Current Issue
- December 3, 2024
- vol. 121
- no. 49
- Highly localized and transient membrane deformations driving membrane fission in the cell often elude experimental observation. Here, we used high-speed atomic force microscopy (HS-AFM) to discriminate between membrane deformation modes ...Dynamin 1 (Dyn1) GTPase, a principal driver of membrane fission during synaptic endocytosis, self-assembles into short mechanoactive helices cleaving the necks of endocytic vesicles. While structural information about Dyn1 helix is abundant, little is ...
- Norrie disease is a form of deaf blindness caused by mutations in NDP (Norrin Cystine Knot Growth Factor NDP gene). While vision loss is present at birth, hearing loss has a later onset making it a focus for treatment. Microvasculature and ...Variants in the gene NDP cause Norrie disease, a severe dual-sensory disorder characterized by congenital blindness due to disrupted retinal vascular development and progressive hearing loss accompanied by sensory hair cell death. NDP encodes the secreted ...
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- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
- Giant meteorite impacts during Earth’s early history likely had significant effects on early life. We studied the effects on the surface environment and life of a Paleoarchean impactor ~50 to 200× larger than the famous K-Pg impactor. The ...Large meteorite impacts must have strongly affected the habitability of the early Earth. Rocks of the Archean Eon record at least 16 major impact events, involving bolides larger than 10 km in diameter. These impacts probably had severe, albeit temporary, ...
- An influential study suggests that Black newborns experience much lower mortality when attended by Black physicians after birth. Using the same data, we replicate those findings and estimate alternative models that include controls for very ... The racial gap in infant mortality is a pressing public-health concern, and [B. N. Greenwood et al., Proc. Natl. Acad. Sci. U.S.A. 117, 21194–21200 (2020), 10.1073/pnas.1913405117] suggest that Black newborns are more likely to survive if cared for by ...
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