Current Issue
- March 18, 2025
- vol. 122
- no. 11
- Humans routinely encounter new microbes, but it remains unclear how the number of introduced microbes affects their ability to colonize the gut microbiome. All else being equal, species are more likely to colonize when more individuals are ...The long-term success of introduced populations depends on both their initial size and ability to compete against existing residents, but it remains unclear how these factors collectively shape colonization dynamics. Here, we investigate how initial ...
- Cardiac adaptation to increased workload, as occurring in hypertension or valvular disease, causes structural and metabolic changes in cardiac cells leading to heart failure. While significant effort has gone into understanding the mechanisms ...Regulation of mitochondrial Ca2+ uptake is critical in cardiac adaptation to chronic stressors. Abnormalities in Ca2+ handling, including mitochondrial uptake mechanisms, have been implicated in pathological heart hypertrophy. Enhancing mitochondrial Ca2+ ...
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- Age-related cognitive decline is associated with metabolic, vascular, and inflammatory changes, making it challenging to distinguish primary causes from secondary (downstream) effects. This study demonstrates that brain aging follows a ...Understanding the key drivers of brain aging is essential for effective prevention and treatment of neurodegenerative diseases. Here, we integrate human brain and physiological data to investigate underlying mechanisms. Functional MRI analyses across four ...
- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
- In sophisticated auditory–motor learning such as musical instrument learning, little is understood about how brain plasticity develops over time and how the related individual variability is reflected in the neural architecture. In a ...The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to ...
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