Table of Contents

Biological Sciences

• Anthropology

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    Genomic data support the hominoid slowdown and an Early Oligocene estimate for the hominoid–cercopithecoid divergence

    Michael E. Steiper, Nathan M. Young, and Tika Y. Sukarna

    PNAS December 7, 2004 101 (49) 17021-17026; https://doi.org/10.1073/pnas.0407270101

• Biochemistry

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    Biography of Jennifer A. Doudna

    • Inaugural Article

    Melissa Marino

    PNAS December 7, 2004 101 (49) 16987-16989; https://doi.org/10.1073/pnas.0408147101

    See companion article:

    • Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA

      - Nov 24, 2004
  • Open Access

    Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA

    • Inaugural Article

    Hong Ji, Christopher S. Fraser, Yonghao Yu, Julie Leary, and Jennifer A. Doudna

    PNAS December 7, 2004 101 (49) 16990-16995; https://doi.org/10.1073/pnas.0407402101

    See companion article:

    • Biography of Jennifer A. Doudna

      - Dec 01, 2004
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    The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat

    Karin Kühnel, Thomas Jarchau, Eva Wolf, Ilme Schlichting, Ulrich Walter, Alfred Wittinghofer, and Sergei V. Strelkov

    PNAS December 7, 2004 101 (49) 17027-17032; https://doi.org/10.1073/pnas.0403069101
  • Open Access

    Printed covalent glycan array for ligand profiling of diverse glycan binding proteins

    Ola Blixt, Steve Head, Tony Mondala, Christopher Scanlan, Margaret E. Huflejt, Richard Alvarez, Marian C. Bryan, Fabio Fazio, Daniel Calarese, James Stevens, Nahid Razi, David J. Stevens, John J. Skehel, Irma van Die, Dennis R. Burton, Ian A. Wilson, Richard Cummings, Nicolai Bovin, Chi-Huey Wong, and James C. Paulson

    PNAS December 7, 2004 101 (49) 17033-17038; https://doi.org/10.1073/pnas.0407902101
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    Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

    Jenn-Han Chen, Yu-Wang Chang, Chen-Wen Yao, Tzong-Shi Chiueh, Su-Chin Huang, Ko-Yi Chien, An Chen, Feng-Yee Chang, Chi-Huey Wong, and Yu-Ju Chen

    PNAS December 7, 2004 101 (49) 17039-17044; https://doi.org/10.1073/pnas.0407992101
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    Glycine as a d-amino acid surrogate in the K⁺-selectivity filter

    Francis I. Valiyaveetil, Matthew Sekedat, Roderick MacKinnon, and Tom W. Muir

    PNAS December 7, 2004 101 (49) 17045-17049; https://doi.org/10.1073/pnas.0407820101
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    Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct

    Leonid Tarassishin, Ye Ingrid Yin, Bhramdeo Bassit, and Yue-Ming Li

    PNAS December 7, 2004 101 (49) 17050-17055; https://doi.org/10.1073/pnas.0408007101
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    Strand invasion promoted by recombination protein β of coliphage λ

    Nataliya Rybalchenko, Efim I. Golub, Baoyuan Bi, and Charles M. Radding

    PNAS December 7, 2004 101 (49) 17056-17060; https://doi.org/10.1073/pnas.0408046101
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    Inorganic polyphosphate in Bacillus cereus: Motility, biofilm formation, and sporulation

    Xiaobing Shi, Narayana N. Rao, and Arthur Kornberg

    PNAS December 7, 2004 101 (49) 17061-17065; https://doi.org/10.1073/pnas.0407787101

• Biophysics

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    Phospholipid bilayer surface configuration probed quantitatively by ³¹P field-cycling NMR

    Mary F. Roberts and Alfred G. Redfield

    PNAS December 7, 2004 101 (49) 17066-17071; https://doi.org/10.1073/pnas.0407565101
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    Single-cell FRET imaging of phosphatase activity in the Escherichia coli chemotaxis system

    Ady Vaknin and Howard C. Berg

    PNAS December 7, 2004 101 (49) 17072-17077; https://doi.org/10.1073/pnas.0407812101
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    The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled

    Scott T. R. Walsh, Juliesta E. Sylvester, and Anthony A. Kossiakoff

    PNAS December 7, 2004 101 (49) 17078-17083; https://doi.org/10.1073/pnas.0403336101
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    Structural basis of activity and allosteric control of diguanylate cyclase

    Carmen Chan, Ralf Paul, Dietrich Samoray, Nicolas C. Amiot, Bernd Giese, Urs Jenal, and Tilman Schirmer

