Current Issue
- November 14, 2023
- vol. 120
- no. 46
- Civil infrastructure will be essential to face the interlinked existential threats of climate change and rising resource demands while ensuring a livable Anthropocene for all. However, conventional infrastructure planning largely neglects the ...
- Insulin-like growth factor 2 (IGF2) is a key regulator of skeletal myogenesis during development. Currently, mechanisms regulating IGF2 expression and the signal transduction pathway induced by IGF2 have been extensively investigated. However, ...The insulin-like growth factor 2 (IGF2) plays critical roles in cell proliferation, migration, differentiation, and survival. Despite its importance, the molecular mechanisms mediating the trafficking of IGF2 along the secretory pathway remain unclear. ...
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In the News
- Measures of well-being have often been found to rise with log (income). Kahneman and Deaton [Proc. Natl. Acad. Sci. U.S.A. 107, 16489–93 (2010)] reported an exception; a measure of emotional well-being (happiness) increased but then flattened ...Do larger incomes make people happier? Two authors of the present paper have published contradictory answers. Using dichotomous questions about the preceding day, [Kahneman and Deaton, Proc. Natl. Acad. Sci. U.S.A. 107, 16489–16493 (2010)] reported a ...
- Our memories define us and connect us to others. Without them, we are lost. This is the driving force behind the global push to treat neurodegenerative diseases of the older population. How does one know they have a disease that has few ...Dementia is a brain disease which results in irreversible and progressive loss of cognition and motor activity. Despite global efforts, there is no simple and reliable diagnosis or treatment option. Current diagnosis involves indirect testing of commonly ...
- Pesticides are critical to agricultural intensification but can negatively impact human health. We show that as soy cultivation spread across Brazil, agricultural pesticide exposure was associated with increased childhood cancer mortality ...Over the last several decades, Brazil has become both the world’s leading soy producer and the world’s leading consumer of hazardous pesticides. Despite identified links between pesticide exposure and carcinogenesis, there has been little population-level ...
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