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Table of Contents
March 09, 2004; vol. 101 no. 10
Biography
- You have accessBiography of Lewis C. Cantley
- Inaugural Article
David BradleySee companion article:
- You have accessBiography of Stephen J. Elledge
- Inaugural Article
Christen BrownleeSee companion article:
Physical Sciences
Applied Physical Sciences
- You have accessScanning electron microscopy of cells and tissues under fully hydrated conditionsStephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses
Chemistry
- You have accessWater in protein structure prediction
- From the Cover
Garegin A. Papoian, Johan Ulander, Michael P. Eastwood, Zaida Luthey-Schulten, and Peter G. WolynesSee companion article:
- Water and proteins: A love–hate relationship- Mar 01, 2004
- You have accessMolecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond
Physics
- You have accessBiological glass fibers: Correlation between optical and structural propertiesJoanna Aizenberg, Vikram C. Sundar, Andrew D. Yablon, James C. Weaver, and Gang Chen
Social Sciences
Economic Sciences
- You have accessGeography, biogeography, and why some countries are rich and others are poorDouglas A. Hibbs Jr. and Ola Olsson
Biological Sciences
Applied Biological Sciences
- You have accessScanning electron microscopy of cells and tissues under fully hydrated conditionsStephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses
Biochemistry
- You have accessThe molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolumMasao Fujinaga, Maia M. Cherney, Hiroshi Oyama, Kohei Oda, and Michael N. G. James
- You have accessSite-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-μm plasmidMagnus Hallberg, Gennady V. Polozkov, Guo-Zhen Hu, Jenny Beve, Claes M. Gustafsson, Hans Ronne, and Stefan Björklund
- You have accessThe specificity of SNARE-dependent fusion is encoded in the SNARE motifFabienne Paumet, Vahid Rahimian, and James E. Rothman
- You have accessDecline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acidJung H. Suh, Swapna V. Shenvi, Brian M. Dixon, Honglei Liu, Anil K. Jaiswal, Rui-Ming Liu, and Tory M. Hagen
- You have accessMolecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond
- You have accessThe role of the allosteric B site in the fumarase reactionIrwin A. Rose and Todd M. Weaver
- You have accessTranscription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosomeShuang Deng, Richard A. Stein, and N. Patrick Higgins
- You have accessBiosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharidesJohn F. Cipollo, Antoine Awad, Catherine E. Costello, Phillips W. Robbins, and Carlos B. Hirschberg
Biophysics
- You have accessDifferential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMRJudith Klein-Seetharaman, Naveena V. K. Yanamala, Fathima Javeed, Philip J. Reeves, Elena V. Getmanova, Michele C. Loewen, Harald Schwalbe, and H. Gobind Khorana
- You have accessSolution structure of dengue virus capsid protein reveals another foldLixin Ma, Christopher T. Jones, Teresa D. Groesch, Richard J. Kuhn, and Carol Beth Post
- You have accessMicroscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusionFumimasa Nomura, Takehiko Inaba, Satoshi Ishikawa, Miki Nagata, Sho Takahashi, Hirokazu Hotani, and Kingo Takiguchi
- You have accessLow-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNANeil P. Johnson, Walter A. Baase, and Peter H. von Hippel
- You have accessIntegrating folding kinetics and protein function: Biphasic kinetics and dual binding specificity in a WW domainJohn Karanicolas and Charles L. Brooks III
Cell Biology
- You have accessThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
- Inaugural Article
Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L. Hurley, Lee A. Witters, Ronald A. DePinho, and Lewis C. CantleySee companion article:
- Biography of Lewis C. Cantley- Mar 01, 2004
- You have accessTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitroKenna R. Mills, Mauricio Reginato, Jayanta Debnath, Bridget Queenan, and Joan S. Brugge
- You have accessAnnexin 2–caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transportEric J. Smart, Robert A. De Rose, and Steven A. Farber
- You have accessIdentification of p53 regulators by genome-wide functional analysisQihong Huang, Angel Raya, Paul DeJesus, Sheng-Hao Chao, Kim C. Quon, Jeremy S. Caldwell, Sumit K. Chanda, Juan C. Izpisua-Belmonte, and Peter G. Schultz
- You have accessAttractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell poleMotohiro Homma, Daisuke Shiomi, Michio Homma, and Ikuro Kawagishi
