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About the Cover
August 24, 2004; vol. 101 no. 34
Editorial
- You have accessLiberalization of PNAS copyright policy: Noncommercial use freely allowedNicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger
Physical Sciences
Applied Physical Sciences
- Open AccessEmissions pathways, climate change, and impacts on CaliforniaKatharine Hayhoe, Daniel Cayan, Christopher B. Field, Peter C. Frumhoff, Edwin P. Maurer, Norman L. Miller, Susanne C. Moser, Stephen H. Schneider, Kimberly Nicholas Cahill, Elsa E. Cleland, Larry Dale, Ray Drapek, R. Michael Hanemann, Laurence S. Kalkstein, James Lenihan, Claire K. Lunch, Ronald P. Neilson, Scott C. Sheridan, and Julia H. Verville
- You have accessFabricating complex three-dimensional nanostructures with high-resolution conformable phase masks
- From the Cover
Seokwoo Jeon, Jang-Ung Park, Ray Cirelli, Shu Yang, Carla E. Heitzman, Paul V. Braun, Paul J. A. Kenis, and John A. Rogers - You have accessDynamic control of liquid-core/liquid-cladding optical waveguidesDaniel B. Wolfe, Richard S. Conroy, Piotr Garstecki, Brian T. Mayers, Michael A. Fischbach, Kateri E. Paul, Mara Prentiss, and George M. Whitesides
Environmental Sciences
- You have accessSulfur pollution suppression of the wetland methane source in the 20th and 21st centuries
- From the Cover
Vincent Gauci, Elaine Matthews, Nancy Dise, Bernadette Walter, Dorothy Koch, Gunnar Granberg, and Melanie Vile
Physics
- You have accessCell mechanosensitivity controls the anisotropy of focal adhesionsAlice Nicolas, Benjamin Geiger, and Samuel A. Safran
Biological Sciences
Biochemistry
- You have accessCreating ribosomes with an all-RNA 30S subunit P siteLee Hoang, Kurt Fredrick, and Harry F. Noller
- You have accessStructural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptorV. A. Streltsov, J. N. Varghese, J. A. Carmichael, R. A. Irving, P. J. Hudson, and S. D. Nuttall
- You have accessAn aminoacyl-tRNA synthetase that specifically activates pyrrolysineCarla Polycarpo, Alexandre Ambrogelly, Amélie Bérubé, SusAnn M. Winbush, James A. McCloskey, Pamela F. Crain, John L. Wood, and Dieter Söll
- You have accessStructure of adeno-associated virus type 2 Rep40–ADP complex: Insight into nucleotide recognition and catalysis by superfamily 3 helicasesJ. Anson James, Aneel K. Aggarwal, R. Michael Linden, and Carlos R. Escalante
- Open AccessDiscovery of an allosteric site in the caspasesJeanne A. Hardy, Joni Lam, Jack T. Nguyen, Tom O'Brien, and James A. Wells
- You have accessSynthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognitionFrederic A. Fellouse, Christian Wiesmann, and Sachdev S. Sidhu
- Open AccessBinding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domainNobutaka Ohgami, Dennis C. Ko, Matthew Thomas, Matthew P. Scott, Catherine C. Y. Chang, and Ta-Yuan Chang
- You have accessA tagging-via-substrate technology for detection and proteomics of farnesylated proteinsYoonjung Kho, Sung Chan Kim, Chen Jiang, Deb Barma, Sung Won Kwon, Jinke Cheng, Janis Jaunbergs, Carolyn Weinbaum, Fuyuhiko Tamanoi, John Falck, and Yingming Zhao
- You have accessCarbon dioxide mediates Mn(II)-catalyzed decomposition of hydrogen peroxide and peroxidation reactionsStefan I. Liochev and Irwin Fridovich
Biophysics
- You have accessRandom-coil behavior and the dimensions of chemically unfolded proteinsJonathan E. Kohn, Ian S. Millett, Jaby Jacob, Bojan Zagrovic, Thomas M. Dillon, Nikolina Cingel, Robin S. Dothager, Soenke Seifert, P. Thiyagarajan, Tobin R. Sosnick, M. Zahid Hasan, Vijay S. Pande, Ingo Ruczinski, Sebastian Doniach, and Kevin W. Plaxco
