Current Issue
- October 29, 2024
- vol. 121
- no. 44
- Transepithelial dendrite (TED) formation of dendritic cells is an important biological process responsible for antigen sampling and immune surveillance in the gut, playing a crucial role in maintaining gut homeostasis. However, factors driving ...The intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules for gut immune cells. G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut luminal signals into host immune ...
- Oncogenic signaling pathways are intricately regulated networks where alterations can lead to malignant progression but also provide opportunities for targeted interventions. This study uncovers an essential interplay between the eIF4F ...The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a function of eIF4F in the negative regulation of the rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (...
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- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
- Giant meteorite impacts during Earth’s early history likely had significant effects on early life. We studied the effects on the surface environment and life of a Paleoarchean impactor ~50 to 200× larger than the famous K-Pg impactor. The ...Large meteorite impacts must have strongly affected the habitability of the early Earth. Rocks of the Archean Eon record at least 16 major impact events, involving bolides larger than 10 km in diameter. These impacts probably had severe, albeit temporary, ...
- An influential study suggests that Black newborns experience much lower mortality when attended by Black physicians after birth. Using the same data, we replicate those findings and estimate alternative models that include controls for very ... The racial gap in infant mortality is a pressing public-health concern, and [B. N. Greenwood et al., Proc. Natl. Acad. Sci. U.S.A. 117, 21194–21200 (2020), 10.1073/pnas.1913405117] suggest that Black newborns are more likely to survive if cared for by ...
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