Table of Contents

Biological Sciences

• Biochemistry

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    Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism

    I. Ruiz-Stewart, S. R. Tiyyagura, J. E. Lin, S. Kazerounian, G. M. Pitari, S. Schulz, E. Martin, F. Murad, and S. A. Waldman

    PNAS January 6, 2004 101 (1) 37-42; https://doi.org/10.1073/pnas.0305080101
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    Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes

    Jiang-Wen Zhang, Qi-Qun Tang, Charles Vinson, and M. Daniel Lane

    PNAS January 6, 2004 101 (1) 43-47; https://doi.org/10.1073/pnas.0307229101
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    A site-specific factor interacts directly with its cognate RNA editing site in chloroplast transcripts

    Tetsuya Miyamoto, Junichi Obokata, and Masahiro Sugiura

    PNAS January 6, 2004 101 (1) 48-52; https://doi.org/10.1073/pnas.0307163101
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    Selective abolition of pancreatic RNase binding to its inhibitor protein

    Kapil Kumar, Michael Brady, and Robert Shapiro

    PNAS January 6, 2004 101 (1) 53-58; https://doi.org/10.1073/pnas.0307268101
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    Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase

    Momi Iwata, Hiromi Imamura, Elizabeth Stambouli, Chiyo Ikeda, Masatada Tamakoshi, Koji Nagata, Hisayoshi Makyio, Ben Hankamer, Jim Barber, Masasuke Yoshida, Ken Yokoyama, and So Iwata

    PNAS January 6, 2004 101 (1) 59-64; https://doi.org/10.1073/pnas.0305165101
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    A deoxyribozyme that harnesses light to repair thymine dimers in DNA

    Daniel J.-F. Chinnapen and Dipankar Sen

    PNAS January 6, 2004 101 (1) 65-69; https://doi.org/10.1073/pnas.0305943101
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    Structure of HrcQ_B-C, a conserved component of the bacterial type III secretion systems

    Vasiliki E. Fadouloglou, Anastasia P. Tampakaki, Nicholas M. Glykos, Marina N. Bastaki, Jonathan M. Hadden, Simon E. Phillips, Nicholas J. Panopoulos, and Michael Kokkinidis

    PNAS January 6, 2004 101 (1) 70-75; https://doi.org/10.1073/pnas.0304579101
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    ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K⁺ channel Kir6.2 revealed by fluorescence resonance energy transfer

    Takashi Tsuboi, Jonathan D. Lippiat, Frances M. Ashcroft, and Guy A. Rutter

    PNAS January 6, 2004 101 (1) 76-81; https://doi.org/10.1073/pnas.0306347101
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    Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster

    Shuji Hanai, Masayuki Kanai, Sayaka Ohashi, Keiji Okamoto, Mitsunori Yamada, Hitoshi Takahashi, and Masanao Miwa

    PNAS January 6, 2004 101 (1) 82-86; https://doi.org/10.1073/pnas.2237114100
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    Sequence determinants of amyloid fibril formation

    Manuela López de la Paz and Luis Serrano

    PNAS January 6, 2004 101 (1) 87-92; https://doi.org/10.1073/pnas.2634884100
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    U4 small nuclear RNA can function in both the major and minor spliceosomes

    Girish C. Shukla and Richard A. Padgett

    PNAS January 6, 2004 101 (1) 93-98; https://doi.org/10.1073/pnas.0304919101
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    Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)

    Jianyin Long, Guannan Wang, Isao Matsuura, Dongming He, and Fang Liu

    PNAS January 6, 2004 101 (1) 99-104; https://doi.org/10.1073/pnas.0307598100

• Biophysics

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    Biomimetic ratcheting motion of a soft, slender, sessile gel

    • From the Cover

    L. Mahadevan, S. Daniel, and M. K. Chaudhury

    PNAS January 6, 2004 101 (1) 23-26; https://doi.org/10.1073/pnas.2637051100
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    Intracellular calmodulin availability accessed with two-photon cross-correlation

