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Proceedings of the National Academy of Sciences: Agricultural SciencesProceedings of the National Academy of Sciencesen-USAtypon Systemshttp://www.atypon.com/images/atypon_logo_small.gif
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Positive effects of public breeding on US rice yields under future climate scenarios
https://www.pnas.org/doi/abs/10.1073/pnas.2309969121?af=R
Proceedings of the National Academy of Sciences, Volume 121, Issue 13, March 2024. <br/>Positive effects of public breeding on US rice yields under future climate scenariosdoi:10.1073/pnas.23099691212024-03-18T07:00:00ZDiane R. WangSajad JamshidiRongkui HanJeremy D. EdwardsAnna M. McClungSusan R. McCouchaDepartment of Agronomy, Purdue University, West Lafayette, IN 47901bDepartment of Plant Sciences, University of California, Davis, CA 95616cDale Bumpers National Rice Research Center, United States Department of Agriculture - Agricultural Research Service, Stuttgart, AR 72160dSection of Plant Breeding and Genetics, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853Proceedings of the National Academy of Sciences121132024-03-26T07:00:00Z2024-03-26T07:00:00Z10.1073/pnas.2309969121https://www.pnas.org/doi/abs/10.1073/pnas.2309969121?af=REnhanced weathering in the US Corn Belt delivers carbon removal with agronomic benefits
https://www.pnas.org/doi/abs/10.1073/pnas.2319436121?af=R
Proceedings of the National Academy of Sciences, Volume 121, Issue 9, February 2024. <br/>Enhanced weathering in the US Corn Belt delivers carbon removal with agronomic benefitsdoi:10.1073/pnas.23194361212024-02-22T08:00:00ZDavid J. BeerlingDimitar Z. EpihovIlsa B. KantolaMichael D. MastersTom ReershemiusNoah J. PlanavskyChristopher T. ReinhardJacob S. JordanSarah J. ThorneJames WeberMaria Val MartinRobert P. FreckletonSue E. HartleyRachael H. JamesChristopher R. PearceEvan H. DeLuciaSteven A. BanwartaLeverhulme Centre for Climate Change Mitigation, School of Biosciences, University of Sheffield, Sheffield S10 2TN, United KingdombInstitute for Sustainability, Energy, and Environment, University of Illinois at Urbana-Champaign, Urbana, IL 61801cYale Center for Natural Carbon Capture, Department of Earth & Planetary Sciences, Yale University, New Haven, CT 06511dSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA 30332eMati Carbon, Houston, TX 77019fSchool of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United KingdomgNational Oceanography Centre, Southampton SO14 3ZH, United KingdomhGlobal Food and Environment Institute, University of Leeds, Leeds LS2 9JT, United KingdomiSchool of Earth and Environment, University of Leeds, Leeds LS2 9JT, United KingdomProceedings of the National Academy of Sciences12192024-02-27T08:00:00Z2024-02-27T08:00:00Z10.1073/pnas.2319436121https://www.pnas.org/doi/abs/10.1073/pnas.2319436121?af=RA universal design of restructured dimer antigens: Development of a superior vaccine against the paramyxovirus in transgenic rice
https://www.pnas.org/doi/abs/10.1073/pnas.2305745121?af=R
Proceedings of the National Academy of Sciences, Volume 121, Issue 4, January 2024. <br/>A universal design of restructured dimer antigens: Development of a superior vaccine against the paramyxovirus in transgenic ricedoi:10.1073/pnas.23057451212024-01-18T08:00:00ZFanshu MaQianru XuAiping WangDaichang YangQingmei LiJunqing GuoLongxian ZhangJiquan OuRui LiHeng YinKunpeng LiLi WangYanan WangXiangyue ZhaoXiangxiang NiuShenli ZhangXueyang LiShujun ChaiErqin ZhangZihe RaoGaiping ZhangaInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, ChinabSchool of Advanced Agriculture Sciences, Peking University, Beijing 100871, ChinacLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, ChinadCollege of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaeChinese Academy of Sciences Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, ChinafSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinagState Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430074, ChinahKey Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, ChinaiWuhan Healthgen Biotechnology Corp., Wuhan 430074, ChinajLaboratory of Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, ChinaProceedings of the National Academy of Sciences12142024-01-23T08:00:00Z2024-01-23T08:00:00Z10.1073/pnas.2305745121https://www.pnas.org/doi/abs/10.1073/pnas.2305745121?af=RA plant virus manipulates the long-winged morph of insect vectors
