Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral gene transfer, adaptive evolution, and gene duplication

Rhoda J. Kinsella, David A. Fitzpatrick, Christopher J. Creevey, and James O. McInerney
PNAS September 2, 2003 100 (18) 10320-10325; https://doi.org/10.1073/pnas.1737230100

  1. Edited by Rita R. Colwell, National Science Foundation, Arlington, VA, and approved June 24, 2003 (received for review November 30, 2002)

Article Figures & SI

Figures

  • Fig. 1.
    Fig. 1.

    Simplified diagram of the Kyoto Encyclopedia of Genes and Genomes fatty acid biosynthetic pathway I indicating the EC numbers of the enzymes involved and the number of sequences in each alignment. The colored boxes indicate that an alignment has been analyzed for this step of the pathway, and the letters of the alphabet (A-G) in order correspond to the tree diagram constructed for that alignment (see Figs. 2, 3, 4, 5 and 7-9).

  • Fig. 2.
    Fig. 2.

    Phylogenetic tree of the acetyl-CoA carboxylase, carboxyl transferase β-subunit, corresponding to Fig. 1 A. The numbers on the branches are Bayesian clade probabilities. The arrow indicates the branch that was analyzed for signatures indicative of adaptive evolution.

  • Fig. 3.
    Fig. 3.

    Phylogenetic tree inferred from the 3-oxoacyl-(acp) synthase III genes. This tree corresponds to Fig. 1C. Numbers on internal branches indicate clade credibility values for those internal branches where the values were <100. All unlabeled branches correspond to credibility values of 100. The arrow indicates the branch that was analyzed for signatures indicative of adaptive evolution.

  • Fig. 4.
    Fig. 4.

    Phylogenetic tree inferred from 3-oxoacyl (acp) reductase genes. This tree corresponds to Fig. 1F. The numbers on the internal branches are Bayesian clade credibility values. The arrow indicates the branch that was analyzed for signatures indicative of adaptive evolution.

  • Fig. 5.
    Fig. 5.

    Phylogenetic tree inferred from enoyl (acp) reductase genes. This tree corresponds to Fig. 1G. The numbers on the internal branches are Bayesian clade credibility values. The arrow indicates the branch that was analyzed for signatures indicative of adaptive evolution.

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Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral gene transfer, adaptive evolution, and gene duplication
Rhoda J. Kinsella, David A. Fitzpatrick, Christopher J. Creevey, James O. McInerney
Proceedings of the National Academy of Sciences Sep 2003, 100 (18) 10320-10325; DOI: 10.1073/pnas.1737230100
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