Current Issue
- August 23, 2022
- vol. 119
- no. 34
- Prudent risk management requires consideration of bad-to-worst-case scenarios. Yet, for climate change, such potential futures are poorly understood. Could anthropogenic climate change result in worldwide societal collapse or even eventual human ...
- Apolipoprotein E4 (APOE4) is the most influential genetic risk factor for late-onset Alzheimer’s disease (AD). Carrying APOE4 increases the risk of developing AD by 4-fold (one allele) to 14-fold (two alleles). Cognitive impairment in AD ...Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer’s disease (AD). Apolipoprotein E4 (APOE4), the highest genetic risk factor for late-onset AD, has been shown to exacerbate tau ...
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