Acosta, G Scott, C Roskelley, EE Medrano, M Linskens, I Rubelj, O Pereira-Smith, M Peacocke, J Campisi
		A Biomarker that Identifies Senescent Human Cells in Culture and in Aging Skin in vivo
		Proc. Natl. Acad. Sci. USA Sep 26, 1995; 92: 9363-9367. (In "Article") [Abstract] [PDF]


22.	Lloyd A. Greene, Arthur S. Tischler
		Establishment of a Noradrenergic Clonal Line of Rat Adrenal Pheochromocytoma Cells which Respond to Nerve Growth Factor
		Proc. Natl. Acad. Sci. USA Jul 15, 1976; 73: 2424-2428. (In "Journal_Article") [Abstract] [PDF]


23.	Stanley B. Prusiner
		Prions
		Proc. Natl. Acad. Sci. USA Nov 10, 1998; 95: 13363-13383. (In "Nobel") [Abstract] [Full Text] [PDF]


24.	A Nagy, J Rossant, R Nagy, W Abramow-Newerly, JC Roder
		Derivation of Completely Cell Culture-Derived Mice from Early-Passage Embryonic Stem Cells
		Proc. Natl. Acad. Sci. USA Sep 15, 1993; 90: 8424-8428. (In "Article") [Abstract] [PDF]


25.	Stanley Tabor, Charles C. Richardson
		A Bacteriophage T7 RNA Polymerase/Promoter System for Controlled Exclusive Expression of Specific Genes
		Proc. Natl. Acad. Sci. USA Feb 15, 1985; 82: 1074-1078. (In "Journal_Article") [Abstract] [PDF]


26.	David H. Figurski, Donald R. Helinski
		Replication of an Origin-Containing Derivative of Plasmid RK2 Dependent on a Plasmid Function Provided in trans
		Proc. Natl. Acad. Sci. USA Apr 15, 1979; 76: 1648-1652. (In "Journal_Article") [Abstract] [PDF]


27.	Takashi Ito, Tomoko Chiba, Ritsuko Ozawa, Mikio Yoshida, Masahira Hattori, Yoshiyuki Sakaki
		A comprehensive two-hybrid analysis to explore the yeast protein interactome
		Proc. Natl. Acad. Sci. USA Apr 10, 2001; 98: 4569-4574. (In "Genetics") [Abstract] [Full Text] [PDF]


28.	S Henikoff, JG Henikoff
		Amino Acid Substitution Matrices from Protein Blocks
		Proc. Natl. Acad. Sci. USA Nov 15, 1992; 89: 10915-10919. (In "Article") [Abstract] [PDF]


29.	Jörg Schultz, Frank Milpetz, Peer Bork, Chris P. Ponting
		SMART, a simple modular architecture research tool: Identification of signaling domains
		Proc. Natl. Acad. Sci. USA May 26, 1998; 95: 5857-5864. (In "Colloquium") [Abstract] [Full Text] [PDF]


30.	P Kubes, M Suzuki, DN Granger
		Nitric Oxide: An Endogenous Modulator of Leukocyte Adhesion
		Proc. Natl. Acad. Sci. USA Jun 01, 1991; 88: 4651-4655. (In "Article") [Abstract] [PDF]


31.	Hisataka Yasuda, Nobuyuki Shima, Nobuaki Nakagawa, Kyoji Yamaguchi, Masahiko Kinosaki, Shin-ichi Mochizuki, Akihiro Tomoyasu, Kazuki Yano, Masaaki Goto, Akihiko Murakami, Eisuke Tsuda, Tomonori Morinaga, Kanji Higashio, Nobuyuki Udagawa, Naoyuki Takahashi, Tatsuo Suda
		Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
		Proc. Natl. Acad. Sci. USA Mar 31, 1998; 95: 3597-3602. (In "Cell Biology") [Abstract] [Full Text] [PDF]


32.	Brydon L. Bennett, Dennis T. Sasaki, Brion W. Murray, Eoin C. O''Leary, Steve T. Sakata, Weiming Xu, Jim C. Leisten, Aparna Motiwala, Steve Pierce, Yoshitaka Satoh, Shripad S. Bhagwat, Anthony M. Manning, David W. Anderson
		SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
		Proc. Natl. Acad. Sci. USA Nov 20, 2001; 98: 13681-13686. (In "Cell Biology") [Abstract] [Full Text] [PDF]


33.	James J. Russo, Roy A. Bohenzky, Ming-Cheng Chien, Jing Chen, Ming Yan, Dawn Maddalena, J. Preston Parry, Daniela Peruzzi, Isidore S. Edelman, Yuan Chang, Patrick S. Moore
		Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
		Proc. Natl. Acad. Sci. USA Dec 10, 1996; 93: 14862-14867. (In "Microbiology") [Abstract] [Full Text] [PDF]


34.	Therese Sørlie, Charles M. Perou, Robert Tibshirani, Turid Aas, Stephanie Geisler, Hilde Johnsen, Trevor Hastie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffrey, Thor Thorsen, Hanne Quist, John C. Matese, Patrick O. Brown, David Botstein, Per Eystein Lønning, Anne-Lise Børresen-Dale
		Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
		Proc. Natl. Acad. Sci. USA Sep 11, 2001; 98: 10869-10874. (In "Medical Sciences") [Abstract] [Full Text] [PDF]


35.	Luda Diatchenko, Yun-Fai Chris Lau, Aaron P. Campbell, Alex Chenchik, Fauzia Moqadam, Betty Huang, Sergey Lukyanov, Konstantin Lukyanov, Nadya Gurskaya, Eugene D. Sverdlov, Paul D. Siebert
		Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
		Proc. Natl. Acad. Sci. USA Jun 11, 1996; 93: 6025-6030. (In "Biochemistry") [Abstract] [PDF]


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