Current Issue
- January 21, 2025
- vol. 122
- no. 3
- Our study addresses a fundamental challenge in the field of neural network modeling, offering critical insights into the training of recurrent neural networks (RNNs) that simulate cognitive processes. Specifically, we demonstrate that by ...Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neural circuits perform cognitive tasks. Training such networks to perform tasks that require information ...
- As a key factor in the type I interferon signaling, Interferon regulatory factor 3 (IRF3) activation must be tightly controlled to efficiently activate innate immunity and avoid overactivation of innate immunity. However, how the IRF3 ...Interferon regulatory factor 3 (IRF3) is the key transcription factor in the type I IFN signaling pathway, whose activation is regulated by multiple posttranslational modifications. Here, we identify SMYD3, a lysine methyltransferase, as a negative ...
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- Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and ...
- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
- Few recent advances in human medicine have been as influential as the finding that an imbalance (dysbiosis) of our resident microbial communities in the colon is linked to many chronic human illnesses. However, translating advances in ...The gut microbiota plays a role in many human diseases, but high-throughput sequence analysis does not provide a straightforward path for defining healthy microbial communities. Therefore, understanding mechanisms that drive compositional changes during ...
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