Current Issue
- October 21, 2025
- vol. 122
- no. 42
- The AAA+ protease LONP1 plays a critical role in regulating mitochondrial proteostasis by removing damaged and unfolded matrix proteins, including certain privileged folded substrates. To better understand LONP1 substrate selection and motor ...AAA+ enzymes use energy from ATP hydrolysis to remodel diverse cellular targets. Structures of substrate-bound AAA+ complexes suggest that these enzymes employ a conserved hand-over-hand mechanism to thread substrates through their central pore. However, ...
- Reliable estimates of digital adoption by gender are essential for tracking progress on global sustainable development targets, such as the United Nations Sustainable Development Goal 5 on gender equality. We construct subnational estimates of ...The digital revolution has ushered in many societal and economic benefits. Yet access to digital technologies such as mobile phones and internet remains highly unequal, especially by gender in the context of low- and middle-income countries (LMICs). While ...
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The Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS), is an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences. The journal is global in scope and submission is open to all researchers worldwide.
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- Organic contaminants partition to indoor surfaces, giving rise to human exposure via dermal uptake and nondietary ingestion pathways. However, the total partitioning capacity of indoor surfaces has not been experimentally quantified in the ...The total partitioning capacity of indoor surface reservoirs determines the mechanism by which humans receive nondietary exposure to organic contaminants, via inhalation, dermal uptake, and dust ingestion. And yet, this capacity is largely unknown. ...
- As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However, despite aging being the primary risk factor for AD, it remains unclear whether men and women differ in the ...
- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
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