- You have accessBasonuclin 2: An extremely conserved homolog of the zinc finger protein basonuclinAmandine Vanhoutteghem and Philippe Djian
Developmental Biology
- You have accessDefective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
- Inaugural Article
- From the Cover
Michael T. Tetzlaff, Wei Yu, Mamie Li, Pumin Zhang, Milton Finegold, Kathleen Mahon, J. Wade Harper, Robert J. Schwartz, and Stephen J. ElledgeSee companion article:
- Biography of Stephen J. Elledge- Mar 01, 2004
- You have accessHearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinaseLily Ng, Richard J. Goodyear, Chad A. Woods, Mark J. Schneider, Edward Diamond, Guy P. Richardson, Matthew W. Kelley, Donald L. St. Germain, Valerie Anne Galton, and Douglas Forrest
Evolution
- You have accessCodon usage between genomes is constrained by genome-wide mutational processesSwaine L. Chen, William Lee, Alison K. Hottes, Lucy Shapiro, and Harley H. McAdams
- You have accessDecreased expression of Cu–Zn superoxide dismutase 1 in ants with extreme lifespanJoel D. Parker, Karen M. Parker, Barbara H. Sohal, Rajindar S. Sohal, and Laurent Keller
- You have accessHigh MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammalAndres Aguilar, Gary Roemer, Sally Debenham, Matthew Binns, David Garcelon, and Robert K. Wayne
- You have accessTransmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanismYang Liu, Mark Gerstein, and Donald M. Engelman
Genetics
- You have accessVenezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onsetThe U.S.–Venezuela Collaborative Research Project* and Nancy S. Wexler
- You have accessA variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicingTimothy W. Hefferon, Joshua D. Groman, Catherine E. Yurk, and Garry R. Cutting
- You have accessSiah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoterGiusy Fiucci, Séverine Beaucourt, Dominique Duflaut, Alexandra Lespagnol, Pamela Stumptner-Cuvelette, Anne Géant, Gilles Buchwalter, Marcel Tuynder, Laurent Susini, Jean-Michel Lassalle, Christine Wasylyk, Bohdan Wasylyk, Moshe Oren, Robert Amson, and Adam Telerman
Immunology
- You have accessToll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionKoichi Tabeta, Philippe Georgel, Edith Janssen, Xin Du, Kasper Hoebe, Karine Crozat, Suzanne Mudd, Louis Shamel, Sosathya Sovath, Jason Goode, Lena Alexopoulou, Richard A. Flavell, and Bruce Beutler
- You have accessIntestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor familyCecilia Garlanda, Federica Riva, Nadia Polentarutti, Chiara Buracchi, Marina Sironi, Maida De Bortoli, Marta Muzio, Raffaella Bergottini, Eugenio Scanziani, Annunciata Vecchi, Emilio Hirsch, and Alberto Mantovani
- You have accessMissing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptorsJames R. Carlyle, Amanda M. Jamieson, Stephan Gasser, Christopher S. Clingan, Hisashi Arase, and David H. Raulet
- You have accessToll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-βZhengfan Jiang, Tak W. Mak, Ganes Sen, and Xiaoxia Li
- You have accessStructural mechanism for affinity maturation of an anti-lysozyme antibodyAna Cauerhff, Fernando A. Goldbaum, and Bradford C. Braden
- You have accessDifferential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cellsStephen J. Turner, Nicole L. La Gruta, John Stambas, Gabriela Diaz, and Peter C. Doherty
- You have accessStructural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune responseMicah T. McClain, Carol S. Lutz, Kenneth M. Kaufman, Ofer Z. Faig, Timothy F. Gross, and Judith A. James
Medical Sciences
- You have accessHuman CD34+ cells differentiate into microglia and express recombinant therapeutic proteinMuriel Asheuer, Françoise Pflumio, Sonia Benhamida, Anne Dubart-Kupperschmitt, Françoise Fouquet, Yoshinori Imai, Patrick Aubourg, and Nathalie Cartier
- You have accessSynergistic activation of NF-κB by nontypeable Haemophilus influenzae and tumor necrosis factor αTakahiro Watanabe, Hirofumi Jono, Jiahuai Han, David J. Lim, and Jian-Dong Li
- You have accessIsolation and characterization of a digoxin transporter and its rat homologue expressed in the kidneyTsuyoshi Mikkaichi, Takehiro Suzuki, Tohru Onogawa, Masayuki Tanemoto, Hiroya Mizutamari, Masahiro Okada, Tatsuji Chaki, Satohiro Masuda, Taro Tokui, Nobuaki Eto, Michiaki Abe, Fumitoshi Satoh, Michiaki Unno, Takanori Hishinuma, Ken-ichi Inui, Sadayoshi Ito, Junichi Goto, and Takaaki Abe
- You have accessSpecific mutations of hepatitis B virus in plasma predict liver cancer developmentShuang-Yuan Kuang, Peta E. Jackson, Jin-Bing Wang, Pei-Xing Lu, Alvaro Muñoz, Geng-Sun Qian, Thomas W. Kensler, and John D. Groopman