https://www.pnas.org/doi/abs/10.1073/pnas.2315341121?af=R
Proceedings of the National Academy of Sciences, Volume 121, Issue 3, January 2024. <br/>A plant virus manipulates the long-winged morph of insect vectorsdoi:10.1073/pnas.23153411212024-01-08T08:00:00ZJinting YuWan ZhaoXiaofang ChenHong LuYan XiaoQiong LiLan LuoLe KangFeng CuiaState Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinabCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaProceedings of the National Academy of Sciences12132024-01-16T08:00:00Z2024-01-16T08:00:00Z10.1073/pnas.2315341121https://www.pnas.org/doi/abs/10.1073/pnas.2315341121?af=RUS–China science collaboration to solve global grand challenges
https://www.pnas.org/doi/abs/10.1073/pnas.2320207120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 52, December 2023. <br/>US–China science collaboration to solve global grand challengesdoi:10.1073/pnas.23202071202023-12-21T08:00:00ZRoger N. BeachyKaren C. SetoaDepartment of Biology, Washington University, St. Louis, MO 63130bYale School of the Environment, Yale University, St. Louis, MO 63130Proceedings of the National Academy of Sciences120522023-12-26T08:00:00Z2023-12-26T08:00:00Z10.1073/pnas.2320207120https://www.pnas.org/doi/abs/10.1073/pnas.2320207120?af=RA tomato bushy stunt virus–based vector for simultaneous editing and sensing to survey the host antiviral RNA silencing machinery
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad436?af=R
PNAS Nexus, Volume 3, Issue 1, December 2023. <br/>A tomato bushy stunt virus–based vector for simultaneous editing and sensing to survey the host antiviral RNA silencing machinerydoi:10.1093/pnasnexus/pgad4362023-12-14T08:00:00Z
April DeMell
Maria R Mendoza
Herman B Scholthof
Edward Bayer
PNAS Nexus312023-12-21T08:00:00Z2023-12-21T08:00:00Z10.1093/pnasnexus/pgad436https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad436?af=RFemale semiochemicals stimulate male courtship but dampen female sexual receptivity
https://www.pnas.org/doi/abs/10.1073/pnas.2311166120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 49, December 2023. <br/>Female semiochemicals stimulate male courtship but dampen female sexual receptivitydoi:10.1073/pnas.23111661202023-11-27T08:00:00ZYaoyao ChenYuhua ZhangShupei AiShuyuan XingGuohua ZhongXin YiaNational Key Laboratory of Green Pesticide, College of Plant Protection, South China Agricultural University, Guangzhou 510642, ChinabKey Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, College of Plant Protection, South China Agricultural University, Guangzhou 510642, ChinacKey Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, ChinaProceedings of the National Academy of Sciences120492023-12-05T08:00:00Z2023-12-05T08:00:00Z10.1073/pnas.2311166120https://www.pnas.org/doi/abs/10.1073/pnas.2311166120?af=RAblation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART)
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad343?af=R
PNAS Nexus, Volume 2, Issue 11, November 2023. <br/>Ablation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART)doi:10.1093/pnasnexus/pgad3432023-10-20T07:00:00Z
Jada L Nix
Gustavo P Schettini
Savannah L Speckhart
Alan D Ealy
Fernando H Biase
Patrick Stover
PNAS Nexus2112023-11-01T07:00:00Z2023-11-01T07:00:00Z10.1093/pnasnexus/pgad343https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad343?af=RA key to wine conservation lies in the glass–cork interface