    PNAS December 7, 2004 101 (49) 17084-17089; https://doi.org/10.1073/pnas.0406134101
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    The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli

    Lei Zheng, Dirk Kostrewa, Simon Bernèche, Fritz K. Winkler, and Xiao-Dan Li

    PNAS December 7, 2004 101 (49) 17090-17095; https://doi.org/10.1073/pnas.0406475101
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    Cooperative extraction of membrane nanotubes by molecular motors

    • From the Cover

    Cécile Leduc, Otger Campàs, Konstantin B. Zeldovich, Aurélien Roux, Pascale Jolimaitre, Line Bourel-Bonnet, Bruno Goud, Jean-François Joanny, Patricia Bassereau, and Jacques Prost

    PNAS December 7, 2004 101 (49) 17096-17101; https://doi.org/10.1073/pnas.0406598101
  • Open Access

    Genetic networks with canalyzing Boolean rules are always stable

    Stuart Kauffman, Carsten Peterson, Björn Samuelsson, and Carl Troein

    PNAS December 7, 2004 101 (49) 17102-17107; https://doi.org/10.1073/pnas.0407783101

• Cell Biology

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    A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

    Rui-Hong Wang, Hongtao Yu, and Chu-Xia Deng

    PNAS December 7, 2004 101 (49) 17108-17113; https://doi.org/10.1073/pnas.0407585101
  • Open Access

    Imaging of receptor trafficking by using α-bungarotoxin-binding-site-tagged receptors

    • From the Cover

    Yoko Sekine-Aizawa and Richard L. Huganir

    PNAS December 7, 2004 101 (49) 17114-17119; https://doi.org/10.1073/pnas.0407563101
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    Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes

    Joshi Venugopal, Kazuhiko Hanashiro, Zhong-Zhou Yang, and Yoshikuni Nagamine

    PNAS December 7, 2004 101 (49) 17120-17125; https://doi.org/10.1073/pnas.0405278101
  • Open Access

    Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α

    Qing Lu, David C. Pallas, Howard K. Surks, Wendy E. Baur, Michael E. Mendelsohn, and Richard H. Karas

    PNAS December 7, 2004 101 (49) 17126-17131; https://doi.org/10.1073/pnas.0407492101

• Developmental Biology

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    Restricted inactivation of serum response factor to the cardiovascular system

    Joseph M. Miano, Narendrakumar Ramanan, Mary A. Georger, Karen L. de Mesy Bentley, Rachael L. Emerson, Robert O. Balza Jr., Qi Xiao, Hartmut Weiler, David D. Ginty, and Ravi P. Misra

    PNAS December 7, 2004 101 (49) 17132-17137; https://doi.org/10.1073/pnas.0406041101
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    ErbB2 is required for ductal morphogenesis of the mammary gland

    Amy J. Jackson-Fisher, Gary Bellinger, Rajani Ramabhadran, Jacqueline K. Morris, Kuo-Fen Lee, and David F. Stern

    PNAS December 7, 2004 101 (49) 17138-17143; https://doi.org/10.1073/pnas.0407057101
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    Tyrosine phosphorylation sites on FRS2α responsible for Shp2 recruitment are critical for induction of lens and retina

    N. Gotoh, M. Ito, S. Yamamoto, I. Yoshino, N. Song, Y. Wang, I. Lax, J. Schlessinger, M. Shibuya, and R. A. Lang

    PNAS December 7, 2004 101 (49) 17144-17149; https://doi.org/10.1073/pnas.0407577101

• Ecology

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    Adapting to an invasive species: Toxic cane toads induce morphological change in Australian snakes

    Ben L. Phillips and Richard Shine

    PNAS December 7, 2004 101 (49) 17150-17155; https://doi.org/10.1073/pnas.0406440101

• Evolution

  • Open Access

    Highly conserved upstream sequences for transcription factor genes and implications for the regulatory network

    Hisakazu Iwama and Takashi Gojobori

    PNAS December 7, 2004 101 (49) 17156-17161; https://doi.org/10.1073/pnas.0407670101

• Genetics

  • Open Access

    Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes

    Mollie D. Winfield and Eduardo A. Groisman

    PNAS December 7, 2004 101 (49) 17162-17167; https://doi.org/10.1073/pnas.0406038101

• Immunology

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    Structural basis for peptidoglycan binding by peptidoglycan recognition proteins

    Rongjin Guan, Abhijit Roychowdhury, Brian Ember, Sanjay Kumar, Geert-Jan Boons, and Roy A. Mariuzza