- You have accessSystemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cellsEstanislao Bachrach, Sheng Li, Antonio L. Perez, Jaclyn Schienda, Kalliopi Liadaki, Jay Volinski, Alan Flint, Jeffrey Chamberlain, and Louis M. Kunkel
- You have accessInactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia
- From the Cover
Carlene K. Chun, Egon A. Ozer, Michael J. Welsh, Joseph Zabner, and E. P. GreenbergSee companion article:
Microbiology
- You have accessCbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaeaJesse D. Woodson and Jorge C. Escalante-Semerena
- You have accessDissecting virulence: Systematic and functional analyses of a pathogenicity islandWanyin Deng, José L. Puente, Samantha Gruenheid, Yuling Li, Bruce A. Vallance, Alejandra Vázquez, Jeannette Barba, J. Antonio Ibarra, Paul O'Donnell, Pavel Metalnikov, Keith Ashman, Sansan Lee, David Goode, Tony Pawson, and B. Brett Finlay
- You have accessThe herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specificAudrey Esclatine, Brunella Taddeo, Linton Evans, and Bernard Roizman
Neuroscience
- You have accessPresynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathwayErika S. Piedras-Rentería, Jason L. Pyle, Max Diehn, Lindsey L. Glickfeld, Nobutoshi C. Harata, Yuqing Cao, Ege T. Kavalali, Patrick O. Brown, and Richard W. Tsien
- You have accessFrontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expressionV. Menon, J. Leroux, C. D. White, and A. L. Reiss
- You have accessOverexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behaviorJohn A. Wemmie, Matthew W. Coryell, Candice C. Askwith, Ejvis Lamani, A. Soren Leonard, Curt D. Sigmund, and Michael J. Welsh
- You have accessInhibition of neuronal phenotype by PTEN in PC12 cellsSergei Musatov, Jill Roberts, Andrew I. Brooks, John Pena, Simone Betchen, Donald W. Pfaff, and Michael G. Kaplitt
- You have accessAmyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patientsRena Li, Kristina Lindholm, Li-Bang Yang, Xu Yue, Martin Citron, Riqiang Yan, Thomas Beach, Lucia Sue, Marwan Sabbagh, Huaibin Cai, Philip Wong, Donald Price, and Yong Shen
- You have accessDelay accuracy in bat sonar is related to the reciprocal of normalized echo bandwidth, or QJames A. Simmons, Nicola Neretti, Nathan Intrator, Richard A. Altes, Michael J. Ferragamo, and Mark I. Sanderson
- You have accessTransgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairmentLucy Anderson, Daniela Rossi, Jackie Linehan, Sebastian Brandner, and Charles Weissmann
- You have accessThe tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release
- From the Cover
Taku Nagai, Kiyofumi Yamada, Masako Yoshimura, Kazuhiro Ishikawa, Yoshiaki Miyamoto, Kazuki Hashimoto, Yukihiro Noda, Atsumi Nitta, and Toshitaka Nabeshima - You have accessThe long-term stability of new hippocampal place fields requires new protein synthesisNaveen T. Agnihotri, Robert D. Hawkins, Eric R. Kandel, and Clifford Kentros
- You have accessTonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptorsValerie B. Caraiscos, Erin M. Elliott, Kong E. You-Ten, Victor Y. Cheng, Delia Belelli, J. Glen Newell, Michael F. Jackson, Jeremy J. Lambert, Thomas W. Rosahl, Keith A. Wafford, John F. MacDonald, and Beverley A. Orser
Pharmacology
- You have accessExpression and activation of the farnesoid X receptor in the vasculatureDavid Bishop-Bailey, Desmond T. Walsh, and Timothy D. Warner
- You have accessModulation of rhythmic brain activity by diazepam: GABAAreceptor subtype and state specificityC. Kopp, U. Rudolph, K. Löw, and I. Tobler
- You have accessPeripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathwayDaniela Sachs, Fernando Q. Cunha, and Sérgio H. Ferreira
Physiology
- You have accessDiethylstilbestrol induces fish oocyte maturationToshinobu Tokumoto, Mika Tokumoto, Ryo Horiguchi, Katsutoshi Ishikawa, and Yoshitaka Nagahama
- You have accessVitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channelHorst Fischer, Christian Schwarzer, and Beate Illek
- You have accessThe cardiovascular physiologic actions of urocortin II: Acute effects in murine heart failureTracy L. Bale, Masahiko Hoshijima, Yusu Gu, Nancy Dalton, Keith R. Anderson, Kuo-Fen Lee, Jean Rivier, Kenneth R. Chien, Wylie W. Vale, and Kirk L. Peterson
Plant Biology
- You have accessMultiple origins of crassulacean acid metabolism and the epiphytic habit in the Neotropical family BromeliaceaeDarren M. Crayn, Klaus Winter, and J. Andrew C. Smith
Population Biology
- You have accessPersistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problemDavid L. Smith, Jonathan Dushoff, Eli N. Perencevich, Anthony D. Harris, and Simon A. Levin
Commentary
See companion article: