Table of Contents

Biological Sciences

• Anthropology

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    Neandertal faces were not long; modern human faces are short

    Erik Trinkaus

    PNAS July 8, 2003 100 (14) 8142-8145; https://doi.org/10.1073/pnas.1433023100

• Biochemistry

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    Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

    Douglas A. Whittington, Kristin M. Rusche, Hyunshun Shin, Carol A. Fierke, and David W. Christianson

    PNAS July 8, 2003 100 (14) 8146-8150; https://doi.org/10.1073/pnas.1432990100
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    On the mechanism of chaperone activity of the small heat-shock protein of Methanococcus jannaschii

    Rosalind Kim, Luhua Lai, Hi-Hong Lee, Gang-Won Cheong, Kyeong Kyu Kim, Zheng Wu, Hisao Yokota, Susan Marqusee, and Sung-Hou Kim

    PNAS July 8, 2003 100 (14) 8151-8155; https://doi.org/10.1073/pnas.1032940100
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    Factors modulating conformational equilibria in large modular proteins: A case study with cobalamin-dependent methionine synthase

    • Inaugural Article

    Vahe Bandarian, Martha L. Ludwig, and Rowena G. Matthews

    PNAS July 8, 2003 100 (14) 8156-8163; https://doi.org/10.1073/pnas.1133218100
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    A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

    Zirong Li, Sara Van Calcar, Chunxu Qu, Webster K. Cavenee, Michael Q. Zhang, and Bing Ren

    PNAS July 8, 2003 100 (14) 8164-8169; https://doi.org/10.1073/pnas.1332764100
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    Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase

    Yoshimitsu Kuwabara, Tomoko Nishino, Ken Okamoto, Tomohiro Matsumura, Bryan T. Eger, Emil F. Pai, and Takeshi Nishino

    PNAS July 8, 2003 100 (14) 8170-8175; https://doi.org/10.1073/pnas.1431485100
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    Identification of the λ integrase surface that interacts with Xis reveals a residue that is also critical for Int dimer formation

    David Warren, My D. Sam, Kate Manley, Dibyendu Sarkar, Sang Yeol Lee, Mohamad Abbani, Jonathan M. Wojciak, Robert T. Clubb, and Arthur Landy

    PNAS July 8, 2003 100 (14) 8176-8181; https://doi.org/10.1073/pnas.1033041100
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    Glycation of the amyloid β-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease

    Tobin J. Dickerson and Kim D. Janda

    PNAS July 8, 2003 100 (14) 8182-8187; https://doi.org/10.1073/pnas.1332847100
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    A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase

    Christian Siebold, Luis Fernando García-Alles, Bernhard Erni, and Ulrich Baumann

    PNAS July 8, 2003 100 (14) 8188-8192; https://doi.org/10.1073/pnas.0932787100
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    The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants

    Osamu Imamura and Judith L. Campbell

    PNAS July 8, 2003 100 (14) 8193-8198; https://doi.org/10.1073/pnas.1431624100
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    A homologue of elongation factor 1γ regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae

    Ingeborg Hanbauer, Emily S. Boja, and Jackob Moskovitz

    PNAS July 8, 2003 100 (14) 8199-8204; https://doi.org/10.1073/pnas.1432898100
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    Optimization of protease-inhibitor interactions by randomizing adventitious contacts

    Tomoko Komiyama, Bryan VanderLugt, Martin Fugère, Robert Day, Randal J. Kaufman, and Robert S. Fuller

    PNAS July 8, 2003 100 (14) 8205-8210; https://doi.org/10.1073/pnas.1032865100
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    Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter

    Tim Veldman, Xuefeng Liu, Hang Yuan, and Richard Schlegel

    PNAS July 8, 2003 100 (14) 8211-8216; https://doi.org/10.1073/pnas.1435900100

• Biophysics

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    Analysis of the distributed computing approach applied to the folding of a small β peptide

    Emanuele Paci, Andrea Cavalli, Michele Vendruscolo, and Amedeo Caflisch

    PNAS July 8, 2003 100 (14) 8217-8222; https://doi.org/10.1073/pnas.1331838100
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    Quantitative modeling of sensitivity in bacterial chemotaxis: The role of coupling among different chemoreceptor species

    Bernardo A. Mello and Yuhai Tu

    PNAS July 8, 2003 100 (14) 8223-8228; https://doi.org/10.1073/pnas.1330839100

• Cell Biology

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    Elucidation of the molecular logic by which misfolded α1-antitrypsin is preferentially selected for degradation

    Ying Wu, Matthew T. Swulius, Kelley W. Moremen, and Richard N. Sifers

    PNAS July 8, 2003 100 (14) 8229-8234; https://doi.org/10.1073/pnas.1430537100
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    Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter

    Ellen M. Judd, Kathleen R. Ryan, W. E. Moerner, Lucy Shapiro, and Harley H. McAdams

    PNAS July 8, 2003 100 (14) 8235-8240; https://doi.org/10.1073/pnas.1433105100
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    Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells

    Lawrence Rajendran, Madhan Masilamani, Samuel Solomon, Ritva Tikkanen, Claudia A. O. Stuermer, Helmut Plattner, and Harald Illges

    PNAS July 8, 2003 100 (14) 8241-8246; https://doi.org/10.1073/pnas.1331629100
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    Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

    Leonard Girnita, Ada Girnita, and Olle Larsson

    PNAS July 8, 2003 100 (14) 8247-8252; https://doi.org/10.1073/pnas.1431613100
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    Functional reconstitution of COPI coat assembly and disassembly using chemically defined components

    Constanze Reinhard, Michael Schweikert, Felix T. Wieland, and Walter Nickel

    PNAS July 8, 2003 100 (14) 8253-8257; https://doi.org/10.1073/pnas.1432391100
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    Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas

    Robson A. S. Santos, Ana C. Simoes e Silva, Christine Maric, Denise M. R. Silva, Raquel Pillar Machado, Insa de Buhr, Silvia Heringer-Walther, Sergio Veloso B. Pinheiro, Myriam Teresa Lopes, Michael Bader, Elizabeth P. Mendes, Virgina Soares Lemos, Maria Jose Campagnole-Santos, Heinz-Peter Schultheiss, Robert Speth, and Thomas Walther

    PNAS July 8, 2003 100 (14) 8258-8263; https://doi.org/10.1073/pnas.1432869100
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    Inhibiting expression of specific genes in mammalian cells with 5′ end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA

    Puri Fortes, Yolanda Cuevas, Fei Guan, Peng Liu, Sara Pentlicky, Stephen P. Jung, Maria L. Martínez-Chantar, Jesús Prieto, David Rowe, and Samuel I. Gunderson

    PNAS July 8, 2003 100 (14) 8264-8269; https://doi.org/10.1073/pnas.1332669100
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    Promotion of Gαi3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP

    Thierry Fischer, Luc De Vries, Timo Meerloo, and Marilyn Gist Farquhar

    PNAS July 8, 2003 100 (14) 8270-8275; https://doi.org/10.1073/pnas.1432965100
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    Nur77 as a survival factor in tumor necrosis factor signaling

    Shinobu Suzuki, Nobutaka Suzuki, Christine Mirtsos, Thomas Horacek, Elizabeth Lye, Seo-Kyu Noh, Alexandra Ho, Denis Bouchard, Tak W. Mak, and Wen-Chen Yeh

    PNAS July 8, 2003 100 (14) 8276-8280; https://doi.org/10.1073/pnas.0932598100

• Developmental Biology

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    Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

    Hester Tidcombe, Amy Jackson-Fisher, Kathleen Mathers, David F. Stern, Martin Gassmann, and Jon P. Golding

    PNAS July 8, 2003 100 (14) 8281-8286; https://doi.org/10.1073/pnas.1436402100
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    Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling

    Georgette L. Sass, Antonio Pannuti, and John C. Lucchesi

    PNAS July 8, 2003 100 (14) 8287-8291; https://doi.org/10.1073/pnas.1332749100
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    Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

    Marika Charalambous, Florentia M. Smith, William R. Bennett, Tracey E. Crew, Francesca Mackenzie, and Andrew Ward

    PNAS July 8, 2003 100 (14) 8292-8297; https://doi.org/10.1073/pnas.1532175100

• Ecology

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    Long-term trends and a sustainability transition

    Robert W. Kates and Thomas M. Parris

    PNAS July 8, 2003 100 (14) 8062-8067; https://doi.org/10.1073/pnas.1231331100
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    Characterizing a sustainability transition: Goals, targets, trends, and driving forces

    Thomas M. Parris and Robert W. Kates

    PNAS July 8, 2003 100 (14) 8068-8073; https://doi.org/10.1073/pnas.1231336100
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    A framework for vulnerability analysis in sustainability science

    B. L. Turner II, Roger E. Kasperson, Pamela A. Matson, James J. McCarthy, Robert W. Corell, Lindsey Christensen, Noelle Eckley, Jeanne X. Kasperson, Amy Luers, Marybeth L. Martello, Colin Polsky, Alexander Pulsipher, and Andrew Schiller

    PNAS July 8, 2003 100 (14) 8074-8079; https://doi.org/10.1073/pnas.1231335100
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    Illustrating the coupled human–environment system for vulnerability analysis: Three case studies

    • From the Cover

    B. L. Turner II, Pamela A. Matson, James J. McCarthy, Robert W. Corell, Lindsey Christensen, Noelle Eckley, Grete K. Hovelsrud-Broda, Jeanne X. Kasperson, Roger E. Kasperson, Amy Luers, Marybeth L. Martello, Svein Mathiesen, Rosamond Naylor, Colin Polsky, Alexander Pulsipher, Andrew Schiller, Henrik Selin, and Nicholas Tyler

    PNAS July 8, 2003 100 (14) 8080-8085; https://doi.org/10.1073/pnas.1231334100
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    Knowledge systems for sustainable development

    David W. Cash, William C. Clark, Frank Alcock, Nancy M. Dickson, Noelle Eckley, David H. Guston, Jill Jäger, and Ronald B. Mitchell

    PNAS July 8, 2003 100 (14) 8086-8091; https://doi.org/10.1073/pnas.1231332100
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    Complete genome sequence of the marine planctomycete Pirellula sp. strain 1

    F. O. Glöckner, M. Kube, M. Bauer, H. Teeling, T. Lombardot, W. Ludwig, D. Gade, A. Beck, K. Borzym, K. Heitmann, R. Rabus, H. Schlesner, R. Amann, and R. Reinhardt

    PNAS July 8, 2003 100 (14) 8298-8303; https://doi.org/10.1073/pnas.1431443100
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    Birds defend trees from herbivores in a Neotropical forest canopy

    • From the Cover

    Sunshine A. Van Bael, Jeffrey D. Brawn, and Scott K. Robinson

    PNAS July 8, 2003 100 (14) 8304-8307; https://doi.org/10.1073/pnas.1431621100

• Evolution

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    Molecular analysis of the evolutionary significance of ultraviolet vision in vertebrates

    • From the Cover

    Yongsheng Shi and Shozo Yokoyama

    PNAS July 8, 2003 100 (14) 8308-8313; https://doi.org/10.1073/pnas.1532535100

    See companion article:

    • Paleomolecular biology unravels the evolutionary mystery of vertebrate UV vision

      - Jun 30, 2003
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    The first tunicate from the Early Cambrian of South China

    Jun-Yuan Chen, Di-Ying Huang, Qing-Qing Peng, Hui-Mei Chi, Xiu-Qiang Wang, and Man Feng

    PNAS July 8, 2003 100 (14) 8314-8318; https://doi.org/10.1073/pnas.1431177100
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    Evolutionary genomics of inversions in Drosophila pseudoobscura: Evidence for epistasis

    Stephen W. Schaeffer, M. Paula Goetting-Minesky, Miro Kovacevic, John R. Peoples, Jennifer L. Graybill, Jonathan M. Miller, Kyungsun Kim, Julie G. Nelson, and Wyatt W. Anderson

    PNAS July 8, 2003 100 (14) 8319-8324; https://doi.org/10.1073/pnas.1432900100
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    The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of the mammalian order Macroscelidea (elephant shrews)

    Christophe J. Douady, François Catzeflis, Jaishree Raman, Mark S. Springer, and Michael J. Stanhope

    PNAS July 8, 2003 100 (14) 8325-8330; https://doi.org/10.1073/pnas.0832467100
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    Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units

    Jinxiu Shi, Huifeng Xi, Ying Wang, Chenghui Zhang, Zhengwen Jiang, Kuixing Zhang, Yayun Shen, Lin Jin, Kaiyue Zhang, Wentao Yuan, Ying Wang, Jie Lin, Qi Hua, Fengqing Wang, Shuhua Xu, Suangxi Ren, Shijie Xu, Guoping Zhao, Zhu Chen, Li Jin, and Wei Huang

    PNAS July 8, 2003 100 (14) 8331-8336; https://doi.org/10.1073/pnas.1332748100
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    Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates

    Jianzhi Zhang and David M. Webb

    PNAS July 8, 2003 100 (14) 8337-8341; https://doi.org/10.1073/pnas.1331721100

• Genetics

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    MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

    Zhen-Biao Xia, Melanie Anderson, Manuel O. Diaz, and Nancy J. Zeleznik-Le

    PNAS July 8, 2003 100 (14) 8342-8347; https://doi.org/10.1073/pnas.1436338100
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    A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae)

    Olga G. Troyanskaya, Kara Dolinski, Art B. Owen, Russ B. Altman, and David Botstein

    PNAS July 8, 2003 100 (14) 8348-8353; https://doi.org/10.1073/pnas.0832373100
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    RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

    Krystyna Mazan-Mamczarz, Stefanie Galbán, Isabel López de Silanes, Jennifer L. Martindale, Ulus Atasoy, Jack D. Keene, and Myriam Gorospe

    PNAS July 8, 2003 100 (14) 8354-8359; https://doi.org/10.1073/pnas.1432104100
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    Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice

    Mitchell L. Klebig, Melissa D. Wall, Mark D. Potter, Erica L. Rowe, Donald A. Carpenter, and Eugene M. Rinchik

    PNAS July 8, 2003 100 (14) 8360-8365; https://doi.org/10.1073/pnas.1432634100

• Immunology

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    TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

    Marco Marini, Giorgos Bamias, Jesús Rivera-Nieves, Christopher A. Moskaluk, Sharon B. Hoang, William G. Ross, Theresa T. Pizarro, and Fabio Cominelli

    PNAS July 8, 2003 100 (14) 8366-8371; https://doi.org/10.1073/pnas.1432897100
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    Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

    Giao Q. Phan, James C. Yang, Richard M. Sherry, Patrick Hwu, Suzanne L. Topalian, Douglas J. Schwartzentruber, Nicholas P. Restifo, Leah R. Haworth, Claudia A. Seipp, Linda J. Freezer, Kathleen E. Morton, Sharon A. Mavroukakis, Paul H. Duray, Seth M. Steinberg, James P. Allison, Thomas A. Davis, and Steven A. Rosenberg

    PNAS July 8, 2003 100 (14) 8372-8377; https://doi.org/10.1073/pnas.1533209100
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    Regulatory CD8⁺ T cells fine-tune the myelin basic protein-reactive T cell receptor Vβ repertoire during experimental autoimmune encephalomyelitis

    H. Jiang, S. Curran, E. Ruiz-Vazquez, B. Liang, R. Winchester, and L. Chess

    PNAS July 8, 2003 100 (14) 8378-8383; https://doi.org/10.1073/pnas.1432871100
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    Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺ T cells in autoimmune diabetes

    Scott M. Lieberman, Anne M. Evans, Bingye Han, Toshiyuki Takaki, Yuliya Vinnitskaya, Jennifer A. Caldwell, David V. Serreze, Jeffrey Shabanowitz, Donald F. Hunt, Stanley G. Nathenson, Pere Santamaria, and Teresa P. DiLorenzo

    PNAS July 8, 2003 100 (14) 8384-8388; https://doi.org/10.1073/pnas.0932778100

    See companion article:

    • A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes

      - Jul 14, 2003
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    Human cerebrospinal fluid central memory CD4⁺ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

    Pia Kivisäkk, Don J. Mahad, Melissa K. Callahan, Corinna Trebst, Barbara Tucky, Tao Wei, Lijun Wu, Espen S. Baekkevold, Hans Lassmann, Susan M. Staugaitis, James J. Campbell, and Richard M. Ransohoff

    PNAS July 8, 2003 100 (14) 8389-8394; https://doi.org/10.1073/pnas.1433000100
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    Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo

    Jennifer L. Matsuda, Laurent Gapin, Jody L. Baron, Stéphane Sidobre, Daniel B. Stetson, Markus Mohrs, Richard M. Locksley, and Mitchell Kronenberg

    PNAS July 8, 2003 100 (14) 8395-8400; https://doi.org/10.1073/pnas.1332805100

• Medical Sciences

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    R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms

    Tatsuyoshi Kawamura, Forrest O. Gulden, Makoto Sugaya, David T. McNamara, Debra L. Borris, Michael M. Lederman, Jan M. Orenstein, Peter A. Zimmerman, and Andrew Blauvelt

    PNAS July 8, 2003 100 (14) 8401-8406; https://doi.org/10.1073/pnas.1432450100
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    Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

    Luis A. Ortiz, Frederica Gambelli, Christine McBride, Dina Gaupp, Melody Baddoo, Naftali Kaminski, and Donald G. Phinney

    PNAS July 8, 2003 100 (14) 8407-8411; https://doi.org/10.1073/pnas.1432929100
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    SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

    Hui Li, Lois Myeroff, Dominic Smiraglia, Michael F. Romero, Theresa P. Pretlow, Lakshmi Kasturi, James Lutterbaugh, Ronald M. Rerko, Graham Casey, Jean-Pierre Issa, Joseph Willis, James K. V. Willson, Christoph Plass, and Sanford D. Markowitz

    PNAS July 8, 2003 100 (14) 8412-8417; https://doi.org/10.1073/pnas.1430846100
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    Repeated observation of breast tumor subtypes in independent gene expression data sets

    Therese Sørlie, Robert Tibshirani, Joel Parker, Trevor Hastie, J. S. Marron, Andrew Nobel, Shibing Deng, Hilde Johnsen, Robert Pesich, Stephanie Geisler, Janos Demeter, Charles M. Perou, Per E. Lønning, Patrick O. Brown, Anne-Lise Børresen-Dale, and David Botstein

    PNAS July 8, 2003 100 (14) 8418-8423; https://doi.org/10.1073/pnas.0932692100
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    Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

    Shunsuke Kato, Shuang-Yin Han, Wen Liu, Kazunori Otsuka, Hiroyuki Shibata, Ryunosuke Kanamaru, and Chikashi Ishioka

    PNAS July 8, 2003 100 (14) 8424-8429; https://doi.org/10.1073/pnas.1431692100
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    Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

    Peter M. Siegel, Weiping Shu, Robert D. Cardiff, William J. Muller, and Joan Massagué

    PNAS July 8, 2003 100 (14) 8430-8435; https://doi.org/10.1073/pnas.0932636100

    See companion article:

    • The two faces of transforming growth factor β in carcinogenesis

      - Jul 14, 2003
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    The lethal effects of transplantation of Socs1^-/- bone marrow cells into irradiated adult syngeneic recipients

    Donald Metcalf, Sandra Mifsud, Ladina Di Rago, and Warren S. Alexander

    PNAS July 8, 2003 100 (14) 8436-8441; https://doi.org/10.1073/pnas.1032925100
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    Human topoisomerase I promotes HIV-1 proviral DNA synthesis: Implications for the species specificity and cellular tropism of HIV-1 infection

    Yuko Shoya, Kenzo Tokunaga, Hirofumi Sawa, Masae Maeda, Tomonori Ueno, Tomoki Yoshikawa, Hideki Hasegawa, Tetsutaro Sata, Takeshi Kurata, William W. Hall, Bryan R. Cullen, and Hidehiro Takahashi

    PNAS July 8, 2003 100 (14) 8442-8447; https://doi.org/10.1073/pnas.1430827100
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    Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia

    Björn Steffen, Hubert Serve, Wolfgang E. Berdel, Shuchi Agrawal, Bryan Linggi, Thomas Büchner, Scott W. Hiebert, and Carsten Müller-Tidow

    PNAS July 8, 2003 100 (14) 8448-8453; https://doi.org/10.1073/pnas.1330293100
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    Does a betaretrovirus infection trigger primary biliary cirrhosis?

    Lizhe Xu, Zhiwei Shen, Linsheng Guo, Brent Fodera, Adrian Keogh, Ruth Joplin, Barbara O'Donnell, James Aitken, William Carman, James Neuberger, and Andrew Mason

    PNAS July 8, 2003 100 (14) 8454-8459; https://doi.org/10.1073/pnas.1433063100
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    Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions

    Yong-Hui Zheng, Ana Plemenitas, Christopher J. Fielding, and B. Matija Peterlin

    PNAS July 8, 2003 100 (14) 8460-8465; https://doi.org/10.1073/pnas.1437453100
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    Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

    Mary Elizabeth Patti, Atul J. Butte, Sarah Crunkhorn, Kenneth Cusi, Rachele Berria, Sangeeta Kashyap, Yoshinori Miyazaki, Isaac Kohane, Maura Costello, Robert Saccone, Edwin J. Landaker, Allison B. Goldfine, Edward Mun, Ralph DeFronzo, Jean Finlayson, C. Ronald Kahn, and Lawrence J. Mandarino

    PNAS July 8, 2003 100 (14) 8466-8471; https://doi.org/10.1073/pnas.1032913100
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    Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

    Erik I. Christensen, Olivier Devuyst, Geneviève Dom, Rikke Nielsen, Patrick Van Der Smissen, Pierre Verroust, Michèle Leruth, William B. Guggino, and Pierre J. Courtoy

    PNAS July 8, 2003 100 (14) 8472-8477; https://doi.org/10.1073/pnas.1432873100

• Microbiology

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    Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

    • From the Cover

    Robert J. Belland, Guangming Zhong, Deborah D. Crane, Daniel Hogan, Daniel Sturdevant, Jyotika Sharma, Wandy L. Beatty, and Harlan D. Caldwell

    PNAS July 8, 2003 100 (14) 8478-8483; https://doi.org/10.1073/pnas.1331135100

    See companion article:

    • Chlamydia uncloaked

      - Jun 30, 2003
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    Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa

    Matthew C. Wolfgang, Bridget R. Kulasekara, Xiaoyou Liang, Dana Boyd, Kai Wu, Qing Yang, C. Garrett Miyada, and Stephen Lory

    PNAS July 8, 2003 100 (14) 8484-8489; https://doi.org/10.1073/pnas.0832438100
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    Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling

    Yuying Liang and Don Ganem

    PNAS July 8, 2003 100 (14) 8490-8495; https://doi.org/10.1073/pnas.1432843100
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    Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress

    Jeffrey M. Schapiro, Stephen J. Libby, and Ferric C. Fang

    PNAS July 8, 2003 100 (14) 8496-8501; https://doi.org/10.1073/pnas.1033133100
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    Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax

    Xiaorong Feng, Jane M. Carlton, Deirdre A. Joy, Jianbing Mu, Tetsuya Furuya, Bernard B. Suh, Yufeng Wang, John W. Barnwell, and Xin-Zhuan Su

    PNAS July 8, 2003 100 (14) 8502-8507; https://doi.org/10.1073/pnas.1232502100
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    Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae

    Long Hang, Manohar John, Muhammad Asaduzzaman, Emily Anna Bridges, Cecily Vanderspurt, Thomas J. Kirn, Ronald K. Taylor, Jeffrey D. Hillman, Ann Progulske-Fox, Martin Handfield, Edward T. Ryan, and Stephen B. Calderwood

    PNAS July 8, 2003 100 (14) 8508-8513; https://doi.org/10.1073/pnas.1431769100

• Neuroscience

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    Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

    Seija Lehnardt, Leon Massillon, Pamela Follett, Frances E. Jensen, Rajiv Ratan, Paul A. Rosenberg, Joseph J. Volpe, and Timothy Vartanian

    PNAS July 8, 2003 100 (14) 8514-8519; https://doi.org/10.1073/pnas.1432609100
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    A neuronal network model linking subjective reports and objective physiological data during conscious perception

    Stanislas Dehaene, Claire Sergent, and Jean-Pierre Changeux

    PNAS July 8, 2003 100 (14) 8520-8525; https://doi.org/10.1073/pnas.1332574100
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    Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

    Ruolan Liu, Ingrid Y. Liu, Xiaoning Bi, Richard F. Thompson, Susan R. Doctrow, Bernard Malfroy, and Michel Baudry

    PNAS July 8, 2003 100 (14) 8526-8531; https://doi.org/10.1073/pnas.1332809100
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    ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

    Lidong Liu, Jane E. Cavanaugh, Yupeng Wang, Hiroyuki Sakagami, Zixu Mao, and Zhengui Xia