    PNAS December 7, 2004 101 (49) 17168-17173; https://doi.org/10.1073/pnas.0407856101
  • Open Access

    Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

    R. Houston Thompson, Michael D. Gillett, John C. Cheville, Christine M. Lohse, Haidong Dong, W. Scott Webster, Kent G. Krejci, John R. Lobo, Shomik Sengupta, Lieping Chen, Horst Zincke, Michael L. Blute, Scott E. Strome, Bradley C. Leibovich, and Eugene D. Kwon

    PNAS December 7, 2004 101 (49) 17174-17179; https://doi.org/10.1073/pnas.0406351101
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    Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis

    Jolanda H. M. van Bilsen, Henrike van Dongen, Leroy R. Lard, Ellen I. H. van der Voort, Diënne G. Elferink, Aleida M. Bakker, André M. M. Miltenburg, Tom W. J. Huizinga, René R. P. de Vries, and René E. M. Toes

    PNAS December 7, 2004 101 (49) 17180-17185; https://doi.org/10.1073/pnas.0407704101

• Medical Sciences

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    Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

    • From the Cover

    Ming Yan, Sebastien A. Burel, Luke F. Peterson, Eiki Kanbe, Hiromi Iwasaki, Anita Boyapati, Robert Hines, Koichi Akashi, and Dong-Er Zhang

    PNAS December 7, 2004 101 (49) 17186-17191; https://doi.org/10.1073/pnas.0406702101

    See companion article:

    • Fusion-protein truncation provides new insights into leukemogenesis

      - Nov 30, 2004
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    Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

    Masaki Inada, Yingmin Wang, Michael H. Byrne, Mahboob U. Rahman, Chisato Miyaura, Carlos López-Otín, and Stephen M. Krane

    PNAS December 7, 2004 101 (49) 17192-17197; https://doi.org/10.1073/pnas.0407788101
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    Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele

    Carrie Graveel, Yanli Su, Julie Koeman, Ling-Mei Wang, Lino Tessarollo, Michele Fiscella, Carmen Birchmeier, Pamela Swiatek, Roderick Bronson, and George Vande Woude

    PNAS December 7, 2004 101 (49) 17198-17203; https://doi.org/10.1073/pnas.0407651101
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    A critical role for p27^kip1 gene dosage in a mouse model of prostate carcinogenesis

    Hui Gao, Xuesong Ouyang, Whitney Banach-Petrosky, Alexander D. Borowsky, Yong Lin, Minjung Kim, Hansol Lee, Weichung-Joseph Shih, Robert D. Cardiff, Michael M. Shen, and Cory Abate-Shen

    PNAS December 7, 2004 101 (49) 17204-17209; https://doi.org/10.1073/pnas.0407693101
  • Open Access

    Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis

    Brunhilde Felding-Habermann, Richard A. Lerner, Antonietta Lillo, Shufei Zhuang, Martin R. Weber, Sandra Arrues, Changshou Gao, Shenlan Mao, Alan Saven, and Kim D. Janda

    PNAS December 7, 2004 101 (49) 17210-17215; https://doi.org/10.1073/pnas.0407869101
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    Liver-targeted disruption of Apc in mice activates β-catenin signaling and leads to hepatocellular carcinomas

    S. Colnot, T. Decaens, M. Niwa-Kawakita, C. Godard, G. Hamard, A. Kahn, M. Giovannini, and C. Perret

    PNAS December 7, 2004 101 (49) 17216-17221; https://doi.org/10.1073/pnas.0404761101
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    Human Rhesus-associated glycoprotein mediates facilitated transport of NH₃ into red blood cells

    Pierre Ripoche, Olivier Bertrand, Pierre Gane, Connie Birkenmeier, Yves Colin, and Jean-Pierre Cartron

    PNAS December 7, 2004 101 (49) 17222-17227; https://doi.org/10.1073/pnas.0403704101

• Microbiology

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    Agrobacterium VirB10, an ATP energy sensor required for type IV secretion

    Eric Cascales and Peter J. Christie

    PNAS December 7, 2004 101 (49) 17228-17233; https://doi.org/10.1073/pnas.0405843101
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    Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation

    Michael Nevels, Christina Paulus, and Thomas Shenk

    PNAS December 7, 2004 101 (49) 17234-17239; https://doi.org/10.1073/pnas.0407933101
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    RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae

    • From the Cover

    Kimberly M. Keene, Brian D. Foy, Irma Sanchez-Vargas, Barry J. Beaty, Carol D. Blair, and Ken E. Olson