    Sally A. Kim, Katrin G. Heinze, M. Neal Waxham, and Petra Schwille

    PNAS January 6, 2004 101 (1) 105-110; https://doi.org/10.1073/pnas.2436461100
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    Local complexity of amino acid interactions in a protein core

    Rajul K. Jain and Rama Ranganathan

    PNAS January 6, 2004 101 (1) 111-116; https://doi.org/10.1073/pnas.2534352100
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    Energetics of ion conduction through the gramicidin channel

    Toby W. Allen, Olaf S. Andersen, and Benoît Roux

    PNAS January 6, 2004 101 (1) 117-122; https://doi.org/10.1073/pnas.2635314100
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    Structural, dynamic, and energetic aspects of long-range electron transfer in photosynthetic reaction centers

    Jan M. Kriegl and G. Ulrich Nienhaus

    PNAS January 6, 2004 101 (1) 123-128; https://doi.org/10.1073/pnas.2434740100
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    Detection of bacteria in suspension by using a superconducting quantum interference device

    H. L. Grossman, W. R. Myers, V. J. Vreeland, R. Bruehl, M. D. Alper, C. R. Bertozzi, and John Clarke

    PNAS January 6, 2004 101 (1) 129-134; https://doi.org/10.1073/pnas.0307128101

• Cell Biology

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    An approach to genomewide screens of expressed small interfering RNAs in mammalian cells

    Lianxing Zheng, Jun Liu, Sergei Batalov, Demin Zhou, Anthony Orth, Sheng Ding, and Peter G. Schultz

    PNAS January 6, 2004 101 (1) 135-140; https://doi.org/10.1073/pnas.2136685100
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    Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation

    Micah Luftig, Teruhito Yasui, Vishal Soni, Myung-Soo Kang, Nils Jacobson, Ellen Cahir-McFarland, Brian Seed, and Elliott Kieff

    PNAS January 6, 2004 101 (1) 141-146; https://doi.org/10.1073/pnas.2237183100
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    Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

    Shahab Uddin, Jeong Ah-Kang, Jodie Ulaszek, Dolores Mahmud, and Amittha Wickrema

    PNAS January 6, 2004 101 (1) 147-152; https://doi.org/10.1073/pnas.0307075101
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    Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

    Xingming Deng, Fengqin Gao, Tammy Flagg, and W. Stratford May Jr.

    PNAS January 6, 2004 101 (1) 153-158; https://doi.org/10.1073/pnas.2533920100

• Developmental Biology

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    A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos

    Yong-Ou Kim, Sang-Joon Park, Robert S. Balaban, Marshall Nirenberg, and Yongsok Kim

    PNAS January 6, 2004 101 (1) 159-164; https://doi.org/10.1073/pnas.0307205101
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    Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis

    Nicholas Marsh-Armstrong, Liquan Cai, and Donald D. Brown

    PNAS January 6, 2004 101 (1) 165-170; https://doi.org/10.1073/pnas.2136755100

• Ecology

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    Genetic introgression as a potential to widen a species' niche: Insights from alpine Carex curvula

    P. Choler, B. Erschbamer, A. Tribsch, L. Gielly, and P. Taberlet

    PNAS January 6, 2004 101 (1) 171-176; https://doi.org/10.1073/pnas.2237235100
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    Variable ecological effects of hurricanes: The importance of seasonal timing for survival of lizards on Bahamian islands

    Thomas W. Schoener, David A. Spiller, and Jonathan B. Losos

    PNAS January 6, 2004 101 (1) 177-181; https://doi.org/10.1073/pnas.0306887101
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    Alleviating spatial conflict between people and biodiversity

    Gary W. Luck, Taylor H. Ricketts, Gretchen C. Daily, and Marc Imhoff

    PNAS January 6, 2004 101 (1) 182-186; https://doi.org/10.1073/pnas.2237148100

• Evolution

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    Random walks in the history of life

    James L. Cornette and Bruce S. Lieberman

    PNAS January 6, 2004 101 (1) 187-191; https://doi.org/10.1073/pnas.2637009100

• Genetics

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    Mutant human cells with constitutive activation of NF-κB