    PNAS July 8, 2003 100 (14) 8532-8537; https://doi.org/10.1073/pnas.1332804100
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    Neural correlates of interindividual differences in the subjective experience of pain

    Robert C. Coghill, John G. McHaffie, and Yi-Fen Yen

    PNAS July 8, 2003 100 (14) 8538-8542; first published June 24, 2003. https://doi.org/10.1073/pnas.1430684100

• Pharmacology

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    Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity

    • From the Cover

    Michael F. Wilkemeyer, Shao-yu Chen, Carrie E. Menkari, Douglas E. Brenneman, Kathleen K. Sulik, and Michael E. Charness

    PNAS July 8, 2003 100 (14) 8543-8548; https://doi.org/10.1073/pnas.1331636100

    See companion article:

    • Linking acquired neurodevelopmental disorders to defects in cell adhesion

      - Jun 30, 2003
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    Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity

    Catherine Rougeot, Michaël Messaoudi, Véronique Hermitte, Anne Gaëlle Rigault, Thierry Blisnick, Christophe Dugave, Didier Desor, and François Rougeon

    PNAS July 8, 2003 100 (14) 8549-8554; https://doi.org/10.1073/pnas.1431850100

• Physiology

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    Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice

    Radia Tamarat, Jean-Sébastien Silvestre, Maya Huijberts, Joelle Benessiano, Teni G. Ebrahimian, Micheline Duriez, Marie-Paule Wautier, Jean Luc Wautier, and Bernard I. Lévy

    PNAS July 8, 2003 100 (14) 8555-8560; https://doi.org/10.1073/pnas.1236929100
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    Glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret

    Laura Clamon Schulz and Janice M. Bahr

    PNAS July 8, 2003 100 (14) 8561-8566; https://doi.org/10.1073/pnas.1531024100
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    A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract

    Gianrico Farrugia, Sha Lei, Xue Lin, Steven M. Miller, Karl A. Nath, Christopher D. Ferris, Michael Levitt, and Joseph H. Szurszewski

    PNAS July 8, 2003 100 (14) 8567-8570; https://doi.org/10.1073/pnas.1431233100

• Plant Biology

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    The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis

    Tim Durfee, Judith L. Roe, R. Allen Sessions, Carla Inouye, Kyle Serikawa, Kenneth A. Feldmann, Detlef Weigel, and Patricia C. Zambryski

    PNAS July 8, 2003 100 (14) 8571-8576; https://doi.org/10.1073/pnas.1033043100
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    A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants

    Paula Hauck, Roger Thilmony, and Sheng Yang He

    PNAS July 8, 2003 100 (14) 8577-8582; https://doi.org/10.1073/pnas.1431173100
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    phot1 and phot2 mediate blue light-induced transient increases in cytosolic Ca²⁺ differently in Arabidopsis leaves

    Akiko Harada, Tatsuya Sakai, and Kiyotaka Okada

    PNAS July 8, 2003 100 (14) 8583-8588; https://doi.org/10.1073/pnas.1336802100
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    A SNARE complex containing SGR3/AtVAM3 and ZIG/VTI11 in gravity-sensing cells is important for Arabidopsis shoot gravitropism

    Daisuke Yano, Masakazu Sato, Chieko Saito, Masa H. Sato, Miyo Terao Morita, and Masao Tasaka

    PNAS July 8, 2003 100 (14) 8589-8594; https://doi.org/10.1073/pnas.1430749100
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    A functional genomics approach toward the understanding of secondary metabolism in plant cells

    Alain Goossens, Suvi T. Häkkinen, Into Laakso, Tuulikki Seppänen-Laakso, Stefania Biondi, Valerie De Sutter, Freya Lammertyn, Anna Maria Nuutila, Hans Söderlund, Marc Zabeau, Dirk Inzé, and Kirsi-Marja Oksman-Caldentey

    PNAS July 8, 2003 100 (14) 8595-8600; https://doi.org/10.1073/pnas.1032967100
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    The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase

    Katja Schneider, Klaus Hövel, Kilian Witzel, Björn Hamberger, Dietmar Schomburg, Erich Kombrink, and Hans-Peter Stuible

    PNAS July 8, 2003 100 (14) 8601-8606; https://doi.org/10.1073/pnas.1430550100