    PNAS December 7, 2004 101 (49) 17240-17245; https://doi.org/10.1073/pnas.0406983101
  • Open Access

    EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin

    Quan Lu, Wensheng Wei, Paul E. Kowalski, Annie C. Y. Chang, and Stanley N. Cohen

    PNAS December 7, 2004 101 (49) 17246-17251; https://doi.org/10.1073/pnas.0407794101
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    Random mutagenesis of the gene encoding a viral ligand for multiple cell entry receptors to obtain viral mutants altered for receptor usage

    Miri Yoon and Patricia G. Spear

    PNAS December 7, 2004 101 (49) 17252-17257; https://doi.org/10.1073/pnas.0407892101
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    A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)

    S. E. Kidd, F. Hagen, R. L. Tscharke, M. Huynh, K. H. Bartlett, M. Fyfe, L. MacDougall, T. Boekhout, K. J. Kwon-Chung, and W. Meyer

    PNAS December 7, 2004 101 (49) 17258-17263; https://doi.org/10.1073/pnas.0402981101
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    The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter

    J. Andrejeva, K. S. Childs, D. F. Young, T. S. Carlos, N. Stock, S. Goodbourn, and R. E. Randall

    PNAS December 7, 2004 101 (49) 17264-17269; https://doi.org/10.1073/pnas.0407639101

• Neuroscience

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    Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

    Deepak R. Thakker, Francois Natt, Dieter Hüsken, Rainer Maier, Matthias Müller, Herman van der Putten, Daniel Hoyer, and John F. Cryan

    PNAS December 7, 2004 101 (49) 17270-17275; https://doi.org/10.1073/pnas.0406214101
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    slo K⁺ channel gene regulation mediates rapid drug tolerance

    Alfredo Ghezzi, Yazan M. Al-Hasan, Leo E. Larios, Rudolf A. Bohm, and Nigel S. Atkinson

    PNAS December 7, 2004 101 (49) 17276-17281; https://doi.org/10.1073/pnas.0405584101
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    7α-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system

    Masahiro Matsunaga, Kazuyoshi Ukena, Etienne-Emile Baulieu, and Kazuyoshi Tsutsui

    PNAS December 7, 2004 101 (49) 17282-17287; https://doi.org/10.1073/pnas.0407176101
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    Neural synchrony indexes disordered perception and cognition in schizophrenia

    Kevin M. Spencer, Paul G. Nestor, Ruth Perlmutter, Margaret A. Niznikiewicz, Meredith C. Klump, Melissa Frumin, Martha E. Shenton, and Robert W. McCarley

    PNAS December 7, 2004 101 (49) 17288-17293; https://doi.org/10.1073/pnas.0406074101

• Physiology

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    Targeted disruption of luteinizing hormone β-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility

    Xiaoping Ma, Yanlan Dong, Martin M. Matzuk, and T. Rajendra Kumar

    PNAS December 7, 2004 101 (49) 17294-17299; https://doi.org/10.1073/pnas.0404743101
  • Open Access

    Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs

    Naohisa Tamura, Lynda K. Doolittle, Robert E. Hammer, John M. Shelton, James A. Richardson, and David L. Garbers

    PNAS December 7, 2004 101 (49) 17300-17305; https://doi.org/10.1073/pnas.0407894101

• Plant Biology

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    SRK2C, a SNF1-related protein kinase 2, improves drought tolerance by controlling stress-responsive gene expression in Arabidopsis thaliana

    Taishi Umezawa, Riichiro Yoshida, Kyonoshin Maruyama, Kazuko Yamaguchi-Shinozaki, and Kazuo Shinozaki

    PNAS December 7, 2004 101 (49) 17306-17311; https://doi.org/10.1073/pnas.0407758101

• Psychology

  • Open Access

    Accelerated telomere shortening in response to life stress

    • From the Cover

    Elissa S. Epel, Elizabeth H. Blackburn, Jue Lin, Firdaus S. Dhabhar, Nancy E. Adler, Jason D. Morrow, and Richard M. Cawthon

    PNAS December 7, 2004 101 (49) 17312-17315; https://doi.org/10.1073/pnas.0407162101
  • Open Access

    Social supports and serotonin transporter gene moderate depression in maltreated children

    Joan Kaufman, Bao-Zhu Yang, Heather Douglas-Palumberi, Shadi Houshyar, Deborah Lipschitz, John H. Krystal, and Joel Gelernter

    PNAS December 7, 2004 101 (49) 17316-17321; https://doi.org/10.1073/pnas.0404376101