    Swati S. Sathe, Nywana Sizemore, Xiaoxia Li, Kalpa Vithalani, Mairead Commane, Shannon M. Swiatkowski, and George R. Stark

    PNAS January 6, 2004 101 (1) 192-197; https://doi.org/10.1073/pnas.0306812101
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    Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch

    Zhengmei Mao, Gregg Roman, Lin Zong, and Ronald L. Davis

    PNAS January 6, 2004 101 (1) 198-203; https://doi.org/10.1073/pnas.0306128101
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    Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules

    • From the Cover

    Charles D. Laird, Nicole D. Pleasant, Aaron D. Clark, Jessica L. Sneeden, K. M. Anwarul Hassan, Nathan C. Manley, Jay C. Vary Jr., Todd Morgan, R. Scott Hansen, and Reinhard Stöger

    PNAS January 6, 2004 101 (1) 204-209; https://doi.org/10.1073/pnas.2536758100

• Immunology

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    Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice

    Stephan Kissler, Linrong Lu, and Harvey Cantor

    PNAS January 6, 2004 101 (1) 210-214; https://doi.org/10.1073/pnas.0307202101
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    The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen

    Young-Sun Kang, Jae Y. Kim, Sandra A. Bruening, Maggi Pack, Anna Charalambous, Alla Pritsker, Thomas M. Moran, Jutta M. Loeffler, Ralph M. Steinman, and Chae Gyu Park

    PNAS January 6, 2004 101 (1) 215-220; https://doi.org/10.1073/pnas.0307124101
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    Shifting foci of hematopoiesis during reconstitution from single stem cells

    Yu-An Cao, Amy J. Wagers, Andreas Beilhack, Joan Dusich, Michael H. Bachmann, Robert S. Negrin, Irving L. Weissman, and Christopher H. Contag

    PNAS January 6, 2004 101 (1) 221-226; https://doi.org/10.1073/pnas.2637010100
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    Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

    Heike Schäcke, Arndt Schottelius, Wolf-Dietrich Döcke, Peter Strehlke, Stefan Jaroch, Norbert Schmees, Hartmut Rehwinkel, Hartwig Hennekes, and Khusru Asadullah

    PNAS January 6, 2004 101 (1) 227-232; https://doi.org/10.1073/pnas.0300372101
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    IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

    • From the Cover

    Sarah M. McWhirter, Katherine A. Fitzgerald, Jacqueline Rosains, Daniel C. Rowe, Douglas T. Golenbock, and Tom Maniatis

    PNAS January 6, 2004 101 (1) 233-238; https://doi.org/10.1073/pnas.2237236100
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    Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo

    Donna Hochberg, Jaap M. Middeldorp, Michelle Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

    PNAS January 6, 2004 101 (1) 239-244; https://doi.org/10.1073/pnas.2237267100
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    T cell chemotaxis to lysophosphatidylcholine through the G2A receptor

    Caius G. Radu, Li V. Yang, Mireille Riedinger, Matthew Au, and Owen N. Witte

    PNAS January 6, 2004 101 (1) 245-250; https://doi.org/10.1073/pnas.2536801100
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    Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation

    Elvira R. Eivazova and Thomas M. Aune

    PNAS January 6, 2004 101 (1) 251-256; https://doi.org/10.1073/pnas.0303919101
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    Hybridoma-free generation of monoclonal antibodies

    Renata Pasqualini and Wadih Arap

    PNAS January 6, 2004 101 (1) 257-259; https://doi.org/10.1073/pnas.0305834101
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    The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern

    Na Xiong, Jeanne E. Baker, Chulho Kang, and David H. Raulet

    PNAS January 6, 2004 101 (1) 260-265; https://doi.org/10.1073/pnas.0303738101

• Medical Sciences

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    Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

    Frank Kuhnert, Corrine R. Davis, Hsiao-Ting Wang, Pauline Chu, Mark Lee, Jenny Yuan, Roel Nusse, and Calvin J. Kuo

    PNAS January 6, 2004 101 (1) 266-271; https://doi.org/10.1073/pnas.2536800100
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    A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria

    • From the Cover

    Ian A. Cockburn, Margaret J. Mackinnon, Angela O'Donnell, Stephen J. Allen, Joann M. Moulds, Moses Baisor, Moses Bockarie, John C. Reeder, and J. Alexandra Rowe

    PNAS January 6, 2004 101 (1) 272-277; https://doi.org/10.1073/pnas.0305306101
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    Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling

    Teruhito Yasui, Micah Luftig, Vishal Soni, and Elliott Kieff

    PNAS January 6, 2004 101 (1) 278-283; https://doi.org/10.1073/pnas.2237224100
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    Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

    Eric M. Reiman, Kewei Chen, Gene E. Alexander, Richard J. Caselli, Daniel Bandy, David Osborne, Ann M. Saunders, and John Hardy

    PNAS January 6, 2004 101 (1) 284-289; https://doi.org/10.1073/pnas.2635903100
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    A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses

    Eric Prieur, Sarah C. Gilbert, Joerg Schneider, Anne C. Moore, Eric G. Sheu, Nilu Goonetilleke, Kathryn J. H. Robson, and Adrian V. S. Hill

    PNAS January 6, 2004 101 (1) 290-295; https://doi.org/10.1073/pnas.0307158101
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    Reversing established sepsis with antagonists of endogenous high-mobility group box 1

    Huan Yang, Mahendar Ochani, Jianhua Li, Xiaoling Qiang, Mahira Tanovic, Helena E. Harris, Srinivas M. Susarla, Luis Ulloa, Hong Wang, Robert DiRaimo, Christopher J. Czura, Haichao Wang, Jesse Roth, H. Shaw Warren, Mitchell P. Fink, Matthew J. Fenton, Ulf Andersson, and Kevin J. Tracey

    PNAS January 6, 2004 101 (1) 296-301; https://doi.org/10.1073/pnas.2434651100

• Microbiology

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    The crystal structure of Pseudomonas avirulence protein AvrPphB: A papain-like fold with a distinct substrate-binding site

    Minfeng Zhu, Feng Shao, Roger W. Innes, Jack E. Dixon, and Zhaohui Xu

    PNAS January 6, 2004 101 (1) 302-307; https://doi.org/10.1073/pnas.2036536100
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    3D structure of the influenza virus polymerase complex: Localization of subunit domains

    Estela Area, Jaime Martín-Benito, Pablo Gastaminza, Eva Torreira, José M. Valpuesta, José L. Carrascosa, and Juan Ortín

    PNAS January 6, 2004 101 (1) 308-313; https://doi.org/10.1073/pnas.0307127101
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    A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

    Damien Portevin, Célia de Sousa-D'Auria, Christine Houssin, Christine Grimaldi, Mohamed Chami, Mamadou Daffé, and Christophe Guilhot

    PNAS January 6, 2004 101 (1) 314-319; https://doi.org/10.1073/pnas.0305439101

• Neuroscience

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    Electroporation and RNA interference in the rodent retina in vivo and in vitro

    Takahiko Matsuda and Constance L. Cepko

    PNAS January 6, 2004 101 (1) 16-22; https://doi.org/10.1073/pnas.2235688100
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    Distinct forms of cholinergic modulation in parallel thalamic sensory pathways

    D. M. Mooney, L. Zhang, C. Basile, V. V. Senatorov, J. Ngsee, A. Omar, and B. Hu

    PNAS January 6, 2004 101 (1) 320-324; https://doi.org/10.1073/pnas.0304445101
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    Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation

    Ludovic Collin, Alessandro Usiello, Eric Erbs, Carole Mathis, and Emiliana Borrelli

    PNAS January 6, 2004 101 (1) 325-330; https://doi.org/10.1073/pnas.0305994101
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    Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures

    Klaus Dinkel, Firdaus S. Dhabhar, and Robert M. Sapolsky

    PNAS January 6, 2004 101 (1) 331-336; https://doi.org/10.1073/pnas.0303510101
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    Learning rules and network repair in spike-timing-based computation networks

