Most-Cited Articles as of July 1, 2008 -- updated monthly.

Rankings based on citations to online articles from HighWire-hosted articles.

  1. Biological Sciences: Biochemistry:
    • F. Sanger,
    • S. Nicklen,
    • and A. R. Coulson
    DNA sequencing with chain-terminating inhibitorsPNAS 1977 74:5463-5467
  2. Research Article:
    • H Towbin,
    • T Staehelin,
    • and J Gordon
    Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsPNAS 1979 76:4350-4354
  3. Biological Sciences - Genetics:
    • Michael B. Eisen,
    • Paul T. Spellman,
    • Patrick O. Brown,
    • and David Botstein
    Cluster analysis and display of genome-wide expression patternsPNAS 1998 95:14863-14868
  4. Research Article:
    • W R Pearson
    • and D J Lipman
    Improved tools for biological sequence comparisonPNAS 1988 85:2444-2448
  5. Research Article:
    • G M Church
    • and W Gilbert
    Genomic sequencingPNAS 1984 81:1991-1995
  6. Physical Sciences - Statistics - Biological Sciences - Genetics:
    • Virginia Goss Tusher,
    • Robert Tibshirani,
    • and Gilbert Chu
    Significance analysis of microarrays applied to the ionizing radiation responsePNAS 2001 98:5116-5121; published ahead of print April 17, 2001, doi:10.1073/pnas.091062498
  7. Research Article:
    • T A Kunkel
    Rapid and efficient site-specific mutagenesis without phenotypic selectionPNAS 1985 82:488-492
  8. Biological Sciences - Genetics:
    • Kirill A. Datsenko
    • and Barry L. Wanner
    One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR productsPNAS 2000 97:6640-6645; published ahead of print May 30, 2000
  9. Biological Sciences - Medical Sciences:
    • Tong-Chuan He,
    • Shibin Zhou,
    • Luis T. da Costa,
    • Jian Yu,
    • Kenneth W. Kinzler,
    • and Bert Vogelstein
    A simplified system for generating recombinant adenovirusesPNAS 1998 95:2509-2514
  10. Research Article:
    • D T Dudley,
    • L Pang,
    • S J Decker,
    • A J Bridges,
    • and A R Saltiel
    A synthetic inhibitor of the mitogen-activated protein kinase cascadePNAS 1995 92:7686-7689
  11. Research Article:
    • M Gossen
    • and H Bujard
    Tight control of gene expression in mammalian cells by tetracycline-responsive promotersPNAS 1992 89:5547-5551
  12. Research Article:
    • W S Pear,
    • G P Nolan,
    • M L Scott,
    • and D Baltimore
    Production of high-titer helper-free retroviruses by transient transfectionPNAS 1993 90:8392-8396
  13. Research Article:
    • J G Herman,
    • J R Graff,
    • S Myöhänen,
    • B D Nelkin,
    • and S B Baylin
    Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsPNAS 1996 93:9821-9826
  14. Research Article:
    • G G Kuiper,
    • E Enmark,
    • M Pelto-Huikko,
    • S Nilsson,
    • and J A Gustafsson
    Cloning of a novel receptor expressed in rat prostate and ovaryPNAS 1996 93:5925-5930
  15. Research Article:
    • J S Beckman,
    • T W Beckman,
    • J Chen,
    • P A Marshall,
    • and B A Freeman
    Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxidePNAS 1990 87:1620-1624
  16. Research Article:
    • M A Frohman,
    • M K Dush,
    • and G R Martin
    Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primerPNAS 1988 85:8998-9002
  17. Research Article:
    • G L Wang,
    • B H Jiang,
    • E A Rue,
    • and G L Semenza
    Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionPNAS 1995 92:5510-5514
  18. Research Article:
    • T R Fuerst,
    • E G Niles,
    • F W Studier,
    • and B Moss
    Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerasePNAS 1986 83:8122-8126
  19. Physical Sciences - Statistics:
    • Cheng Li
    • and Wing Hung Wong
    Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detectionPNAS 2001 98:31-36; published ahead of print December 26, 2000
  20. Research Article:
    • G P Dimri,
    • X Lee,
    • G Basile,
    • M Acosta,
    • G Scott,
    • C Roskelley,
    • E E Medrano,
    • M Linskens,
    • I Rubelj,
    • and O Pereira-Smith