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad344?af=R
PNAS Nexus, Volume 2, Issue 11, November 2023. <br/>A key to wine conservation lies in the glass–cork interfacedoi:10.1093/pnasnexus/pgad3442023-10-21T07:00:00Z
Julie Chanut
Jean-Pierre Bellat
Régis D Gougeon
Thomas Karbowiak
Adelia Bovell-Benjamin
PNAS Nexus2112023-11-01T07:00:00Z2023-11-01T07:00:00Z10.1093/pnasnexus/pgad344https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad344?af=RDownregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armyworm
https://www.pnas.org/doi/abs/10.1073/pnas.2306932120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 44, October 2023. <br/>Downregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armywormdoi:10.1073/pnas.23069321202023-10-24T07:00:00ZMinghui JinYinxue ShanYan PengWenhui WangHuihui ZhangKaiyu LiuDavid G. HeckelKongming WuBruce E. TabashnikYutao XiaoaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518116, ChinabThe State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinacCollege of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinadInstitute of Entomology, School of Life Sciences, Central China Normal University, Wuhan 430079, ChinaeDepartment of Entomology, Max Planck Institute for Chemical Ecology, Jena D-07745, GermanyfDepartment of Entomology, University of Arizona, Tucson, AZ 85721Proceedings of the National Academy of Sciences120442023-10-31T07:00:00Z2023-10-31T07:00:00Z10.1073/pnas.2306932120https://www.pnas.org/doi/abs/10.1073/pnas.2306932120?af=RAdenylate kinase 9 is essential for sperm function and male fertility in mammals
https://www.pnas.org/doi/abs/10.1073/pnas.2305712120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 42, October 2023. <br/>Adenylate kinase 9 is essential for sperm function and male fertility in mammalsdoi:10.1073/pnas.23057121202023-10-09T07:00:00ZElena O’CallaghanPaula Navarrete-LopezMiriama ŠtiavnickáJosé M. SánchezMaria MarotoEva PericuestaRaul Fernández-GonzálezCiara O’MearaBernard EiversMargaret M. KelleherRoss D. EvansXena M. MapelAudald Lloret-VillasHubert PauschMiriam Balastegui-AlarcónManuel AvilésAna Sanchez-RodriguezEduardo R. S. RoldanMichael McDonaldDavid A. KennySean FairAlfonso Gutiérrez-AdánPatrick LonerganaAnimal and Crop Sciences, School of Agriculture and Food Science, University College Dublin, Belfield, Dublin D04 V1W8, IrelandbDepartamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria-Centro Nacional integrado en la Agencia Estatal Consejo Superior de Investigaciones Científicas, Madrid 28040, SpaincDepartment of Biological Sciences, Bernal Institute, Faculty of Science and Engineering, University of Limerick, Limerick V94 T9PX, IrelanddNational Cattle Breeding Centre, County Kildare W91 WF59, IrelandeIrish Cattle Breeding Federation, Link Road, Ballincollig, County Cork P31 D452, IrelandfAnimal Genomics, Institute of Agricultural Sciences, ETH Zürich, Zürich 8092, SwitzerlandgDepartamento de Biología Celular e Histología, Universidad de Murcia-Instituto Murciano de Investigación Biosanitaria Pascual Parrilla, Murcia 30120, SpainhDepartmento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales, Madrid 28006, SpainiAnimal and Bioscience Department, Teagasc, Animal and Grassland Research and Innovation Centre, Grange, Dunsany, County Meath C15 PW93, IrelandProceedings of the National Academy of Sciences120422023-10-17T07:00:00Z2023-10-17T07:00:00Z10.1073/pnas.2305712120https://www.pnas.org/doi/abs/10.1073/pnas.2305712120?af=REdible fire buffers: Mitigation of wildfire with multifunctional landscapes
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad315?af=R
PNAS Nexus, Volume 2, Issue 10, September 2023. <br/>Edible fire buffers: Mitigation of wildfire with multifunctional landscapesdoi:10.1093/pnasnexus/pgad3152023-10-24T07:00:00Z
Xiao Fu