    J. J. Hopfield and Carlos D. Brody

    PNAS January 6, 2004 101 (1) 337-342; https://doi.org/10.1073/pnas.2536316100
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    Increased hippocampal neurogenesis in Alzheimer's disease

    Kunlin Jin, Alyson L. Peel, Xiao Ou Mao, Lin Xie, Barbara A. Cottrell, David C. Henshall, and David A. Greenberg

    PNAS January 6, 2004 101 (1) 343-347; https://doi.org/10.1073/pnas.2634794100
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    DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains

    M. Veldic, H. J. Caruncho, W. S. Liu, J. Davis, R. Satta, D. R. Grayson, A. Guidotti, and E. Costa

    PNAS January 6, 2004 101 (1) 348-353; https://doi.org/10.1073/pnas.2637013100
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    Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test

    Takashi Yoshitake, Fu-Hua Wang, Eugenia Kuteeva, Kristina Holmberg, Masatoshi Yamaguchi, Jacqueline N. Crawley, Robert Steiner, Tamas Bartfai, Sven Ove Ögren, Tomas Hökfelt, and Jan Kehr

    PNAS January 6, 2004 101 (1) 354-359; https://doi.org/10.1073/pnas.0307042101
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    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

    John Kim, Anna Krichevsky, Yonatan Grad, Gabriel D. Hayes, Kenneth S. Kosik, George M. Church, and Gary Ruvkun

    PNAS January 6, 2004 101 (1) 360-365; https://doi.org/10.1073/pnas.2333854100
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    An egalitarian network model for the emergence of simple and complex cells in visual cortex

    Louis Tao, Michael Shelley, David McLaughlin, and Robert Shapley

    PNAS January 6, 2004 101 (1) 366-371; https://doi.org/10.1073/pnas.2036460100
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    Role of serotonin in cocaine effects in mice with reduced dopamine transporter function

    Yolanda Mateo, Evgeny A. Budygin, Carrie E. John, and Sara R. Jones

    PNAS January 6, 2004 101 (1) 372-377; https://doi.org/10.1073/pnas.0207805101

• Pharmacology

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    Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors

    Cyril Goudet, Florence Gaven, Julie Kniazeff, Claire Vol, Jiangfeng Liu, Martin Cohen-Gonsaud, Francine Acher, Laurent Prézeau, and Jean Philippe Pin

    PNAS January 6, 2004 101 (1) 378-383; https://doi.org/10.1073/pnas.0304699101

• Physiology

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    Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins

    Anup Ramachandran, Erin Ceaser, and Victor M. Darley-Usmar

    PNAS January 6, 2004 101 (1) 384-389; https://doi.org/10.1073/pnas.0304653101
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    Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator

    Valerie Chappe, Deborah A. Hinkson, L. Daniel Howell, Alexandra Evagelidis, Jie Liao, Xiu-Bao Chang, John R. Riordan, and John W. Hanrahan

    PNAS January 6, 2004 101 (1) 390-395; https://doi.org/10.1073/pnas.0303411101
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    Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

    J. Vriens, H. Watanabe, A. Janssens, G. Droogmans, T. Voets, and B. Nilius

    PNAS January 6, 2004 101 (1) 396-401; https://doi.org/10.1073/pnas.0303329101

• Plant Biology

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    The Arabidopsis LUT1 locus encodes a member of the cytochrome P450 family that is required for carotenoid ε-ring hydroxylation activity

    Li Tian, Valeria Musetti, Joonyul Kim, Maria Magallanes-Lundback, and Dean DellaPenna

    PNAS January 6, 2004 101 (1) 402-407; https://doi.org/10.1073/pnas.2237237100

• Population Biology

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    Anatomy of a chaotic attractor: Subtle model-predicted patterns revealed in population data

    Aaron A. King, R. F. Costantino, J. M. Cushing, Shandelle M. Henson, Robert A. Desharnais, and Brian Dennis

    PNAS January 6, 2004 101 (1) 408-413; https://doi.org/10.1073/pnas.2237266100