    A biomarker that identifies senescent human cells in culture and in aging skin in vivoPNAS 1995 92:9363-9367
  21. Research Article:
    • O Thastrup,
    • P J Cullen,
    • B K Drøbak,
    • M R Hanley,
    • and A P Dawson
    Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPasePNAS 1990 87:2466-2470
  22. Research Article:
    • L A Greene
    • and A S Tischler
    Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorPNAS 1976 73:2424-2428
  23. Nobel Lecture:
    • Stanley B. Prusiner
    Nobel Lecture: PrionsPNAS 1998 95:13363-13383
  24. Research Article:
    • A Nagy,
    • J Rossant,
    • R Nagy,
    • W Abramow-Newerly,
    • and J C Roder
    Derivation of completely cell culture-derived mice from early-passage embryonic stem cellsPNAS 1993 90:8424-8428
  25. Biological Sciences - Genetics:
    • Takashi Ito,
    • Tomoko Chiba,
    • Ritsuko Ozawa,
    • Mikio Yoshida,
    • Masahira Hattori,
    • and Yoshiyuki Sakaki
    A comprehensive two-hybrid analysis to explore the yeast protein interactomePNAS 2001 98:4569-4574; published ahead of print March 13, 2001, doi:10.1073/pnas.061034498
  26. Research Article:
    • S Tabor
    • and C C Richardson
    A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genesPNAS 1985 82:1074-1078
  27. Biological Sciences: Biochemistry:
    • David H. Figurski
    • and Donald R. Helinski
    Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in transPNAS 1979 76:1648-1652
  28. Research Article:
    • S Henikoff
    • and J G Henikoff
    Amino acid substitution matrices from protein blocksPNAS 1992 89:10915-10919
  29. Colloquium Paper:
    • Jörg Schultz,
    • Frank Milpetz,
    • Peer Bork,
    • and Chris P. Ponting
    Colloquium Paper: SMART, a simple modular architecture research tool: Identification of signaling domainsPNAS 1998 95:5857-5864
  30. Research Article:
    • P Kubes,
    • M Suzuki,
    • and D N Granger
    Nitric oxide: an endogenous modulator of leukocyte adhesionPNAS 1991 88:4651-4655
  31. Biological Sciences - Cell Biology:
    • Hisataka Yasuda,
    • Nobuyuki Shima,
    • Nobuaki Nakagawa,
    • Kyoji Yamaguchi,
    • Masahiko Kinosaki,
    • Shin-ichi Mochizuki,
    • Akihiro Tomoyasu,
    • Kazuki Yano,
    • Masaaki Goto,
    • Akihiko Murakami,
    • Eisuke Tsuda,
    • Tomonori Morinaga,
    • Kanji Higashio,
    • Nobuyuki Udagawa,
    • Naoyuki Takahashi,
    • and Tatsuo Suda
    Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLPNAS 1998 95:3597-3602
  32. Biological Sciences - Medical Sciences:
    • Therese Sørlie,
    • Charles M. Perou,
    • Robert Tibshirani,
    • Turid Aas,
    • Stephanie Geisler,
    • Hilde Johnsen,
    • Trevor Hastie,
    • Michael B. Eisen,
    • Matt van de Rijn,
    • Stefanie S. Jeffrey,
    • Thor Thorsen,
    • Hanne Quist,
    • John C. Matese,
    • Patrick O. Brown,
    • David Botstein,
    • Per Eystein Lønning,
    • and Anne-Lise Børresen-Dale
    Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsPNAS 2001 98:10869-10874; doi:10.1073/pnas.191367098
  33. Biological Sciences - Cell Biology:
    • Brydon L. Bennett,
    • Dennis T. Sasaki,
    • Brion W. Murray,
    • Eoin C. O'Leary,
    • Steve T. Sakata,
    • Weiming Xu,
    • Jim C. Leisten,
    • Aparna Motiwala,
    • Steve Pierce,
    • Yoshitaka Satoh,
    • Shripad S. Bhagwat,
    • Anthony M. Manning,
    • and David W. Anderson
    SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinasePNAS 2001 98:13681-13686; doi:10.1073/pnas.251194298
  34. Biological Sciences - Microbiology:
    • James J. Russo,
    • Roy A. Bohenzky,
    • Ming-Cheng Chien,
    • Jing Chen,
    • Ming Yan,
    • Dawn Maddalena,
    • J. Preston Parry,
    • Daniela Peruzzi,
    • Isidore S. Edelman,
    • Yuan Chang,
    • and Patrick S. Moore
    Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)PNAS 1996 93:14862-14867
  35. Biological Sciences - Biochemistry:
    • Robert E. Campbell,
    • Oded Tour,
    • Amy E. Palmer,
    • Paul A. Steinbach,
    • Geoffrey S. Baird,
    • David A. Zacharias,