- Open AccessReassessing random-coil statistics in unfolded proteinsNicholas C. Fitzkee and George D. Rose
- Open AccessSingle-molecule recognition imaging microscopyC. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S. M. Lindsay, and P. Hinterdorfer
- You have accessStructural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridgeJong-Myoung Kim, Christian Altenbach, Masahiro Kono, Daniel D. Oprian, Wayne L. Hubbell, and H. Gobind Khorana
- You have accessNonspecific hydrophobic interactions stabilize an equilibrium intermediate of apomyoglobin at a key position within the AGH regionAngela M. Bertagna and Doug Barrick
- You have accessCell mechanosensitivity controls the anisotropy of focal adhesionsAlice Nicolas, Benjamin Geiger, and Samuel A. Safran
Cell Biology
- You have accessRho overexpression leads to mitosis-associated detachment of cells from epithelial sheets: A link to the mechanism of cancer dissemination
- From the Cover
J. M. Vasiliev, T. Omelchenko, I. M. Gelfand, H. H. Feder, and E. M. Bonder - You have accessEmi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrestKeita Ohsumi, Ayako Koyanagi, Tomomi M. Yamamoto, Tetsuya Gotoh, and Takeo Kishimoto
- You have accessCotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membraneSuraj Saksena, Yuanlong Shao, Sharon C. Braunagel, Max D. Summers, and Arthur E. Johnson
Developmental Biology
- You have accessDerivation of midbrain dopamine neurons from human embryonic stem cells
- From the Cover
Anselme L. Perrier, Viviane Tabar, Tiziano Barberi, Maria E. Rubio, Juan Bruses, Norbert Topf, Neil L. Harrison, and Lorenz Studer - You have accessThe Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasomeSibylle Jäger, Hillel T. Schwartz, H. Robert Horvitz, and Barbara Conradt
- You have accessA gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesisVeraragavan P. Eswarakumar, Mark C. Horowitz, Rachel Locklin, Gillian M. Morriss-Kay, and Peter Lonai
- Open AccessInhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signalingPilar Sanchez, Ana Maria Hernández, Barbara Stecca, Andrea J. Kahler, Amy M. DeGueme, Andrea Barrett, Mercedes Beyna, Milton W. Datta, Sumana Datta, and Ariel Ruiz i Altaba
- You have accessA myocardin-related transcription factor regulates activity of serum response factor in DrosophilaZhe Han, Xiumin Li, Jiang Wu, and Eric N. Olson
- You have accessGATA4 is essential for formation of the proepicardium and regulates cardiogenesisAlistair J. Watt, Michele A. Battle, Jixuan Li, and Stephen A. Duncan
Ecology
- Open AccessEmissions pathways, climate change, and impacts on CaliforniaKatharine Hayhoe, Daniel Cayan, Christopher B. Field, Peter C. Frumhoff, Edwin P. Maurer, Norman L. Miller, Susanne C. Moser, Stephen H. Schneider, Kimberly Nicholas Cahill, Elsa E. Cleland, Larry Dale, Ray Drapek, R. Michael Hanemann, Laurence S. Kalkstein, James Lenihan, Claire K. Lunch, Ronald P. Neilson, Scott C. Sheridan, and Julia H. Verville
- You have accessEconomic value of tropical forest to coffee productionTaylor H. Ricketts, Gretchen C. Daily, Paul R. Ehrlich, and Charles D. Michener
Environmental Sciences
- You have accessSulfur pollution suppression of the wetland methane source in the 20th and 21st centuries
- From the Cover
Vincent Gauci, Elaine Matthews, Nancy Dise, Bernadette Walter, Dorothy Koch, Gunnar Granberg, and Melanie Vile
Evolution