Abigail Lidar
Michael Kantar
Barath Raghavan
Joann Whalen
PNAS Nexus2102023-09-29T07:00:00Z2023-09-29T07:00:00Z10.1093/pnasnexus/pgad315https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad315?af=RSequencing 4.3 million mutations in wheat promoters to understand and modify gene expression
https://www.pnas.org/doi/abs/10.1073/pnas.2306494120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 38, September 2023. <br/>Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expressiondoi:10.1073/pnas.23064941202023-09-13T07:00:00ZJunli ZhangHongchun XiongGermán F. BurguenerHans Vasquez-GrossQiujie LiuJuan M. DebernardiAlina AkhunovaKimberly Garland-CampbellShahryar F. KianianGina Brown-GuediraCurtis PozniakJustin D. FarisEduard AkhunovJorge DubcovskyaDepartment of Plant Sciences, University of California, Davis, CA 95616bInstitute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinacHHMI, Chevy Chase, MD 20815dNevada Bioinformatics Center, University of Nevada, Reno, NV 89557eDepartment of Plant Pathology, Kansas State University, Manhattan, KS 66506fUnited States Department of Agriculture - Agricultural Research Service, Wheat Health, Genetics and Quality Research Unit, Pullman, WA 99164gUnited States Department of Agriculture - Agricultural Research Service, Cereal Disease Laboratory, Saint Paul, MN 55108-6086hUnited States Department of Agriculture - Agricultural Research Service, Plant Science Research Unit, Raleigh, NC 27695iCrop Development Centre, University of Saskatchewan, Saskatoon S7N 5A8, CanadajUnited States Department of Agriculture - Agricultural Research Service, Cereal Crops Research Unit, Northern Crop Science Laboratory, Fargo, ND 58102Proceedings of the National Academy of Sciences120382023-09-19T07:00:00Z2023-09-19T07:00:00Z10.1073/pnas.2306494120https://www.pnas.org/doi/abs/10.1073/pnas.2306494120?af=RDivergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobiotics
https://www.pnas.org/doi/abs/10.1073/pnas.2308685120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 37, September 2023. <br/>Divergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobioticsdoi:10.1073/pnas.23086851202023-09-05T07:00:00ZYu ShiQingqing LiuWenjie LuJing YuanYihua YangJohn OakeshottYidong WuaCollege of Plant Protection, Nanjing Agricultural University, Nanjing, Jiangsu 210095, ChinabApplied Biosciences, Macquarie University, Sydney, NSW 2109, AustraliaProceedings of the National Academy of Sciences120372023-09-12T07:00:00Z2023-09-12T07:00:00Z10.1073/pnas.2308685120https://www.pnas.org/doi/abs/10.1073/pnas.2308685120?af=RExtensive rewiring of the gene regulatory interactions between in vitro–produced conceptuses and endometrium during attachment
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad284?af=R
PNAS Nexus, Volume 2, Issue 9, September 2023. <br/>Extensive rewiring of the gene regulatory interactions between in vitro–produced conceptuses and endometrium during attachmentdoi:10.1093/pnasnexus/pgad2842023-09-02T07:00:00Z
Fernando H Biase
Sarah E Moorey
Julie G Schnuelle
Soren Rodning
Marta Sofia Ortega
Thomas E Spencer
Marisa Bartolomei
PNAS Nexus292023-09-05T07:00:00Z2023-09-05T07:00:00Z10.1093/pnasnexus/pgad284https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad284?af=RPopulation genomics reveals meiotic recombination in Fusarium oxysporum
https://www.pnas.org/doi/abs/10.1073/pnas.2309677120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 30, July 2023. <br/>Population genomics reveals meiotic recombination in Fusarium oxysporumdoi:10.1073/pnas.23096771202023-07-18T07:00:00ZLike FokkensMartijn RepaLaboratory of Phytopathology, Plant Sciences Group, Wageningen University and Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the NetherlandsbMolecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, the NetherlandsProceedings of the National Academy of Sciences120302023-07-25T07:00:00Z2023-07-25T07:00:00Z10.1073/pnas.2309677120https://www.pnas.org/doi/abs/10.1073/pnas.2309677120?af=RRoot-knot nematodes produce functional mimics of tyrosine-sulfated plant peptides