    • and Roger Y. Tsien
    A monomeric red fluorescent proteinPNAS 2002 99:7877-7882; doi:10.1073/pnas.082243699
  36. Research Article:
    • L Diatchenko,
    • Y F Lau,
    • A P Campbell,
    • A Chenchik,
    • F Moqadam,
    • B Huang,
    • S Lukyanov,
    • K Lukyanov,
    • N Gurskaya,
    • E D Sverdlov,
    • and P D Siebert
    Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and librariesPNAS 1996 93:6025-6030
  37. Biological Sciences - Microbiology:
    • Martin C. J. Maiden,
    • Jane A. Bygraves,
    • Edward Feil,
    • Giovanna Morelli,
    • Joanne E. Russell,
    • Rachel Urwin,
    • Qing Zhang,
    • Jiaji Zhou,
    • Kerstin Zurth,
    • Dominique A. Caugant,
    • Ian M. Feavers,
    • Mark Achtman,
    • and Brian G. Spratt
    Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganismsPNAS 1998 95:3140-3145
  38. Biological Sciences - Biochemistry:
    • Barry Marc Forman,
    • Jasmine Chen,
    • and Ronald M. Evans
    Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δPNAS 1997 94:4312-4317
  39. Research Article:
    • B N Ames,
    • M K Shigenaga,
    • and T M Hagen
    Oxidants, antioxidants, and the degenerative diseases of agingPNAS 1993 90:7915-7922
  40. Research Article:
    • L J Ignarro,
    • G M Buga,
    • K S Wood,
    • R E Byrns,
    • and G Chaudhuri
    Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxidePNAS 1987 84:9265-9269
  41. Physical Sciences - Statistics - Biological Sciences - Genetics:
    • John D. Storey
    • and Robert Tibshirani
    Statistical significance for genomewide studiesPNAS 2003 100:9440-9445; published ahead of print July 25, 2003, doi:10.1073/pnas.1530509100
  42. Biological Sciences - Genetics:
    • Pablo Tamayo,
    • Donna Slonim,
    • Jill Mesirov,
    • Qing Zhu,
    • Sutisak Kitareewan,
    • Ethan Dmitrovsky,
    • Eric S. Lander,
    • and Todd R. Golub
    Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiationPNAS 1999 96:2907-2912
  43. Biological Sciences - Cell Biology:
    • Michael Shtutman,
    • Jacob Zhurinsky,
    • Inbal Simcha,
    • Chris Albanese,
    • Mark D’Amico,
    • Richard Pestell,
    • and Avri Ben-Ze’ev
    The cyclin D1 gene is a target of the β-catenin/LEF-1 pathwayPNAS 1999 96:5522-5527
  44. Biological Sciences - Developmental Biology:
    • Fernando L. Rock,
    • Gary Hardiman,
    • Jackie C. Timans,
    • Robert A. Kastelein,
    • and J. Fernando Bazan
    A family of human receptors structurally related to Drosophila  TollPNAS 1998 95:588-593
  45. Research Article:
    • D S Bredt
    • and S H Snyder
    Isolation of nitric oxide synthetase, a calmodulin-requiring enzymePNAS 1990 87:682-685
  46. Biological Sciences: Medical Sciences:
    • Alfred G. Knudson, Jr.
    Mutation and Cancer: Statistical Study of RetinoblastomaPNAS 1971 68:820-823
  47. Biological Sciences - Biochemistry:
    • Steven A. Kliewer,
    • Scott S. Sundseth,
    • Stacey A. Jones,
    • Peter J. Brown,
    • G. Bruce Wisely,
    • Cecilia S. Koble,
    • Pallavi Devchand,
    • Walter Wahli,
    • Timothy M. Willson,
    • James M. Lenhard,
    • and Jürgen M. Lehmann
    Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γPNAS 1997 94:4318-4323
  48. Biological Sciences - Biochemistry:
    • L. Eric Huang,
    • Jie Gu,
    • Maureen Schau,
    • and H. Franklin Bunn
    Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathwayPNAS 1998 95:7987-7992
  49. Biological Sciences - Genetics:
    • Stefano Censini,
    • Christina Lange,
    • Zhaoying Xiang,
    • Jean E. Crabtree,
    • Paolo Ghiara,
    • Mark Borodovsky,
    • Rino Rappuoli,
    • and Antonello Covacci
    cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsPNAS 1996 93:14648-14653
  50. Research Article:
    • D B Lubahn,
    • J S Moyer,
    • T S Golding,
    • J F Couse,
    • K S Korach,
    • and O Smithies
    Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor genePNAS 1993 90:11162-11166

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