- You have accessTissue-specific codon usage and the expression of human genesJoshua B. Plotkin, Harlan Robins, and Arnold J. Levine
Genetics
- You have accessRapid recent growth and divergence of rice nuclear genomes
- Inaugural Article
Jianxin Ma and Jeffrey L. Bennetzen - You have accessA mechanical basis for chromosome functionNancy Kleckner, Denise Zickler, Gareth H. Jones, Job Dekker, Ruth Padmore, Jim Henle, and John Hutchinson
- You have accessThe RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatisJessica L. Flint, Joseph C. Kowalski, Pavan K. Karnati, and Keith M. Derbyshire
- You have accessVariation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F. Egan, Richard E. Straub, Terry E. Goldberg, Imtiaz Yakub, Joseph H. Callicott, Ahmad R. Hariri, Venkata S. Mattay, Alessandro Bertolino, Thomas M. Hyde, Cynthia Shannon-Weickert, Mayada Akil, Jeremy Crook, Radha Krishna Vakkalanka, Rishi Balkissoon, Richard A. Gibbs, Joel E. Kleinman, and Daniel R. Weinberger
- You have accessMultiple-stress analysis for isolation of Drosophila longevity genesHorng-Dar Wang, Parsa Kazemi-Esfarjani, and Seymour Benzer
- You have accessRole of the yeast acetyltransferase Mpr1 in oxidative stress: Regulation of oxygen reactive species caused by a toxic proline catabolism intermediateMichiyo Nomura and Hiroshi Takagi
Immunology
- You have accessEvolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cellsMaria Shnyreva, William M. Weaver, Mathieu Blanchette, Scott L. Taylor, Martin Tompa, David R. Fitzpatrick, and Christopher B. Wilson
- You have accessAromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren's syndromeGil-Jin Shim, Margaret Warner, Hyun-Jin Kim, Sandra Andersson, Lining Liu, Jenny Ekman, Otabek Imamov, Margaret E. Jones, Evan R. Simpson, and Jan-Åke Gustafsson
- You have accessImaging inflammation of the pancreatic islets in type 1 diabetesMaria C. Denis, Umar Mahmood, Christophe Benoist, Diane Mathis, and Ralph Weissleder
- You have accessIdentification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysisRoberta Castriconi, Alessandra Dondero, Raffaella Augugliaro, Claudia Cantoni, Barbara Carnemolla, Angela Rita Sementa, Francesca Negri, Romana Conte, Maria Valeria Corrias, Lorenzo Moretta, Alessandro Moretta, and Cristina Bottino
- You have accessEnhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 geneMalin Hultqvist, Peter Olofsson, Jens Holmberg, B. Thomas Bäckström, Jesper Tordsson, and Rikard Holmdahl
- Open AccessMycobacterium tuberculosis (Mtb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patientsSharmistha Banerjee, Ashok Nandyala, Raviprasad Podili, V. M. Katoch, K. J. R. Murthy, and Seyed E. Hasnain
Medical Sciences
- You have accessDevelopmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrierAkihiko Urayama, Jeffrey H. Grubb, William S. Sly, and William A. Banks
- You have accessMechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplificationLoen M. Hansford, Wayne D. Thomas, Joanna M. Keating, Catherine A. Burkhart, Anne E. Peaston, Murray D. Norris, Michelle Haber, Patricia J. Armati, William A. Weiss, and Glenn M. Marshall
- You have accessInsulin resistance in skeletal muscles of caveolin-3-null miceJin Oshikawa, Koji Otsu, Yoshiyuki Toya, Takashi Tsunematsu, Raleigh Hankins, Jun-ichi Kawabe, Susumu Minamisawa, Satoshi Umemura, Yasuko Hagiwara, and Yoshihiro Ishikawa
- You have accessMetabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identificationYulan Wang, Elaine Holmes, Jeremy K. Nicholson, Olivier Cloarec, Jacques Chollet, Marcel Tanner, Burton H. Singer, and Jürg Utzinger
- You have accessA small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcriptionKatayoon H. Emami, Cu Nguyen, Hong Ma, Dae Hoon Kim, Kwang Won Jeong, Masakatsu Eguchi, Randall T. Moon, Jia-Ling Teo, Se Wong Oh, Hak Yeop Kim, Sung Hwan Moon, Jong Ryul Ha, and Michael Kahn
Microbiology
- You have accessMutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism
- Inaugural Article
Sharmila Manoj, Cheryl R. Jogger, Dawn Myscofski, Miri Yoon, and Patricia G. Spear - You have accessHigh-resolution structure of a picornaviral internal cis-acting RNA replication element (cre)Varatharasa Thiviyanathan, Yan Yang, Kumaralal Kaluarachchi, Rene Rijnbrand, David G. Gorenstein, and Stanley M. Lemon
- You have accessMajor genetic marker of nidoviruses encodes a replicative endoribonucleaseKonstantin A. Ivanov, Tobias Hertzig, Mikhail Rozanov, Sonja Bayer, Volker Thiel, Alexander E. Gorbalenya, and John Ziebuhr
Neuroscience
- You have accessRegional glucose metabolism and glutamatergic neurotransmission in rat brain in vivoRobin A. de Graaf, Graeme F. Mason, Anant B. Patel, Douglas L. Rothman, and Kevin L. Behar
- You have accessNociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory painMohammed A. Nassar, L. Caroline Stirling, Greta Forlani, Mark D. Baker, Elizabeth A. Matthews, Anthony H. Dickenson, and John N. Wood
- You have accessCorrelates of transsaccadic integration in the primary visual cortex of the monkeyPaul S. Khayat, Henk Spekreijse, and Pieter R. Roelfsema
- You have accessSpatial patterns of gene expression in the olfactory bulbDavid M. Lin, Yee Hwa Yang, Jonathan A. Scolnick, Lisa J. Brunet, Heather Marsh, Vivian Peng, Yasushi Okazaki, Yoshihide Hayashizaki, Terence P. Speed, and John Ngai
- Open AccessModality maps within primate somatosensory cortexRobert M. Friedman, Li Min Chen, and Anna Wang Roe
- Open AccessGranulocyte-macrophage colony-stimulating factor-induced arteriogenesis reduces energy failure in hemodynamic strokeEdda Schneeloch, Günter Mies, Hans-Jörg Busch, Ivo R. Buschmann, and Konstantin-Alexander Hossmann
- You have accessHuntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating γ-aminobutyric acid type A receptor membrane traffickingJosef T. Kittler, Philip Thomas, Verena Tretter, Yuri D. Bogdanov, Volker Haucke, Trevor G. Smart, and Stephen J. Moss
- You have accessY1 receptors regulate aggressive behavior by modulating serotonin pathwaysTim Karl, Shu Lin, Christoph Schwarzer, Amanda Sainsbury, Michelle Couzens, Walter Wittmann, Dana Boey, Stephan von Hörsten, and Herbert Herzog
Physiology
- You have accessEvidence for conformational coupling between two calcium channelsC. Paolini, James D. Fessenden, Isaac N. Pessah, and C. Franzini-Armstrong
Plant Biology
- You have accessArabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions
- From the Cover
Yukio Kurihara and Yuichiro Watanabe - You have accessRegulation of flowering time in Arabidopsis by K homology domain proteinsTodd C. Mockler, Xuhong Yu, Dror Shalitin, Dhavan Parikh, Todd P. Michael, Jasmine Liou, Jie Huang, Zachery Smith, Jose M. Alonso, Joseph R. Ecker, Joanne Chory, and Chentao Lin
- You have accessMutations in ClpC2/Hsp100 suppress the requirement for FtsH in thylakoid membrane biogenesisSungsoon Park and Steven R. Rodermel
- You have accessRecessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZYLucia C. Strader, Siân Ritchie, Jonathan D. Soule, Karen M. McGinnis, and Camille M. Steber
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