https://www.pnas.org/doi/abs/10.1073/pnas.2304612120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 29, July 2023. <br/>Root-knot nematodes produce functional mimics of tyrosine-sulfated plant peptidesdoi:10.1073/pnas.23046121202023-07-10T07:00:00ZHenok Zemene YimerDee Dee LuuAlison Coomer BlundellMaria Florencia ErcoliPaulo VieiraValerie M. WilliamsonPamela C. RonaldShahid SiddiqueaDepartment of Entomology and Nematology, University of California, Davis, CA 95616bDepartment of Plant Pathology and the Genome Center, University of California, Davis, CA 95616cU. S. Department of Agriculture-Agricultural Research Service Mycology and Nematology Genetic Diversity and Biology Laboratory, Beltsville, MD 20705Proceedings of the National Academy of Sciences120292023-07-18T07:00:00Z2023-07-18T07:00:00Z10.1073/pnas.2304612120https://www.pnas.org/doi/abs/10.1073/pnas.2304612120?af=RHiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity in Fusarium oxysporum f.sp. ciceris
https://www.pnas.org/doi/abs/10.1073/pnas.2220570120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 27, July 2023. <br/>Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity in Fusarium oxysporum f.sp. cicerisdoi:10.1073/pnas.22205701202023-06-26T07:00:00ZAmna FayyazGuy RobinsonPeter L. ChangDagnachew BekeleSultan YimerNoelia Carrasquilla-GarciaKassaye NegashAnandkumar SurendraraoEric J. B. von WettbergSeid-Ahmed KemalKassahun TesfayeAsnake FikreAndrew D. FarmerDouglas R. CookaDepartment of Plant Pathology, University of California, Davis, CA 95616bDebre Zeit Agricultural Research Center, Ethiopian Institute for Agricultural Research, 32, Debre Zeit, EthiopiacInstitute of Biotechnology, Addis Ababa University, Addis Ababa 32853, EthiopiadDepartment of Plant Pathology, Woldia University, 400, Woldia, EthiopiaeEthiopian Institute of Agricultural Research, Melkassa Agricultural Research Center, 436, Nazareth, EthiopiafPlant Biology Graduate Group, University of California, Davis, CA 95616gDepartment of Plant and Soil Science, University of Vermont, Burlington, VT 05405hBiodiversity and Integrated Gene Management Program, International Center for Agricultural Research in the Dry Areas, Rabat, 10100 MoroccoiBio and Emerging Technology Institute, Addis Ababa, EthiopiajNational Center for Genome Resources, Santa Fe, NM 87505Proceedings of the National Academy of Sciences120272023-07-04T07:00:00Z2023-07-04T07:00:00Z10.1073/pnas.2220570120https://www.pnas.org/doi/abs/10.1073/pnas.2220570120?af=RSUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice
https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad229?af=R
PNAS Nexus, Volume 2, Issue 7, July 2023. <br/>SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in ricedoi:10.1093/pnasnexus/pgad2292023-07-11T07:00:00Z
Chih-Cheng Lin
Wan-Jia Lee
Cyong-Yu Zeng
Mei-Yi Chou
Ting-Jhen Lin
Choun-Sea Lin
Meng-Chiao Ho
Ming-Che Shih
Edward Bayer
PNAS Nexus272023-07-03T07:00:00Z2023-07-03T07:00:00Z10.1093/pnasnexus/pgad229https://www.pnas.org/doi/abs/10.1093/pnasnexus/pgad229?af=RCRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii
https://www.pnas.org/doi/abs/10.1073/pnas.2301525120?af=R
Proceedings of the National Academy of Sciences, Volume 120, Issue 25, June 2023. <br/>CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukiidoi:10.1073/pnas.23015251202023-06-12T07:00:00ZAmarish K. YadavCole ButlerAkihiko YamamotoAnandrao A. PatilAlun L. LloydMaxwell J. ScottaDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC 27615bBiomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, NC 27615Proceedings of the National Academy of Sciences120252023-06-20T07:00:00Z2023-06-20T07:00:00Z10.1073/pnas.2301525120https://www.pnas.org/doi/abs/10.1073/pnas.2301525120?af=R